Simpulan
Ekstrak rosela dan ciplukan dapat
menghambat kerja xantin oksidase dalam mengubah xantin menjadi asam urat Dari seluruh ekstrak rosela dan ciplukan, ekstrak etanol ciplukan memiliki daya inhibisi terbesar (70.08%) namun masih lebih kecil dibandingkan dengan daya inhibisi alopurinol (98.63%). Berdasarkan hasil ini terbukti bahwa etanol ciplukan berpotensi sebagai obat antigout dengan cara menghambat enzim xantin oksidase karena memiliki daya inhibisi di atas 50% sedangkan ekstrak rosela daya inhibisinya masih tergolong rendah. Metode turbidimetri tidak dapat digunakan untuk melihat laju pertumbuhan kristal natrium urat karena kristal natrium urat tidak menimbulkan kekeruhan dalam proses pembentukannya dan dibuktikan dengan rendahnya kelinearan kurva hubungan konsentrasi natrium asetat
terhadap nilai TRI ( R= 0).
Saran
Perlu dilakukan penelitian lebih lanjut untuk mengetahui daya inhibisi ekstrak rosela
dan ciplukan secara in vivo dan uji
farmakologi lain agar memenuhi syarat sebagai obat. Selain itu, perlu dilakukan fraksinasi, analisis ultraviolet serta inframerah
dan analisis NMR. Untuk mengetahui
senyawa aktif yang terkandung di dalam ekstrak, yang secara khusus berpotensi menghambat aktivitas xantin oksidase. Perlu pengembangan metode yang tepat seperti
metode gravimetri untuk meneliti laju
pertumbuhan kristal natrium urat.
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