BAB 6 Kesimpulan dan Saran
6.2 Saran
6.2.1 Perlu penelitian lanjutan tentang peranan COX-2 sebagai penyebab terjadinya inflamasi di mukosa sinonasal, dengan jumlah sampel yang lebih banyak dan dengan disain longitudinal (cohort, cross sectional, case control).
6.2.2 COX-2 diperkirakan berperan penting sebagai mediator dalam terjadinya rinosinusitis kronis karena itu perlu penelitian lebih lanjut tentang penggunaan obat-obatan selektif anti COX-2 yang nantinya berperan dalam penatalaksanaan rinosinusitis kronis sebagai anti inflamasi yang lebih tepat di mukosa sinonasal.
6.2.3 Ada perbedaan yang bermakna antara jumlah sinus yang terlibat dengan peningkatan ekspresi COX-2 pada penderita rinosinusitis kronis, karena itu perlu penelitian lebih lanjut untuk mengetahui apakah ada hubungan peningkatan ekspresi COX-2 dengan luasnya inflamasi yang melibatkan beberapa sinus pada penderita rinosinusitis kronis.
6.2.4 Perlunya penelitian yang lebih mendalam tentang obat-obatan selektif anti COX-2 yang ada saat ini seperti (Celecoxib, Rofecoxib, Valdecoxib, Etoricoxib, Parecoxib, Lumiracoxib) yang nantinya dapat digunakan sebagai analgetik dan anti inflamasi di mukosa sinonasal yang berperan penting sebagai penatalaksanaan rinosinusitis kronik (berdasarkan bukti ilmiah kedokteran yang mutakhir dan sahih (evidence based medicine). 6.2.5 Perlu penelitian lanjutan tentang peranan ekspresi COX-3 di mukosa
sinonasal dikarenakan COX-3 merupakan pecahan dari COX-1 yang sampai saat ini COX-3 mRNA telah diisolasi dibanyak jaringan termasuk korteks otak anjing dan manusia, aorta manusia, endotelium otak binatang pengerat, jantung, ginjal dan jaringan saraf dimana COX-3 sensitif dengan pemberian asetaminofen, yang nantinya memungkinkan untuk penggunaan terapi tambahan dalam pengobatan rinosinusitis kronis.
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