24. Liver cirrhosis Epidemiological and Clinical Aspects Department of Internal Medicine Sahlgrenska University Hospital, Goteborg University, Sweden

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Lampiran 1. Analisis Univariat beberapa Variabel

NPar Tests

Statistics 303 245 259 226 303 2 60 46 79 2 54.17 4.4606 2.3448 8.1827 10.46 54.00 1.9800 2.3000 5.3000 9.00 11.755 5.92105 .60094 12.46432 7.626 16 .11 .90 -.90 0 81 36.31 4.66 106.30 48 Valid Missing N Mean Median St d. Dev iation Minimum Maximum

Usia Bilirubin Total

Albumin

serum PPT

Lama perawatan

One-Sample Kolmogorov-Smirnov Test

303 245 259 226 303 54.17 4.4606 2.3448 8.1827 10.46 11.755 5.92105 .60094 12.46432 7.626 .062 .231 .064 .239 .145 .062 .221 .064 .232 .145 -.055 -.231 -.040 -.239 -.101 1.080 3.620 1.023 3.589 2.522 .193 .000 .246 .000 .000 N Mean St d. Dev iation Normal Parametersa,b

Absolute Positiv e Negativ e Most Extreme Dif f erences Kolmogorov -Smirnov Z Asy mp. Sig. (2-tailed)

Usia Bilirubin Total

Albumin

serum PPT

Lama perawatan

Test distribution is Normal. a.

Calculated f rom data. b.

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Frequency Table

Jenis kel amin

205 67,7 67,7 67,7 98 32,3 32,3 100,0 303 100,0 100,0 Laki-laki Perempuan Total Valid

Frequency Percent Valid Percent

Cumulat iv e Percent Usia 10 3.3 3.3 3.3 21 6.9 6.9 10.2 79 26.1 26.1 36.3 104 34.3 34.3 70.6 59 19.5 19.5 90.1 30 9.9 9.9 100.0 303 100.0 100.0 < 31 31 - 40 41 - 50 51 - 60 61 - 70 > 70 Total Valid

Cumulat iv e Percent HBV 184 60.7 60.7 60.7 119 39.3 39.3 100.0 303 100.0 100.0 Y a Tidak Total Valid

Cumulativ e Percent HCV 55 18.2 18.2 18.2 248 81.8 81.8 100.0 303 100.0 100.0 Y a Tidak Total Valid

Cumulativ e Percent

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NAFL 21 6.9 6.9 6.9 282 93.1 93.1 100.0 303 100.0 100.0 Y a Tidak Total Valid

Cumulativ e Percent Alkohol 303 100.0 100.0 100.0 Tidak Valid

Cumulativ e Percent Lain-lain 59 19.5 19.5 19.5 244 80.5 80.5 100.0 303 100.0 100.0 Y a Tidak Total Valid

Cumulativ e Percent Klasifikasi CHILD-PUGH 15 5,0 6,4 6,4 75 24,8 32,1 38,5 144 47,5 61,5 100,0 234 77,2 100,0 69 22,8 303 100,0 A B C Total Valid Sy stem Missing Total

Cumulat iv e Percent

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Perdarahan var. Esof 59 19,5 19,5 19,5 244 80,5 80,5 100,0 303 100,0 100,0 Y a Tidak Total Valid

Cumulativ e Percent Ensefalopati Hepatikum 66 21,8 21,8 21,8 237 78,2 78,2 100,0 303 100,0 100,0 Y a Tidak Total Valid

Cumulativ e Percent Karsinoma Hepatoseluler 34 11,2 11,2 11,2 269 88,8 88,8 100,0 303 100,0 100,0 Y a Tidak Total Valid

Cumulativ e Percent Sindr. Hepatorenal 5 1,7 1,7 1,7 298 98,3 98,3 100,0 303 100,0 100,0 Y a Tidak Total Valid

Cumulativ e Percent

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Hematemesis 79 26,1 26,1 26,1 224 73,9 73,9 100,0 303 100,0 100,0 Y a Tidak Total Valid

Cumulativ e Percent Melena 85 28,1 28,1 28,1 218 71,9 71,9 100,0 303 100,0 100,0 Y a Tidak Total Valid

Cumulativ e Percent Ascites 224 73,9 73,9 73,9 79 26,1 26,1 100,0 303 100,0 100,0 Y a Tidak Total Valid

Cumulativ e Percent

Peritonitis bakterial spontan

1 ,3 ,3 ,3 302 99,7 99,7 100,0 303 100,0 100,0 Y a Tidak Total Valid

Cumulativ e Percent Gastropati HT Porta 39 12,9 12,9 12,9 264 87,1 87,1 100,0 303 100,0 100,0 Y a Tidak Total Valid

Cumulativ e Percent

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Efusi pleura 38 12,5 12,5 12,5 265 87,5 87,5 100,0 303 100,0 100,0 Y a Tidak Total Valid

Cumulativ e Percent Pneumonia 37 12,2 12,2 12,2 266 87,8 87,8 100,0 303 100,0 100,0 Y a Tidak Total Valid

Cumulativ e Percent TB paru 5 1,7 1,7 1,7 298 98,3 98,3 100,0 303 100,0 100,0 Y a Tidak Total Valid

Cumulativ e Percent Syok 7 2,3 2,3 2,3 296 97,7 97,7 100,0 303 100,0 100,0 Y a Tidak Total Valid

Cumulativ e Percent

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Sepsi s 19 6,3 6,3 6,3 284 93,7 93,7 100,0 303 100,0 100,0 Y a Tidak Total Valid

Cumulativ e Percent Penyakit ginjal 10 3,3 3,3 3,3 293 96,7 96,7 100,0 303 100,0 100,0 Y a Tidak Total Valid

Cumulativ e Percent Penyakit jantung 3 1,0 1,0 1,0 300 99,0 99,0 100,0 303 100,0 100,0 Y a Tidak Total Valid

Cumulativ e Percent Survival rate 60 19,8 19,8 19,8 243 80,2 80,2 100,0 303 100,0 100,0 Meninggal Hidup Total Valid

Cumulat iv e Percent Perut membesar 111 36.4 36.4 36.4 194 63.6 63.6 100.0 305 100.0 100.0 Y a Tidak Total Valid

Cumulativ e Percent

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Nyeri perut 17 5.6 5.6 5.6 288 94.4 94.4 100.0 305 100.0 100.0 Y a Tidak Total Valid

Cumulativ e Percent Berak darah 32 10.5 10.5 10.5 273 89.5 89.5 100.0 305 100.0 100.0 Y a Tidak Total Valid

Cumulativ e Percent Muntah darah 63 20.7 20.7 20.7 242 79.3 79.3 100.0 305 100.0 100.0 Y a Tidak Total Valid

Cumulativ e Percent Badan lemas 15 4.9 4.9 4.9 290 95.1 95.1 100.0 305 100.0 100.0 Y a Tidak Total Valid

Cumulativ e Percent Penurunan kesadaran 18 5.9 5.9 5.9 287 94.1 94.1 100.0 305 100.0 100.0 Y a Tidak Total Valid

Cumulativ e Percent

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Mata kuni ng 13 4.3 4.3 4.3 292 95.7 95.7 100.0 305 100.0 100.0 Y a Tidak Total Valid

Cumulativ e Percent Lain2 48 15.7 15.7 15.7 257 84.3 84.3 100.0 305 100.0 100.0 Y a Tidak Total Valid

Cumulativ e Percent Ensefalopati 32 10.5 44.4 44.4 40 13.1 55.6 100.0 72 23.6 100.0 233 76.4 305 100.0 grade I-I I grade III -IV Total Valid

Sy stem Missing

Total

Cumulat iv e Percent Ascites 180 59.0 80.4 80.4 44 14.4 19.6 100.0 224 73.4 100.0 81 26.6 305 100.0 ringan-sedang berat Total Valid Sy stem Missing Total

Cumulat iv e Percent

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Lampiran 2. Analisis Bivariat beberapa Variabel terhadap Survival Rate

Jenis kelamin * Survival rate Crosstabul ation

39 166 205 65,0% 68,3% 67,7% 12,9% 54,8% 67,7% 21 77 98 35,0% 31,7% 32,3% 6,9% 25,4% 32,3% 60 243 303 100,0% 100,0% 100,0% 19,8% 80,2% 100,0% Count

% wit hin Surv iv al rate % of Total

Count

% wit hin Surv iv al rate % of Total Laki-laki Perempuan Jenis kelamin Total Meninggal Hidup Surv iv al rate Total

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HBV * Survival rate Crosstabul ation 35 149 184 58.3% 61.3% 60.7% 11.6% 49.2% 60.7% 25 94 119 41.7% 38.7% 39.3% 8.3% 31.0% 39.3% 60 243 303 100.0% 100.0% 100.0% 19.8% 80.2% 100.0% Count

% wit hin Surv iv al rat e % of Total

Count

% wit hin Surv iv al rat e % of Total Y a Tidak HBV Total Meninggal Hidup Surv iv al rate Total

HCV * Survival rate Crosstabul ation

8 47 55 13.3% 19.3% 18.2% 2.6% 15.5% 18.2% 52 196 248 86.7% 80.7% 81.8% 17.2% 64.7% 81.8% 60 243 303 100.0% 100.0% 100.0% 19.8% 80.2% 100.0% Count

Count

% wit hin Surv iv al rat e % of Total Y a Tidak HCV Total Meninggal Hidup Surv iv al rate Total

NAFL * Survi val rate Crosstabulation

3 18 21 5.0% 7.4% 6.9% 1.0% 5.9% 6.9% 57 225 282 95.0% 92.6% 93.1% 18.8% 74.3% 93.1% 60 243 303 100.0% 100.0% 100.0% 19.8% 80.2% 100.0% Count

Count

% wit hin Surv iv al rat e % of Total Y a Tidak NAFL Total Meninggal Hidup Surv iv al rate Total

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Alkohol * Survival rate Crosstabul ation 60 243 303 100.0% 100.0% 100.0% 19.8% 80.2% 100.0% 60 243 303 100.0% 100.0% 100.0% 19.8% 80.2% 100.0% Count

Count

% wit hin Surv iv al rate % of Total Tidak Alkohol Total Meninggal Hidup Surv iv al rate Total

Lain-lain * Survi val rate Crosstabulation

18 41 59 30.0% 16.9% 19.5% 5.9% 13.5% 19.5% 42 202 244 70.0% 83.1% 80.5% 13.9% 66.7% 80.5% 60 243 303 100.0% 100.0% 100.0% 19.8% 80.2% 100.0% Count

% within Surv iv al rate % of Total

Count

% within Surv iv al rate % of Total Y a Tidak Lain-lain Total Meninggal Hidup Surv iv al rate Total

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Klasifikasi CHILD-PUGH * Survi val rate Crosstabulation 0 15 15 ,0% 8,2% 6,4% ,0% 6,4% 6,4% 4 71 75 7,7% 39,0% 32,1% 1,7% 30,3% 32,1% 48 96 144 92,3% 52,7% 61,5% 20,5% 41,0% 61,5% 52 182 234 100,0% 100,0% 100,0% 22,2% 77,8% 100,0% Count

Count

% within Surv iv al rate % of Total A B C Klasif ikasi CHI LD-PUGH Total Meninggal Hidup Surv iv al rate Total

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**Usia * Survival rate**

Crosstab 1 9 10 2.0 8.0 10.0 1.7% 3.7% 3.3% .3% 3.0% 3.3% 3 18 21 4.2 16.8 21.0 5.0% 7.4% 6.9% 1.0% 5.9% 6.9% 15 64 79 15.6 63.4 79.0 25.0% 26.3% 26.1% 5.0% 21.1% 26.1% 19 85 104 20.6 83.4 104.0 31.7% 35.0% 34.3% 6.3% 28.1% 34.3% 15 44 59 11.7 47.3 59.0 25.0% 18.1% 19.5% 5.0% 14.5% 19.5% 7 23 30 5.9 24.1 30.0 11.7% 9.5% 9.9% 2.3% 7.6% 9.9% 60 243 303 60.0 243.0 303.0 100.0% 100.0% 100.0% 19.8% 80.2% 100.0% Count Expected Count % wit hin Surv iv al rate % of Total

Count

Expected Count % wit hin Surv iv al rate % of Total

Count

Expected Count % wit hin Surv iv al rate % of Total < 31 31 - 40 41 - 50 51 - 60 61 - 70 > 70 Usia Total Meninggal Hidup Surv iv al rate Total Chi-Square Tests 2.604a 5 .761 2.663 5 .752 1.882 1 .170 303 Pearson Chi-Square Likelihood Ratio Linear-by -Linear Association N of Valid Cases Value df Asy mp. Sig. (2-sided)

2 cells (16.7%) hav e expected count less t han 5. The minimum expected count is 1.98.

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**Efusi pleura * Survival rate**

Crosstab 3 35 38 7.5 30.5 38.0 5.0% 14.4% 12.5% 1.0% 11.6% 12.5% 57 208 265 52.5 212.5 265.0 95.0% 85.6% 87.5% 18.8% 68.6% 87.5% 60 243 303 60.0 243.0 303.0 100.0% 100.0% 100.0% 19.8% 80.2% 100.0% Count Expected Count % wit hin Surv iv al rate % of Total

Count

Expected Count % wit hin Surv iv al rate % of Total Y a Tidak Ef usi pleura Total Meninggal Hidup Surv iv al rate Total Chi-Square Tests 3.879b 1 .049 3.069 1 .080 4.649 1 .031 .051 .032 3.866 1 .049 303 Pearson Chi-Square Continuity Correctiona Likelihood Ratio Fisher's Exact Test Linear-by -Linear Association N of Valid Cases Value df Asy mp. Sig. (2-sided) Exact Sig. (2-sided) Exact Sig. (1-sided)

Computed only f or a 2x2 table a.

0 cells (.0%) hav e expected count less than 5. The minimum expected count is 7. 52.

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**Pneumonia * Survival rate**

Count

Expected Count % wit hin Surv iv al rate % of Total Y a Tidak Pneumonia Total Meninggal Hidup Surv iv al rate Total Chi-Square Tests 11.414b 1 .001 9.975 1 .002 9.780 1 .002 .002 .002 11.377 1 .001 303 Pearson Chi-Square Continuity Correctiona Likelihood Ratio Fisher's Exact Test Linear-by -Linear Association N of Valid Cases Value df Asy mp. Sig. (2-sided) Exact Sig. (2-sided) Exact Sig. (1-sided)

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**TB paru * Survival rate**

Crosstab 0 5 5 1.0 4.0 5.0 .0% 2.1% 1.7% .0% 1.7% 1.7% 60 238 298 59.0 239.0 298.0 100.0% 97.9% 98.3% 19.8% 78.5% 98.3% 60 243 303 60.0 243.0 303.0 100.0% 100.0% 100.0% 19.8% 80.2% 100.0% Count Expected Count % wit hin Surv iv al rate % of Total

Count

Expected Count % wit hin Surv iv al rate % of Total Y a Tidak TB paru Total Meninggal Hidup Surv iv al rate Total Chi-Square Tests 1.255b 1 .263 .308 1 .579 2.227 1 .136 .587 .329 1.251 1 .263 303 Pearson Chi-Square Continuity Correctiona Likelihood Ratio Fisher's Exact Test Linear-by -Linear Association N of Valid Cases Value df Asy mp. Sig. (2-sided) Exact Sig. (2-sided) Exact Sig. (1-sided)

2 cells (50.0%) hav e expected count less than 5. The minimum expected count is . 99.

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**Syok * Survival rate**

Crosstab 7 0 7 1.4 5.6 7.0 11.7% .0% 2.3% 2.3% .0% 2.3% 53 243 296 58.6 237.4 296.0 88.3% 100.0% 97.7% 17.5% 80.2% 97.7% 60 243 303 60.0 243.0 303.0 100.0% 100.0% 100.0% 19.8% 80.2% 100.0% Count Expected Count % wit hin Surv iv al rat e % of Total

Count

Expected Count % wit hin Surv iv al rat e % of Total

Count

Expected Count % wit hin Surv iv al rat e % of Total Y a Tidak Sy ok Total Meninggal Hidup Surv iv al rate Total Chi-Square Tests 29.020b 1 .000 24.081 1 .000 23.359 1 .000 .000 .000 28.925 1 .000 303 Pearson Chi-Square Continuity Correctiona Likelihood Ratio Fisher's Exact Test Linear-by -Linear Association N of Valid Cases Value df Asy mp. Sig. (2-sided) Exact Sig. (2-sided) Exact Sig. (1-sided)

1 cells (25.0%) hav e expected count less than 5. The minimum expected count is 1. 39.

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**Sepsis * Survival rate**

Crosstab 18 1 19 3.8 15.2 19.0 30.0% .4% 6.3% 5.9% .3% 6.3% 42 242 284 56.2 227.8 284.0 70.0% 99.6% 93.7% 13.9% 79.9% 93.7% 60 243 303 60.0 243.0 303.0 100.0% 100.0% 100.0% 19.8% 80.2% 100.0% Count Expected Count % wit hin Surv iv al rate % of Total

Count

Expected Count % wit hin Surv iv al rate % of Total Y a Tidak Sepsis Total Meninggal Hidup Surv iv al rate Total Chi-Square Tests 71.676b 1 .000 66.730 1 .000 55.730 1 .000 .000 .000 71.439 1 .000 303 Pearson Chi-Square Continuity Correctiona Likelihood Ratio Fisher's Exact Test Linear-by -Linear Association N of Valid Cases Value df Asy mp. Sig. (2-sided) Exact Sig. (2-sided) Exact Sig. (1-sided)

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**Penyakit ginjal * Survival rate**

Count

Expected Count % wit hin Surv iv al rate % of Total Y a Tidak Peny akit ginjal Total Meninggal Hidup Surv iv al rate Total Chi-Square Tests 2.657b 1 .103 1.504 1 .220 2.231 1 .135 .114 .114 2.648 1 .104 303 Pearson Chi-Square Continuity Correctiona Likelihood Ratio Fisher's Exact Test Linear-by -Linear Association N of Valid Cases Value df Asy mp. Sig. (2-sided) Exact Sig. (2-sided) Exact Sig. (1-sided)

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**Penyakit jantung * Survival rate**

Crosstab 0 3 3 .6 2.4 3.0 .0% 1.2% 1.0% .0% 1.0% 1.0% 60 240 300 59.4 240.6 300.0 100.0% 98.8% 99.0% 19.8% 79.2% 99.0% 60 243 303 60.0 243.0 303.0 100.0% 100.0% 100.0% 19.8% 80.2% 100.0% Count Expected Count % wit hin Surv iv al rate % of Total

Count

Expected Count % wit hin Surv iv al rate % of Total Y a Tidak Peny akit jantung Total Meninggal Hidup Surv iv al rate Total Chi-Square Tests .748b 1 .387 .019 1 .891 1.331 1 .249 1.000 .515 .746 1 .388 303 Pearson Chi-Square Continuity Correctiona Likelihood Ratio Fisher's Exact Test Linear-by -Linear Association N of Valid Cases Value df Asy mp. Sig. (2-sided) Exact Sig. (2-sided) Exact Sig. (1-sided)

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**Perdarahan var. Esof * Survival rate**

Count

Expected Count % wit hin Surv iv al rate % of Total Y a Tidak Perdarahan v ar. Esof Total Meninggal Hidup Surv iv al rate Total Chi-Square Tests 2.907b 1 .088 2.319 1 .128 3.197 1 .074 .102 .059 2.897 1 .089 303 Pearson Chi-Square Continuity Correctiona Likelihood Ratio Fisher's Exact Test Linear-by -Linear Association N of Valid Cases Value df Asy mp. Sig. (2-sided) Exact Sig. (2-sided) Exact Sig. (1-sided)

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**Ensefalopati Hepatikum * Survival rate**

Count

Expected Count % wit hin Surv iv al rate % of Total Y a Tidak Ensef alopati Hepatikum Total Meninggal Hidup Surv iv al rate Total Chi-Square Tests 95.157b 1 .000 91.781 1 .000 81.663 1 .000 .000 .000 94.843 1 .000 303 Pearson Chi-Square Continuity Correctiona Likelihood Ratio Fisher's Exact Test Linear-by -Linear Association N of Valid Cases Value df Asy mp. Sig. (2-sided) Exact Sig. (2-sided) Exact Sig. (1-sided)

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**Karsinoma Hepatoseluler * Survival rate**

Count

Expected Count % wit hin Surv iv al rate % of Total Y a Tidak Karsinoma Hepatoseluler Total Meninggal Hidup Surv iv al rate Total Chi-Square Tests .626b 1 .429 .317 1 .573 .668 1 .414 .502 .296 .624 1 .429 303 Pearson Chi-Square Continuity Correctiona Likelihood Ratio Fisher's Exact Test Linear-by -Linear Association N of Valid Cases Value df Asy mp. Sig. (2-sided) Exact Sig. (2-sided) Exact Sig. (1-sided)

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**Sindr. Hepatorenal * Survival rate**

Crosstab 2 3 5 1.0 4.0 5.0 3.3% 1.2% 1.7% .7% 1.0% 1.7% 58 240 298 59.0 239.0 298.0 96.7% 98.8% 98.3% 19.1% 79.2% 98.3% 60 243 303 60.0 243.0 303.0 100.0% 100.0% 100.0% 19.8% 80.2% 100.0% Count Expected Count % wit hin Surv iv al rate % of Total

Count

Expected Count % wit hin Surv iv al rate % of Total Y a Tidak Sindr. Hepatorenal Total Meninggal Hidup Surv iv al rate Total Chi-Square Tests 1.306b 1 .253 .333 1 .564 1.093 1 .296 .258 .258 1.302 1 .254 303 Pearson Chi-Square Continuity Correctiona Likelihood Ratio Fisher's Exact Test Linear-by -Linear Association N of Valid Cases Value df Asy mp. Sig. (2-sided) Exact Sig. (2-sided) Exact Sig. (1-sided)

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**Hematemesis * Survival rate**

Count

Expected Count % wit hin Surv iv al rate % of Total Y a Tidak Hematemesis Total Meninggal Hidup Surv iv al rate Total Chi-Square Tests .198b 1 .656 .079 1 .779 .196 1 .658 .743 .384 .198 1 .657 303 Pearson Chi-Square Continuity Correctiona Likelihood Ratio Fisher's Exact Test Linear-by -Linear Association N of Valid Cases Value df Asy mp. Sig. (2-sided) Exact Sig. (2-sided) Exact Sig. (1-sided)

(32)

**Melena * Survival rate**

Count

Expected Count % wit hin Surv iv al rate % of Total Y a Tidak Melena Total Meninggal Hidup Surv iv al rate Total Chi-Square Tests .141b 1 .708 .046 1 .830 .139 1 .709 .749 .410 .140 1 .708 303 Pearson Chi-Square Continuity Correctiona Likelihood Ratio Fisher's Exact Test Linear-by -Linear Association N of Valid Cases Value df Asy mp. Sig. (2-sided) Exact Sig. (2-sided) Exact Sig. (1-sided)

(33)

**Ascites * Survival rate**

Count

Expected Count % wit hin Surv iv al rate % of Total Y a Tidak Ascites Total Meninggal Hidup Surv iv al rate Total Chi-Square Tests .753b 1 .385 .495 1 .482 .777 1 .378 .417 .243 .751 1 .386 303 Pearson Chi-Square Continuity Correctiona Likelihood Ratio Fisher's Exact Test Linear-by -Linear Association N of Valid Cases Value df Asy mp. Sig. (2-sided) Exact Sig. (2-sided) Exact Sig. (1-sided)

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**Peritonitis bakterial spontan * Survival rate**

Crosstab 1 0 1 .2 .8 1.0 1.7% .0% .3% .3% .0% .3% 59 243 302 59.8 242.2 302.0 98.3% 100.0% 99.7% 19.5% 80.2% 99.7% 60 243 303 60.0 243.0 303.0 100.0% 100.0% 100.0% 19.8% 80.2% 100.0% Count Expected Count % wit hin Surv iv al rate % of Total

Count

Expected Count % wit hin Surv iv al rate % of Total Y a Tidak Peritonitis bakterial spontan Total Meninggal Hidup Surv iv al rate Total Chi-Square Tests 4.063b 1 .044 .576 1 .448 3.252 1 .071 .198 .198 4.050 1 .044 303 Pearson Chi-Square Continuity Correctiona Likelihood Ratio Fisher's Exact Test Linear-by -Linear Association N of Valid Cases Value df Asy mp. Sig. (2-sided) Exact Sig. (2-sided) Exact Sig. (1-sided)

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**Gastropati HT Porta * Survival rate**

Count

Expected Count % wit hin Surv iv al rate % of Total Y a Tidak Gastropati HT Porta Total Meninggal Hidup Surv iv al rate Total Chi-Square Tests 1.374b 1 .241 .916 1 .339 1.503 1 .220 .288 .170 1.369 1 .242 303 Pearson Chi-Square Continuity Correctiona Likelihood Ratio Fisher's Exact Test Linear-by -Linear Association N of Valid Cases Value df Asy mp. Sig. (2-sided) Exact Sig. (2-sided) Exact Sig. (1-sided)

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Ensefalopati * Survival rate Crosstabulation 5 27 32 12.5% 84.4% 44.4% 6.9% 37.5% 44.4% 35 5 40 87.5% 15.6% 55.6% 48.6% 6.9% 55.6% 40 32 72 100.0% 100.0% 100.0% 55.6% 44.4% 100.0% Count

Count

% within Surv iv al rate % of Total grade I-II grade III-IV Ensef alopati Total Meninggal Hidup Surv iv al rate Total

Ascites * Survival rate Crosstabul ation

36 143 179 76.6% 81.3% 80.3% 16.1% 64.1% 80.3% 11 33 44 23.4% 18.8% 19.7% 4.9% 14.8% 19.7% 47 176 223 100.0% 100.0% 100.0% 21.1% 78.9% 100.0% Count

Count

% wit hin Surv iv al rate % of Total ringan-sedang berat Ascites Total Meninggal Hidup Surv iv al rate Total

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**Klasifikasi CHILD-PUGH * Survival rate**

Tahun * Survival rate Crosstabulation

22 90 112 36.7% 37.0% 37.0% 7.3% 29.7% 37.0% 22 101 123 36.7% 41.6% 40.6% 7.3% 33.3% 40.6% 16 52 68 26.7% 21.4% 22.4% 5.3% 17.2% 22.4% 60 243 303 100.0% 100.0% 100.0% 19.8% 80.2% 100.0% Count

Count

% wit hin Surv iv al rat e % of Total 2010 2011 2012 Tahun Total Meninggal Hidup Surv iv al rate Total Crosstab 0 15 15 .0% 8.2% 6.4% .0% 6.4% 6.4% 4 71 75 7.7% 39.0% 32.1% 1.7% 30.3% 32.1% 48 96 144 92.3% 52.7% 61.5% 20.5% 41.0% 61.5% 52 182 234 100.0% 100.0% 100.0% 22.2% 77.8% 100.0% Count

Count

% within Surv iv al rate % of Total A B C Klasif ikasi CHI LD-PUGH Total Meninggal Hidup Surv iv al rate Total

(38)

Chi-Square Tests 26.949a 2 .000 33.354 2 .000 24.502 1 .000 234 Pearson Chi-Square Likelihood Ratio Linear-by -Linear Association N of Valid Cases Value df Asy mp. Sig. (2-sided)

1 cells (16.7%) hav e expected count less t han 5. The minimum expected count is 3.33.

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Lampiran 3. Tabel Frekuensi dari beberapa Variabel

Variabel Frekuensi Prosentase

Jenis kelamin Laki-laki 205 67,7 Perempuan 98 32,3 Usia < 31 tahun 10 3,3 31 – 40 tahun 21 6,9 41 – 50 tahun 79 26,1 51 – 60 tahun 104 34,3 61 – 70 tahun 59 19,5 > 70 tahun 30 9,9 Keluhan utama Perut membesar 111 36,4 Nyeri perut 17 5,6 Berak darah 32 10,5 Muntah darah 63 20,7 Badan lemas 15 4,9 Penurunan kesadaran 18 5,9 Mata kuning 13 4,3 Lain2 48 15,7 Etiologi Virus HBV 184 60,7 HCV 55 18,2 HBV dan HCV 17 30,9 Non Virus NAFL 21 6,9 Lain-lain 59 19,5 Klasifikasi CHILD-PUGH A 15 6,4 B 75 32,1 C 144 61,5 Komplikasi

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Ensefalopati Hepatikum 66 21,8 Karsinoma hepatoseluler 34 11,2 Sindrom hepatorenal 5 1,7 Hematemesis 79 26,1 Melena 85 28,1 Ascites 224 73,9

Peritonitis bacterial spontan 1 0,3

Gastropati HT Porta 29 12,9 Komorbid Efusi pleura 38 12,5 Pneumonia 37 12,2 TB paru 5 1,7 Syok 7 2,3 Sepsis 19 6,3 Penyakit ginjal 10 3,3 Penyakit jantung 3 1 Ensefalopati Hepatikum Tidak ada 233 76,4 Grade I-II 32 10,5 Grade III-IV 40 13,1 Ascites Tidak ada 81 26,6 Ringan-sedang 180 59 Berat 44 14,4 Survival rate Meninggal 60 19,8 Hidup 243 80,2

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Lampiran 4. Tabel Tabulasi Silang Berdasarkan Survival Rate

Variabel

Status

Meninggal Hidup Jumlah

n % n % n % Jenis kelamin Laki-laki 39 65 166 68,3 205 67,7 Perempuan 21 35 77 31,7 98 32,3 Usia < 31 tahun 1 1,7 9 3,7 10 3,3 31 – 40 tahun 3 5 18 7,4 21 6,9 41 – 50 tahun 15 25 64 26,3 79 26,1 51 – 60 tahun 19 31,7 85 35 104 34,3 61 – 70 tahun 15 25 44 18,1 59 19,5 > 70 tahun 7 11,7 23 9,5 30 9,9 Etiologi Virus HBV 35 58,3 149 61,3 184 60,7 HCV 8 13,3 47 19,3 55 18,2 HBV dan HCV 4 50 13 27,7 17 30,9 Non Virus NAFL 3 5 18 7,4 21 6,9 Lain-lain 18 30 41 16,9 59 19,5 Klasifikasi CHILD-PUGH A 0 0 15 8,2 15 6,4 B 4 7,7 71 39 75 32,1 C 48 92,3 96 52,7 144 61,5 Komplikasi

Perdarahan varises esophagus 7 11,7 52 21,4 59 19,5

Ensefalopati hepatikum 41 68,3 25 10,3 66 21,8 Karsinoma hepatoseluler 5 8,3 29 11,9 34 11,2 Sindroma hepatorenal 2 3,3 3 1,2 5 1,7 Hematemesis 17 28,3 62 25,5 79 26,1 Melena 18 30 67 27,6 85 28,1 Ascites 47 78,3 177 72,8 224 73,9

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Peritonitis bakterial spontan 1 1,7 0 0 1 0,3 Gastropati HT Porta 5 8,3 34 14 39 12,9 Komorbid Efusi pleura 3 5 35 14,4 38 12,5 Pneumonia 15 25 22 9,1 37 12,2 TB paru 0 0 5 2,1 5 1,7 Syok 7 11,7 0 0 7 2,3 Sepsis 18 30 1 0,4 19 6,3 Penyakit ginjal 4 6,7 6 2,5 10 3,3 Penyakit jantung 0 0 3 1,2 3 1 Ensefalopati Hepatikum Grade I-II 5 12,5 27 84,4 32 44,4 Grade III-IV 35 87,5 5 15,6 40 55,6 Ascites Ringan-sedang 36 76,6 143 81,3 179 80,3 Berat 11 23,4 33 18,8 44 19,7 Tahun 2010 22 36,7 90 37 112 37 2011 22 36,7 101 41,6 123 40,6 2012 16 26,7 52 21,4 68 22,4

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Tabel uji normalitas kolmogorov smirnov

Variabel

p

Usia

0,193

Bilirubin Total

0,000

Albumin serum

0,246

PPT

0,000

Lama perawatan

0,000

Tabel deskriptif

Variabel

N

Mean

SD

Usia

303 54,17

11,755

Albumin serum

259 2,345

0,6009

Variabel

N

Median

Min.

Max.

Bilirubin Total

245 1,98

0,11

36,31

PPT

226 5,3

-0,9

106,3

Lama perawatan

303

9

0

48

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Klasifikasi CHILD-PUGH

Status

p

Meninggal Hidup Jumlah

n % n % n %

A 0 0 15 8,2 15 6,4 < 0,001

B 4 7,7 71 39 75 32,1

C 48 92,3 96 52,7 144 61,5

Dari uji Chi Square antara Klasifikasi CHILD-PUGH terhadap status survival

didapatkan nilai p = < 0,001, karena p < 0,05 maka dapat disimpulkan terdapat

hubungan yang signifikan antara klasifikasi CHILD-PUGH dengan status survival.

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Tabel sebaran usia berdasarkan survival rate

Usia Survival Rate p Meninggal Hidup n (60) % n (243) % < 31 1 1,7 9 3,7 0,761£ 31 – 40 3 5 18 7,4 41 – 50 15 25 64 26,3 51 – 60 19 31,7 85 35 61 – 70 15 25 44 18,1 > 70 7 11,7 23 9,5

Keterangan :

£

Pearson Chi Square

Tabel Hubungan comorbid terhadap survival rate

Comorbid Survival Rate p Meninggal Hidup n (60) % n (243) % Efusi pleura 3 5 35 14,4 0,049*£ Pneumonia 15 25 22 9,1 0,001*£ TB paru 0 0 5 2,1 0,587¥ Syok 7 11,7 0 0 0,000*¥ Sepsis 18 30 1 0,4 0,000*¥ Penyakit ginjal 4 6,7 6 2,5 0,114¥ Penyakit jantung 0 0 3 1,2 1,000¥

Keterangan :

* Signifikan p < 0,05

£

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¥

Fisher’s Exact Test

Tabel Hubungan komplikasi terhadap survival rate

Komplikasi

Survival Rate

p

Meninggal Hidup

n (60) % n (243) %

Perdarahan varises Esofagus 7 11,7 52 21,4 0,088£

Ensefalopati Hepatikum 41 68,3 25 10,3 0,001*£ Karsinoma Hepatoseluler 5 8,3 29 11,9 0,429£ Sindroma Hepatorenal 2 3,3 3 1,2 0,258¥ Hematemesis 17 28,3 62 25,5 0,656£ Melena 18 30 67 27,6 0,708£ Ascites 47 78,3 177 72,8 0,385£

Peritonitis bacterial spontan 1 1,7 0 0 0,198¥

Gastropati HT Porta 5 8,3 34 14 0,241£

Keterangan :

* Signifikan p < 0,05

£

Pearson Chi Square

¥

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Lampiran 7. Dokumentasi Penelitian

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