Association of serum uric acid level and blood pressure in type 2 diabetes mellitus

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IOP Conference Series: Earth and Environmental Science

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Association of serum uric acid level and blood

pressure in type 2 diabetes mellitus

To cite this article: M Savira et al₂₀₁₈IOP Conf. Ser.: Earth Environ. Sci.125₀₁₂₁₆₉

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Association of serum uric acid level and blood pressure in type

2 diabetes mellitus

M Savira1*, Rusdiana2 and M Syahputra3

1

Department of Physiology,Faculty of Medical, University of Sumatera Utara, Jl. dr. Mansur Kampus USU Medan 20155, Indonesia

2

Department of Biochemistry,Faculty of Medical, University of Sumatera Utara, Jl. dr. Mansur Kampus USU Medan 20155, Indonesia

3

Department of Biochemistry,Faculty of Medical, University of Sumatera Utara, Jl. dr. Mansur Kampus USU Medan 20155, Indonesia

*

Corresponding author: dr.mayasavira@yahoo.co.id

Abstract. Uric acid is an end product of purine degradation in humans and primarily excreted through urine. In adulthood, concentrations rise steadily over time and vary with height, body weight, blood pressure, renal function, and alcohol intake. Uric acid is known as anti-oxidant, it has a beneficial role in diseases. Elevated serum uric acid associated with anincreased risk of cardiovascular disease. It has been found that elevated levels of uric acid associated with high risks of acomplication of type 2 diabetes mellitus and It has astrong association between elevated uric acid levels and obesity, metabolic syndrome, diabetes mellitus, hypertension, cardiovascular and renal disorders. The aim of the study analyzed the association between serum uric acid level and blood pressure in type 2 diabetes mellitus patients. This research is descriptive analytic research with a cross sectional design included 50 diabetic subjects aged over 40 years old. Subjects picked by consecutive sampling then we examined the weight, height, waist size, blood pressure, fasting blood sugar, and serum uric acid level. Statistical analysis using chi-square found that there was no significant association between serum uric acid level and systole and diastole pressure in type 2 diabetes mellitus patients (p>0.005).

1. Introduction

Uric acid is an end product of purine degradation in humans and is primarily excreted through urine.1Uric acid is developed by breakingdownpurines and by direct synthesis from 5-phosphoribosyl pyrophosphate and glutamine. Serum urate levels vary by age and sex. Mean serum urate values of

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dyslipidemia and the metabolic syndrome, are more prevalent in patients with Type 2 Diabetes Mellitus (T2DM) than in those without T2DM.13

Diabetes mellitus is considered a cardiovascular risk equivalent, and cardiovascular disease is the most common cause of death in patients with diabetes mellitus.13_{Hyperuricemia has recently} obtainedthe attention because it has been reported that it not only plays amajor role in the establishment of metabolic diseases but it is also a cardiovascular risk factor.Potential mechanisms by which serum uric acid may directly affect cardiovascular risk include enhanced platelet aggregation,14 and inflammatory activation of the endothelium.15_{Early study has shown that hyperuricemia, induced} by a uricase inhibitor, triggered hypertension and impaired nitric oxide generation in the macula densa, while both hypertension and renal injury are reduced by inducing nitric oxide.16,17,18,19Therefore this study aimed to analyze the association of uric acid level and blood pressure in type 2 diabetes mellitus patients.

2. Method

This study is descriptive analytic research method with across-sectional design. It involved 50 subjects. Subjects picked by consecutive sampling, Sample population is all of type 2 diabetes mellitus patients in accordance with the inclusion criteria.They are aged >40 years old and cooperative and have a will to join this research by signing agreement sheet after being explained with informed consent and the exclusion criteria which are, using diuretic and/or antihypertension medication and in the middle of cancer therapy. This research was approved by Health Research Ethical Committee, Medical Faculty of Universitas Sumatera Utara/ H. Adam Malik General Hospital by No: 263/TGL/KEPK FK USU-RSUP HAM/2017.

First, we examined the weight, height, waist size, blood sugar level (BSL) and serum uric acid level measured by using Autocheck portable measuring instruments then Blood Pressure measured using NOVA sphygmomanometer. All statistical analyses were done using Microstat Statistical Programme on an IBM compatible computer. Chi-square was used to analyze the association of uric acid level and blood pressure in type 2 diabetes mellitus patients. p<0.05 was considered as significant.

3. Results and Discussions

Table 1. Baseline characteristic of 50 subjects.

N Mean ± SD P hypertension. Many studies showed that uric acid level also associated with cardiovascular morbidity.20-21 Animal studies and clinical observations showed direct relation between uric acid and blood pressure in pathogenesis of hypetension.22Studies have reported a strong association between elevated uric acid levels and obesity, metabolic syndrome, diabetes mellitus, hypertension, cardiovascular and renal disorders.12

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thepathogenesis of hypertension.In the research that analyzed relation between uric acid level and risk for incident hypertension among men found there was no independent relation between uric acid level and risk for incident hypertension.23-25 _{Increased serum uric acid levels associated with elevated blood} pressure and cardiovascular morbidity and mortality. But the causal role of uric acid in hypertension and pathogenesis of cardiovascular events has not been clear.

4. Conclusions

In our study, we have found that there was no significant association between uric acid and blood pressure (p >0.005).

5. Acknowledgments

T

he authors gratefully acknowledge that the present research is supported by

Ministry of Research and Technology and Higher Education Republic Indonesia, under research grant TALENTA USU of theYear 2017

.

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Association of serum uric acid level and blood pressure in type 2 diabetes mellitus

IOP Conference Series: Earth and Environmental Science

Association of serum uric acid level and blood

pressure in type 2 diabetes mellitus

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Association of serum uric acid level and blood pressure in type

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