Analisis Kualitatif dengan KCKT

LAPORAN PRAKTIKUM METODE ANALISIS INSTRUMEN LAPORAN PRAKTIKUM METODE ANALISIS INSTRUMEN

PERCOBAAN 3.1 PERCOBAAN 3.1

ANALISIS KUALITATIF DAN KUANTITATIF BAHAN BAKU DENGAN ANALISIS KUALITATIF DAN KUANTITATIF BAHAN BAKU DENGAN

METODE KROMATOGRAFI CAIR KINERJA TINGGI METODE KROMATOGRAFI CAIR KINERJA TINGGI

Disusun oleh : Disusun oleh : KELOMPOK 3B KELOMPOK 3B Y YEENNI I SSAARRII ((1100006600331122004466 M MAARRSS!!A A BBEE""AARRI I AA ((11000066003311220044## IIMMAAS S $$AAKKIIAA!! ((11000066003311220044%% & &IIDDYYAA ((110000660033112200''00 

AA))RRI I $$AAKKIIYYYYAA""* * SS ((110000660033112200''11 A

A++EEP P SSOOMMAANN""RRII ((110000660033112200''22 ",

",n--,l n--,l P.,/i/u P.,/i/u : : 2 2 e.u,.i e.u,.i 201201 "

",,nn----,,l l LL,,oo..,,nn : : 4 4 MM,,..ee  220011 Asisen

Asisen : : Sh,ni Sh,ni &il,n&il,n5,.i 5,.i S7,.S7,.

LABORATORIUM FARMASI INSTRUMEN LABORATORIUM FARMASI INSTRUMEN

PROGRAM STUDI FARMASI PROGRAM STUDI FARMASI

FAKULTAS MATEMATIKA DAN ILMU PENGETAHUAN ALAM FAKULTAS MATEMATIKA DAN ILMU PENGETAHUAN ALAM

UNIVERSITAS ISLAM BANDUNG UNIVERSITAS ISLAM BANDUNG

2015 2015

PERCOBAAN 3.1

ANALISIS KUALITATIF DAN KUANTITATIF BAHAN BAKU DENGAN METODE KROMATOGRAFI CAIR KINERJA TINGGI

I. Tujua

,7 Mel,/u/,n ,n,lisis /u,li,i8 ,h,n ,/u 5en-,n eo5e /.o,o-.,8i 9,i.  /ine., in--i

 7 Mel,/u/,n ,n,lisis /u,ni,i8 ,h,n ,/u 5en-,n eo5e /.o,o-.,8i 9,i. /ine., in--i

97 Men;iul/,n uu ,h,n ,/u 5en-,n 5,, /.o,o-., 5,n h,sil  ene,,n /,5,. 

II. T!"#$ Da%a#

 High Performance Liquid Chromatography (HPLC) ,,u ;,n- se.in-5iseu /.o,o-.,8i 9,i. /ine., in--i (K+K" ,5,l,h enis /.o,o-.,8i ;,n- en--un,,nn;, ,lin- lu,s7 Ke-un,,n uu !PL+ ,5,l,h unu/   eis,h,n 5,n oeu.ni,n sen;,<, o, se., unu/ ,n,lisis /u,ni,i8  sen;,<, o, 5,l, se5i,,n 8,.,sei/,7 Dis,in- iu !PL+ u-, 5i-un,/,n unu/ i5eni8i/,si /u,li,i8 sen;,<, o, e.5,s,./,n ,5,  ,.,ee. <,/u .eensi sen;,<, o, s,n5,. se., sen;,<, o, 5,l, s,el (=,n5,. 5,n Roh,n 20127 Menu.u =,n5,. 5,n Roh,n 200# Ke-un,,n !PL+ ,n,., l,in :

17 *nu/ eis,h,n seul,h sen;,<, o.-,ni/ ,no.-,ni/ ,uun sen;,<,  iolo-is

27 An,lisis /ei5,/u.ni,n

37 An,lisis sen;,<, > sen;,<, i5,/ u5,h en-u,

47 Penenu,n ole/ul > ole/ul ne.,l ioni/ ,uun ?<ie. ion 7 Isol,si 5,n eu.ni,n sen;,<,

67 Peis,h,n sen;,<, > sen;,<, ;,n- s.u/u.n;, h,i. s,,

#7 Peis,h,n sen;,<, > sen;,<, 5,l, ul,h ;,n- se/elui 5,l,  ul,h ,n;,/ 5,n 5,l, s/,l, .oses in5us.i

J!$% & j!$% '#"(a)"*#a+$, -a$)u  1. K#"(a)"*#a+$ /aa)a a$# LSC

"e/ni/ ini e.-,nun- ,5, e.,5so.sin;, ?, ,5, ,5, ,5so.en ;,n- ol,. see.i sili/, -el ,,u ,luin,7 K.o,o-.,8i l,is,n iis ("L+ ,5,l,h s,l,h s,u enu/ 5,.i LS+7 D,l, K+K" /olo 5i,5,i ,,u 5i,/ 5en-,n ,.i/el@,.i/el i9.o o. ,9.o ,.i9ul,e o. elli9ul,.  (e./uli iis 3# @44 7Se,-i,n es,. 5,.i K+K" se/,.,n- ini 5iu,

unu/ en9,,i ,.i/el@,.i/el i9.o,.i9ul,e leih /e9il 5,.i 20 7 "e/ni/ ini i,s,n;, 5i-un,/,n unu/ ?, ,5, ;,n- u5,h l,.u 5,l,  el,.u o.-,ni/ 5,n i5,/ e.ionis,si7 "e/ni/ ini e.u,, s,n-, /u, unu/   eis,h,n isoe.@isoe.7

2. K#"(a)"*#a+$ /a#)$%$

"e/ni/ ini e.-,nun- ,5, ,.isi ?, ,5, 5i,n,., 5u, el,.u ;,n-i5,/ 5,, e.9,u. s,l,h s,u 5i,n,.,n;, e.in5,/ se,-,i .,s, 5i, 5,n ;,n- l,inn;, se,-,i 8,s, -e.,/7 P,5, /e,5,,n ,<,l 5,.i /.o,o-.,8i 9,i. (LS+ .,s, 5i,n;, 5iu, 5en-,n 9,., ;,n- s,, see.i en5u/un- ,5, /.o,o-.,8i -,s (=+7 ,s, 5i, (ol,. ,,u nonol,. 5il,isi ,5, su,u en5u/un- ine. 5,n 5i,/ /e5,l, seu,h /olo7 Keu5i,n .,s, -e.,/ 5ile<,/,n el,lui /olo7 Benu/ /.o,o-.,8i ,.isi ini 5iseu /.o,o-.,8i 9,i. 9,i. (LL+7

*nu/ eenuhi /euuh,n ,/,n /olo@/olo ;,n- 5,, leih ,h,n l,, el,h 5i/e,n-/,n en-e,/,n 8,se 5i, ;,n- e.i/,,n se9,., /ii, 5en-,n en5u/un- ine.7 Benu/ /.o,o-.,8i ,.isi ini 5iseu /.o,o-.,8i 8,se e.i/, (BP+  Bon5e5 Ph,se +h.o,o-.,h;7 BP+ 5en-,n 9e, en,5i s,l,h s,u enu/ ;,n- ,lin- oule. 5,.i K+K"7 K.o,o-.,8i ,.isi (LL+ 5,n BP+ 5iseu C8,se no.,lC il, 8,se 5i, leih ol,. 5,.i 8,se -e.,/ 5,n C8,se e.,li/C il, 8,se -e.,/ leih ol,.  5,.i ,5, 8,se 5i,7

3. K#"(a)"*#a+$ /!u'a# $" IEC

"e/ni/ ini e.-,nun- ,5, enu/,.,n (,5so.si ion@ion 5i ,n,., 8,se -e.,/ 5,n e,@e, e.ion 5,.i en-e,/7 Ke,n;,/,n esin@esin  e.,s,l 5,.i /oolie. 5iinilen?en si.en 5i,n, -u-us@-u-us 8un-sin;, el,h 5i,,h7 As, sul8on, 5,n ,in /u,.e.ne. e.u,/,n enis .esin  ilih,n ,lin- ,i/ unu/ 5i-un,/,n Ke5u,n;, 8,se e.i/, 5,n .esin el,h 5i-un,/,n7 "e/ni/ ini 5i-un,/,n se9,., lu,s 5,l, li8e s9ien9es 5,n 5i/en,l unu/ eis,h,n ,s,@,s, ,ino7 "e/ni/ ini 5,, 5i,/,i unu/ /e5u,n;, /,ion 5,n ,nion7

4. K#"(a)"*#a+$ !'%'u%$

"e/ni/ ini uni/ /,.en, 5,l, eis,h,n 5i5,s,./,n ,5, u/u.,n ole/ul 5,.i ?, ,5,7 Pen-e,/ ,5,l,h su,u -el 5en-,n e.u/,,n  e.lu,n-@lu,n- s,n-, /e9il (o.ous ;,n- ine.7 Mole/ul@.nole/ul /e9il 5,, ,su/ 5,l,.n ,.in-,n 5,n 5i,h,n 5,l, 8,se -e.,/

;,n-en--en,n- (s,-n, oile h,se7 Mole/ul@ ole/ul ;,n- leih es,. i5,/ 5,, ,su/ /e5,l, ,.in-,n 5,n le<, el,lui /olo ,n, 5i,h,n7

K.o,o-.,8i e/s/lusi .ne.nun;,i ,n;,/ n,, ;,n- ,lin- uu 5iseu e.e,si -el (=P+ 5,n 8il.,si -el7 A,un n,,n;, e/,nisen;, e, s,,7 D,l, i5,n- iolo-i Seh,5e su,u +.oss@ lin/e5 5e.,n -el el,h 5i-un,/,n se9,., lu,s h,n;, en-e,/ /e.,s 5,n sei /e.,s (olisi.en sili/, -l,ss ;,n- 5i-un,/,n 5,l, K+K"7 De.,n -el lun,/ i5,/ 5,, en,h,n /ine., 5i,,s 1 ,,u 2 ,os8e.7 "eni/ ini 5i/e,n-/,n unu/ ,n,lisis olie.@olie. 5,n ,h,n@,h,n iolo-i e.u,, 5i-un,/,n unu/ .nole/ul@ole/ul /e9il7

5. K#"(a)"*#a+$ /a%a*a $" IPC

K.o,o-,8i ,s,n-,n ion se,-,i en;esu,i,n e.h,5, K+K" e.,su/ ,.u e,/,i,n e.,, se/,li ,5, e.en-,h,n ,hun 1'#07 Die.i,n;, IP+ se,-,i eo5e ,.u K+K" e.u,/,n h,sil /e., S9hill 5,n /,<,n@/,<,n 5,n 5,.i ee.,, /eunun-,n ;,n- uni/7 K,5,n-@ /,5,n- IP+ 5iseu u-, /.o,o-.,8i e/s.,/si /.o,o-.,8i 5en-,n su,u 9,i.,n enu/,. ion 5,n ,i.e5 ion 9h.o,o-.,h; (PI+7 Sei, e/ni/@e/ni/ ini eun;,i 5,s,. ;,n- s,,7

Poul,.i,s IP+ un9ul e.u,, se/,li 5,.i /ee.,,s,n IE+ 5,n 5,.i su/,n;, en,n-,ni s,el@s,el e.enu 5en-,n eo5e@eo5e L+ l,inn;, (see.i sen;,<, ;,n- s,n-, ol,. sen;,<, ;,n- e.ionis,si se9,., /ole/s 5,n sen;,<, ,s, /u,7

IP+ 5,, 5il,/s,n,/,n 5,l, 5u, ie ;,iu 8,se no.,l 5,n 8,se  ,li/7 ,se 5i, 5,.i .,se ,li/ IP+ 5,, e.5i.i 5,.i su,u en-e,/ 

sili/, ;,n- 5isil,nis,si (is,ln;, +% ,,u +1% Bon5e5 Ph,se ,,u 5,.i su,u en-e,/ ;,n- 5ie.oleh se9,., e/,ni/ 8,se o.-,ni/ ;,n- i5,/  5,, e.9,u. 5en-,n ,i. see.i 1 en,nol7 ,se 5i, ;,n- 5i,/,i ,5,l,h +s ,,u +IS BP+ P,9/in-7 ,se -e.,/ e.5i.i 5,.i su,u l,.u,n  u8e. (5i,,h su,u /osolen o.-,ni/ see.i e,nol ,,u ,seoni.il

unu/ eis,h,n 8,se e.i/, 5,n su,u en,,h,n ion ,n5in-;,n-u,,nn;, e.l,<,n,n 5en-,n ole/ul s,el7

Menu.u +.,<8o.5 ,5, ,hun 2011 P,.,ee. ;,n- 5,, 5i-un,/,n unu/ en-e,hui /u,li,s su,u /.o,o-., ,5,l,h .esolusi (R s 8,/o. 

.eensi (/ 8,/o. sele/i8i,s (  e8isiensi 5,n ul,h eo.iis (N @ Resolusi (R  s

!,l ;,n- e.enin- 5,.i !PL+ ,5,l,h en-oi,si .esolusi 5,l, <,/u ;,n- iniu7 Nil,i .esolusi ;,n- eleihi 1 5i,n,., 5u,  un9,/ ,/,n ee.i/,n eis,h,n ;,n- ,i/7 Resolusi 5ien-,.uhi

oleh ee.,, ,.,ee.7 @ ,/o. .eensi (/

,/o. .eensi ,5,l,h <,/u ;,n- 5ie.lu/,n unu/ e,<, /elu,.  su,u /oonen 5,.i 5,l, /olo /.o,o-.,8i7 Nil,i / ;,n- in--i en-in5i/,si/,n s,el ee.lu/,n <,/u 5,l, e.ine.,/si 5en-,n 8,se 5i, e.leih 5,hulu hin--, /elu,. 5,.i /olo s,, e, 5,l, /onsen.,si ,/siu7

@ ,/o. sele/i8i,s ( 

Sele/i8i,s e.u,/,n /e,u,n ins.uen 5,l, en-en,li sen;,<,@sen;,<, 5,l, 9,u.,n unu/ en5,, sele/i8i,s ;,n-,/siu 5ie.lu/,n ine.,/si ;,n- sesu,i (,.isi ,5so.si si?e e9lusion ,,u ion e9h,n-e7 A,il, /e5u, sen;,<, eili/i / ,,u nil,i F  1 /e5u, sen;,<, i5,/ 5,, 5iis,h/,n7 A/i, <,/u .eensin;, i5eni/7 A-,. e.,5i eis,h,n ;,n- ,i/ ,/, nil,i sele/ii,s (F h,.us leih es,. 5,.i,5, 1 se,/in es,. nil,i F ,/, eis,h,nn;, ,/,n se,/in ,i/7 Nil,i F 5,, 5iu,h@u,h 5en-,n 9,., en-u,h 8,s, -e.,/ (is,ln;, 5en-,n ee.es,.   ol,.i,s en-u,h 8,s, 5i, en-u,h ee.,u. /,.en, ,5,

uun;, /en,i/,n ee.,u. ,/,n ee./e9il <,/u .eensi 5,n en-u,h enu/ /oonen7

@ E8isiensi

E8isiensi /olo e.u,/,n /e,u,n /olo en-elu,./,n h,sil ;,n- 5iin-in/,n 5en-,n eu,s/,n 5,n 5,l, <,/u ;,n- sin-/,7 !,sil i5e,l /olo e8isien ,/,n en-h,sil/,n un9,/ ;,n-,,7 E8isiensi s,n-, 5ien-,.uhi oleh /,,si,s 5,.i /olo7

@ ul,h eo.iis (N

Me.u,/,n ,.,ee. ;,n- en-hiun- e8isiensi /.o,o-.,8i7 Men;,,/,n ul,h e.isi<, ,.isi ;,n- 5i,l,i oleh ,n,li ,5,

sei, s,, ;,n- 5i,<, oleh 8,se -e.,/ sel,, elusi7 Di,n, se,/in  es,. h,.-, N ,/,n ee.i/,n un9,/ ;,n- leih e8isien7

I%)#u(! HPLC

,7 Po, (Pu

,se -e.,/ 5,l, K+K" ,5,l,h su,u 9,i.,n ;,n- e.-e.,/ el,lui /olo7 A5, 5u, ie o, ;,n- 5i-un,/,n ;,iu /ine., /ons,n (9ons,n .essu.e 5,n ein5,h,n /ons,n (9ons,n 5isl,9een7 Pein5,h,n /ons,n 5,, 5i,-i en,5i 5u, ;,iu : o, .e9i.o9,in- 5,n o, s;.in-e7

Po, .e9i.o9,in- en-h,sil/,n su,u ,li.,n ;,n- e.5en;u e.,u. (uls,in- oleh /,.en, iu euuh/,n e.e5, uls, ,,u  e.e5, ele/.oni/ unu/ en-h,sil/,n -,.is 5,s,. (,se line 5ee/o. 

;,n- s,il il, 5ee/o. sensii8 e.h,5,,n ,li.,n7 Keunun-,n u,,n;, i,l,h u/u.,n .ese.oi. i5,/ e.,,s7 Po, s;.in-e ee.i/,n ,li.,n ;,n- i5,/ e.5en;u e,i .ese.oi.n;, e.,,s (Pu., 20047

 7 Ine/o. (Ine9o. 

A5, i-, ie 5,s,. ine/o. ;,n- 5,, 5i-un,/,n :

17 So@lo< : Ali.,n 5iheni/,n ine/si 5il,/u/,n ,5, /ine., ,os8i.sise e.uu 5,n ,li.,n 5il,nu/,n l,-i7 "e/ni/ ini is, 5i-un,/,n /,.en, 5i8usi 5i 5,l, 9,i.,n /e9il 5,n .esolusi i5,/  5ien-,.uhi7

27 Seu : Seu ;,n- 5i-un,/,n ,5, K+K" s,, 5en-,n ;,n-5i-un,/,n ,5, K.o,o-.,8i =,s7 Ine/o. ini 5,, 5i-un,/,n ,5,/ine., s,,i 60 @#0 ,os8i.7 "e,i seu ini i5,/ ,h,n 5en-,n seu, el,.u > el,.u /.o,o-.,8i 9,i.7 P,.i/el /e9il 5,.i seu ;,n- e./o;,/ (,/i, ,.u ine/o. 5,, en;e,/,n en;u,,n7

37 Loo G,le : "ie ine/o. ini uun;, 5i-un,/,n unu/  en-ine/si olue leih es,. 5,.i 10 L 5,n 5il,/u/,n 5en-,n

9,., oo,is (5en-,n en--un,/,n ,5,o. ;,n- sesu,i olue ;,n- leih /e9il5,, 5iine/si/,n se9,., ,nu,l7 P,5, osisi lo,5 s,el 5iisi /e5,l, loo ,5, /ine., ,os8e. il, ,le 5i8un-si/,n ,/, s,el ,/,n ,su/ /e 5,l, /olo (Pu., 20047

97 Kolo (+olun

Kolo 5,, 5i/l,si8i/,si/,n en,5i 5u, /eloo/ ;,iu : 17 Kolo ,n,lii/ : Di,ee. 5,l, 2 @ 6 7

P,n,n- /olo e.-,nun- ,5, enis ,e.i,l en-isi /olo7

*nu/ /e,s,n elli9ul,. ,n,n- ;,n- 5i-un,/,n ,5,l,h 0 @ 100 97 *nu/ /e,s,n o.osi/.o ,.i/ul, 10 @ 30 97 De<,s, ini ,5, ;,n-  97

27 Kolo .e,.,i8: uun;, eili/i 5i,ee. 6  ,,u leih  es,. 5,n ,n,n- /olo 2 @100 9 (Pu., 20047

57 Dee/o. 

Dee/o. 5,, 5i,-i en,5i ee.,, ,9, ;,iu se,-,i e.i/u : 17 Dee/o. se/.o8ooe.i *G > Gis7

Dee/o. enis ini e.u,/,n 5ee/o. ;,n- ,lin- ,n;,/  5i-un,/,n 5,n s,n-, e.-un, unu/ ,n,lisis 5i i5,n- 8,.,si /,.en, /e,n;,/,n sen;,<, o, eun;,i s.u/u. ;,n- 5,, en;e., sin,. *G > Gis7 Dee/o. ini 5i5,s,./,n ,5, ,5,n;,  en;e.,,n .,5i,si *G 5,n sin,. ,,/ ,5, /is,.,n

,n,n--elo,n- 1'0 > %00 n oleh sesies solu ;,n- eun;,i s.u/u. ,,u -u-us /.oo8o.i/7 Sel5ee/o. uun;, e.u, ,un- 5en-,n 5i,ee. 1  5,n ,n,n- 9el,h oi/n;, 10  se., 5i,u. se5ei/i,n .u, sehin--, ,u en-hil,n-/,n  en-,.uh in5e/s i,s 5,, en-u,h ,so.,nsi

;,n-e.u/u.7

27 Dee/o. In5e/s Bi,s

Dee/o. in5e/s i,s ,,u .e8.,/oee. 5i8e.ensi,l ,5,l,h su,u 5ee/o. unie.s,l ;,n- ee.i ,n--, ,5, sei, ?, e.l,.u ,s,l/,n in5e/s i,sn;, ,uh e.e5, 5en-,n in5e/s i,s 8,se -e.,/7 Kele,h,nu,,n;, ,5,l,h ,h<, in5e/s i,s ini e/, e.h,5, suhu7 K,.en, iu suhu 8,se -e.,/ /olo 5,n 5ee/o. h,.us 5i/en5,li/,n 5en-,n se/s,, il, en-u/u.,n ;,n- 9e., 5il,/u/,n ,5, /ee/,,n in--i7

B,n;,/ ole/ul o.-,ni/ e.,su/ o, 5,, 5io/si5,si ,,u 5i.e5u/si se9,., ele/.o/ii, ,5, ele/.o5e ;,n- 9o9o/7 A.us ;,n- 5ih,sil/,n ,5, .oses ini 5,, 5ie./u, unu/  en-h,sil/,n en,-, ;,n- sesu,i7 Mes/iun 5ee/o. ele/.o/ii, 9u/u e/, n,un ,5, ul, /ele,h,nn;,7 A5,n;, i.un-,n lis.i/ 5,n -on9,n-,n ,.us u-, h,.us 5ie.h,i/,n7

47 Dee/o. Phoo5io5e > A..,; (PDA

Dee/o. PDA e.u,/,n 5ee/o. *G > Gis 5en-,n e.,-,i /eisie<,,n7 Dee/o. ini ,u ee.i/,n /uul,n /.o,o-., se9,., siul,n ,5, ,n,n- -elo,n- ;,n- e.e5, 5,l, se/,li .oses (sin-le .un7 Sel,, .oses e.,l,n

su,u /.o,o-.,

 ,5, ,n,n- -elo,n- ;,n- 5iin-in/,n (i,s,n;, ,n,., 1'0 >  400 5,, 5i,il/,n7 Den-,n 5ei/i,n PDA ee.i/,n  ,n;,/ leih ,n;,/ in8o.,si /oosisi s,el 5i,n5in-5en-,n 5ee9o. *G > Gis7Den-,n 5ee/o. ini u-, 5ie.oleh se9.u *G i, un9,/ ;,n- e.is,h sehin--, 5,, 5i,5i/,n se,-,i ,l, ;,n- enin- unu/ eilih ,n,n- -elo,n-,/si,l unu/ sise K+K" ;,n- 5i-un,/,n7 D,n ,/hi.n;, 5en-,n 5ee/o. ini ul, 5,, 5il,/u/,n ui /eu.ni,n un9,/  5en-,n e,n5in-/,n ,n,., se9., ,n,li 5en-,n se9., sen;,<, ;,n- su5,h 5i/e,hui7

K!u)u*a KCKT

K+K" 5,, 5i,n5,n- se,-,i elen-/, K.o,o-.,8i =,s (K=7 D,l, ,n;,/ h,l /e5u, e/ni/ ini 5,, 5i-un,/,n unu/ ee.oleh e8e/ eis,h,n ;,n- s,, e,i/n;,7 Bil, 5e.i,is,si 5ie.lu/,n ,5, K= n,un ,5, K+K" ?,@?, ;,n- i5,/ 5i5e.i,is,si 5,, 5i,n,lisis7 *nu/ ?,@?, ;,n- l,il ,5, e,n,s,n ,,u i5,/ en-u, K+K" ,5,l,h ilih,n u,,7 N,un 5ei/i,n u/,n e.,.i K+K" en--,ni/,n K= e,i ,/,n e,in/,n e.,n,n ;,n- leih es,. ,-i  ,., ,n,lis l,o.,o.iu7 De.i,is,si u-, en,5i oule. ,5, K+K"

/,.en, e/ni/ ini 5,, 5i-un,/,n unu/ en,,h sensiii,s 5ee/o.  *G Gisiel ;,n- uun;, 5i-un,/,n7

K+K" en,<,./,n ee.,, /eunun-,n 5i,n5in- 5en-,n /.o,o-.,8i 9,i. /l,si/ ,n,., l,in :

,7 C!/a) : &,/u ,n,lisis uun;, /u.,n- 5,.i 1 ,7 B,n;,/ ,n,lisis ;,n- 5,, 5iseles,i/,.i se/i,. 1@30 eni7 *nu/ ,n,lisis ;,n- i5,/  .ui (un9oli9,e5 <,/u ,n,lisi /u.,n- 5,.i  eni is, 5i9,,i  7 R!%"u%$ : Be.e5, 5en-,n K= K.o,o-.,8i +,i. eun;,i 5u,

.,s, 5i,n, ine.,/si sele/i8 5,, e.,5i7 P,5, K= -,s ;,n-en-,li. se5i/i e.ine.,/si 5en-,n ?, ,5,H eis,h,n e.u,, 5i9,,i h,n;, 5en-,n .,s, 5i,7 Ke,u,n ?, ,5, e.ine.,/si se9,., sele/i8 5en-,n .,s, 5i, 5,n .,s, -e.,/ ,5, K+K" ee.i/,n ,.,ee. ,,h,n unu/ en9,,i eis,h,n ;,n-5iin-in/,n7

97 S!%$)$6$)a% !)!')"# : Dee/o. ,so.si *G ;,n- i,s, 5i-un,/,n 5,l, K+K" 5,, en5ee/si /,5,. 5,l, ul,h n,no-., (10 > ' -., 5,.i e.,9, @ ,9, ?,7 Dee/o. > 5ee/o. luo.esensi 5,n Ele/.o/ii, 5,, en5ee/si ul,h s,,i i9o-., (10 > 12 -.,7 Dee/o. > 5ee/o. see.i Se/.o8ooee. M,ss, In5e/s Re8.,/si R,5ioe.i 5ll 5,, u-, 5i-un,/,n 5,l, K+K"

57 K""( -a* a/a) $*ua'a '!(7a$ : Be.e5, 5en-,n /olo /.o,o-.,8i /l,si/ /olo K+K" 5,, 5i-un,/,n /e,li (.eus,le7 B,n;,/ ,n,lisis is, 5il,/u/,n 5en-,n /olo ;,n-s, seelu 5,.i enis s,el ;,n- 5iine/si /ee.sih,n 5,.i solen 5,n enis solen ;,n- 5i-un,/,n

e7 I!a u)u' 8a) 7!#("!'u 7!%a# a 7!#$"$' : ?, > ?, ;,n- i5,/   is, 5i,n,lisis 5en-,n K= /,.en, ol,ili,s .en5,h  i,s,n;,

5i5e.i,is,si unu/ en-,n,lisis sesies ioni/7 K+K" 5en-,n ie e/s/lusi 5,n enu/,. ion i5e,l se/,li unu/ en-,lissis ?, > ?, e.seu7

87 Mua9 #!'"6!#$ %a(/! : *un;, see/o. ;,n- 5i-un,/,n 5,l, K+K" i5,/ en;e,/,n 5es.u/i8 (/e.us,/,n ,5, /oonen s,el ;,n- 5ie.i/s, oleh /,.en, iu /oonen s,el e.seu 5,, 5en-,n u5,h 5i/uul/,n seel,h ele<,i 5ee9o.7 Solenn;, 5,, 5ihil,n-/,n 5en-,n en-u,/,n /e9u,li unu/  /.o,o-.,8i enu/,. ion ee.lu/,n .ose5u. /husus7

III. Aa) a Ba9a ,7 Al,

- !PL+ A-illen - Gi,l - Pie - L,u ,/,.  - Ine/,si 8ile.  - =el,s u/u.  - Pie u/u.  - S,el  7 B,h,n 5,n MSDS

- B,/u e,n5in- ,.,9e,ol

P,.9e,ol en-,n5un- i5,/ /u.,n- 5,.i '%0 5,n i5,/ leih 5,.i 1010 

Pee.i,n : h,lu. ,,u se.u/ h,lu. uih H i5,/ e.,u H .,s, ,hi7

Kel,.u,n : l,.u 5,l, #0 ,-i,n ,i. 5,l, # ,-i,n e,nol 5,l, 13 ,-i,n ,seon 5,n 40 ,-i,n -.ise.ol 5,n 5,l, ' ,-i,n .oilen-/liol7

Suhu leu. : 16' > 1#2 J+

"i,l : i5,/ leih 5,.i 10 7

Pen;i,n,n : 5,l, <,5,h e.uu ,i/ 5,n e.lin5un-i 5,.i 9,h,;,7

Kh,si, : ,n,l-ei/ ,nii.ei/

- Meh,nol .o !PL+

Pee.i,n : 9,i.,n i5,/ e.<,.n, e.nih ,u /h,s7

Kel,.u,n : 5,, e.9,u. 5en-,n ,i. eenu/ 9,i.,n  e.nih i5,/ e.<,.n,7

Boo enis : 0#'6@ 07#'%7 "ii/ 5i5ih : 64o_{+ > 6}o₊

In5e/s i,s : 132% s,,,i 132'7

- Ai. i5esil,si

Pee.i,n : 9,i.,n e.nih  i5,/ e.<,.n,  i5,/ e.,u i5,/ eun;,i .,s,7

Sis, en-u,,n : i5,/ leih 5,.i 07001   en-u,,n 5il,/u/,n 5i,,s ,n-,s ,i. hin--, /e.in-7

Pen;i,n,n : 5,l, <,5,h e.uu ,i/7

- Kolo !PL+ +1%

O9,5e9;l sili9, (+1% e.u, ,5,,n e.<,.n, uih i5,/ l,.u 5,l, ,i.7

S;se K.o,o-.,8i

,se 5i, : ODS ,9/in- L1 ,se -e.,/ : ,i. : eh,nol  3:1 L,u ,li. : 17 leni

Leen- eo.iis : 1000 ",ilin- 8,9o. : ,/si,l 2 Dee9o. : *G 243 n 17 *i Kesesu,i,n Sise

*nu/ elih, ,,/,h s;se /.o,o-.,8i ;,n- 5ise su5,h eenuhi s;,., ,,u i5,/ ,/, 5il,/u/,n ui /esesu,i,n s;se7 *i 5il,/u/,n 5en-,n en-ine/si/,n e.u.u@u.u se,n;,/ # /,li l,.u,n s,n5,. /e 5,l, ins.uen K+K"7 Sel,nun;, lu,s ,.e, s,n5,. <,/u .eensi 8,9o. ilu,n 5ihiun- nil,i si,n-,n ,/u .el,ie (SBR 7 ui /esesu,i,n s;se 5in;,,/,n eenuhi s;., ,,il, nil,i SBR 2707

27 *i Ku,li,i8 

,7 L,.u,n S,n5,. 

Dii,n- 2 - ,/u e,n5in- ,.,9e,ol 5i,su/,n /e 5,l, l,u ,/,. 0 L7 5ien9e./,n 5en-,n 8,se -e.,/ hin--, ,n5, ,,s7 Di/o9o/ l,.u,n hin--, hoo-en7 Diie 10 L 5il,.u,n /e 5,l, l,u ,/,. 10 L7 5ien9e./,n 5en-,n 8,se -e.,/ hin--, ,,s7 Dis,.in- l,.u,n 5en-,n e.,ne 8ile. P"E u/u.,n 04 7 l,.u,n si, unu/ 5iine/si/,n /e 5,l, ,l, K+K"7

 7 L,.u,n *i

Dii,n- 2 - ,h,n ,/u ,.,9e,ol 5i,su/,n /e 5,l, l,u ,/,.  0 L 5ien9e./,n 5en-,n 8,se -e.,/ hin--, s,,i ,,s 7 Diie 170 L l,.u,n /e 5,l, l,u ,/,. 10 L7 5ien9e./,n 5en-,n 8,se -e.,/ hin--, ,n5, ,,s7 Dis,.in- l,.u,n 5en-,n e.,ne 8ile. P"E u/u.,n 074 7 l,.u,n si, unu/ 5iine/si/,n /e 5,l, ,l, K+K"7 Diine/si/,n ,sin-@,sin- l,.u,n s,n5,.5 ,n l,.u,n ui /e 5,l, ,l, K+K"7 Re/, /.o,o-., ;,n- e.enu/7 Di,n5in-/,n /.o,o-., l,.u,n ui 5,n l,.u,n s,n5,.7 &,/u .eensi un9,/  l,.u,n ui h,.us s,, 5en-,n <,/u .eensi un9,/ l,.u,n s,n5,.7

37 An,lisis Ku,ni,i8  ,7 L,.u,n S,n5,. 

Dii,n- 2 - ,/u ,.,9e,ol /e 5i,su/,n /e5,l, l,u ,/,. 0 L7 5ien9e./,n 5en-,n 8,se -e.,/ hin--, ,n5, ,,s7 Di/o9o/ l,.u,n hin--, hoo-en; (l,.u,n so/ ,/u e,n5in- ,.,seol7 Bu, se.n-/,i,n  en-en9e.,n l,.u,n s,n5,. unu/ eu,,n /u., /,li.,si7 Di Pie ,sin-@ ,sin- 02H 04H 076H07%H170H 5,n 1 L l,.u,n so/ e,n5in- /e 5,l, l,u ,/,. 10 L7 5ien9e./,n 5en-,n 8,se -e.,/ hin--, ,n5, ,,s7 Dis,.in- l,.u,n 5en-,n e.,ne 8ile. P"E u/u.,n 074 7 l,.u,n si, 5iine/si/,n /e 5,l, ,l, K+K"7 Dihiun- /onsen.,si ,sin-@,sin- l,.u,n /u., /,li.,si7

 7 L,.u,n *i

Dii,n- 2 n- ,h,n ,/u ,.,se,ol /e5,l, l,u ,/,. 0 L7 5ien9e./,n 5en-,n 8,se -e.,/ hin--, ,n5, ,,s7 Di/o9o/ l,.u,n hin--, hoo-en; 7 5iie 10 L l,.u,n /e5,l, l,u ,/,. 10 L7 5ien9e./,n 5en-,n en--un,/,n 8,se -e.,/ hin--, ,n5, ,,s7 Dis,.in- l,.u,n 5en-,n e.,ne 8ile. nilon u/u.,n 04  7 l,.u,n si, unu/ 5iine/si/,n /e5,l, ,l, K+K"7

47 +,., Ku., K,li.,si

Diine/si/,n ,sin- ,sin- /onsen.,si l,.u,n s,n5,.5 ,n l,.u,n ui7 Di 9,, lu,s ,.e, /.o,o-., ,sin-@,sin- l,.u,n s,n5,.5 ,n l,.u,n ui7 Den-,n en--un,/,n /u., /,li.,si ,,u e.s,,n -,.is7 Dihiun- /,5,. l,.u,n s,el7

7 +,., one oin

Di,il lu,s ,.e, /.o,o-., s,l,h s,u l,.u,n e,n5in-,n /eu5i,n 5i-un,/,n unu/ en-hiun- /,5,. l,.u,n s,el 5en-,n en--un,/,n eo5e one oin

V. Ha%$ P!*a(a)a a P!#9$)u*a

- Ai. :   100  #l

@ Me,nol : 100 > #  2l

@ B,h,n ,/u P,.,9e,ol : 2 - 5,l, 0 l 0 l  00 L

Pen-en9e.,n ,h,n ,/u ,.,9e,ol G17 N1  G27 N2 1 l 7 10   10 l 7 N2  N2  1  @ L,.u,n S,n5,. ,.,9e,ol 23% - 5,l, 0 L 0 l  00 L     0#6 

Pen-en9e.,n l,.u,n s,n5,. ,.,9e,ol G17 N1  G27 N2

1 l 7 0#6   10 l 7 N2

N2  0#6 

Ta7! Uj$ K!%!%ua$a S$%)!(

P!-u)$'a TR Lua% A#!a

1 3#43 3''6'11 2 36%3 3'4#'%#' 3 36# 3%%#3%3' 4 364# 3%#31%0  376# 3'0#'02 6 363 3'041#32 # 363# 3'24#60 Ra)a:#a)a 376# 3'20423#7# SD 07032'331 41##07416 SBR  07'6%10161 10604#6%

Pen-en9e.,n Ku., l,.u,n S,n5,. P,.,9e,ol

• G₁7 N₁  G₂7 N₂

02 L 7 0#6   10 L 7 N2

 N2  1012  • G₁7 N₁  G₂7 N₂

 N2  20304  • G17 N1  G27 N2 06 L 7 0#6   10 L 7 N2  N2  3046  • G₁7 N₁  G₂7 N₂ 0% L 7 0#6   10 L 7 N2  N2  4060%  • G17 N1  G27 N2 10 L 7 0#6   10 L 7 N2  N2  0#6  • G₁7 N₁  G₂7 N₂ 12 L 7 0#6   10 L 7 N2  N2  60'12 

Ta7! Ku#6a Ka$7#a%$ K"%!)#a%$ ; Lua% A#!a - 1012 %#342 20304 142664 3046 212#''# 4060% 2'133' 07#6 3#10644 60'12 4461226 ;   Q , 4461226  #16'6413' Q 46%#'%333 #16'6413'  4461226 @ 46%#'%333

  61# 

Kaa# Pa#a!)a(" !*a M!)"! Ku#6a Ka$7#a%$ L,.u,n *i

R"  3613

Lu,s A.e,  6602121'

 /,5,. ,.,9e,ol   100   120#2 

Kaa# Pa#a!)a(" !*a M!)"! <O! P"$)=

+u   +s

  1

#4#4 

 /,5,.   100   14#'% 

VI. P!(7a9a%a

P.insi /e., 5,.i K+K" ,5,l,h eis,h,n /oonen ,n,li e.5,s,./,n /eol,.,nn;, ,.in;, /oonen ,5, su,u ,n,li (s,el ,/,n e.is,h  e.5,s,./,n si8, /eol,.,n ,sin-@,sin- /oonen 5,l, s,el ,,/,h /eol,.,nn;, leih i.i 5en-,n 8,s, 5i, ,/, 5i, ,/,n e.in--,l 5i 8,s, 5i, ,,u e.-e.,/ leih l,, ,,u/,h /eol,.,nn;, leih i.i 5en-,n 8,s, -e.,/ sehin--, 5i, ,/,n e.-e.,/ e.5is.iusi leih ,uh 5,n leih 9e,7 Se5,n-/,n unu/ .insi /e., 5,.i ,l, K+" e.seu ,5,l,h /ei/, su,u s,el ;,n- ,/,n 5iui 5iine/si/,n /e 5,l, /olo ,/, s,el e.seu /eu5i,n ,/,n e.u.,i 5,n e.is,h en,5i sen;,<,@sen;,<, /ii, ( ,n,li 

sesu,i 5en-,n e.e5,,n ,8ini,sn;,7 +,i.,n ;,n- ,/,n 5iis,h/,n e.u,/,n 8,s, 9,i. 5,n ?, ,5,n;, e.u,/,n 8,s, 5i, (s,sione.7

,s, -e.,/ 5,l, K+K" ,5,l,h e.u, ?, 9,i. 5,n 5iseu u-, eluen ,,u el,.u7 ,s, -e.,/ ;,n- 5i-un,/,n ,5,l,h ,i. 5,n e,nol 5en-,n  e.,n5in-,n 3:1 ;,n- e.si8, leih ol,. se5,n-/,n 8,se 5i,n;, e.u, /olo +1% esi8, leih nonol,.7 !,l ini 5ise,/,n /,.en, sen;,<, ;,n-5i,n,lisis ;,iu ,.,9e,ol e.si8, leih ol,.7 Mole/ul ol,. 5,l, 9,u.,n iu ,/,n en-h,is/,n se,-i,n es,. <,/u e.e/, e.-e.,/  5en-,n el,.u7 Sen;,<, non@ol,. 5,l, 9,u.,n ,/,n 9en5e.un-eenu/ ,.,/si 5en-,n -u-us hi5.o/,.on /,.en, -,;, 5ise.si ,n 5e.  &,,ls7 Me.e/, u-, ,/,n /u.,n- l,.u 5,l, el,.u /,.en, euuh/,n  euus,n i/,,n h;5.o-en se,-,i,n, h,ln;, 5i ,n,., ole/ul@ole/ul ,i. 

,,u e,nol7 M,/, enis e/ni/ /.o,o-.,8i ;,n- 5i-un,/,n ,5,l,h /.o,o-.,8i 8,se ,li/7

P,5, K+K" 8,s, -e.,/ sel,in e.8un-si e,<, /oonen@/oonen 9,u.,n enuu 5ee9o. 8,s, -e.,/ 5,, e.ine.,/si 5en-,n solu@solu7 Oleh /,.en, iu 8,s, -e.,/ 5,l, K+K" e.u,/,n s,l,h s,u 8,/o. enenu /ee.h,sil,n .oses eis,h,n7 ,se -e.,/ seelu 5i-un,/,n h,.us 5is,.in-e.leih 5,hulu unu/ en-hin5,.i ,5,n;, ,.i/el@,.i/el /e9il 7 Sel,in iu ,5,n;, -,s 5,l, 8,se -e.,/ u-, h,.us 5ihil,n-/,n se, ,5,n;, -,s ,/,n  e./uul 5en-,n /oonen l,in e.u,, 5i o, 5,n 5ee/o. sehin--,

,/,n en-,9,u/,n ,n,lisis7

Seelu el,/u/,n ,n,lisis sei, h,.i seo.,n- ,n,lis h,.us e,si/,n  ,h<, sise 5,n .ose5u. ;,n- 5i-un,/,n h,.us ,u ee.i/,n 5,, ;,n- 5,, 5ie.i,7 !,l ini 5il,/u/,n 5en-,n e.9o,,n /esesu,i,n sise ;,n- 5i5e8inisi/,n se,-,i se.,n-/,i,n ui unu/ en,in ,h<, eo5e e.seu 5,, en-h,sil/,n ,/u.,si 5,n .esisi ;,n- 5,, 5ie.i,7 *i /esesu,i,n s;se 5iuu/,n u/ e,si/,n e8e/ii,s sise oe.,sion,l 5,.i sise /.o,o-.,8i seelu 5i-un,/,n u/ ,n,lisis (e.u,, ,n,lisis /u,ni,i87

,.,/oe Ae.i/, (United States Pharmacopeia *SP enenu/,n  ,.,ee.@,.,ee. ;,n- 5,, 5i-un,/,n unu/ ene,/,n /esesu,i,n sise seelu 5i,n,lisis7 P,.,ee.@,.,ee. ;,n- 5,, 5i-un,/,n eliui: il,n-,n leen- eo.i (N 8,9o. tailing  /,,si,s (/ ,,u F 5,n nil,i s,n5,. 5ei,si .el,ie (RSD in--i un9,/ 5,n lu,s un9,/ 5,.i se.,n-/,i,n ine/si7 *i /esesu,i,n s;se 5in;,,/,n eenuhi s;,., ,,il, nil,i Si,n-,n B,/u Rel,i8 (SBR  207 D,l, en-ui,n ;,n-/,i l,/u/,n 5ie.oleh nil,i SBR 0'6% 5,n 106 enunu/,n ,h<, s;se ;,n- 5i-un,/,n el,h eenuhi s;,.,7

An,lisis ;,n- 5il,/u/,n 5,l, e.9o,,n ini ,5,l,h ,n,lisis /u,li,i8 5,n ,n,lisis /u,ni,i87 An,lisis /u,li,i8 5il,/u/,n 5en-,n e,n5in-/,n <,/u .eensi l,.u,n ui 5en-,n <,/u .eensi l,.u,n s,n5,.7 &,/u .eensi ,5,l,h <,/u ;,n- 5ie.lu/,n s,el unu/ /elu,. /olo7 Se5,n-/,n ,n,lisis /u,ni,i8 5il,/u/,n 5en-,n en-hiun- /onsen.,si s,el  e.5,s,./,n lu,s ,.e, un9,/ /.o,o-., 5en-,n en--un,/,n eo5e /u., ;,n- en-hiun-,n /onsen.,si 5en-,n en--un,/,n e.s,,,n -,.is ;   Q , se., eo5e one point.

Pen-ui,n /u,li,i8 ,.,se,ol en--un,/,n e/ni/ !PL+ 5,l,  .oses ,n,lisisn;, !PL+ eili/i ee.,, ,h,,n7 Di,<,li 5en-,n en-ine/si/,n s,el ui 5,n s,n5,. ;,iu l,.u,n ;,n- seelun;, el,h 5is,.in- 5en-,n e.,n P"E /e 5,l, /olo !PL+ 5en-,n ine/o.  /husus ;,n- e.olue 20 L en;,.in-,n seelu en-ine/si,n ini 5il,/u/,n ,-,. i5,/ e.,5i en;u,,n 5i5,l, /olo 5,n en-hil,n-/,n -,s 5,.i el,.un;,7 L,.u,n 5i5o.on- 9e, s,, el,lui /olo 5en-,n  ,nu,n o, e.e/,n,n in--i7 Koonen ,/,n /elu,. 5,.i /olo 5en-,n

/e9e,,n ;,n- e.e5, 5,n e.5ee/si oleh 5ee/o.7 Dee/o. ;,n- 5i-un,/,n ,5,l,h 5ee/o. *G /,.en, ,.,se,ol e.u,/,n sen;,<, o.-,ni/ ;,n-5,, en;e., sin,. *G /,.en, eili/i -u-us /.oo8o. ,5, s.u/u.n;,7 Pen-ui,n ini en--un,/,n ,n,n- -elo,n- 243 n 5en-,n ee.i,n-/,n ,n,n- -elo,n- eh,nol ;,iu 20 n 5,n ,i. ;,iu 1'0 n7 Sel,nun;, h,sil ,n,lisis 5en-,n !PL+ ini en-h,sil/,n su,u 9i.,  e.u, /.o,o-.,7 K.o,o-., e.u,/,n -.,8i/ ,n,., inensi,s

/oonen ;,n- 5i,<, oleh 8,s, -e.,/ e.h,5, <,/u .eensi 7 ",il,n /.o,o-., ;,n- ,i/ e.u, -.,8i/ lu.us l,n9i 5,n sie.is7

S,el ele<,i /olo !PL+ enun;, eili/i ,n-/, <,/u ;,n-e.u/u. 5,n u-, en,5i ,.,ee. <,/u ;,n- 5iuuh/,n s,el unu/  ele<,i /olo ini 5iseu <,/u .eensi7 K.o,o-., ;,n- 5ih,sil/,n 5,.i sei, /onsen.,si l,.u,n s,n5,. 5ie.oleh <,/u .eensi 5,n lu,s ,.e, /.o,o-.,7 An,lisis /u,li,i8 5il,/u/,n 5en-,n enenu/,n <,/u .eensi 5,n lu,s ,.e, /.o,o-., l,.u,n s,elui7 &,/u .eensi l,.u,n ui ,5,l,h 37613 5en-,n lu,s ,.e, 6602121'7 Keu5i,n 5i,nin-/,n 5en-,n <,/u .eensi ,5, l,.u,n s,n5,.7 A5,n;, /es,,,n <,/u .eensi ;,iu ,5, 3613 enunu/,n l,.u,n ui en,. en-,n5un- ,.,9e,ol7

Seel,h ,n,lisis /u,li,i8 sel,nun;, 5il,/u/,n ,n,lisis /u,ni,i8 ;,n- e.uu,n unu/ enenu/,n /,5,. 5,.i ,.,9e,ol 5en-,n 9,., /u.,

/,li.,si 5,n 9,., one point 7 *nu/ 9,., /u., /,li.,si e.hiun-,n /,5,.  5il,/u/,n 5en-,n e.s,,,n -,.is ;   Q ,7

; : lu,s ,.e, ;,n- 5i5,, seel,h s,el 5iine/si/,n /e ,l, K+K" ; ;,n- 5iilih ,5,l,h ; ,5, /onsen.,si 607'12  ;,iu 4461226

  : 5i5,, 5,.i e.s,,,n .e-.esi ;,iu #16'67413'  : /onsen.,si 5,.i l,.u,n s,n5,. ;,iu 607'12

, : 5i5,, 5,.i e.s,,,n .e-.esi ;,iu 46%#'%7333

5,.i 5,, 5i,,s 5i5,,  ,5,l,h 617# 7 Seel,h 5,,  5i5,, ,/, 5,, 5ihiun- /,5,. 5,.i ,.,9e,ol ,5,l,h 1207#27 *nu/ enenu,n /,5,. ,.,9e,ol 5en-,n 9,., one point  /,5,. ;,n- 5i5,, ,5,l,h 14#7'%7 Be.5,s,./,n lie.,u.e 5,.i 8,.,/oe P,.9e,ol en-,n5un- i5,/ /u.,n-5,.i '%0 5,n i5,/ leih /u.,n-5,.i 1010 7 D,.i /e5u, 9,., 5i,,s eo5e /u., /,li.,si leih ,i/ 5,.i,5, eo5e one point. D,, 5ilih, 5,.i h,sil  e.hiun-,n /,5,. 5i,n, 9,., /u., /,li.,si h,siln;, leih en5e/,i

/onsen.,si sesu,i lie.,u. 5i,n5in-/,n 5en-,n 9,., one point 7

VII. K!%$(/ua

@ An,lisis /u,li,i8 ,h,n ,/u 5en-,n K.o,o-.,8i +,i. Kine., "in--i 5il,/u/,n e.5,s,./,n nil,i "R (<,/u .eensi 5,n lu,s ,.e, /.o,o-., ;,n- 5i,n5in-/,n 5en-,n l,.u,n s,n5,.7

@ An,lisis /u,ni,i8 ,h,n ,/u 5en-,n K.o,o-.,8i +,i. Kine., "in--i 5il,/u/,n 5en-,n Meo5e Ku., K,li.,si 5,n Meo5e One Poin

@ K,5,. ,.,9e,ol ;,n- e./,n5un- 5,l, s,el 5en-,n eo5e /u., /,li.,si ;,iu 120#2 se5,n-/,n 5en-,n en--un,/,n eo5e One Poin ;,iu 14#'%

VIII. Da+)a# Pu%)a'a

Di.e/o., )en5.,l Pen-,<,s,n O, 5,n M,/,n,n7 1'#'7  Farmakope  ndonesia !disi . De,.een Keseh,,n R7I ),/,.,

Di.e/o., )en5.,l Pen-,<,s,n O, 5,n M,/,n,n7 1''7  Farmakope  ndonesia !disi ". De,.een Keseh,,n R7I ),/,.,

=,n5,. =holi7 5,n Roh,n 200'7 #imia Farmasi $nalisis7 Pus,/, Pel,,.: Yo-;,/,.,7

)ohnson E7 L7 ,n5 Seen son R7 1'#%7  %asic liquid chromatography. G,.i,n +,li8o.ni,

Lin5s,; S7 1''27  High performance liquid chrotomagraphy  second edition& )ohn &ile; Sons +his9he. Ne< Yo./ B.is,ne "o.ono Sin-,o.e Ru9/e. = 71'%%7  nstrumentelle pharma'eutische $nalytik  lehuch 'u

 spektroskop& chrotograph.u. elektrochem.$nalysemethoden*+on =7 Ru9/e.7 M7 Neu-e,ue. H =7=7 &iles 7 Su-,. : &iss7 Ge.l > =es7 =e.,n;

Sn;5e. L7 R ,n5 Ki./l,n5 )7)7 1'#'7  ntroduktion to modern liquid  chromatography. second edition7 )ohn &ile;  Sons7In9 Ne<Yo./ +hihese. B.ie,ne "o.ono Sin-,o.e