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Hom e > Vol 1, No 2 ( 2 01 2 ) > Basit h
Efek Nefroprotektor Ekstrak Daun Kemangi
(Ocimum sanctum) Terhadap Kerusakan Sel Ginjal
M encit (M us musculus) Yang Diinduksi Parasetamol
M Ab du l Basit h , En dan g List yan in gsih, Self i Han d ay an i
Abstract
Ba ckg rou nd : Tod ay, con sum ing p aracet am ol as an an algesic an t ip y ret ic d ru gs h as
in creased . Paracet am ol wh ich u sed in inap p rop riat e d ose has b ad eff ect t o our bod y, such as n efrot ox ic. Basil leaf ex t ract h as ant iox id ant as a prot ect ion of f ree radicals and red ucing NAPQI w hich p rod uced by p aracet am ol. The ob j ect iv es of t his research are t o k now t he n efrop rot ect or eff ect an d t h is resear ch w ill shown t h e m u lt ilevel d ose of basil leaf ex t ract as a n efroprot ect or in t he ren al cell dam age ind u ced b y p araset am ol.
M e t ho ds: Th is was exp erim en t al lab orat ory wit h t he p ost t est on ly cont rolled grou p
d esign . Sam ple grou p con sist ed of m ale m ice Sw iss Web st er, 2 - 3 m ont h , + 2 0 g . Sam p les d iv id ed int o 4 g rou ps, each gr ou p has seven m ice. Mice for con t rol g roup ( K) an d t h e fir st t reat m en t g roup ( P1 ) were g iv en aq uad es f or 14 d ay s. Th e secon d t reat m ent grou p ( P2 ) will be g iv en basil leaf ex t ract d ose I for 1 4 day s. The t h ir d t reat m ent grou p ( P3 ) will be g iv en basil leaf ex t ract d ose I I for 1 4 day s.
Paracet am ol will b e g iv en t o P1 , P2 , and P3 , wit h dose 0 ,1 m l/ 2 0 gr weig ht of m ice on t he d ay 1 2 , 1 3, and 1 4 . Fin ally on d ay 1 5t h, m ice are sacr ificed wit h neck d islocat ion t h en t h e renal of m ice was m ade p reparat ions w it h p araffin block s m et hod s and Hem at ox illin Eosin st ain in g . Renal cell d am ag e observed and cou nt ed a m oun t of scored on r en al h ist olog ical k ary op y kn osis, k aryorrh ex is, an d kary oly sis.
Data are analized by One-Way ANOVA test (α= 0,05) and continued by Post Hoc Multiple Comparisons test (LSD) (α = 0,05).
Re sul t s: Resu lt of On e- Way ANOVA sh ow n t hat t h ere was a sig nifican t of d egree
b et w een 4 g roup s. Result of LSD m et h od t h ere was a sig nificant of d eg ree b et w een K- P1, K- P2 , P1 - P2, an d P1- P3 g rou p s; and also it wasn ’t a sign if icant of deg ree b et w een K- P3 an d P2- P3 .
Co ncl usio ns: Th e basil leaf ex t ract s was able t o d ecrease t he ren al cell d am ag in g
of m ice an d t he increase of b asil leaf ex t ract s dose followed b y t h e in crease of p rot ect ion eff ect t o t h e ren al cell d am ag in g of m ice wh ich is ind u ced b y p aracet am ol.
Ke y w ord s: basil leaf ex t ract , paracet am ol, r en al cell d am ag e.
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