V i e t n a m J o u m a l o f Physiology 20(4), 11/2016 I S S N : 1 8 5 9 - 2 3 7 6 SV THAY 0 6 l MtJT S 6 CH[ S 6 H U Y f T HOC
TRONG TH&I GIAN C H A Y M A U KINH NGUYET
Vi Thi Phuwng Lan'-', Hoang Thu S c a n ' , Nguyen Thu H ? n h ' , NguySn Thj Phuwng Thao', Nguyen Thu P h u w n g ' , Dinh Thi Thu Hu-teig' T 6 M T A T :
Mgc tieu: Dinh gia sv thay ddi mil si chi si mau ngoai via sinh viin trong thoi gian chay mau kinh nguyit Boi tugng nghien cOv: Nghiin cuu dupc bin hinh trin 30 sinh vidn cdchuky kinh nguyit diu (28-32 ngay) vol s6 ngiy chay miu kinh nguyit trong gidl han binh thudng (2-7 ngay), va 16 sinh viin cd chu kj kinh nguyit khing diu vii thdi gian chiy miu kinh keo dai > 7 ngiy. Phmmg phip nghien cHu: Md ta cit ngang va nghiin cuu theo doi dQC. Kit qua nghiin cdv: 0 ci hai nhdm nghiin cdu chi so RBC, HGB. HCT, MCH, MCHC cd xu hudng glim tir ngay bit diu chay miu din ngiy sacii kinh, cd hiin tuvng thiiu miu nhupc sic vao thai diim bit diu sach kinh, chi si MCV, ROW, chi si bach ciu va sS Iuvng tiiu aiu khdng cd stf khic biit & cic Ihoi diim nghiin cuu. Sit huyit thanh 8- nhim cfl kinh nguyit diu cd xu huimg giim khi dang hinh kinh vS ting trir lai vao ngay sach kinh. Sil huyit thanh d nhdm cd CKKN khdng diu kem
•gheo rong kinh cfl xu hudng giim tir ngiy bit diu cd hinh kinh din ngiy sach kinh.
Tir khda: Chu ky kinh nguydt, chi si huyit hqc, sit huyit thanh.
I . O A T v A N o e .
Kinh nguySt la " t i m guong" phan anh sii-c khfle sinh sSn cjia ngu-W phy nu-, dieu nay cfl nghTa mflt ngofl-i phy nO- cfl chu ky kinh nguydt deu dJn thi cfl the cfl su-c khfle sinh san t i t . Cac truOng hyp r l i loan kinh nguylt nhu vflng kinh n g i n ngay s i ngay hanh kinh k6o dai (rong kinh), cuirng kinh cfl t h i gay m i t m'Su nhilu. Ngoai ra.
hi|n toong bong ni6m mac ti> cung, mau kinh thu-fl-ng x u y l n chSy trong giai dean hanh kinh la y l u t l thuin loi khiln ngtitri phy nO d l mSc cac b|nh viSm nhiSm du-l-ng sinh dye. Do dfl, trong gial dogn sinh san cua ngu-fl-i phy nu- n l u khflng cung d p d l , kjp thfl-l cac y l u t l tgo may va c h i t dinh du&ng cfl t h i d i n d i n tinh trang thilu m l u , va v i n d l v§ sinh kinh nguy$t la e i n t h i l t d l dam bao su-c khfle n i l Chung va si>c khfle sinh san nOi rISng.
TnrOng Dai hgc Y du-oc Thdi Nguyfin
* Tae gia chiu trach nhi$m chlnh:
VI Th| Phifong Lan Email; lansltnlSQmall.cnfn Ngdy nhdn bai: 30/8/2016 Ngay nhfln bai phdn bi§n: 15/10/2016 Ngdy chap nhdn dang: 21/10/2016
Hi#n nay, t r l n t h i gifl-i da cfl mflt s i nghian cuu thee dfli s y thay d l l chi s i huyit hoc mau ngogi vi 6- cac giai dogn khac nhau ciia chu ki kinh nguydt. VI dy nghien cuu tgi An Dfl o nhO-ng ngu-dri cfl kinh nguylt d i u cho t h i y trong CKKN s i luong h i n g d u , bgch d u , t i l u d u khflng cfl Stf khac bilt cfl y nghta, tuy nhiln nghien euu tai Philipin Igi cho thay cfl sy- g i l m sat huyit thanh treng thfl-l gian hanh kinh [2], [3], [4J.
Tgi Viet Nam chiing tfli chu-a tim t h i y nghiin cii-u nao thee del s y thay d l l ciia cac chi so huyit hoc trong CKKN, cQng nhu- theo doi cac chi s6 dfl treng giai dogn hanh kinh d a cac d l l tuong d CKKN d i u va d r l i logn. X u l t phat t i i nhO-ng v i n d l h-an chiing tfli t i l n hanh d l tai nghifln ci>u vfl-i myc tiflu: Dinh gii sw thay dii mil si chi si huyit hoc miu ngoai vi d- phu nu' cfl CKKN binh thuing vi phu niy c6 chu kl kinh nguyit khdng diu kim theo tong kinh.
2. 0 6 l TU-tJfNG VA PHU'ONG PHAP NGHI&N CCru
2.1 Bii ttrgng nghiin ciru
Vietnam J o u m a l of Physiology 20(4), 11/2016 I S S N : 1 8 5 9 - 2 3 7 6 - Doi bpcmg nghien CIPU; 46 sinh vien
nif CO kinh t y nhien, chia thanh 2 nhom:
- N h i m 1; 30 sinh vt6n co CKKN d i u (28-32 ngdy) va then" gian hdnh kinh binh thudng (2-7 ngay).
- Nhom 2: 16 sinh vi6n c» CKKN khong deu vd c6 thoi gian hdnh krnh tr^n 7 ngdy.
- Tifiu chuan loai tjir: Dang dung thuoc n i l tiit, dang co tinh trgng n h i i m trung, benh nhdn co cac tienh ve mau.
2.2. Dia diem vd thoi gian nghidn ciru - Thir\ gian nghien ci>u: tir thdng 1-11 nam 2015.
- Dja d i i m nghidn ciJu: BO mon Sinh
\9 hgc Ini'i'ng Dgi hpe Y Dugc T>idi Nguyen.
2.3. Phiromg phdp nghidn cOv - Nghidn ci>u m6 td d i t ngang vd nghiSn ci>u theo doi dpc.
2.4. N$i dung nghien ctpu - Thdng tin hdnh chfnh: TSn, tuii.
- Cdc chf s6 nghiSn cdu: Vdng kinh, tlnh chit kinh nguydt (diu hay khdng diu), ^ ngdy hdnh kinh.
- Chi si vi mdu: RBC, HGB, HCT, MCV, MCH. MCHC. ROW. WBC. NE. LY, MO. EO. BA. sit huyit thanh.
2.5. Qui trlnh nghidn c i j u : B$nh nhdn liy mdu vdo edc thdi diim:
Nhdm 1: liy mdu vdo 3 thdi diim:
Khodng 1-2 ngdy tnpdc khi hdnh kinh;
Ngdy bdt dSu c6 kinh; Ngdy b i t aku sgch kinh
Nhdm 2: liy mdu vdo 2 thdi diim:
Ngdy b i t 6ku c6 kinh; Ngdy bat d i u sgch kinh
D&tu'(?Tigdu'gT:huT>ngd^nhindntrwte ^ khi liy mdu, lay 3nfy n*du vao bufii sdng cNa vao2ong:
+ 6 n g 1: 1ml c^o vdo 6ng nghidm c6 ch6ng ddng (EDTA) d4 i^nh Iu'png cdc i'- chi s6 RBC, HGB. HCT. MCV, MCH.
MCHC. RDW, WBC, NE. LY, MO. EO, BA.
+ Ong 2: 2ml cho vdo 6ng nghi$m c6 chong dong ly tdm tach h u y i t tuang d i xdc djnh chr so s i t h u y i t thanh.
2.6. V$t li^u nghidn cu-u - M i u phiiu nghiSn cu-u.
- Mdy d i m t i bao t y dOng Celiac E, Coulter LH780; Celtac F cOa trung tdm HHTM Thdi NguySn.
- Mdy djnh lu-p-ng s i t huyit thanh cua khoa huyit hpe bSnh vipn tryd-ng dgi hpe Y Du-pc Thdi NguySn nhdn hiSu AU480 cua Beckman Coulter.
2.7. Xdl:^si liiu
- B^ng phyo-ng phdp th6ng kd y sinh hpe b i n g p h i n m i m exel vd Stata 10.
3. K £ T Q U A N G H l i N CCfU K i t qud nghiSn ci>u trSn bdng 1 cho t h i y cdc chf so h6ng c i u cd xu hu-dng gidm d i n tir ngdy chya cd kinh d i n ngdy sgch kinh. Ket qud gidm cd ^ t h i n g kS d chr s6 HGB vd MCHC (p < 0.05). Ch? s6 s i t h u y i t thanh c6 xu hu-dng gidm d ngdy cd kinh nguySt vd c6 xu hydng tdng t r * igi vdo ngdy sgch kinh. Tuy nhiSn, s y thay d i i chu-a c6 y nghTa t h i n g kS.
90
V i e t n a m Journal o f Physiology 20(4), 1 1 / 2 0 1 6 I S S N : 1 8 5 9 - 2 3 7 6 Bang 1 . CSc chi so dflng h i n g d u va s i t huyet thanh (sat HT) 6 d c th&i d i l m
nghien cCm d a d c d l l tu-ong d chu ky kinh nguygt deu (n = 30) (-h,^< L l n 1(1) L i n 2 (2) L l n 3 (3)
XtSD X ± S D X±SD
4.69±0.67 4.55±0.88 4 53*0 80 P<1.2)>0.05: p(2,3)>0.05:
• p(1.3)>0.05 HGB(g/L) 128.73±26.8r 123.42±7.78 1 1 9 4 8 1 1 9 0 9 P(1-2)^-'>5; P(2.3)>0.06;
P(1,3)«0.01 Htrrca) 39.59±5.80 38.25±141 3 8 1 2 ± 1 7 7 P(1.2)>005; p(2.3)>0.05;
p(1,3)>0.05 M C V ( f L ) 86.03±20.51 84.65115 5 6 8 4 82±15 7 0 Pd-ZJ^OOS: P(2,3)>0.05;
• p(1,3)>0.06 M C H ( p g ) 27.69±8.06 27.34±5 8 0 2 6 6 6 ± 7 6 4 P(1.2)>0.05: p(2,3)>0.05;
' p(1,3)>0.05 l«ICHC(g/L) 326±25.46 323.08±8.49 3 1 3 2±35 36 p(1.2)>0.06:
p(2.3)>0.05: p(1,3)<0.05 R D W ( % ) 13.31±3.32 12.50±0.35 12 5 0 4 3 1 1 P(1.2)>0.05;p(2.3)>0.05:
• p(1.3)>0.05 FeHT
(mmol/Ll Mt'7±1.34 11.98±4.88 13.77±8.31 P(1 •2)>0.06: P(2.3)>0.05:
immoiru) p(1.3)>0.05 B i n g 2. Cac chi so dflng bgch c l u va s i luy-ng t i l u d u * d c thai d i l m nghien cilu d a
cac d l l tirong d chu ky kinh nguygt d i u (n = 30) ChisI
RBC (G/L) NE(%) LYM (%)
M0(%) E0(%) BA(%) PLT (G/L)
Lln 1 (1) JCtSD 7.73±0.21 65.92±2.33 26.58±3.18 5.87±0.07 0.91±0.85 0.33±0.07 298.50±39.60
Lin 2 (2)
6.54±2.26 63.26±11.67 29.98±11.46 4.81±0.71 0.93±0.71 0.26±0.21 297,23±44.55
Lln 3 (3) J ± S D
6.02±0.07 56.85±36.98 36.04±35.99 5.6ttt0.71 0.84±0.00 0.27±0.28 324.80±163.34
P p(1,2)<0.01;
p(2.3)>0.05: p(1,3)<0.01 p(1.2)>0.05:p(2,3)>0.05:
p(1,3)>0.05 p(1.2)>0.06;p(2,3)>0.06;
p(1,3)>0.05 p(1.2)>0.05; p(2,3)>0.05:
p(1.3)>0.05 p(1.2)>0.05; p(2,3)>0.05:
p(1,3)>0.05 P{1.2)>0.05: p(2.3)>0.05;
p(1.3)>0.05 p(1.2)>0.05: p(2,3)>0.05:
p(1,3)>0.05 N h i n xflt: S I luong bgch d u giam khi sgch kinh d j nghta t h i n g k l (o <
d i n tCr ngay tn,6c khi d hanh kinh d i n 0.01). Tj Ig bgch d u thay d i i khflng theo
Vietnam Joumal of Physiology 20(4), 11/2016 ISSN: 1 8 5 9 - 2 3 7 6 qui lugt So luong Slu d u khflng d sy khac higt giaa 3 thoi diem nghiin ci>u.
Bang 3. Cac chi so dflng hong d u va s i t huyit thanh (sat HT) 6 d c th&i dilm nghien ci>u d a d c doi tuo-ng d d u kl KN rli logn kdm theo rong kinh (n = 16)
^ ^ ^ - ^ ^ ^ ^ TTiOT d i l m C h i s I ^ ^ ~ - ^ _ _ _ _ ^
RBC (T/L) HGB (gn.) HCT(%) MCV (fL) MCH (pg) MCHC (g/L)
RDW(%) Fe huyet thanh (mmol/L)
L I n l X ± S D 4.63±0,40 126,89±14,08
3g,69±3,77 85,B4±4,15 27,44±2,06 319,56±16,34
12,24±1,47 9,14±7,46
L l n 2 X ± S O 4,29±0,30 115,00±10,04
36,93±2,95 86,21i4,33 26,87±2,16 311,67±14,61
12,33±1,23 B,10±5.71
P
>0.05
>0,05
>0,05
>0,05
>0,05
>0,05
>0,05
>0,05
MCH, MCHC va sit HTthO, dllm bit diu ngay bat diu hanh kinh (p > 0.05).
Bang 4. cac chi s i dflng bgch d u va s i lu-ong tilu d u * d c thM dilm nghiSn cuu cua d c dll tupng d chu kl KN rli logn kSm theo rong kinh (n = 16)
WBC (G/l) NE (%) LYM (%) MO (%) EO(%) BA(%) PLT (G/L)
e,24±1,18 62,68±15.76 28,70*15,06 7,42±4,94 0,83±0,56 0,37±0,38 338,56±94,94
5,B6±0,72 65,14±9,55 26,96±6,64 6,49±3,88 0,97±0,84 0,44±0,63 316,56±75,06
cacrb:*'h I'Tl'iZg-'n ^---^^..-cacthoidilm
I
Vietnam Joumal of Physiology 20(4), 11/2016 ISSN: 1859 - 2376 Bang 5. So sanh d c d i so h i n g d u va s i t huyet thanh o nhom d l l tu-ong d CKKN
blnh thu-fl-ng vdi nhflm doi tuong d d CKKN khflng deu kem theo rong kinh
Bat dau Chi s o \ hanh kinh
(1)(n = 30) Kinh n g u y l t binh
thifflTig
Hanh kinh keo dai B i t d i u
sgch kinh (2)(n-=30)
Bat dau hanh kinh (3)(n = 16)
Bat dau sgch kinh (4)
<n-=16)
4.55+0.88 4.53+0,80 4,63±0,40 4.29±0,30 p(1,3)>0.05 p(2,4)>0,05 123.42±7.78 119.48±19.09 126,89±14.08 116.00±10,04 p(1.3)>0.05 p (2.4)>0,05 38,25±1.41 38.12±1,77 39,69±3,77 36,93±2,95 MCV(fL)
J±SD
P(1,3)>0,05 p (2,4)>0.05 84,65±15,56 84.82±15,70 85,84±4,15 86,21±4,33 MCH (pg)
A ' t S D MCHC (g/L)
p(1,3)>0,05 p (2,4)>0,05 27,34±5,80 26,66±7,64 27,44t2,06 26,87±2.16 p(1.3)>0,06
p (2,4)>0,05 JtSD ^^^-^^^--tS 313,2135,36 319,56±16,34 311,67*14,61 RDW (%)
XtSD
p(1,3)>0,06 p (2.4)>0.05 12,50±0.35 12,50±3,11 12,2411,47 12,3311.23 FeHT(tnmol/L)
p(1.3)>0,05 p (2,4)>0,05
X±i
11,9814,88 13.7718,31 9.1417.46 8.1015.71 p(1,3)>0,06 p (2,4)>0,05 Nh§n x i t : Cac chi s i h i n g d u 6 nhflmd l l tu-ip-ng d kinh nguylt blnh thu*ng khflng d sg- khao b i l l d j nghTa thing k l se vfl'i nhflm d l l tuong cfl CKKN khflng d i u k i m theo rang kinh khi so s i n h ir dc thfl'i d i l m nghiSn cii-u tuong Ci-ng. Chi s i s i t huyit thanh d a nhflm d KN d i u d xu hu-ftng cao hon nhflm cfl CKKN khflng d i u kflm theo rang kinh, s i / khac b i | t khing d y nghfa thing k l . 4. BAN LU/I>N
Thflng thufl-ng s6 ngay hSnh kinh du-oc tinh tCf ngay d i u t i l n t h i y kinh d i n ngay sgch kinh d i u Bin (1). Tuy nhiSn.
thu-o t l ngay t h i y kinh d i u tiSn khing p h i i I I ngay c h i y mau d i u tiSn vl h i j n tinyng kinh nguylt dS x l y ra trode dfl 1-2 ngay. De dfl. tgi nghiin ci>u n i y chiing t i l
aa t i l n hanh l l y mau o' ba t h i i d i l m a l l vOi d c d l l tuvng d CKKN d i u IS: 1-2 ngay truOc khi hanh kinh, ngay bat d i u d kinh, va ngay sgch kinh. B l l v6i cac d l l tuong d hanh kinh k l o d i i (hanh kinh trSn 7 ngay) do CKKN khflng d i u nen khong t h i x i e djnh duoc chinh x i e ngay d kinh d i u t i l n . vl vay chiing tfli t l l n hanh l l y m l u ir 2 thoi d i l m la n g i y bat dau d kinh va ngay b l l d i u sgch kinh.
- cac chi s i dflng hong d u : Ti> d c k i t quS nghien c m i o- b4ng 1 va 3 chiing tfli nhJn t h i y , a- d 2 nhflm d c d l l tuong, h i | n toong c h i y mau kinh nguylt da lam cho t i t d d c chi s i h i n g d u d xu hudng giam d i n tCr ngay chua d kinh d i n ngay sgch kinh, dgc bi|t chi s i HGB va MCHC
Vietnam J o u m a l o f Physiology 20(4), 11/2016 I S S N : 1 8 5 9 - 2 3 7 6 giam d y nghTa thong ke. Cac chi so nay
giam den mi>c d the k i t I u i n la da so d c tnrirng hop sau vai ngay hanh kinh da roi vao tinh trgng thieu mau nhu-oc s l e (HGB <120g/L, MCH < 27pg, M C t i c
< 320 g/l). Hien hfong thilu mau nay nguySn nhSn ligu d phai do rong kinh hay khflng?, chiing tfli da tien hanh so sanh d e d i s i hong d u or bang 5 vi thay d c d l so h i n g d u khflng t h i y d su khac b i l l giua hal nhflm nghiSn eCpu.
- Chi s d sat huyet thanh: K i t qua nghiSn ci>u d bang 1 cho thay nhflm d CKKN d i u d d i s i sat huyet thanh giam vao nhung ngay d kinh nguySt va tang vao ngay s g d kinh, dieu nay hoan loan phu hop vOI hign tuong giam d a chi s i HGB va MCH, MCHC. NguySn n h i n h i | n tuong dfl la do khi m i t mau trong giai dogn hanh kmh da khien co t h i dap i>ng b i n g tang t i n g hop HGB do dfl p h i i tang tiSu thu s i t huyit thanh, khiln co t h i phai tang huy dflng s i t du- trO vao mau n l n chi s i s i t huyit thanh tang t n j Igi vao ngay s g d kinh. D i l u nay chung tfl sy- cung d p s i t cho qua trlnh t i n g hop hemoglobin d a nhflm d vflng kinh d i u la t i t . Nguoc Igi. fl- nhflm d CKKN khflng d i u k i m theo rong kinh chiing tfli Igi nhJn t h i y s i t h u y l l thanh 6 thOi d i l m sgch kinh khflng d d i u h l l u tang so vdi thfll d l l m dang hanh kinh (bang 3), thSm nira tgi bang 5 d i i n g tfli n h | n t h i y nhflm d thOi gian hanh kinh k6o dfli d ham luong s i t huyit thanh t h i p hon se vdi nhflm d CKKN blnh thudng. Ly giai h i l n tuong nay thee chung tfli cfl t h i do s i ngay hanh kinh kSo dai da gay m i t mau nhilu hon vi|c Uiu thu s i t d n g Idn hon se vdi nhflm d kinh nguySt binh thudng
Chi s i MCV, RDW khflng d s u khac but gliia d c thdl d i l m nghidn d u va gi&a 2 nhflm nghlSn cOu, chi so nay cho t h i y tinh trgng thilu mau d a d c d l l tuong d l xay ra d giai dogn hanh kinh
ma khflng kflo dai d l gSy n l n tlnh tigng t h i l u mau mgn tinh.
- Cac chi so bgch c l u va s 6 lu^'ng t i l u d u : K i t qud d bang 2 va 4 d o t h i y fl nhom d l l tttvng c6 kinh nguylt blnh thuvng chi s6 s i Iuvng bgch d u giSm dan ti> ngay tru-o-c khi d hanh kinh din khi sgch kinh d y nghTa t h i n g k l (p <
0.01), nhung v i n nam trong gidi hgn blnh thu-dng. Cl nhflm d l l tuvng d CKKN khong d i u k i m theo rong kinh d ty IS d c bgch d u khong d sy- khac biSt gii>a d e t h d i d i l m nghiSn eu-u. Chiing tSi d n g khflng tim t h i y d sg- khfle biSt v l s i lu-ong t i l u d u glO-a d c thdl d l l m nghiin cuu d ca 2 nhflm d l l tuong. D i l u nSy chdng to hi§n tuong kinh nguylt da khflng lam thay d l l d n g thde bgch d u va s i luong t i l u d u . K i t qua nghlSn dm ciia chiing toi tuong t y nghlSn cdu cda Dapper tren 61 n u sinh viSn f u l l t d 17-30 d a dgi hoc Port Harcourt, Nigeria cQng cho t h i y , khflng d su- thay d i i v l d c ohi s i bgch c i u d l i t d cac glal dogn d a chu kl kinh nguyjt trang dfl bao g i m d giai dogn hanh kinh [3).
5. K f T L U ^ N
Cy d hai nhflm nghiSn ci>u chi s i RBC, HGB, HCT, MCH, MCHC d xu hudng giam t d ngfly b i t d i u c h i y mSu d i n ngay sgch kinh, d hISn tuyng thilu mau nhuvc s i c vao thdi d i l m b i t diu sgch kinh, chi s i MCV, RDW, chi s i bgch d u va s i Iuvng t i l u d u khing d sy khac bISt d d c thdl d i l m nghiSn cdu. Sit huyit thanh d nhflm d kinh nguydt d i u d xu hu-dng giSm khi dang hanh kinh va tang trd igi vao ngay sgch kinh. S i t huySt thanh d nhflm d CKKN khflng d i u kSm thee rong kinh d xu hudng giam t d ngay b i t d i u cfl hanh kinh d i n ngay sgch kinh 6. K H U Y C N N G H I
Sy- m i t mau trong thdi gian h i n h kinh ciia phy n d , dgc bi^t d d c d l l tuong d hanh kinh kSo dai IS nguyin nhan gay t h i l u mau nhuoc s i c . Do dfl. d n d d l
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Vietnam Joumal of Physiology 20(4), 11/2016 ISSN: 1 8 5 9 - 2 3 7 6 dfl an d i y du c h i t dinh dirSng dac higt la 3. Dapper DV, Kote N (2012) ySu tfl sat d l phong ngua thieu mau d o "Changes in total and differential white d c d l l t u v n g nO- d hanh kinh. cell counts, total lymphocyte and CD4 cell T A I LIEU THAM K H A O counts during the menstrual cycle In 1. Nguyen Van Tu- (2005) Bai giang healthy female undergraduate students In srn/j d^ hoc. Tnidng Dgl hoc Y Duvc Thai Port Harcourt. Nigeria-, Port Hanxiuri NguySn, Bo men Sinh ly hoc, Nha xuat ban Medical Joumal, 6 ( 1 ) .
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SUMMARY
THE CHANGE OF HEMATOLOGICAL INDICATORS IN MENSTRUATION PERIOD
Vi Thi Phuong U n ' , Hoang Tliu Soan', Nguyen Thu Hanh', Nguyen Thi Phuong Thao',
^ Nguyen Thu Phuong', Dlnh Thi Thu Huong' Physiology Department, Thai Nguyen Medical University Objective: To evaluate the change of hematological indices hom peripheral blood in menstniahon period Subjects: The study has been performed in 30 students with regular menstrual cycle (28-30 days) with the length of (he period lasts from 2 to 7 days and 18 irregular menstnial students with the length of the period lasts more than 7 days Methods: Descriptive cross-sectional end follow-up study. Results: Both groups showed that the RBC, HGB, HCT, MCH MCHC indices decreased from first day to the ended bleeding day. There was hypochromie at the time of ended bleeding. MCV, RDW, WBC platele count showed no signlHoant between two groups. Iron senim of 'regular menstniation group tended to decrease during menslniation and rised again on the day of cleaning. Iron serum of irregular menstruation group with menorrhagia tended to decrease from first day to the ended menstnjal bleeding.
Keywords: Menstrual cycle, blood index, serum iron.
