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中華民國九十六年七月 第十四卷 第三期 1

έ̚ၷᓁᘽੈ!

VGHTC Drug Bulletin

發行人:王丹江 總編輯:陳本源

(04)23592539

編 輯:鄭鴻基、湯念湖、董侑淳、劉媖媚、劉兆鴻

地 址:台中市中港路三段 160 號 藥劑部 毒藥物諮詢中心 網 址:http://www3.vghtc.gov.tw:8082/pharmacy/pharmacy1.htm 電子信箱:[email protected]

創刊日期:八十三年一月二十日

Tigecycline

཭ׇ୳ ᘽर

݈֏!

ᓜԖ˯׍੼ޘԩᘽّෂঀдۤડ̈́ᗁ

ੰ͟႙೼࿆Ă׎̚тvancomycin-resistant Enterococci (VRE) Ă glycopeptides -resistant S. aureus (GRSA)Ă̈́penicillin -resistant S. pneumoniae (PRSP)̏ᚑࢦ ރ ਎ ז ˠ ᙷ ۞ ઉ ૵ ć າ ˘ ΃ ԩ Ϡ ৵ ᚶ linezolid׶ daptomycin̝ ޢ ࡁ ൴ ΍ ֽ ۞ tigecycline (Tygacil® , ҁ܎ឣ৵)Ă၆ࢭᜋ

ͩวّ̈́ࢭᜋͩౚّ௟ෂ࠰ѣԩෂ߿ّĂֹ

଀ᓜԖᗁरдڼᒚ੼ޘԩᘽّෂঀ͔੓۞

ຏߖГᆧ୹˘ีӀጡĄ

үϡ፟ᖼᄃԩෂቑಛ!

Tigecyclineߏдminocycline۞ௐ9࣎

჆Ҝཉΐ˯ N,N-dimethylglycylaminoĂ҃

ԛјБາ۞glycylcycline類ԩϠ৵Ă׎үϡ

፟ᖼౌߏᖣϤᄃ௟ෂ८ᔝវ 30S ඕЪ҃Ժ טకϨኳЪјĂ྿זԺෂड़ڍĄTigecycline

າᆧΐ۞͚ᙥΞᆧૻ၆௟ෂ८ᔝវ 30S ۞ Ꮠ׶力ࡗ྿̣ࢺĂ֭ഴ͌జ௟ෂ۞ᘽۏଵ΍

ᑒ঒χ΍ෂវγĂЯѩ௟ෂ၆ tetracycline

ٙயϠ۞ԩᘽ፟ט(८ᔝវ᜕ܲ̈́ᘽۏଵ΍

ᑒ঒)д tigecycline ҃֏֭൑үϡĄҭѣֱ

௟ෂּтP. aeruginosa, Proteus spp., K.

pneumoniaë́E. coliЯ׍ѣᇴ჌кࢦᘽۏ ଵ΍ᑒ঒Ă఺ֱ̰Ϡّ۞ԩᘽ፟טౌົഴ͌

௟ෂ၆tigecycline۞ຏצޘĄ

Tigecycline ۞ԩෂቑಛܧ૱ᇃھĂϫ

݈۞̂ݭˠវྏរ͹ࢋߏ੫၆ኑᗔّϩቲ

ຏߖᄃኑᗔّཛට̰ຏߖ۞ڼᒚĂЯѩ઼࡚

ࢴݡᄃᘽۏგநԊд2005ѐ6఼͡࿅ϡٺ

఺׌჌ዋᑕাĄѩγtigecycline၆ధк੼ޘ ԩᘽّ۞ෂ჌̪׍ѣ։р۞ୂຏّĂдវγ

ྏរ۞ࡁտ൴ன၆ VRE, PRSP, кࢦԩᘽ

ّᐮ̙ͩજ୛ෂ(A. baumannii), ̈́யϠᇃ ड़ّ̰㈢῔酶ĞESBLğ̂བ୛ෂඈෂ჌̝

າ ᘽ ̬ ௜ !

第 三 期

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第十四卷 第三期 台中榮總藥訊 2

90% ౵ Ҳ Ժ ෂ ፧ ޘ(MIC90) ࠰ ̈ ٺ 4 mcg/mLćҭϡٺڼᒚ఺ֱ௟ෂঀ͔੓۞ຏ

ߖ̪ᑕѣୂຏّྏរඕڍүࠎֶፂĂͽؼܜ ԩϠ৵ᓜԖ˯۞ֹϡѐࢨĄ

ᘽۏજ˧ጯ!

Tigecyclineд ˠ វ ۞ ̶ Ҷ វ ᎕ ޝ ̂ (VdĈ7~9 L/kg)Ăੵ˞੻ᐪ׶໣ᝃ୵γĂਕ ᇃھ̶ҶҌЧ௡ᖐ׶វ୵̚ćᄃҕልకϨኳ ඕЪதࠎ71Ʀ~89%ĂϤٺдҕል̚ഫᗓၗ

۞፧ޘྵҲĂ߇̙ޙᛉϡٺ׀൴ෂҕা۞ঽ ˠĄTigecyclineΪѣ10%ົజք᝙΃ᔁĂ̂

ొ̶ͽࣧݭགྷᓙ྽̈́ᒵ便ଵ΍(59 %)Ă׎ዶ Ϥ尿୵ଵ΍(33 %)ćགྷкѨගᘽޢ̝ଵੵΗ

਽ഇࠎ42.4̈ॡĂдᚑࢦքΑਕצຫ۞ঽˠ

୻ੵதົࢫҲĂΗ਽ഇؼܜ43%Ą

጗ณᄃϡڱ!

јˠ۞ޙᛉ੓ؕ጗量ࠎ100 mgĂ̝ޢ ჯ޺጗量ࠎՏ12̈ॡ50 mgĂᅮϤᐖਔڦड ගᘽĂቤၙႍڦ30~60̶ᛗć়ֶঽᚑࢦ඀

ޘ̙Тͽՙؠֹϡ͇ᇴâਠᒚ඀ࠎ5Ҍ14

͇Ą၆ٺඪΑਕ̙Бٕତצҕ୵౅ژ۞ঽ

ଈ Ă Я ҕ ୵ ౅ ژ ൑ ڱ ொ ੵ ҕ ̚ ۞ tigecyclineĂ߇̙ᅮአፋ጗ณĂҭ၆ٺᚑࢦ քΑਕ̙Б۞ঽଈ݋ืࢫҲჯ޺጗ณࠎՏ 12̈ॡ 25 mgĄ

Tigecycline੨ᄦॡАֹϡ 0.9% saline

ٕ 5% dextrose໘ྋĂ̝ޢГϲӈංᛖҌ 100 ml۞Ꮾڦ୵̚ćѩᏮڦ୵ٺވ໢Ξܲх 6̈ॡăҽᖟ(2~8℃)Ξܲх 24̈ॡĄ ڦຍְี!

Tigecycline۞ᘃθ̶৺ࠎDĂЯѩ༊

ϡٺᘃθ૎̃ॡĂυืАෞҤ၆ࡩ׊Ξਕౄ

ј۞ࢲᐍĄ˫ЯtigecyclineΞਕ̶کҌ֯ϗ

̚Ă૎̃дڼᒚഇม̙ޙᛉࣲ֯Ą

TigecyclineົԺט̈ޅ੻ᐝ۞Ϡܜֹ̈́Ͱ ጎតҒĂ߇不ޙᛉϡٺᘃθ૎女̈́̈ٺˣ໐

۞ޅආĄдᘽۏϹ̢үϡ͞ࢬĂtigecycline

ົֹwarfarin۞୻ੵத˭ࢫĂ༊׌۰׀ϡॡ

ืႾീঽˠ۞጖ҕன෪࠹ᙯ޽ᇾĄ૱見۞不 良ͅᑕ͹ࢋߏࡤབ྽͞ࢬĂΒ߁⪰͕(29.5

%)ăယФ(19.7 %) ̈́ཛᕫ(12.7 %)Ăᚑࢦ

̙։ͅᑕࠎΞਕ͔੓ާّ਍᝙ۆĄ

ણ҂ྤफ़Ĉ!

1. Micromedex® Healthcare Series, 2007

2. Ellis-Grosse EJ, Babinchak T, Dartois N, et al: The efficacy and safety of tigecycline in the treatment of skin and skin-structure infection: Result of 2 double-blind phase 3 comparison studies with vancomycine-azitreonam. Clin Infect Dis 2005; 41:341-53.

3. Babinchak T, Ellis-Grosse EJ, Dartois N, et al: The efficacy and safety of

tigecycline in the treatment of complicated intra-abdominal infections: Analysis of pooled clinical trial data. Clin Infect Dis 2005; 41:354-66.

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第十四卷 第三期 台中榮總藥訊 2

ڦड጗ݭ Quinolone ᙷԩϠ৵ֹϡืۢ!

ᘽर Quinolone ᙷԩϠ৵Ϥٺԩෂᇃھ၆

̂ొЊ۞ࢭᜋͩวّෂᄃౚّෂౌѣԩෂ ड़ڍĂдᓜԖ˯ֹϡ͟႙ᆧкć͍׎ߏڦ ड጗ݭ૱ϡٺڼᒚјˠĞ18໐ͽ˯ğЯຏ

צّ௟ෂ͔੓۞ຏߖাĂּтײӛ྽ຏ

ߖăඪ᝙̈́کԌ྽ຏߖăཛొຏߖă̈́ϩ ቲ׶హ௡ᖐຏߖඈĄ

ϫ݈ώੰֹϡ۞ڦड጗ݭ Quinolone ᙷԩϠ৵Вѣα჌Ğ֍ܢܑğϤٺ఺ᙷᘽ ݡ۞ᆊҜౌޝ੼Ăࠎ˞̙ࢋౄјᘽݡ঎

෱Ăֹϡॡኛڦຍͽ˭ְีĈ

1. Я Quinolone ᙷԩϠ৵۞ڦडᏮڦ୵

࠰ᛳᅕّ (pH: 4~5), ߇඗၆̙Ξͽᄃ

ែّᘽۏ஄ЪĂӎ݋ົயϠՕ፥Ăּ

т Ĉ furosemide inj, NaHCO3 inj, Aminophylline, Heparin ඈĄ

2. ගᘽॡυืଂྵ̂۞ᐖਔቤၙᏮڦ 60

̶ᛗĂࡶଂ 3-WAY ᏮڦĂֽࣧ۞͹Ꮾ ڦ୵υืᇶઃගᘽĄ

3. ఺ᙷᘽݡ၆ЍୂຏĂᇷᜨдҋ൒Ѝቢ˭

ົቤၙ̶ྋĂ߇ืᔖЍ෬хĂֹϡ݈̖

Ξଂ஼̰פ΍ֹϡćͽҺݡኳצຫĄ֭

ͷቁؠࢋගᘽॡГฟ஬ć̙ࢋ࿰Аฟ

஬ćͽҺౄј঎෱Ą

4. ఺ֱ Quinolone ᙷԩϠ৵۞ڦड୵ౌ

ӣѣྵ੼۞ทៃĂ၆ٺࢨטៃ̶ᛷפ۞

ঽˠֹϡॡืপҾ͕̈Ą

ώੰڦड጗ݭQuinolone ᙷԩϠ৵̝ͧྵ

ᘽЩ Ciprofloxacin Ciprofloxacin Levofloxacin Moxifloxacin

થݡЩ Cixa

Ğಈ֝ğ

Ciproxin Ğి౾າğ

Cravit ĞΞሄυԁğ

Avelox Ğރࠃిğ

ዋᑕা

ײӛ྽ຏߖăඪ᝙̈́کԌ྽ຏߖăཛ

ొຏߖăϩቲ׶హ௡ᖐຏߖă੻ᐝ̈́

ᙯ༼ຏߖăୀҕা

ײӛ྽ຏߖăඪ᝙

̈́کԌ྽ຏߖăϩ ቲ׶హ௡ᖐຏߖ

ײӛ྽ຏߖăඪ

᝙̈́کԌ྽ຏ

ߖăཛొຏߖă ϩቲ׶హ௡ᖐຏ

ߖ ј̶ӣณ/ 100 mg/50 ml 200 mg/100 ml 500 mg/100 ml 400 mg/250 ml ทៃӣณ/ 178.3 mg 353.8 mg 354 mg 786 mg

PH 3.9~4.5 3.9~4.5 4.8 4.8

ڦडॡม/ ŵ 30̶ᛗ ŵ 60̶ᛗ ŵ 60̶ᛗ ŵ 60̶ᛗ ᆊॾ(NT$/) 159̮ 995̮ 1462̮ 1059̮ ᄦౄᘽᇄ Ϡ྿ ޵҅ ᄂ៉ௐ˘ˬВ ޵҅

ણ҂ྤफ़Ĉ

1. Trissel’s Handbook on Injectable Drug 14th ed., 2007.

2. ᘽݡϼಏ ϡ ᘽ щ Б !

3

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第十四卷 第三期 台中榮總藥訊 4

96 ѐ 4-6 ͡າ˯ቢᘽݡ!

ᆒЏᕃ ᘽर

ีѨ ˯ቢ͟ഇ າᘽᘽЩ ᄦౄᇄ ᘽቅ ઉܲᆊ ᄲځ

1 96.05.09 Tygacil inj 50 mg

(Tigecycline) ೎ͩ BT320 1,754.00

ዋᑕাĈ၆ Tigecycline ׍ѣ

ຏצّ̝௟ෂ͔ٙ੓̝ኑᗔ

ّϩቲ̈́ϩቲඕၹຏߖٕኑ ᗔّཛට̰ຏߖাĄ

2 96.05.11 Seroquel tab 200 mg (Quetiapine)

ܠ೻প

ଥӀ૵ AQ010 65.00 ዋᑕাĈჟৠ̶ෘাĂᗕໂّ

়ଈ̝ᛒা൴үĄ

3 96.05.11 Seroquel tab 25 mg (Quetiapine)

ܠ೻প

ଥӀ૵ AQ020 20.40 ዋᑕাĈჟৠ̶ෘাĂᗕໂّ

়ଈ̝ᛒা൴үĄ

4 96.05.25

Harnalidge D tab 0.2 mg

(Tamsulosine HCl)

щ೻঍ֽ BT300 22.10 ዋᑕাĈ݈Еཛྷ۲̂া(ᆧϠ)

ٙҡᐌ۞ଵԌᅪᘣĄ

5 96.05.25 U-Save cap 250 mg

(Cephradine) ᐹ։ BC370 4.14

ዋᑕাĈཬ෈஧ෂăᙥ஧ෂă ۱ۆᗕ஧ෂăཝቯۆ஧ෂ̈́׎

΁׍ѣຏצّ௟ෂ͔੓̝ຏ

ߖা

ᘽ ݡ ள જ !

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