BAB V KESIMPULAN DAN SARAN
B. Saran
1. Sebaiknya perlu dilakukan uji iritasi untuk mendukung tingkat keamanan dari sediaan gel anti-aging ekstrak Spirulina platensis
2. Sebaiknya perlu dilakukan uji aktivitas antioksidan pada sediaan untuk mengetahui persen (%) peredaman radikal bebas dalam sediaan gel anti-aging ekstrak Spirulina platensis
3. Sebaiknya perlu dilakukan penelitian lebih lanjut mengenai efikasi sediaan gel anti-aging ekstrak Spirulina platensis dalam memberikan perlindungan anti- aging terhadap kulit dengan uji in vivo
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DAFTAR PUSTAKA
Adam, M., 2005, Superfood for Optimum Health: Chorella and Spirulina, Truth Publishing International, New York, hal. 42.
Aeni, L.N., Sulaiman, T.N.S., dan Mulyan, S., 2012, Formulasi Gel Mukoadhesif Kombinasi Minyak Cengkeh dan Getah Jarak Pagar serta Uji Aktivitas Antibakteri terhadap Streptococcus mutant, Majalah Farmaseutik, 8(1), 108-112.
Allen, L.V., Popovich, N.G., dan Ansel, H.C., 2013, Ansel Bentuk sediaan Farmasetis dan Sistem Penghantaran Obat, Edisi IX, EGC, Jakarta, hal. 298.
Arlyza, I.S., 2005, Isolasi Pigmen Biru dari Mikroalga Spirulina platensis, Oseanologi dan Limnologi Indonesia, 38, 79-92.
Arunyanart, T., dan Charoenrein, S., 2008, Effect of Sucrose on The Freeze-Thaw Stability of Rice Starch Gels: Correlation with Microstructure and Freezable Water, Carbohydrate Polymers, 74, 514-518.
Badan Pengawas Obat dan Makanan, 2012, Database Registrasi, http://ceknie.pom.go.id/index.php/home/produk/37ebf8b58f39a2c1a8fb5 62c4a38b08d/all/row/10/page/7/order/4/DESC/search/1/Spirulina, diakses tanggal 9 Oktober 2015.
Barel, A.O., Paye, M., dan Maibach, H.I., 2009, Handbook of Cosmetic Science and Technology, 3rd ed., Informa Healthcare, New York, hal. 107, 222. Benson, H.A.E., dan Watkinson, A.C., 2012, Transdermal and Topical Drug
Delivery Principles and Practice, A John Wiley & Sons, Inc., New Jersey, hal. 281.
Binic, I., Lazarevic, V., Ljubenovic, M., Mojsa, J., dan Sokolovic, D., 2013, Skin Ageing: Natural Weapons and Strategies, Evidence-Based Complementary and Alternative Medicine, 2013, 1-10.
Bolton, S., dan Bon, C., 2010, Pharmaceutical Statistics Practical and Clinical Applications, 5th ed., Informa Healthcare, New York, hal. 222-225, 427. Contreras, M.D., dan Sanchez, R., 2002, Application of A Factorial Design to The
Study of The Flow Behavior, Spreadability and Transparency of A Carbopol ETD 2020 Gel. Part II, International Journal of Pharmaceutics, 234, 149–157.
Demirezer, L.O., Kuruuzum-Uz, A., Bergere, I., Schiewe, H.J., dan Zeeck, A., 2001,The Structures of Antioxidant and Cytotoxic Agents from Natural Source: Anthraquinones and Tannins from Roots of Rumex patientia, Phytochemistry, 58, 1213-1217.
Direktorat Jenderal Pengawasan Obat dan Makanan RI, 2014, Farmakope Indonesia, jilid V, Departemen Kesehatan Republik Indonesia, Jakarta, hal. 63.
Dumitriu, S., 2001, Polymeric Biomaterials, 2nd ed., Marcel Dekker, Inc., New York, hal. 383.
El-Samragy, Y., 2012, Food Additive, InTech, Rijeka, hal. 195.
Gad, S.C., 2008, Pharmaceutical Manufacturing Handbook: Production and Processes, John Wiley & Sons, USA, hal. 288, 291.
Garg, A., Aggarwal, D., Garg, S., dan Singla, A.K., 2002, Spreading of Semisolid Formulation: An Update, Pharmaceutical Tecnology, 84-102.
Healthfavo, 2013, Health Medicine and Anatomy Reference Pictures, http://healthfavo.com/labeled-skin-diagrams.html, diakses tanggal 15 Januari 2016.
Helal, D.A., El-Rhman, D.A., Abdel-Halim, S.A., dan El-Nabarawi, M.A., 2012, Formulation and Evaluation of Fluconazole Topical Gel, Int J Pharm Pharm Sci., 4(5), 176-183.
Hirata, T., Tanaka, M., Ooike, M., Tsunomora, T., dan Sakaguchi, M., 2000, Antioxidant Activities of Phycocyanobilin Prepared from Spirulina platensis, Journal of Applied Phycology, 12, 435–439.
Ibrahim, R.C., Polii, H., dan Wungouw, H., 2015, Pengaruh Latihan Peregangan terhadap Fleksibilitas Lansia, Jurnal e-Biomedik, 3(1), 328-333.
Islam, M.T., Rodriguez-Hornedo, N., Ciotti, S., dan Ackermann, C., 2004, Rheological Characterization of Topical Carbomer Gels Neutralized to Different pH, Pharmaceutical Research, 21(7), 1193-1199.
Jusuf, N.K., 2005, Kulit Menua, Majalah Kedokteran Nusantara, 38(2), 184-188. Kabinawa, I.N.K., 2006, Spirulina; Ganggang Penggempur Aneka Penyakit,
Kannahi, M., dan Suganya, R., 2013, Isolation and Identification of Phycocyanin Producing Cyanobacterial Species from Paddy Field, International Journal if Universal Pharmacy and Bio Sciences, 2(5), 67-73.
Kannan, R.R.R., Arumugam, R., dan Meenakshi, S., 2010, Thin Layer Chromatography Analysis of Antioxidant Constituents from Seagrasses of Gulf of Mannar Biosphere Reserve, South India, Int. J. ChemTech Res., 2(3), 1526-1530.
Kedare, S.B., dan Singh, R.P., 2011, Genesis and Development of DPPH method of Antioxidant Assay, J. Food Sci. Technol., 48(4), 412-422.
Kikuzaki, H., Hisamoto, M., Hirose, K., Akiyama, K., dan Taniguchi, H., 2002, Antioxidants Properties of Ferulic Acid and Its Related Compound, J. Agric. Food Chem., 50(7), 2161-2168.
Kuncari, E.S., Iskandarsyah, dan Praptiwi, 2014, Evaluasi, Uji Stabilitas Fisik dan Sineresis Sediaan Gel yang Mengandung Minoksidil, Apigenin dan Perasan Herba Seledri (Apium Graveolens L.), Bul. Penelit. Kesehat., 42(4), 213-222.
Kusumowati, I.T.D., Sudjono,T.A., Suhendi, A., Da’I, M., dan Wirawati, R., 2012, Korelasi Kandungan Fenolik dan Aktivitas Antiradikal Ekstrak Etanol Daun Empat Tanaman Obat Indonesia (Piper bettle, Sauropus androgynous, Averrhoa bilimbi, dan Guazuma ulmifolia), Jurnal Farmasi Indonesia, 13(1), 1-5.
Lu, G., dan Jun, H.W., 1998, Diffusion Studies of Methotrexate in Carbopol and Poloxamer Gels, International Journal of Pharmaceutics, 160, 1-9. Lubrizol Corporation, 2011, Thickening Properties, Pharmaceutical Bulletin, 6, 1-
8.
Madan, J., dan Singh, R., 2010, Formulation and Evaluation of Aloe Vera Topical Gels, International Journal of Pharmaceutical Sciences, 2, 551-515. Masoko, P., dan Eloff, J.N., 2007, Screening of Twenty-Four South African
Combretum an Six Terminalia Species for Antioxidant Activities, Afr. J. Trad., 4(2), 231-239.
Med Express, 2009, Bebas Masalah Kulit, Kanisius, Yogyakarta, hal. 27-31. Molyneux, P., 2004, The Use of The Stable Free Radical Diphenylpicrylhydrazil
(DPPH) for Estimating Antioxidant Activity, Songklanakarin J. Sci. Technol., 26(2), 211-219.
Munawir, Yuniarti, Agustina, N., Umini, S., Pujiyanto, Y., Sunartom, D., dkk., 2006, Cakrawala Geografi 2, Yudistira Ghalia Indonesia, Jakarta, hal. 6. Narayanaswamy, R., dan Ismail, I.S., 2015, Cosmetic Potential of Southeast Asian
Herbs: An Overview, Phytochem Rev., 1-10.
Nurachman, E., dan Angriani, R., 2011, Dasar-dasar Anatomi & Fisiologi, Edisi X, Salemba Medika, Jakarta, hal. 210, 214-219.
Pai, V.V., Shukla, P., dan Kikkeri, N.N., 2014, Antioxidants in Dermatology, Indian Dermatology Online Journal, 5(2), 210-214.
Parker, S., 2009, Ensiklopedia Tubuh Manusia, Dorling Kindersley Limited, London, hal. 146-153.
Rastogi, R.P., Sonani, R.R., dan Madamwar, D., 2015, Physico-chemical Factors Affecting The In Vitro Stability of Phycobiliproteins from Phormidium rubidum A09DM, Bioresource Technology, 190, 219-226.
Rowe, R.C., Sheskey, P.J., dan Quinn, M.E., 2009, Handbook of Pharmaceutical Excipients, 6th ed., Pharmaceutical Press, London, hal. 110, 283, 442, 443, 754.
Schueller, R., dan Romanowski, P., 1999, Conditioning Agents for Hair and Skin, Volume 21, Marcel Dekker, Inc., New York, hal. 101.
Setiadi, 2007, Anatomi & Fisiologi Manusia, Edisi I, Graha Ilmu, Yogyakarta, hal. 25-31.
Setyawan, P.E. dan Satria, Y., 2013, Optimalisasi Ekstraksi dan Uji Stabilitas Phycocyanin dan Mikroalga Spirulina Platensis, Jurnal Teknologi Kimia dan Industri, 2(2), 61-67.
Shalaby dan Shanab, 2013, Antiradical and Antioxidant Activities of Different Spirulina platensis Extracts against DPPH and ABTS Radical Assays, J Mar Biol Oceanogr., 2(1), 1-8.
Silvia, Arreneuz, S., dan Wibowo, M.A., 2015, Aktivitas Antimikroba Ekstrak Daun Soma (Ploiarium Alternifolium Melch) terhadap Jamur Malassezia Furfur dan Bakteri Staphylococcus Aureus, Jurnal JKK., 4(3), 84-93. Spiegel, M.R., dan Stephens, L.J., 2007, Schaum’s Outlines Teori dan Soal-soal
Spirulina source, 1999, Resource Center for Spirulina, Algae and Green Superfoods, http://www.spirulinasource.com/, diakses tanggal 16 Januari 2016.
Sudhakar, M.P., Jagatheesan, A., Perumal, K., dan Arunkumar, K., 2015, Methods of Phycobiliprotein Extraction from Gracilaria crassa and Its Applications in Food Colourants, Alga Research, 8(8), 115-120.
Supriyatna, Moelyono, M.W., Iskandar, Y., dan Febriyanti R.M., 2015, Prinsip Obat Herbal: Sebuah Pengantar untuk Fitoterapi, Deepublish, Yogyakarta, hal. 49.
Vaya, J., dan Aviram, M., 2001, Nutritional Antioxidants: Mechanisms of Action, Analyses of Activities and Medical Applications, Curr. Med. Chem., 1(1), 99-117.
Wikanta, T., Januar, H.I., dan Nursid, M., 2005, Uji Aktivitas Antioksidan, Toksisitas dan Sitotoksisitas Ekstrak Alga Merah Rhodymenia palmate, Jurnal Pascapanen dan Bioteknologi Kelautan dan Perikanan, 11(4), 41- 49.
Wirakusumah, E.S., 2007, Cantik dan Awet Muda dengan Buah, Sayur, dan Herbal, Penebar Plus, Jakarta, hal. 8.
Yin, L., Morita, A., dan Tsuji, T., 2001, Skin Premature Aging Induced by Tobacco Smoking: The Objective Evidence of Skin Replica Analysis, Journal of Dermatological Science, 27(1), 26-31.
Yudiati, E., Sedjati, S., dan Agustian, R., 2011, Aktivitas Antioksidan dan Toksisitas Ekstrak Methanol dan Pigmen Kasar Spirulina sp. Ilmu Kelautan, Indonesian Journal of Marine Sciences, 16(4), 187-192. Yuliani, S.H., 2005, Formulasi Gel Repelan Minyak Atsiri Tanaman Akar Wangi
(Vetivera zizanioidesi (L) Nogh): Optimasi Komposisi Carbopol 3%.b/v.– Propilenglikol, Majalah Farmasi Indonesia, 16(4), 197 – 203. Zullaikah, S., Fulanah, D., dan Fitri, L., 2015, Subcritical Water Extraction of
Essential Oils from Indonesia Basil (Kemangi) Leaf: Effects of Temperature and Extraction Time on Yield and Product Composition, Prosiding Pengembangan Teknologi Kimia untuk Pengolahan Sumber Daya Alam Indonesia, Fakultas Teknik Kimia ITS, Yogyakarta.
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