Correlation Study of Pseudomonas aeruginosa Antibiotics Sensitivity and Antibiotics Consumption in a Private Hospital in Surabaya, Indonesia
Fauna Herawati, MFarm-Klin., Apt
Centre for Medicines Information and Pharmaceutical Care, Pharmacy Faculty, University of Surabaya, Surabaya, Indonesia
Addresses: Jl. Raya Kalirungkut Surabaya 60293 Indonesia Email address: fauna@ubaya.ac.id
Objective
This study evaluates the correlation of Pseudomonas aeruginosa antibiotics sensitivity and antibiotics consumption at a private hospital in Surabaya, Indonesia from 2001 to 2010.
Methods
The data of antibiotics sensitivity testing to Pseudomonas aeruginosa and antibiotics consumption were collected retrospectively and correlated annually from 2001 to 2010. The Defined Daily Dose (DDD) per 100 bed days was used as an antibiotic measuring unit. The strength of the relationship between antibiotics sensitivity and antibiotics consumption is quantified by Pearson product moment correlation coefficient (r).
Results
correlation (r) between antibiotics sensitivity and ceftazidime (0.36) was higher than the correlation between antibiotics sensitivity and amikacin (0.03).
Discussion
Pseudomonas aeruginosa has an outer membrane and a capability to transfer mutational genes which are resistant to antibiotics. Some antibiotics are not able to permeate the membrane of Pseudomonas aeruginosa, while the others could enter into its periplasmic space and are limited by the permeability mutation. A judicious use of antibiotics will minimize the resistance of antibiotics.
Conclusion
The strength of the relationship between antibiotics sensitivity and antibiotics consumption varied. The higher ceftazidime consumption was more likely to reduce antibiotics sensitivity than amikacin consumption.
