HIFU mediated drug delivery:
Vascular shutdown facilitates drug
depot effect
Gasselhuber A.1, Appanaboyina S. 1, Dreher M.R.2, Wood B.J.2, Haemmerich D.1
1Dept. Pediatrics, Medical Univ. of South Carolina
Disclosures
3
Low-Temperature Sensitive
Liposomes (LTSL)
Drug release (Doxorubicin) at hyperthermic temperatures
Doxorubicin Release from LTSL (from Gasselhuber et al.,
HIFU-mediated targeted
drug delivery
Computer Simulation of HIFU+LTSL drug delivery
• Heat transfer model • Drug Delivery Model
Two heating scenarios:
7 min hyperthermia (42 ºC)
7 min hyperthermia + brief ablation pulse
(to shut down blood flow)
Computer Model:
HIFU + LTSL
Tissue Temperature
Perfusion
Heat-Transfer Model
LTSL Release LTSL Release
Pharmacokinetic Model
Intravascular Space
Mathematical Drug
Delivery Model
7
Drug delivery from LTSL in tumor
Hyperthermia vs.
HT+Ablation
Temperature
Perfusion
9
Drug Concentrations: HT
+ Ablation
Elimination of blood flow by brief high-temperature
heating pulse considerably increases tissue drug uptake
Depot Effect
Other blood flow reducing methods
(embolization) would have similar effect
