ON THE ALKALOID OF CROTALARIA DAMARENSIS.
(a) 2·610 mg. 0·362 ml. N2 at 762 mm. and 23° C.
(b) 3·660 mg. 0·509 ml. N2 at 763 mm. and 25° C.
(c) 3·622 mg. 0·494 mi. N2 at 761 mm. and 24° C.
(d) 3 ·445 mg. 0·460 ml. N2 at 761 mm. and 24° C.
Found(a) C=48·19, H=4·51, N=16·00%.
(b) C=47·99, H=4·48, N = 16·00%.
(c) C=47·60, H=4·27, N= 15·7%. fd) C=47 ·75, H=4·40, N = 15 ·4%.
Calculated for C18H2tN500:C=47·92, H=4·69, N= 15·51%
Chloro-platinate.
The platinate was prepared by addition of platinum-chloride to the acid solution of the hydrochloride of the base. On careful evaporation of the solution, the platinate crystallised with melting point 162° C.
Molecular weight of the base.
(a) 8 · 40 mg. platinate: 2 · 580 mg. Pt.
(b) 6·97 mg. platinate: 2·195 mg. Pt.
:. Molecular weight (dibasic alkaloid): (a) 226 · 9 (b)211·1
Toxicity of the Alkaloid.
Except for some salivation, no ill-effects were observed when rats weighing 250 gr. were dosed per os with 160 mgm. of the hydrochloride. Subcutaneous inJection of 40 mg. of the hydrochloride caused marked necrosis at the site of injection, the rats remaining otherwise apparently normal.
REFERENCES.
MARAIS, J. S. C. (1944). Dicrotaline. The toxic alkaloid from Crotalaria dura (Wood and Evans) and C~ota/aria globifera (E. Mey). Onderstepoort Jl. Vol. 20, No. I, pp. 61-65.
NEAL, W. M. et a/. (1935). The isolation and some properties o.f an alkaloid from Crota/aria spectabilis Roth, !. Am. Chern. Soc., Vol. 57, p. 2560.
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