DDRG Publications - University of Sharjah

DDRG Publications

2022

1. [N.N. Shahin, R.N. Shamma, I.S. Ahmed, A Nano-Liposomal Formulation of Caffeic Acid Phenethyl Ester Modulates Nrf2 and NF-κβ Signaling and Alleviates Experimentally Induced Acute

Pancreatitis in a Rat Model, Antioxidants. 11 (2022) 1536.

https://doi.org/10.3390/antiox11081536.

2. M. Pandey, N. Jain, J. Kanoujia, Z. Hussain, B. Gorain, Advances and Challenges in Intranasal Delivery of Antipsychotic Agents Targeting the Central Nervous System, Front. Pharmacol. 13 (2022). https://doi.org/10.3389/fphar.2022.865590.

3. N. Batool, R.M. Sarfraz, A. Mahmood, N. Zafar, M.U. Minhas, Z. Hussain, U. Rehman, Biocompatible polymeric blend for pH driven delivery of cytarabine: Effect of feed contents on swelling and release kinetics, J. Biomed. Mater. Res. - Part B Appl. Biomater. 110 (2022) 1545–

1562. https://doi.org/10.1002/jbm.b.35016.

4. U. Ijaz, M. Sohail, M.U. Minhas, S. Khan, Z. Hussain, M. Kazi, S.A. Shah, A. Mahmood, M.

Maniruzzaman, Biofunctional Hyaluronic Acid/κ-Carrageenan Injectable Hydrogels for Improved Drug Delivery and Wound Healing, Polymers (Basel). 14 (2022).

https://doi.org/10.3390/polym14030376.

5. Z. Hussain, H.E. Thu, M. Rawas-Qalaji, M.C.I. Mohd Amin, S. Khan, M. Sohail, R.M. Sarfraz, Curcumin-based strategies in wound healing and skin tissue regeneration, 2022.

https://doi.org/10.1016/b978-0-323-90514-5.00001-8.

6. N.N. Al-Rawi, M. Rawas-Qalaji, Dissolving microneedles with antibacterial functionalities: A systematic review of laboratory studies, Eur. J. Pharm. Sci. 174 (2022).

https://doi.org/10.1016/j.ejps.2022.106202.

7. B.Q. Saeed, M.R. Qalaji, N. Akbar, R. Siddiqui, C. Roberta, S. Manzoor, J.S. Muhammad, A.O.

Adrees, R. Al-Shahrabi, N.A. Khan, Evaluation of nanoparticles with 5-fluorouracil and chloroquine on Acanthamoeba castellanii activity, Mol. Biochem. Parasitol. 250 (2022).

https://doi.org/10.1016/j.molbiopara.2022.111492.

8. N. Zafar, M. Akhlaq, A. Mahmood, H. Ijaz, R.M. Sarfraz, Z. Hussain, Z. Masood, Facile synthesis and in vitro evaluation of semi-interpenetrating polymeric network, Polym. Bull. (2022).

https://doi.org/10.1007/s00289-022-04168-4.

9. Z. Hussain, M. Pandey, H.E. Thu, T. Kaur, G.W. Jia, P.C. Ying, T.M. Xian, M.A.S. Abourehab, Hyaluronic acid functionalization improves dermal targeting of polymeric nanoparticles for management of burn wounds: In vitro, ex vivo and in vivo evaluations, Biomed. Pharmacother.

150 (2022). https://doi.org/10.1016/j.biopha.2022.112992.

10. M. Haider, A. Elsherbeny, V. Pittalà, V. Consoli, M.A. Alghamdi, Z. Hussain, G. Khoder, K. Greish, Nanomedicine Strategies for Management of Drug Resistance in Lung Cancer, Int. J. Mol. Sci. 23 (2022). https://doi.org/10.3390/ijms23031853.

11. M.B. Najm, M. Rawas-Qalaji, N.H. Assar, R. Yahia, R. El Hosary, I.S. Ahmed, Optimization, characterization and in vivo evaluation of mupirocin nanocrystals for topical administration, Eur.

J. Pharm. Sci. 176 (2022). https://doi.org/10.1016/j.ejps.2022.106251.

12. R.B. Al-Humaidi, B. Fayed, S.B. Shakartalla, J. Jagal, M.N. Jayakumar, Z.M. Al Shareef, S.I. Sharif, A.

Noreddin, M.H. Semreen, H.M. Omar, M. Haider, S.S.M. Soliman, Optimum inhibition of MCF-7 breast cancer cells by efficient targeting of the macropinocytosis using optimized paclitaxel- loaded nanoparticles, Life Sci. 305 (2022). https://doi.org/10.1016/j.lfs.2022.120778.

13. L. Al Ali, J. Jagal, J. Joseph, I.S. Ahmed, M. Rawas-Qalaji, Pharmaceutical equivalency of locally and regionally manufactured generic pharmaceutical products in UAE, Saudi Pharm. J. (2022).

https://doi.org/10.1016/j.jsps.2022.06.027.

14. M. Haider, K.Z. Zaki, M.R. El Hamshary, Z. Hussain, G. Orive, H.O. Ibrahim, Polymeric nanocarriers:

A promising tool for early diagnosis and efficient treatment of colorectal cancer, J. Adv. Res. 39 (2022) 237–255. https://doi.org/10.1016/j.jare.2021.11.008.

15. Z. Hussain, H.E. Thu, M. Rawas-Qalaji, M. Naseem, S. Khan, M. Sohail, Recent developments and advanced strategies for promoting burn wound healing, J. Drug Deliv. Sci. Technol. 68 (2022).

https://doi.org/10.1016/j.jddst.2022.103092.

16. T. Khaliq, M. Sohail, M.U. Minhas, S. Ahmed Shah, N. Jabeen, S. Khan, Z. Hussain, A. Mahmood, M. Kousar, H. Rashid, Self-crosslinked chitosan/κ-carrageenan-based biomimetic membranes to combat diabetic burn wound infections, Int. J. Biol. Macromol. 197 (2022) 157–168.

https://doi.org/10.1016/j.ijbiomac.2021.12.100.

17. S. Hanif, R.M. Sarfraz, M.A. Syed, A. Mahmood, Z. Hussain, Smart mucoadhesive buccal chitosan/

HPMC scaffold for sore throat: In vitro, ex vivo and pharmacokinetic profiling in humans, J. Drug Deliv. Sci. Technol. 71 (2022) 103271. https://doi.org/10.1016/j.jddst.2022.103271.

18. R. Al homsi, S. Eltahir, J. Jagal, M. Ali Abdelkareem, M.M. Ghoneim, M.M. Rawas-Qalaji, K. Greish, M. Haider, Thermosensitive injectable graphene oxide/chitosan-based nanocomposite hydrogels for controlling the in vivo release of bupivacaine hydrochloride, Int. J. Pharm. 621 (2022).

https://doi.org/10.1016/j.ijpharm.2022.121786.

2021

1. S.M. Shah, H.O. Alsaab, M.M. Rawas-Qalaji, M.N. Uddin, A review on current covid-19 vaccines and evaluation of particulate vaccine delivery systems, Vaccines. 9 (2021).

https://doi.org/10.3390/vaccines9101086.

2. M. Rawas-Qalaji, R. Bafail, R. Cagliani, M. Haider, Z. Hussain, Assessment of epinephrine sublingual stability and permeability pathways to enhance its permeability for the treatment of anaphylaxis, Eur. J. Pharm. Sci. 167 (2021). https://doi.org/10.1016/j.ejps.2021.106025.

3. M. Shafique, M. Sohail, M.U. Minhas, T. Khaliq, M. Kousar, S. Khan, Z. Hussain, A. Mahmood, M.

Abbasi, H.C. Aziz, S.A. Shah, Bio-functional hydrogel membranes loaded with chitosan nanoparticles for accelerated wound healing, Int. J. Biol. Macromol. 170 (2021) 207–221.

https://doi.org/10.1016/j.ijbiomac.2020.12.157.

4. Z. Hussain, M.A. Rahim, N. Jan, H. Shah, M. Rawas-Qalaji, S. Khan, M. Sohail, H.E. Thu, N.A. Ramli, R.M. Sarfraz, M.A.S. Abourehab, Cell membrane cloaked nanomedicines for bio-imaging and immunotherapy of cancer: Improved pharmacokinetics, cell internalization and anticancer efficacy, J. Control. Release. 335 (2021) 130–157. https://doi.org/10.1016/j.jconrel.2021.05.018.

5. S.A. Shah, M. Sohail, M.U. Minhas, S. Khan, Z. Hussain, A. Mahmood, M. Kousar, H.E. Thu, M.

Abbasi, M. ur R. Kashif, Curcumin-laden hyaluronic acid-co-Pullulan-based biomaterials as a potential platform to synergistically enhance the diabetic wound repair, Int. J. Biol. Macromol.

185 (2021) 350–368. https://doi.org/10.1016/j.ijbiomac.2021.06.119.

6. S.M. Hassan Shah, S.M. Mukarram Shah, S. Khan, F. Ullah, S.W. Ali Shah, M. Ghias, M. Shahid, H.D.

Smyth, Z. Hussain, M. Sohail, A. Elhissi, M. Isreb, Efficient design to fabricate smart Lumefantrine nanocrystals using DENA® particle engineering technology: Characterisation, in vitro and in vivo antimalarial evaluation and assessment of acute and sub-acute toxicity, J. Drug Deliv. Sci. Technol.

61 (2021). https://doi.org/10.1016/j.jddst.2020.102228.

7. F. Bahman, V. Pittalà, M. Haider, K. Greish, Enhanced anticancer activity of nanoformulation of dasatinib against triple-negative breast cancer, J. Pers. Med. 11 (2021).

https://doi.org/10.3390/jpm11060559.

8. S. Bashir, M. Aamir, R.M. Sarfaraz, Z. Hussain, M.U. Sarwer, A. Mahmood, M.R. Akram, M.N.

Qaisar, Fabrication, characterization and in vitro release kinetics of tofacitinib-encapsulated polymeric nanoparticles: a promising implication in the treatment of rheumatoid arthritis, Int. J.

Polym. Mater. Polym. Biomater. 70 (2021) 449–458.

https://doi.org/10.1080/00914037.2020.1725760.

9. N. Batool, A. Mahmood, R.M. Sarfraz, H. Ijaz, N. Zafar, Z. Hussain, Formulation and evaluation of interpenetrating polymeric network for controlled drug delivery, Drug Dev. Ind. Pharm. 47 (2021) 931–946. https://doi.org/10.1080/03639045.2021.1954939.

10. Z. Hussain, D. Jamal Ahmed, R. Mohammed Alkabra, H.E. Thu, S. Khan, M. Sohail, R.M. Sarfraz, N.A. Ramli, Hyaluronic acid based nanomedicines as promising wound healers for acute-to- chronic wounds: a review of recent updates and emerging trends, Int. J. Polym. Mater. Polym.

Biomater. (2021). https://doi.org/10.1080/00914037.2021.2006655.

11. M. Haider, I. Elsayed, I.S. Ahmed, A.R. Fares, In situ-forming microparticles for controlled release of rivastigmine: In vitro optimization and in vivo evaluation, Pharmaceuticals. 14 (2021) 1–21.

https://doi.org/10.3390/ph14010066.

12. M. Rawas-Qalaji, R. Bafail, I.S. Ahmed, M.N. Uddin, S. Nazzal, Modulation of the sublingual microenvironment and pH-dependent transport pathways to enhance atropine sulfate permeability for the treatment of organophosphates poisoning, Int. J. Pharm. 606 (2021).

https://doi.org/10.1016/j.ijpharm.2021.120898.

13. L.A.A. Moti, Z. Hussain, H.E. Thu, S. Khan, M. Sohail, R.M. Sarfraz, Multi-functionalization, a Promising Adaptation to Overcome Challenges to Clinical Translation of Nanomedicines as Nano- diagnostics and Nano-therapeutics for Breast Cancer, Curr. Pharm. Des. 27 (2021) 4356–4375.

https://doi.org/10.2174/1381612827666210830092539.

14. W. Chen, L. Jiang, Y. Hu, G. Fang, B. Yang, J. Li, N. Liang, L. Wu, Z. Hussain, Nanomedicines, an emerging therapeutic regimen for treatment of ischemic cerebral stroke: A review, J. Control.

Release. 340 (2021) 342–360. https://doi.org/10.1016/j.jconrel.2021.10.020.

15. Z. Hussain, Nanotechnology guided newer intervention for treatment of osteoporosis: efficient bone regeneration by up-regulation of proliferation, differentiation and mineralization of osteoblasts, Int. J. Polym. Mater. Polym. Biomater. 70 (2021) 1–13.

https://doi.org/10.1080/00914037.2019.1683558.

16. M.A. Khan, S. Khan, M. Kazi, S.M. Alshehri, M. Shahid, S.U. Khan, Z. Hussain, M. Sohail, M.

Shafique, H.A. Hamid, M. Kamran, A. Elhissi, M. Wasim, H.E. Thu, Norfloxacin loaded lipid polymer hybrid nanoparticles for oral administration: Fabrication, characterization, in silico modelling and toxicity evaluation, Pharmaceutics. 13 (2021). https://doi.org/10.3390/pharmaceutics13101632.

17. H.A. Hamid, S. Khan, S.M.N. Shah, M. Asghar, M. Shahid, Z. Hussain, M. Sohail, B.A. Khan, F. Amin, S.U. Jan, A. Elhissi, S.M.H. Shah, M.U. Minhas, S.W.A. Shah, N. Ahmad, Piroxicam loaded polymer hybrid microspheres based tablets with modified release kinetics: Development, characterization and in vivo evaluation, Pak. J. Pharm. Sci. 34 (2021) 327–335.

https://doi.org/10.36721/PJPS.2021.34.1.SUP.327-335.1.

18. M.A. Rahim, N. Jan, S. Khan, H. Shah, A. Madni, A. Khan, A. Jabar, S. Khan, A. Elhissi, Z. Hussain, H.C. Aziz, M. Sohail, M. Khan, H.E. Thu, Recent advancements in stimuli responsive drug delivery platforms for active and passive cancer targeting, Cancers (Basel). 13 (2021) 1–52.

https://doi.org/10.3390/cancers13040670.

19. U. Rehman, R.M. Sarfraz, A. Mahmood, Z. Hussain, H.E. Thu, N. Zafar, M.U. Ashraf, N. Batool, Smart pH-responsive Co-polymeric Hydrogels for Controlled Delivery of Capecitabine: Fabrication, Optimization and In Vivo Toxicology Screening, Curr. Drug Deliv. 18 (2021) 1256–1271.

https://doi.org/10.2174/1567201818666210212085912.

20. M. Haider, A. Elsherbeny, V. Pittalà, A.N. Fallica, M.A. Alghamdi, K. Greish, The potential role of sildenafil in cancer management through epr augmentation, J. Pers. Med. 11 (2021).

https://doi.org/10.3390/jpm11060585.

21. N.S. Awad, M. Haider, V. Paul, N.M. Alsawaftah, J. Jagal, R. Pasricha, G.A. Husseini, Ultrasound- triggered liposomes encapsulating quantum dots as safe fluorescent markers for colorectal cancer, Pharmaceutics. 13 (2021). https://doi.org/10.3390/pharmaceutics13122073.

2020

1. Z. Hussain, H.E. Thu, M. Haider, S. Khan, M. Sohail, F. Hussain, F.M. Khan, M.A. Farooq, A.N. Shuid, A review of imperative concerns against clinical translation of nanomaterials: Unwanted biological interactions of nanomaterials cause serious nanotoxicity, J. Drug Deliv. Sci. Technol. 59 (2020) 101867. https://doi.org/10.1016/j.jddst.2020.101867.

2. A.R. Abbasi, M. Sohail, M.U. Minhas, T. Khaliq, M. Kousar, S. Khan, Z. Hussain, A. Munir, Bioinspired sodium alginate based thermosensitive hydrogel membranes for accelerated wound

healing, Int. J. Biol. Macromol. 155 (2020) 751–765.

https://doi.org/10.1016/j.ijbiomac.2020.03.248.

3. S.S.M. Soliman, T.B. Alhamidi, S. Abdin, A.M. Almehdi, M.H. Semreen, R.B. Alhumaidi, S.B.

Shakartalla, M. Haider, M.I. Husseiny, H.A. Omar, Effective targeting of breast cancer cells (MCF7) via novel biogenic synthesis of gold nanoparticles using cancer-derived metabolites, PLoS One. 15 (2020). https://doi.org/10.1371/journal.pone.0240156.

4. H.A. Hameed, S. Khan, M. Shahid, R. Ullah, A. Bari, S.S. Ali, Z. Hussain, M. Sohail, S.U. Khan, T.T.

Htar, Engineering of naproxen loaded polymer hybrid enteric microspheres for modified release tablets: Development, characterization, in silico modelling and in vivo evaluation, Drug Des. Devel.

Ther. 14 (2020) 27–41. https://doi.org/10.2147/DDDT.S232111.

5. R. Hamdy, B. Fayed, A.M. Hamoda, M. Rawas-Qalaji, M. Haider, S.S.M. Soliman, Essential oil-based design and development of novel anti-Candida azoles formulation, Molecules. 25 (2020).

https://doi.org/10.3390/molecules25061463.

6. M.A. Zia, M. Sohail, M.U. Minhas, R.M. Sarfraz, S. Khan, M. de Matas, Z. Hussain, M. Abbasi, S.A.

Shah, M. Kousar, N. Ahmad, HEMA based pH-sensitive semi IPN microgels for oral delivery; a rationale approach for ketoprofen, Drug Dev. Ind. Pharm. 46 (2020) 272–282.

https://doi.org/10.1080/03639045.2020.1716378.

7. M.M. Abd-Rabo, L.F. Wahman, R. El Hosary, I.S. Ahmed, High-fat diet induced alteration in lipid enzymes and inflammation in cardiac and brain tissues: Assessment of the effects of Atorvastatin- loaded nanoparticles, J. Biochem. Mol. Toxicol. 34 (2020). https://doi.org/10.1002/jbt.22465.

8. Z. Hussain, M. Pandey, H. Choudhury, P.C. Ying, T.M. Xian, T. Kaur, G.W. Jia, B. Gorain, Hyaluronic acid functionalized nanoparticles for simultaneous delivery of curcumin and resveratrol for management of chronic diabetic wounds: Fabrication, characterization, stability and in vitro

release kinetics, J. Drug Deliv. Sci. Technol. 57 (2020).

https://doi.org/10.1016/j.jddst.2020.101747.

9. N.N. Al-Rawi, B.A. Anwer, N.H. Al-Rawi, A.T. Uthman, I.S. Ahmed, Magnetism in drug delivery: The marvels of iron oxides and substituted ferrites nanoparticles, Saudi Pharm. J. 28 (2020) 876–887.

https://doi.org/10.1016/j.jsps.2020.05.003.

10. I.S. Ahmed, O.S. Elnahas, N.H. Assar, A.M. Gad, R. El Hosary, Nanocrystals of fusidic acid for dual enhancement of dermal delivery and antibacterial activity: In vitro, ex vivo and in vivo evaluation, Pharmaceutics. 12 (2020). https://doi.org/10.3390/pharmaceutics12030199.

11. I.S. Ahmed, H.M. Rashed, H. Fayez, F. Farouk, R.N. Shamma, Nanoparticle-mediated dual targeting: An approach for enhanced baicalin delivery to the liver, Pharmaceutics. 12 (2020).

https://doi.org/10.3390/pharmaceutics12020107.

12. W. Talaat, A.C. Smriti Aryal, S. Al Kawas, A.B.R. Samsudin, N.G. Kandile, D.R.K. Harding, M.M.

Ghoneim, W. Zeiada, J. Jagal, A. Aboelnaga, M. Haider, Nanoscale thermosensitive hydrogel scaffolds promote the chondrogenic differentiation of dental pulp stem and progenitor cells: A minimally invasive approach for cartilage regeneration, Int. J. Nanomedicine. 15 (2020) 7775–

7789. https://doi.org/10.2147/IJN.S274418.

13. Z. Hussain, H.E. Thu, I. Elsayed, M.A.S. Abourehab, S. Khan, M. Sohail, R.M. Sarfraz, M.A. Farooq, Nano-scaled materials may induce severe neurotoxicity upon chronic exposure to brain tissues: A critical appraisal and recent updates on predisposing factors, underlying mechanism, and future

prospects, J. Control. Release. 328 (2020) 873–894.

https://doi.org/10.1016/j.jconrel.2020.10.053.

14. M. Haider, S.M. Abdin, L. Kamal, G. Orive, Nanostructured lipid carriers for delivery of chemotherapeutics: A review, 2020. https://doi.org/10.3390/pharmaceutics12030288.

15. M. Haider, A. Elsherbeny, J. Jagal, A. Hubatová-Vacková, I.S. Ahmed, Optimization and evaluation of poly(Lactide-co-glycolide) nanoparticles for enhanced cellular uptake and efficacy of paclitaxel in the treatment of head and neck cancer, Pharmaceutics. 12 (2020) 1–22.

https://doi.org/10.3390/pharmaceutics12090828.

16. M. Alozi, M. Rawas-Qalaji, Treating organophosphates poisoning: management challenges and potential solutions, Crit. Rev. Toxicol. 50 (2020) 764–779.

https://doi.org/10.1080/10408444.2020.1837069.

2019

1. C. Yamada, C. Beron-Pelusso, N. Algazzaz, A. Heidari, D. Luz, M. Rawas-Qalaji, I. Toderas, A.K.

Mascarenhas, T. Kawai, A. Movila, Age-dependent effect between MARCO and TLR4 on PMMA particle phagocytosis by macrophages, J. Cell. Mol. Med. 23 (2019) 5827–5831.

https://doi.org/10.1111/jcmm.14494.

2. S.A. Shah, M. Sohail, S. Khan, M.U. Minhas, M. de Matas, V. Sikstone, Z. Hussain, M. Abbasi, M.

Kousar, Biopolymer-based biomaterials for accelerated diabetic wound healing: A critical review, Int. J. Biol. Macromol. 139 (2019) 975–993. https://doi.org/10.1016/j.ijbiomac.2019.08.007.

3. U. Ahmad, M. Sohail, M. Ahmad, M.U. Minhas, S. Khan, Z. Hussain, M. Kousar, S. Mohsin, M.

Abbasi, S.A. Shah, H. Rashid, Chitosan based thermosensitive injectable hydrogels for controlled delivery of loxoprofen: development, characterization and in-vivo evaluation, Int. J. Biol.

Macromol. 129 (2019) 233–245. https://doi.org/10.1016/j.ijbiomac.2019.02.031.

4. I.S. Ahmed, R. El-Hosary, M. Hassan, M. Haider, M.M. Abd-Rabo, Correction to: Efficacy and safety profiles of oral atorvastatin-loaded nanoparticles: Effect of size modulation on biodistribution (Molecular Pharmaceutics (2018) 15: 11 (247-255) DOI: 10.1021/acs.molpharmaceut.7b00856), Mol. Pharm. 16 (2019) 468. https://doi.org/10.1021/acs.molpharmaceut.8b01025.

5. S.T. Ndlovu, N. Ullah, S. Khan, P. Ramharack, M. Soliman, M. de Matas, M. Shahid, M. Sohail, M.

Imran, S.W.A. Shah, Z. Hussain, Domperidone nanocrystals with boosted oral bioavailability:

fabrication, evaluation and molecular insight into the polymer-domperidone nanocrystal interaction, Drug Deliv. Transl. Res. 9 (2019) 284–297. https://doi.org/10.1007/s13346-018- 00596-w.

6. A. Aodah, M. Rawas-Qalaji, R. Bafail, M. Rawas-Qalaji, Effect of Fast-Disintegrating Tablets’

Characteristics on the Sublingual Permeability of Atropine Sulfate for the Potential Treatment of Organophosphates Toxicity, AAPS PharmSciTech. 20 (2019). https://doi.org/10.1208/s12249- 019-1420-1.

7. R. Bafail, M. Rawas-Qalaji, M. Rawas-Qalaji, A. Aodah, Effect of the filler grade on the characteristics and the sublingual permeability of atropine sulfate fast disintegrating sublingual

tablets, Drug Dev. Ind. Pharm. 45 (2019) 1617–1623.

https://doi.org/10.1080/03639045.2019.1648499.

8. L. Zakaria, T.W. Wong, N.K. Anuar, I. Naharudin, M. Tripathy, R. Sheshala, Z. Hussain, Enhancing sustained drug release property of chitosan in spheroids through crosslinking reaction and

coacervation, Powder Technol. 354 (2019) 815–821.

https://doi.org/10.1016/j.powtec.2019.07.006.

9. H.E. Thu, Z. Hussain, I.N. Mohamed, A.N. Shuid, Eurycoma longifolia, a promising suppressor of RANKL-induced differentiation and activation of osteoclasts: An in vitro mechanistic evaluation, J.

Ayurveda Integr. Med. 10 (2019) 102–110. https://doi.org/10.1016/j.jaim.2017.07.014.

10. M. Pandey, H. Choudhury, T.A.P. Gunasegaran, S.S. Nathan, S. Md, B. Gorain, M. Tripathy, Z.

Hussain, Hyaluronic acid-modified betamethasone encapsulated polymeric nanoparticles:

fabrication, characterisation, in vitro release kinetics, and dermal targeting, Drug Deliv. Transl.

Res. 9 (2019) 520–533. https://doi.org/10.1007/s13346-018-0480-1.

11. Z. Hussain, H.E. Thu, M. Sohail, S. Khan, Hybridization and functionalization with biological macromolecules synergistically improve biomedical efficacy of silver nanoparticles:

Reconceptualization of in-vitro, in-vivo and clinical studies, J. Drug Deliv. Sci. Technol. 54 (2019).

https://doi.org/10.1016/j.jddst.2019.101169.

12. S. Md, J.K.A. Kuldeep Singh, M. Waqas, M. Pandey, H. Choudhury, H. Habib, F. Hussain, Z. Hussain, Nanoencapsulation of betamethasone valerate using high pressure homogenization–solvent evaporation technique: optimization of formulation and process parameters for efficient dermal

targeting, Drug Dev. Ind. Pharm. 45 (2019) 323–332.

https://doi.org/10.1080/03639045.2018.1542704.

13. G. Fang, Q. Zhang, Y. Pang, H.E. Thu, Z. Hussain, Nanomedicines for improved targetability to inflamed synovium for treatment of rheumatoid arthritis: Multi-functionalization as an emerging strategy to optimize therapeutic efficacy, J. Control. Release. 303 (2019) 181–208.

https://doi.org/10.1016/j.jconrel.2019.04.027.

14. M. Sohail, Mudassir, M.U. Minhas, S. Khan, Z. Hussain, M. de Matas, S.A. Shah, S. Khan, M. Kousar, K. Ullah, Natural and synthetic polymer-based smart biomaterials for management of ulcerative colitis: a review of recent developments and future prospects, Drug Deliv. Transl. Res. 9 (2019) 595–614. https://doi.org/10.1007/s13346-018-0512-x.

15. M. Abbasi, M. Sohail, M.U. Minhas, S. Khan, Z. Hussain, A. Mahmood, S.A. Shah, M. Kousar, Novel biodegradable pH-sensitive hydrogels: An efficient controlled release system to manage ulcerative colitis, Int. J. Biol. Macromol. 136 (2019) 83–96.

https://doi.org/10.1016/j.ijbiomac.2019.06.046.

16. Z. Hussain, S. Khan, M. Imran, M. Sohail, S.W.A. Shah, M. de Matas, PEGylation: a promising strategy to overcome challenges to cancer-targeted nanomedicines: a review of challenges to clinical transition and promising resolution, Drug Deliv. Transl. Res. (2019).

https://doi.org/10.1007/s13346-019-00631-4.

17. S.A. Shah, M. Sohail, M.U. Minhas, Nisar-ur-Rehman, S. Khan, Z. Hussain, Mudassir, A. Mahmood, M. Kousar, A. Mahmood, pH-responsive CAP-co-poly(methacrylic acid)-based hydrogel as an efficient platform for controlled gastrointestinal delivery: fabrication, characterization, in vitro and in vivo toxicity evaluation, Drug Deliv. Transl. Res. 9 (2019) 555–577.

https://doi.org/10.1007/s13346-018-0486-8.

18. N.S. Ayumi, S. Sahudin, Z. Hussain, M. Hussain, N.H.A. Samah, Polymeric nanoparticles for topical delivery of alpha and beta arbutin: preparation and characterization, Drug Deliv. Transl. Res. 9 (2019) 482–496. https://doi.org/10.1007/s13346-018-0508-6.

19. M.W. Chik, Z. Hussain, M. Zulkefeli, M. Tripathy, S. Kumar, A.B.A. Majeed, K. Byrappa, Polymer- wrapped single-walled carbon nanotubes: a transformation toward better applications in healthcare, Drug Deliv. Transl. Res. 9 (2019) 578–594. https://doi.org/10.1007/s13346-018-0505- 9.

20. L. Zhang, Z. Hussain, Z. Ren, Recent Advances in Rational Diagnosis and Treatment of Normal Pressure Hydrocephalus: A Critical Appraisal on Novel Diagnostic, Therapy Monitoring and Treatment Modalities, Curr. Drug Targets. 20 (2019) 1041–1057.

https://doi.org/10.2174/1389450120666190214121342.

21. M.A. Farooq, M. Aquib, D.H. Khan, Z. Hussain, A. Ahsan, M.M.F.A. Baig, D.P. Wande, M.M. Ahmad, H.M. Ahsan, J. Jiajie, B. Wang, Recent advances in the delivery of disulfiram: a critical analysis of promising approaches to improve its pharmacokinetic profile and anticancer efficacy, DARU, J.

Pharm. Sci. 27 (2019) 853–862. https://doi.org/10.1007/s40199-019-00308-w.

22. Z. Hussain, M.A.S. Abourehab, S. Khan, H.E. Thu, Silver nanoparticles: A promising nanoplatform for targeted delivery of therapeutics and optimized therapeutic efficacy, 2019.

https://doi.org/10.1016/B978-0-12-816960-5.00009-4.

23. C. Yousry, I.S. Ahmed, M.M. Amin, O.N.E. Gazayerly, Superhydrophobic substrates for ultrahigh encapsulation of hydrophilic drug into controlled- release polyelectrolyte complex beads:

Statistical optimization and in vivo evaluation, Pharmaceutics. 11 (2019).

https://doi.org/10.3390/pharmaceutics11060257.

24. S.N.A. Bukhari, F. Hussain, H.E. Thu, Z. Hussain, Synergistic effects of combined therapy of curcumin and Fructus Ligustri Lucidi for treatment of osteoporosis: cellular and molecular evidence of enhanced bone formation, J. Integr. Med. 17 (2019) 38–45.

https://doi.org/10.1016/j.joim.2018.08.003.

2018

1. F. Amin, S. Khan, S.M.H. Shah, H. Rahim, Z. Hussain, M. Sohail, R. Ullah, M.S. Alsaid, A.A. Shahat, A new strategy for taste masking of azithromycin antibiotic: Development, characterization, and evaluation of azithromycin titanium nanohybrid for masking of bitter taste using physisorption and panel testing studies, Drug Des. Devel. Ther. 12 (2018) 3855–3866.

https://doi.org/10.2147/DDDT.S183534.

2. B. Gorain, H. Choudhury, M. Pandey, P. Kesharwani, M.M. Abeer, R.K. Tekade, Z. Hussain, Carbon nanotube scaffolds as emerging nanoplatform for myocardial tissue regeneration: A review of recent developments and therapeutic implications, Biomed. Pharmacother. 104 (2018) 496–508.

https://doi.org/10.1016/j.biopha.2018.05.066.

3. S. Khan, M. Imran, T.T. Butt, S.W. Ali Shah, M. Sohail, A. Malik, S. Das, H.E. Thu, A. Adam, Z.

Hussain, Curcumin based nanomedicines as efficient nanoplatform for treatment of cancer: New developments in reversing cancer drug resistance, rapid internalization, and improved anticancer efficacy, Trends Food Sci. Technol. 80 (2018) 8–22. https://doi.org/10.1016/j.tifs.2018.07.026.

4. G. Li, P. Li, Q. Chen, H.E. Thu, Z. Hussain, Current Updates on Bone Grafting Biomaterials and Recombinant Human Growth Factors Implanted Biotherapy for Spinal Fusion: A Review of Human

Clinical Studies, Curr. Drug Deliv. 16 (2018) 94–110.

https://doi.org/10.2174/1567201815666181024142354.

5. J. Dong, L. Tao, M.A.S. Abourehab, Z. Hussain, Design and development of novel hyaluronate- modified nanoparticles for combo-delivery of curcumin and alendronate: fabrication, characterization, and cellular and molecular evidences of enhanced bone regeneration, Int. J. Biol.

Macromol. 116 (2018) 1268–1281. https://doi.org/10.1016/j.ijbiomac.2018.05.116.

6. I.S. Ahmed, R. El Hosary, M.A. Hassan, M. Haider, M.M. Abd-Rabo, Efficacy and Safety Profiles of Oral Atorvastatin-Loaded Nanoparticles: Effect of Size Modulation on Biodistribution, Mol. Pharm.

15 (2018) 247–255. https://doi.org/10.1021/acs.molpharmaceut.7b00856.

7. O. Rachid, M. Rawas-Qalaji, K.J. Simons, Epinephrine in anaphylaxis: Preclinical study of pharmacokinetics after sublingual administration of taste-masked tablets for potential pediatric use, Pharmaceutics. 10 (2018). https://doi.org/10.3390/pharmaceutics10010024.

8. S. Ahmed, T. Govender, I. Khan, N. ur Rehman, W. Ali, S.M.H. Shah, S. Khan, Z. Hussain, R. Ullah, M.S. Alsaid, Experimental and molecular modeling approach to optimize suitable polymers for fabrication of stable fluticasone nanoparticles with enhanced dissolution and antimicrobial activity, Drug Des. Devel. Ther. 12 (2018) 255–269. https://doi.org/10.2147/DDDT.S148912.

9. H. Thu, Z. Hussain, I. Mohamed, A. Shuid, Exploring dynamic biomedical algorithm of Eurycoma longifolia Jack and its bioactive phytochemicals: A review of pharmacokinetic and pharmacodynamic implications and future prospects, Asian Pac. J. Trop. Med. 11 (2018) 89–97.

https://doi.org/10.4103/1995-7645.225015.

10. H.E. Thu, I.N. Mohamed, Z. Hussain, A.N. Shuid, Exploring molecular mechanism of bone-forming capacity of Eurycoma longifolia: Evidence of enhanced expression of bone-related biomarkers, J.

Ayurveda Integr. Med. 9 (2018) 272–280. https://doi.org/10.1016/j.jaim.2017.04.005.

11. F. Hussain, A. Malik, M. Qureshi, M. Imran, S. Waquar, H. Shafique, Z. Rana, H. Thu, Z. Hussain, Homeostatic relevance of Vitamin D in maintaining male fertility in human: Down-regulation of oxidative stress and up-regulation of anti-oxidative defense and steroidal hormones, Asian Pacific J. Reprod. 7 (2018) 56–61. https://doi.org/10.4103/2305-0500.228014.

12. F. Zhuo, M.A.S. Abourehab, Z. Hussain, Hyaluronic acid decorated tacrolimus-loaded nanoparticles: Efficient approach to maximize dermal targeting and anti-dermatitis efficacy, Carbohydr. Polym. 197 (2018) 478–489. https://doi.org/10.1016/j.carbpol.2018.06.023.

13. S.N.A. Bukhari, N.L. Roswandi, M. Waqas, H. Habib, F. Hussain, S. Khan, M. Sohail, N.A. Ramli, H.E.

Thu, Z. Hussain, Hyaluronic acid, a promising skin rejuvenating biomedicine: A review of recent updates and pre-clinical and clinical investigations on cosmetic and nutricosmetic effects, Int. J.

Biol. Macromol. 120 (2018) 1682–1695. https://doi.org/10.1016/j.ijbiomac.2018.09.188.

14. L.H. Chen, J.F. Xue, Z.Y. Zheng, M. Shuhaidi, H.E. Thu, Z. Hussain, Hyaluronic acid, an efficient biomacromolecule for treatment of inflammatory skin and joint diseases: A review of recent

developments and critical appraisal of preclinical and clinical investigations, Int. J. Biol. Macromol.

116 (2018) 572–584. https://doi.org/10.1016/j.ijbiomac.2018.05.068.

15. O. Rachid, K.J. Simons, M. Rawas-Qalaji, In Vivo Evaluation of Taste-Masked Fast-Disintegrating Sublingual Tablets of Epinephrine Microcrystals, AAPS PharmSciTech. 19 (2018) 3886–3894.

https://doi.org/10.1208/s12249-018-1171-4.

16. H.E. Thu, Z. Hussain, I.N. Mohamed, A.N. Shuid, Mechanistic insight into the efficient osteogenic potential of dihydrotestosterone: Exploring sequential expression of bone-related protein biomarkers, Acta Med. Iran. 56 (2018) 234–243.

17. Z. Hussain, M. Arooj, A. Malik, F. Hussain, H. Safdar, S. Khan, M. Sohail, M. Pandey, H. Choudhury, H. Ei Thu, Nanomedicines as emerging platform for simultaneous delivery of cancer therapeutics:

new developments in overcoming drug resistance and optimizing anticancer efficacy, Artif. Cells,

Nanomedicine Biotechnol. 46 (2018) 1015–1024.

https://doi.org/10.1080/21691401.2018.1478420.

18. X. Gao, L. Guo, J. Li, H.E. Thu, Z. Hussain, Nanomedicines guided nanoimaging probes and nanotherapeutics for early detection of lung cancer and abolishing pulmonary metastasis: Critical appraisal of newer developments and challenges to clinical transition, J. Control. Release. 292 (2018) 29–57. https://doi.org/10.1016/j.jconrel.2018.10.024.

19. M.H. Safdar, Z. Hussain, M.A.S. Abourehab, H. Hasan, S. Afzal, H.E. Thu, New developments and clinical transition of hyaluronic acid-based nanotherapeutics for treatment of cancer: reversing multidrug resistance, tumour-specific targetability and improved anticancer efficacy, Artif. Cells,

Nanomedicine Biotechnol. 46 (2018) 1967–1980.

https://doi.org/10.1080/21691401.2017.1397001.

20. H. Ei Thu, Z. Hussain, A.N. Shuid, New Insight in Improving Therapeutic Efficacy of Antipsychotic Agents: An Overview of Improved In Vitro and In Vivo Performance, Efficacy Upgradation and Future Prospects, Curr. Drug Targets. 19 (2018) 865–876.

https://doi.org/10.2174/1389450117666161125174625.

21. M.A. Tumpang, N.A. Ramli, Z. Hussain, Phytomedicines are Efficient Complementary Therapies for the Treatment of Atopic Dermatitis: A Review of Mechanistic Insight and Recent Updates, Curr.

Drug Targets. 19 (2018) 674–700. https://doi.org/10.2174/1389450118666170913162147.

22. H.E. Thu, Z. Hussain, I.N. Mohamed, A.N. Shuid, Recent Advances in Antibacterial, Antiprotozoal and Antifungal Trends of Eurycoma longifolia: A Review of Therapeutic Implications and Future

Prospects, Curr. Drug Targets. 19 (2018) 1657–1671.

https://doi.org/10.2174/1389450119666180219123815.

23. M. Pandey, H. Choudhury, C.X. Yi, C.W. Mun, G.K. Phing, G.X. Rou, B.J.K.A.A.J. Singh, A.N.A. Jhee, L.K. Chin, P. Kesharwani, B. Gorain, Z. Hussain, Recent Updates on Novel Approaches in Insulin

Drug Delivery: A Review of Challenges and Pharmaceutical Implications, Curr. Drug Targets. 19 (2018) 1782–1800. https://doi.org/10.2174/1389450119666180523092100.

24. N.A.F.A. Hassan, S. Sahudin, Z. Hussain, M. Hussain, Self-assembled chitosan nanoparticles for percutaneous delivery of caffeine: Preparation, characterization and in vitro release studies, Int.

J. Appl. Pharm. 10 (2018) 172–185. https://doi.org/10.22159/ijap.2018v10i4.25947.

25. M. Haider, M.A. Hassan, I.S. Ahmed, R. Shamma, Thermogelling Platform for Baicalin Delivery for Versatile Biomedical Applications, Mol. Pharm. 15 (2018) 3478–3488.

https://doi.org/10.1021/acs.molpharmaceut.8b00480.

26. H. Choudhury, M. Pandey, P.X. Chin, Y.L. Phang, J.Y. Cheah, S.C. Ooi, K.K. Mak, M.R. Pichika, P.

Kesharwani, Z. Hussain, B. Gorain, Transferrin receptors-targeting nanocarriers for efficient targeted delivery and transcytosis of drugs into the brain tumors: a review of recent advancements and emerging trends, Drug Deliv. Transl. Res. 8 (2018) 1545–1563.

https://doi.org/10.1007/s13346-018-0552-2.

2017

1. H.E. Thu, Z. Hussain, I.N. Mohamed, A.N. Shuid, Eurycoma longifolia, A Potential Phytomedicine for the Treatment of Cancer: Evidence of p53-mediated Apoptosis in Cancerous Cells, Curr. Drug Targets. 19 (2017) 1109–1126. https://doi.org/10.2174/1389450118666170718151913.

2. M.H. Safdar, H. Hasan, S. Afzal, Z. Hussain, Exploring Promising Immunomodulatory Potential of Natural and Synthetic 1,3-Diphenyl-2-propen-1-one Analogs: A Review of Mechanistic Insight,

Mini-Reviews Med. Chem. 18 (2017) 1047–1063.

https://doi.org/10.2174/1389557517666171123212039.

3. A. Aodah, R.S. Bafail, M. Rawas-Qalaji, Formulation and Evaluation of Fast-Disintegrating Sublingual Tablets of Atropine Sulfate: the Effect of Tablet Dimensions and Drug Load on Tablet Characteristics, AAPS PharmSciTech. 18 (2017) 1624–1633. https://doi.org/10.1208/s12249-016- 0631-y.

4. H.O. Ammar, M. Haider, M. Ibrahim, N.M. El Hoffy, In vitro and in vivo investigation for optimization of niosomal ability for sustainment and bioavailability enhancement of diltiazem after nasal administration, Drug Deliv. 24 (2017) 414–421.

https://doi.org/10.1080/10717544.2016.1259371.

5. Z. Hussain, H.E. Thu, A.N. Shuid, H. Katas, F. Hussain, Recent Advances in Polymer-based Wound Dressings for the Treatment of Diabetic Foot Ulcer: An Overview of State-of-the-art, Curr. Drug Targets. 19 (2017) 527–550. https://doi.org/10.2174/1389450118666170704132523.