BAB V KESIMPULAN DAN SARAN
B. Saran
1. Perlu dilakukan penelitian lebih lanjut untuk memastikan konsentrasi surfaktan yang optimum.
2. Perlu dilakukan penelitian lebih lanjut mengenai aktivitas antibakteri sediaan nanoemulgel terhadap Staphylococcus aureus.
48
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53 LAMPIRAN Lampiran 1. Sertifikat Analisis (CoA) Kuersetin
Lampiran 2. Hasil Pembuatan Sediaan Nanoemulsi
Lampiran 3. Hasil Uji Tipe Nanoemulsi
Lampiran 4. Perhitungan Nilai HLB Campuran Pada Formula Acuan
Formula Optimasi Surfaktan Total HLB
Campuran Tween 80 Span 80
F1 11 3 14 12,71
Fa 12 3 15 12,86
Fb 11 3,5 14,5 12,42
Fab 12 3,5 15,5 12,59
Lampiran 5. Perhitungan Nilai HLB Campuran Formula F1
HLB = ( ππ€πππ 80
ππ€πππ 80 + ππππ 80Γ 15) + ( ππ€πππ 80
ππ€πππ 80 + ππππ 80Γ 4,3) HLB = (1
14Γ 15) + (3
14Γ 4,3) = 12,71
Lampiran 6. Hasil Analisis Ukuran Droplet 1. Nanoemulsi F1 Replikasi 1
2. Nanoemulsi F1 Replikasi 2
3. Nanoemulsi F1 Replikasi 3
4. Nanoemulsi Fa Replikasi 1
5. Nanoemulsi Fa Replikasi 2
6. Nanoemulsi Fa Replikasi 3
7. Nanoemulsi Fb Replikasi 1
8. Nanoemulsi Fb Replikasi 2
9. Nanoemulsi Fb Replikasi 3
10. Nanoemulsi Fab Replikasi 1
11. Nanoemulsi Fab Replikasi 2
12. Nanoemulsi Fab Replikasi 3
Lampiran 7. Hasil Pembuatan Nanoemulgel
Lampiran 8. Hasil Uji Organoleptis Sediaan Nanoemulgel
Lampiran 9. Hasil Uji Homogenitas Sediaan Nanoemulgel
Lampiran 10. Hasil Uji pH Sediaan Nanoemulgel
Formula Siklus ke-0 Siklus ke-3
Rata-rata Rata-rata
F1 6,5 Β± 0,0 6,2 Β± 0,1
Fa 6,4 Β± 0,1 6,4 Β± 0,2
Fb 6,5 Β± 0,1 6,4 Β± 0,1
Fab 6,5 Β± 0,0 6,4 Β± 0,1
Lampiran 11. Hasil Perhitungan Pergeseran pH F1 Replikasi 1 = ππ» πΉ1 π 1 π ππππ’π ππ 3 β ππ» πΉ1 π 1 π ππππ’π ππ 0
ππ» πΉ1 π 1 π ππππ’π ππ 0 x 100%
= 6,3β6,5
6,5 x 100%
= -3,08%
Fa Replikasi 1 = ππ» πΉπ π 1 π ππππ’π ππ 3 β ππ» πΉπ π 1 π ππππ’π ππ 0
ππ» πΉπ π 1 π ππππ’π ππ 0 x 100%
= 6,5β6,5
6,5 x 100%
= 0%
= -4,69%
Fb Replikasi 1 = ππ» πΉπ π 1 π ππππ’π ππ 3 β ππ» πΉπ π 1 π ππππ’π ππ 0
ππ» πΉπ π 1 π ππππ’π ππ 0 x 100%
= 6,4β6,6
6,6 x 100%
= -3,03%
Fab Replikasi 1= ππ» πΉππ π 1 π ππππ’π ππ 3 β ππ» πΉππ π 1 π ππππ’π ππ 0
ππ» πΉππ π 1 π ππππ’π ππ 0 x 100%
= 6,4β6,5
6,5 x 100%
= -1,54%
Lampiran 12. Hasil Uji Viskositas Sediaan Nanoemulgel
Formula Siklus ke-0 Siklus ke-3
Rata-rata Rata-rata
F1 127 Β± 5,774 125 Β± 5
Fa 128 Β± 2,887 116 Β± 4,042
Fb 123 Β± 5,774 122 Β± 2,887
Fab 137 Β± 5,774 145 Β± 5
Lampiran 13. Hasil Perhitungan Pergeseran Viskositas
F1 Replikasi 1 = Viskositas πΉ1 π 1 π ππππ’π ππ 3 β Viskositas πΉ1 π 1 π ππππ’π ππ 0
Viskositas πΉ1 π 1 π ππππ’π ππ 0 x 100%
= 125β130
130 x 100%
= -0,04%
Fa Replikasi 1 = Viskositas πΉπ π 1 π ππππ’π ππ 3 β Viskositas πΉπ π 1 π ππππ’π ππ 0
Viskositas πΉπ π 1 π ππππ’π ππ 0 x 100%
= 115β130
130 x 100%
= -0,12%
Fb Replikasi 1 = Viskositas πΉπ π 1 π ππππ’π ππ 3 β Viskositas πΉπ π 1 π ππππ’π ππ 0
Viskositas πΉπ π 1 π ππππ’π ππ 0 x 100%
= 125β120
120 x 100%
= 0,04%
Fab Replikasi 1= Viskositas πΉππ π 1 π ππππ’π ππ 3 β Viskositas πΉππ π 1 π ππππ’π ππ 0
Viskositas πΉππ π 1 π ππππ’π ππ 0 x 100%
= 140β130
130 x 100%
= 0,08%
Lampiran 14. Hasil Uji Daya Sebar Sediaan Nanoemulgel
Formula Siklus ke-0 Siklus ke-3
Rata-rata Rata-rata
F1 6,6 Β± 0,2 6,2 Β± 0,1
Fa 6,6 Β± 0,1 6,4 Β± 0,2
Fb 6,8 Β± 0,1 6,4 Β± 0,1
Fab 6,5 Β± 0,1 6,4 Β± 0,1
Lampiran 15. Hasil Perhitungan Pergeseran Daya Sebar
F1 Replikasi 1 = π·ππ¦π π ππππ πΉ1 π 1 π ππππ’π ππ 3 β π·ππ¦π π ππππ πΉ1 π 1 π ππππ’π ππ 0
π·ππ¦π π ππππ πΉ1 π 1 π ππππ’π ππ 0 x 100%
= 6,3β6,7
6,7 x 100%
= -2,99%
Fa Replikasi 1 = π·ππ¦π π ππππ πΉπ π 1 π ππππ’π ππ 3 β π·ππ¦π π ππππ πΉπ π 1 π ππππ’π ππ 0
π·ππ¦π π ππππ πΉπ π 1 π ππππ’π ππ 0 x 100%
= 6,5β6,7
6,7 x 100%
= 0%
Fb Replikasi 1 = π·ππ¦π π ππππ πΉπ π 1 π ππππ’π ππ 3 β π·ππ¦π π ππππ πΉπ π 1 π ππππ’π ππ 0
π·ππ¦π π ππππ πΉπ π 1 π ππππ’π ππ 0 x 100%
= 6,4β6,6
6,6 x 100%
= -3,03%
Fab Replikasi 1= π·ππ¦π π ππππ πΉππ π 1 π ππππ’π ππ 3 β π·ππ¦π π ππππ πΉππ π 1 π ππππ’π ππ 0
π·ππ¦π π ππππ πΉππ π 1 π ππππ’π ππ 0 x 100%
= 6,4β6,5
6,5 x 100%
= -3,08%
Lampiran 16. Hasil Uji Daya Lekat Sediaan Nanoemulgel
Formula Siklus ke-0 Siklus ke-3
Rata-rata Rata-rata
F1 5,20 Β± 0,02 5,31 Β± 0,22
Fa 5,22 Β± 0,11 5,24 Β± 0,1
Fb 5,54 Β± 0,26 5,27 Β± 0,1
Fab 5,43 Β± 0,1 5,45 Β± 0,16
Lampiran 17. Hasil Perhitungan Pergeseran Daya Lekat
F1 Replikasi 1 = π·ππ¦π πππππ‘ πΉ1 π 1 π ππππ’π ππ 3 β π·ππ¦π πππππ‘ πΉ1 π 1 π ππππ’π ππ 0
π·ππ¦π πππππ‘ πΉ1 π 1 π ππππ’π ππ 0 x 100%
= 5,14β5,22
5,22 x 100%
= -1,53%
Fa Replikasi 1 = π·ππ¦π πππππ‘ πΉπ π 1 π ππππ’π ππ 3 β π·ππ¦π πππππ‘ πΉπ π 1 π ππππ’π ππ 0
π·ππ¦π πππππ‘ πΉπ π 1 π ππππ’π ππ 0 x 100%
= 5,13β5,25
5,25 x 100%
=-2,29%
Fb Replikasi 1 = π·ππ¦π πππππ‘ πΉπ π 1 π ππππ’π ππ 3 β π·ππ¦π πππππ‘ πΉπ π 1 π ππππ’π ππ 0
π·ππ¦π πππππ‘ πΉπ π 1 π ππππ’π ππ 0 x 100%
= 5,2β5,43
65,43 x 100%
= -4,24%
Fab Replikasi 1= π·ππ¦π πππππ‘ πΉππ π 1 π ππππ’π ππ 3 β π·ππ¦π πππππ‘ πΉππ π 1 π ππππ’π ππ 0
π·ππ¦π πππππ‘ πΉππ π 1 π ππππ’π ππ 0 x 100%
= 5,26β5,36
5,36 x 100%
= -1,87%
Lampiran 48. Persamaan, Efek, Kontribusi, dan p-value Respon Persen Transmitan
Lampiran 19. Dokumentasi Alat dan Bahan
Kuersetin Tween 80 Span 80
Olive oil Alkohol 70% Tragakan
Mikropipet dan yellow tip
Sonicator bath Hotplate
Spektrofotometer UV-Vis
Alat Uji Daya Lekat Homogenizer (Ultra turrax)
Pemberat
pH Meter Timbangan Analitik
Mixer Viskometer RION Biological Safety Cabinet (BSC)