Tit le :
Th e I m por t a n ce of solve n t flow r a t e on t he e x t r a ct ion of Andr ogr a pholide
Re se a r che r ( s) :
A.C. Kum or o* and M. Hasan* *
I n st it ut ion :
Depart m ent of Chem ical Engineer ing, Facult y of Engineer ing, Univer sit y of Malay a 50603 Kuala Lum pur
Abst r a ct :
Andrographis paniculat a NEES has been ex t ensively used in t r adit ional m edicine and helps against fever, dysent ery, diar rhoea, inflam m at ion, and sore t hroat . Andr ographolide, t he m ain com ponent of t his plant was ext r act ed from t he leaves w it h super crit ical car bon diox ide ext ract or at 40 º C and 100 bar. The effect of supercrit ical solvent flow rat e ( ranging from 0.5 t o 4 m L/ m in) on t he ext ract yield and select ivit y w as st udied. The ext r act yield incr eased w it h solvent flow rat e. However furt her increase of solvent flow rat e decreased t he t ot al yield. This m ay due t o int rapart icle diffusion resist ance effect in t he ext ract ion process. The opt im um solvent flow rat e w as 2m L/ m in.
Ke y w or ds:
