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Hom e > Vol 1, No 1 ( 2 01 2) > Fat i m a h R
Perbedaan Efek Ekstrak Etanol Stevia Dibandingkan
M adu Terhadap Perubahan Glukosa Darah Tikus
Wistar M odel Diabetik
Sit i Fat im ah R, Kisrin i ., Rat ih Pusp it a Feb rin asari
Abstract
Ba ckg rou nd :St ev ia’s leaf cont ains st ev iol, st evioside an d rebau dioside wh ich h ave
effect t o increase secret ion insu lin. Honey , n at u ral sweet ener con t ains sev eral ant ioxidan t su ch as p ropolis, f lavon oid and v it am in . I t will elim in at e free radicals and ind irect ly im pr ov e p an k reas glan d s cells t o p rodu ce in sulin . Th is resear ch w as aim ed t o k now t he d iff er en ce effect of st ev ia’s et h anol ex t ract com p ared t o h on ey on chan g in g of blood g lu coselev el on diabet ic m od el Wist ar rat s.
M e t ho ds:This was ex perim en t al resear ch w it h p re an d p ost t est con t rolled g roup
d esign . Sam ples w er e 32 m ale rat s, Wist ar St r ain, 6- 8 w eek s and + 20 0 gw eigh t . Sam p ling t echn iq u e used in t h is research w as in ciden t al sam plin g. Sam p les were d iv id ed int o 4 g rou ps: n egat ive con t rol g roup ( aq uad est ) , posit iv e con t rol ( g lib enclam ide d ose 0.0 9 m g/ 2 0 0 g b ody w eigh t ) , t reat m en t g roup 1 ( st ev ia’s et han ol ex t ract d ose 2 0 m g/ 2 0 0 g b ody w eigh t ) , t reat m en t g roup 2 ( h on ey dose 2 m l/ 2 0 0 g b ody w eigh t ) . Dat a were analy ze u sin g Saph iro- Wilk ’s t est of n orm alit y
and Friedmann test (α = 0.05) and Post Hoc Multiple Comparison (Wilcoxon) (α = 0 .05 ) u sin g SPSS 1 7 for Win d ow s.
Re sul t s:Th ere was a sig nifican t d ifferen ce ( p = 0 .00 2 ) on t he Wist ar’s b lood
g lu cose lev el w hich w as given st evia’s et h an ol ex t ract or h oney . St evia’s et han ol ext ract effect m ore on d ecreasing t h e blood g lu cose t h an hon ey. Bu t , t he b ot h of t h em ar e ab le t o d ecrease t h e Wist ar’s blood g lu cose on diab et ic m od el
Co ncl usio ns:St ev ia’s et han ol ext ract has t h e effect of d ecreasing b lood g lu cose
lev el on d iabet ic m od el Wist ar rat s bet t er t han h on ey.
Ke y w ord s:et h anol ex t ract of st ev ia, hon ey, allox an, chan ges in b lood glucose
lev els.
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