Saran

BAB V KESIMPULAN DAN SARAN

5.2 Saran

Disarankan kepada peneliti selanjutnya untuk menelaah lebih jauh mekanisme antikanker dari tumbuhan bangun-bangun (Plectranthus amboinicus Lour.) dengan berbagai metode pengujian antikanker.

DAFTAR PUSTAKA

Aisyah, I.S., Rusmiyati, H., Sukma, D., Damanik, R., Nurcholis, W. 2020.

Analisis Komparatif Kandungan Metabolit pada Daun Mutan Comparative Analysis on Metabolites of Torbangun (Plectranthus amboinicus (Lour.) Spreng.). Jurnal Ilmu dan Teknologi Pertanian. 4(1): 10–16.

Andayani,N., Julisafrida, L. 2020. Peranan Immunoterapi Pada Kanker Paru.

Jurnal Kedokteran Syiah Kuala. 20(2): 70–77.

Andriyanto, M., Dalimunthe, C.I., Sembiring, Y.R.V. 2017. Pemanfaatan Tanaman Bangun-Bangun (Coleus amboinicus) di Gawangan TBM Karet Untuk Pengendalian Jamur Akar Putih dan Kesuburan Tanah. Warta Perkaretan. 36(2): 137-146.

Arifin, B., Ibrahim, S. 2018. Struktur, Bioaktivitas Dan Antioksidan Flavonoid.

Jurnal Zarah. 6(1): 21–29.

Cahyawati, P.N. 2018. Imunoterapi pada Kanker Payudara. WICAKSANA Jurnal Lingkungan & Pembangunan. 2(1): 52–55.

Ekawati, R., Aziz, S.A. 2016. Respon Pertumbuhan dan Fisiologi Plectranthus amboinicus (Lour.) Spreng Pada Sekaman Naungan. Agrovigor. 9(2): 82–89.

Fachrunisa, D., Hasibuan, P.A.Z., Harahap, U. 2019. Cell Cycle Inhibition and Apoptotic Induction of Vernonia amygdalina Del. Leaves Extract on MCF-7 Cell Line. Open Access Macedonian Journal of Medical Sciences. 7(22):

3807–3810.

Farida, S., Susanti, D., Yuniarachma, A. 2020. Pengaruh Naungan Dan Variasi Pupuk Organik Cair Terhadap Kadar Flavonoid Daun Bangun Bangun (Plectranthus amboinicus (Lour) Spreng). Jurnal Jamu Indonesia. 4(3): 81–

86.

Fitriatuzzakiyyah, N., Sinuraya, R.K., Puspitasari, I.M. 2017. Cancer Therapy with Radiation: The Basic Concept of Radiotherapy and Its Development in Indonesia. Indonesian Journal of Clinical Pharmacy. 6(4): 311–320.

Gupta, S.K., Bhatt, P., Joseph, G.S., Negi, P.S., Varadaraj, M.C. 2013. Phenolic Constituents and Biological Activities of Leaf Extracts of Traditional Medical Plant Plectranthus amboinicus Benth (Lamiaceae). Tang Humanitas Medicine. 3(4): 1-6.

Hasanah, S.N., Widowati, L. 2016. Jamu Pada Pasien Tumor/Kanker sebagai Terapi Komplementer Herbal as A Compelementary Therapy for Tumor/

Cancer Patients. Jurnal Kefarmasian Indonesia. 6(1): 49–59.

Hasibuan, P.A.Z., Rosidah., Ilyas, S., Nasution, M.P. 2013. Antioxidant and Cytotoxic Activities of Plectranthus amboinicus (Lour.) Spreng. Extracts.

International Journal of Pharmacy Teaching & Practices. 4(3): 755-758.

Hasibuan, P.A.Z., Chrestella, J., Satria, D. 2015. Combination Effect of Ethylacetate Extracts of Plectranthus amboinicus (Lour.) Spreng. with Doxorubicin Againts T47D Breast Cancer Cells. International Journal of Pharmacy and Pharmaceutical Sciences. 7(10): 156-159.

Hasibuan, P.A.Z., Rosidah.. 2015. Combination Effect of N-Hexane Extract of Plectranthus amboinicus (Lour.) Spreng. with Doxorubicin Againts HeLa Cell Lines. Indonesian Journal of Cancer Chemoprevention. 6(3): 111-115.

Hasibuan, P.A.Z., Sitorus, P., Satria, D., Sibuea, R.D. 2019. Antioxidant Properties and Cytotoxic Activity of Ethyl Acetate Fraction of Plectranthus

amboinicus (Lour.) Spreng. Leaves on HeLa and T47D Cell Lines.

Indonesian Journal of Cancer Chemoprevention. 10(1): 37-45.

Hasibuan, P.A.Z., Sumaiyah, S. 2019. Cyclin D1 , Caspase 9 and P53 Expressions in T47D Cell Lines after Treatment of Plectranthus amboinicus, (Lour.) Spreng. Leaves Ethanolic Extract Nanoparticles. Open Access Macedonian Journal of Medical Sciences. 7(22): 3786-3789.

Hasibuan, P.A.Z., Sumaiyah, S. 2019. The anti-proliferative and pro-apoptotic properties of Ethanol Plectranthus amboinicus (Lour.) Spreng. Leaves ethanolic extract nanoparticles on T47D cell lines. Asian Pacific Journal of Cancer Prevention. 20(3): 897-901.

Hasibuan, P.A.Z., Rosidah., Nasution, P., Ilyas, S. 2020. Effect of Plectranthus amboinicus, Lour. Spreng. n-Hexane Extract on T47D Cells Line:

Proliferation, Apoptosis and It’s Combination with Doxorubicine.

Indonesian Journal of Pharmaceutical and Clinical Research. 3(1): 8-17.

Iwansyah, A.C., Damanik, R.M., Kustiyah, L., Hanafi, M. 2016. Relationship Between Antioxidant Properties and Nutritional Composition of Some Galactopoietics Herbs Used in Indonesia: A comparative Study.

International Journal of Pharmacy and Pharmaceutical Sciences. 8(12):

236–243.

K, M., P, S., J, D., G, G., D, T.P.D. 2016. Anti-biofilm Efficacy of Plectranthus amboinicus Against Streptococcus pyogenes Isolated From Pharyngitis Patients. Asian Journal of Pharmaceutical and Clinical Research. 9(4): 348-358.

Kaban, V.E., Yusmarlisa, S. 2018. Uji Aktivitas Kandungan Antioksidan Pada Daun Bangun-Bangun (Plectranthus amboinicus) Secara Spektrofotometri Ultraviolet-Visible. Farmasimed. 1(1): 16–20.

Kalonio, D.E., Hendriani, R., Barung, E.N. 2017. Aktivitas Antikanker Tanaman Genus Clerodendrum (Lamiaceae): Sebuah Kajian. Traditional Medicine Journal. 22(3): 182–189.

Khanum, H., Ramalakshmi, K., Srinivas, P., Borse, B.B. 2011. Synergistic Antioxidant Action of Oregano, Ajowan and Borage Extracts. Food and Nutrition Sciences. 2(5): 387–392.

Leu, W.J., Chen, J.C., Guh, J.H. 2019. Extract from Plectranthus amboinicus Inhibit Maturation and Release of Interleukin 1β Through Inhibition of NF-κB Nuclear Translocation and NLRP3 Inflammasome activation. Frontiers in Pharmacology. 10: 1-12.

Manjamlai, A., Grace, V.M.B. 2013. The Chemotherapeutic Effect of Essential Oil of Plectranthus amboinicus (Lour) on Lung Metastasis Developed by B16F-10 Cell Line in C57BL/6 Mice. Informa Healthcare. 31: 74-82.

Megha, M.A., Unnma, U., Rameshpathy, M., Karikalan, K., Vickram, S., Kumar, S.V., dkk. 2013. Formulation of Nano-Encapsulated Poly-Herbal Oinment for Anti-Inflammation. Der Pharmacia Lettre. 5(6): 164-170.

Mota, A.P.P., Dantas, J.C.P., Frota, C.C. 2018. Antimicrobial Activity of Essential oils from Lippia alba, Lippia sidoides, Cymbopogon citrates, Plectranthus amboinicus, and Cinnamomum zeylanicum against Mycobacterium Tuberculosis. Ciencia Rural. 48(6): 1-9.

Nazliniwaty, N., Laila, L. 2019. Formulation and Antibacterial Activity of Plectranthus amboinicus (Lour.) Spreng Leaves Ethanolic Extract as Herbal

Mouthwash Against Halitosis Caused Bacteria. Open Access Macedonian Journal of Medical Sciences. 7(22): 3900-3903.

Nguyen, N.Q., Minh, L.V., Trieu, L.H., Bui, L.M., Lam, T.D., Hieu, V.Q., dkk.

2020. Evaluation of Total Polyphenol Content, Total Flavonoid Content, and Antioxidant Activity of Plectranthus amboinicus Leaves. IOP Conference Series: Materials Science and Engineering. 736(6): 8–13.

Nurhidayah, I., Hendrawati, S., Mediani, H.S., Adistie, F. 2016. Kualitas Hidup pada Anak dengan Kanker. Jurnal Keperawatan Padjadjaran. 4(1): 45–59.

Palani, S., Raja, S., Naresh, R., Kumar, B.S. 2010. Evaluation of nephroprotective, diuretic, and antioxidant activities of plectranthus amboinicus on acetaminophen-induced nephrotoxic rats. Toxicology Mechanisms and Methods. 20(4): 213-221.

Pato, U. 2016. Potensi Bakteri Asam Laktat yang diisolasi dari Dadih untuk Menurunkan Resiko Penyakit Kanker. Jurnal Natur Indonesia. 5(2): 162-166.

Pinheiro, G.P., Galbiatti, M.I., Carneiro, M.J., Sawaya, A.C.H.F. 2019.

Comparison of Four Different Solid-Phase Microextraction Fibers for Analysis of Plectranthus amboinicus (Lour.) Spreng. Leaf Volatiles.

Advancement in Medicinal Plant Research. 7(2): 38–43.

Pratiwi, S.R., Widianti, E., Solehati, T. 2017. Gambaran Faktor-Faktor yang Berhubungan dengan Kecemasan Pasien Kanker Payudara dalam Menjalani Kemoterapi. Jurnal Pendidikan Keperawatan Indonesia. 3(2): 167-174.

Puspita, N.A. 2016. Kemoprevensi Untuk Pencegahan Kanker : Fakta Atau Mitos?. Jurnal Kedokteran Syiah Kuala. 16(2): 112-119.

Putri, R.H. 2017. Kualitas Hidup Pasien Kanker Ginekologi yang Menjalani Terapi. Jurnal Aisyah : Jurnal Ilmu Kesehatan. 2(1): 69–74.

Rai, V., Pai, V.R., Kedilaya, P. 2016. A Preliminary Evaluation of Anticancer and Antioxidant Potential of Two Traditional Medicinal Plants from Lamiaceae-pogostemon Heyneanus and Plectranthus amboinicus. Journal of Applied Pharmaceutical Science. 6(8): 73-78.

Romadhon, Y.A. 2013. Gangguan Siklus Sel dan Mutasi Gen Pada Kanker Payudara. CDK. 40(10): 786-789.

Rosidah., Hasibuan, P.A.Z. 2014. Cytotoxic Effect of n-Hexane, Ethylacetate and Ethanol Extracts of Plectranthus amboinicus, (Lour.) Spreng.) on HeLa and Vero Cells Lines. International Journal of PharmTech Research. 6(6): 1806-1809.

Ryamizard, R., P. C.H.N., Margawati, A. 2018. Gambaran Penggunaan Pengobatan Tradisional, Komplementer Dan Alternatif Pada Pasien Kanker Yang Menjalani Radioterapi. Diponegoro Medical Journal (Jurnal Kedokteran Diponegoro). 7(2): 1568–1584.

S, L.D.M., Menon, D.B. 2017. Essential Oil Extracted from Plectranthus amboinicus Induces Apoptosis in the Lung Cancer Cells via Mitochondrial Pathway. International Journal of Pharmaceutical Sciences and Drug Research. 9(2): 83-89.

Sanif, R., Nurwany, R. 2017. Vitamin A dan Perannya dalam Siklus Sel. Jurnal Kedokteran dan Kesehatan. 4(2): 83–88.

Sari, T.T., Windiastuti, E., Cempako, G.R., Devaera, Y. 2016. Prognosis Leukemia Limfoblastik Akut pada Anak Obes. Sari Pediatri. 12(1): 58-62.

Silalahi, M. 2018. Plectranthus amboinicus (Lour.) Spreng Sebagai Bahan Pangan

Dan Obat Serta Bioaktivitasnya. Jurnal Dinamika Pendidikan. 11(2): 123-138.

Siregar, R., Fati, N., Wahono, S., Sondang, Y. 2019. Peningkatan Produksi Tanaman Bangun-Bangun (Coleus amboinicus L.) Daerah Sumatera Barat Dengan Penggunaan Kompos Eceng Gondok. Lumbung. 18(1): 33–44.

Siregar, R., Fati, N., Sondang, Y. 2019. Kandungan Gizi dan Bahan Aktif Fenol Daun Bangun-Bangun (Coleus amboinicus L.) Pada Metoda Pengeringan yang Berbeda. Lumbung. 18(2): 98-104.

Sofia, R., Tahlil, T., Marthoenis. 2018. Pengalaman Pasien Kanker dalam Menghadapi Kemoterapi. Jurnal Ilmu Keperawatan. 6(2): 81–91.

Sukohar, A., Ria, A. 2016. Seledri (Apium graveolens L.) sebagai Agen Kemopreventif bagi Kanker Celery (Apium graveolens L.) as Chemopreventive Agent for Cancer. Majority. 5(2): 95–100.

Sukohar, A., Ria, A. 2016. Potensi Annonaceous acetogenins dari Sirsak (Annona muuricata) sebagai Agen Kemoterapi melalui Induksi Apoptosis dan Inhibisi HIF-1. Majority. 5(5): 97–101.

Sulaiman, C.T., Deepak, M., Balachandran, I. 2018. Spectrophotometric and Tandem Mass Spectroscopic Analysis of Indian Borage (Plectranthus amboinicus (Lour.) Spreng.) for Its Polyphenolics Characterization. Beni-Suef University Journal of Basic and Applied Sciences. 7(4): 471–473.

Suryawinata, A., & Sukohar, A. (2016). Potensi Annonaceous acetogenins dari Sirsak (Annona muricata) sebagai Agen Kemoterapi melalui Induksi Apoptosis dan Inhibisi HIF-1. Majority, 5(5), 97–101.

Swamy, M.K., Arumugam, G., Kaur, R., Ghasemzadeh, A., Yusoff, M.M., Sinniah, U.R. 2017. GC-MS Based Metabolite Profiling, Antioxidant and Antimicrobial Properties of Different Solvent Extracts of Malaysian Plectranthus amboinicus Leaves. Hindawi Evidence-Based Complementary and Alternative Medicine. 2017: 1-10.

Tafzi, F., Andarwulan, N., Giriwonob, P.E., Dewid, F.N. 2017. Uji Efikasi Ekstrak Metanol Daun Torbangun (Plectranthus amboinicus) pada Sel Epitel Kelenjar Susu Manusia MCF-12A. Jurnal Ilmu Kefarmasian Indonesia.

15(1): 17–24.

Thayil., M, S., P, T. 2016. PA-9: A Flavonoid Extracted from Plectranthus amboinicus Inhibits HIV-1 Protease. International Journal of Pharmacognosy and Phytochemical Research. 8(6): 1020–1024.

Virginia, D.M. 2020. Sindrom Metabolik pada Pasien Kanker di Yogyakarta , Indonesia. PHARMACY: Jurnal Farmasi Indonesia. 17(01): 118–127.

Warganegara, E., Nur, N.N. 2016. Faktor Risiko Perilaku Penyakit Tidak Menular. Majority. 5(2): 88–94.

Werdhasari, A. 2014. Peran Antioksidan Bagi Kesehatan. Jurnal Biotek Medisiana Indonesia. 3(2): 59-68.

Widyanto, R.M., Putri, J.A., Rahmi, Y., Proborini, W.D., Utomo, B. 2020.

Aktivitas Antioksidan dan Sitotoksik In Vitro Ekstrak Metanol Buah Nanas (Ananas comosus) Pada Sel Kanker Payudara T-47D. Jurnal Pangan Dan Agroindustri. 8(2): 95–103.

Wulandari, T., Marji., Muflikhah, L. 2018. Klasifikasi Jenis Kanker Berdasarkan Struktur Protein Menggunakan Algoritma Naive Bayes. Jurnal Pengembangan Teknologi Informasi Dan Ilmu Komputer (J-PTIIK)

Universitas Brawijaya. 2(10): 3738–3743.

Yuliana, N. D., Sugiharto, M.A., Lioe, H.N., Goto, M., Ishikawa, Y.T. 2018.

NMR Metabolomics Revealed Metabolites and Bioactivity Variation in Torbangun leaves Plectranthus amboinicus L. With Different Origins.

Indonesian Journal of Biotechnology. 23(2): 91–101.

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