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DAFTAR PUSTAKA

1. Kemendag. Kemendag Mendorong Masyarakat Untuk Beralih Dari Minyak

Goreng Curah Ke Minyak Goreng Kemasan. www.kemendag.go.id.

Published 2013.

2. Ng C, Kamisah Y, Faizah O, et al. Involvement of Inflammation and

Adverse Vascular Remodelling in the Blood Pressure Raising Effect of

Repeatedly Heated Palm Oil in Rats. 2012.

3. Martin J, Joffre F, Vernevaut M. Biochemical and Molecular Action of

Nutrients Cyclic Fatty Acid Monomers from Heated Oil Modify the

Activities of Lipid Synthesizing and Oxidizing Enzymes in Rat Liver 1 , 2.

2000:1524-1530.

4. Adam S, Das S, Jaarin K. A Detailed Microscopic Study of The Changes in

The Aorta of Experimental Model of Postmenopausal Rats Fed with

Repeatedly Heated Palm Oil. Int J Exp Pathol. 2009;90(3):321-327.

5. Leong X, Aishah A, Nor AU, Das S, Jaarin K. Heated Palm Oil Causes

Rise in Blood Pressure and Cardiac Changes in Heart Muscle in

Experimental Rats. Acheives Med Res. 2008;39(6):567-572.

6. Goodman LS, Gilman A. Dasar Farmakologi Terapi. X. (Hardman JG,

Limbird LE, Aisyah C, eds.). Jakarta: ECG; 2012.

7. Wilmana PF, Gunawan SG. Analgesik-Antipiretik Analgesik Anti-Inflamasi

Nonsteroid Dan Obat Gangguan Sendi Lainnya. Dalam: Farmakologi Dan Terapi. V. Jakarta: Balai Penerbit FKUI; 2007.

(2)

Faces of Glutathione, A Cellular Protagonist. Biochem Pharmacol. 2003;66

(8):1499-1503.

9. Ulilalbab A. Aktivitas Antioksidan Tablet Effervescent Rosella Ungu

Sebagai Suplement Penghambat Laju Peroksidasi Melalui Pengujian In

Vivo. PKM-P. 2010.

10. Qinna NA, Mallah EM, Arafat TA, Idkaidek NM. Effect Of Licorice and

Grapefruit Juice on Paracetamol Pharmacokinetics in Human Saliva. Int J

Pharm Pharm Sci. 2012;4(4):158-162.

11. Barshop NJ, Capparelli E V, Sirlin CB, Jeffrey B, Lavine JE.

Acetaminophen Pharmacokinetics in Children with Nonalcoholic Fatty

Liver Disease. J Pediatr Gastroenterol Nutr. 2012;52(2):198-202.

12. Kumdi BV, Kolawole JA, Apeh E. The Effect of Yoyo Bitters on The

Pharmacokinetics of Single Oral Dose Paracetamol Tablet in Human

Volunteers. Int J Biol Chem Sci. 2011;5:717-723.

13. Pradana DA, Hayati F, Samudra AG, Setya A. Effect of Curcumin and

Honey to Pharmacokinetics of Paracetamol in Male Wistar Rats. Eksakta.

2013;12(1):193.

14. Simaremare P, Andrie M, Bambang Wijianto. Effect of Durian Fruit Juice

(Durio zibethinus Murr.) to Pharmacokinetic Profile of Paracetamol on

Wistar Male Rats (Rattus norvegicus L.). Tradit Med J.

2013;18(3):178-186.

(3)

16. Sartika RAD. Pengaruh Suhu dan Lama Proses Menggoreng (Deep Frying)

Terhadap Pembentukan Asam Lemak Trans. Markara Sains. 2009;13:23-28.

17. Lestari P. Pemanfaatan Minyak Goreng Jelantah Pada Pembuatan Sabun

Cuci Piring. Tesis. 2010.

18. Rukmini A. Regenerasi Minyak Goreng Bekas dengan Arang Sekam

Menekan Kerusakan Organ Tubuh. Semin Nas Teknol 2007 (SNT 2007). 2007:1978-9777.

19. Mulyati S, Meilina H. Pemurnian Minyak Jelantah dengan Menggunakan

Sari Mengkudu. 2007.

http://222.124.186.229/gdl40/go.php?id=gdlnode-gdl-res-2007-srimulyati-1082&node-3517&start=6 .

20. Oktaviani ND. Hubungan Lamanya Pemanasan dengan Kerusakan Minyak

Goreng Curah Ditinjau dari Bilangan Peroksida. J Biomedika.

2009;1:31-34.

21. Lee J, Lee S, Lee H, Park K, Choe E. Spinach (Spinacia oleracea) as A

Natural Food Grade Antioxidant in Deep Fat Fried Products. J Agric Food

Chem. 2002;50:5664-5669.

22. Herawati, Akhlus S. Kinerja (Bht) sebagai Antioksidan Minyak Sawit pada

Perlindungan terhadap Oksidasi Oksigen Singlet. Akta Kim. 2006;2:1-8. 23. Azeredo HMC, Faria JAF, Silva. Minimization of Proxide Formation Rate

in Soybean Oil by Antioxidant Combinations. Food Res Int.

2004;37:689-694.

(4)

Lemak Bebas (FFA), Bilangan Peroksida, dan Warna Gelap Minyak

Goreng Bekas. Semin Nas Tek Kim Indones – SNTKI 2009. 2009:1-14. 25. Ghidurus M, Turtoi M, Boskou G, Niculita P, Stan V. Nutritional and

Health Aspects Related to Frying. Rom Biotechnol Lett. 2010;15(6).

26. Castillo’n PG, Artalejo FR, Fornés NS, et al. Intake of Fried Foods is

Associated with Obesity in The Cohort of Spanish Adults from The

European Prospective Investigation into Cancer and Nutrition. Am J Clin

Nutr. 2007;86:198-205.

27. Koch A, KÖnig B, Spielmann J, Leitner A, Stang GL, Eder K. Thermally

Oxidized Oil Increases the Expression of Insulin-Induced Genes and

Inhibits Activation of Sterol Regulatory Element-Binding Protein-2 in Rat

Liver. J Nutr Biochem Mol Genet Mech. 2007;137:2018-2023.

28. Toussaint K, Yang XC, Zielinski MA, et al. What Do We (Not) Know

About How Paracetamol (Acetaminophen) Works? J Clin Pharm Ther. 2010:617-638. doi:10.1111/j.1365-2710.2009.01143.x.

29. Liudmila LM, Sangkuhl K, Caroline FT, Garret AF, Russ BA, Teri EK.

PharmGKB Summary: Pathways of Acetaminophen Metabolism at The

Therapeutic Versus Toxic Doses. Pharmacogenet Genomics. 2015.

30. Katzung BG. Farmakologi: Dasar Dan Klinik Buku 2. I. Jakarta: Salemba Medika; 2002.

31. Ubaldo C, Hall NS, Le B. Postmarketing Review of Intravenous

Acetaminophen Dosing Based on Food and Drug Administration

(5)

32. Parkinson A. Biotransformation of Xenobiotics. V. (Klaassen C, ed.). New

York: McGraw-Hill; 1996.

33. Gibson G. Introduction to Drug Metabolism. II. London: Blackie

Academics and Professional; 1994.

34. Mitchell R, McGill, Jaeschke H. Metabolism And Disposition of

Acetaminophen: Recent Advances in Relation to Hepatotoxicity and

Diagnosis. Pharm Res. 2013;30(9):2174-2187.

35. Short Communication. Involvement of Human Cytochrome P450 2D6 in

The Bioactivation of Acetaminophen. 2000;28(12):1397-1400.

36. Winarsi H. Antioksidan Alami Dan Radikal Bebas: Potensi Dan

Aplikasinya Dalam Kesehatan. V. Yogyakarta: Penerbit Kanisius; 2011.

37. Tjay TH, Rahardja K. Obat-Obat Penting : Khasiat, Penggunaan, Dan

Efek-Efek Sampingnya. VI. Jakarta: Penerbit PT. Elex Media Komputindo;

2002.

38. Katzung BG. Basic and Clinical Pharmacology. XII. New York:

McGraw-Hill; 2011.

39. WHO. Research Guideliness For Evaluating The Safety and Efficacy of

Herbal Medicines. Manila: Regional Office for The Western Pasific; 2003.

40. Leong X-F, Mustafa MR, Das S, Jaarin K. Association of Elevated Blood

Pressure and Impaired Vasorelaxation in Experimental Sprague-Dawley

Rats Fed with Heated Vegetable Oil. Lipids Health Dis. 2010;9(66):1-10.

(6)

42. Laurence DR, Bacharach AL. Evaluation of Drug Activities:

Pharmacometrics, Ed. by D.R. Laurence and A.L. Bacharach. London: Academic Press; 1964.

43. Rusdiana T, Sjuib F, Asyarie S. Interaksi Farmakokinetik Kombinasi Obat

Parasetamol dan Fenilpropanolamin Hidroklorida sebagai Komponen Obat

Flu. Skripsi. 2009:2-4.

44. Depkes RI. Farmakope Indonesia. IV. Jakarta: Departemen Kesehatan Republik Indonesia; 1995.

45. Sarwono J. Pintar Menulis Karya Ilmiah Kunci Sukses Dalam Menulis

Ilmiah. Yogyakarta: CV. Andi OFFSET; 2010.

46. Hakim L. Farmakokinetik. Yogyakarta: Bursa Ilmu; 2010.

47. Slattery JT, Wilson JM, BS TFK, Nelson SD. Dose-dependent

pharmacokinetics of acetaminophen: Evidence of glutathione depletion in

humans. Clin Pharmacol Ther. 1987;41(4):413-418.

48. Forrest JAH, Clements JA, Prescott LF. Clinical Pharmacokinetics of

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Lampiran 6. Tabel konversi perhitungan dosis

TABEL KONVERSI PERHITUNGAN DOSIS LAURENCE & BACHARACH42

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Lampiran 7.Berat badan tikus dan rerata sisa pakan perlakuan

1. Berat badan tikus

No. Kelompok Berat Dosis

1 K1 233 gram 1,45 mL

2 K2 189 gram 1,18 mL

3 K3 249 gram 1,55 mL

4 K4 217 gram 1,36 mL

5 K5 176 gram 1,1 mL

6 P1 255 gram 1,59 mL

7 P2 211 gram 1,31 mL

8 P3 274 gram 1,71 mL

9 P4 300 gram 1,87 mL

10 P5 257 gram 1,60 mL

2. Rerata sisa pakan perlakuan

No. Kelompok Rerata sisa pakan

1 P1 2,83 gram

2 P2 3,38 gram

3 P3 2,36 gram

4 P4 1,87 gram

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Lampiran 8.Absorbansi parasetamol pada darah tikus

1. Absorbansi parasetamol pada darah kelompok kontrol

Menit

2. Absorbansi parasetamol pada darah kelompok perlakuan

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Lampiran 9. Kadar parasetamol pada darah tikus

1. Kadar parasetamol pada darah kelompok kontrol

Menit

2. Kadar parasetamol pada darah kelompok perlakuan

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Lampiran 10. Ln kadar paraseamol pada darah tikus

1. Ln kadar parasetamol pada darah kelompok kontrol

Menit

2. Ln kadar parasetamol pada darah kelompok perlakuan

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Lampiran 11. Parameter farmakokinetik

1. Parameter farmakokinetik kelompok kontrol

Parameter Farmakokinetik

Kelompok

K1 K2 K3 K4 K5 Rerata

Kel 0,00445 0,00389 0,00416 0,00416 0,00374 0,00408

t1/2e 155,800 178,392 166,587 166,461 185,155 170,479

Ka 0,123 0,156 0,089 0,205 0,144 0,143

t1/2a 5,657 4,457 7,831 3,386 4,800 5,226

tmaks 28,086 24,335 36,252 19,428 25,972 26,815

Cmax 36,848 35,168 33,419 37,554 35,505 35,699

AUC0-inf 9386,096 9950,508 9341,139 9780,476 10454,477 9782,539

Vd 277,849 244,213 319,101 267,207 224,897 266,653

Cl 1,236 0,949 1,327 1,112 0,842 1,093

2. Parameter farmakokinetik kelompok perlakuan

Parameter Kelompok

Farmakokinetik P1 P2 P3 P4 P5 Rerata

Kel 0,00271 0,00272 0,00292 0,00248 0,00265 0,00269

t1/2e 255,720 254,779 237,329 278,806 261,509 257,629

Ka 0,152 0,107 0,084 0,182 0,126 0,130

t1/2a 4,547 6,448 8,278 3,818 5,495 5,717

tmaks 26,917 35,096 41,533 23,967 31,286 31,760

Cmaks 45,102 43,890 43,555 44,400 45,201 44,430

AUC0-inf 17902,400 17752,205 16839,270 18959,450 18531,310 17996,927

Vd 262,184 217,040 278,215 317,449 260,650 267,108

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Lampiran 12. Hasil uji statistik

1. Jumlah sampel tiap kelompok

Case Processing Summary

Tikus

Cases

Valid Missing Total

N Percent N Percent N Percent

K Kontrol 5 100,0% 0 0,0% 5 100,0%