LAMPIRAN A. Hasil Uji Mutu Fisik Granul

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LAMPIRAN A

Hasil Uji Mutu Fisik Granul Mutu fisik Batch

Di

uji Formula Tablet Salbutamol Persyaratan yang diuji FA FB FC FD

I 1 4,67 4,75 4,39 4,3 II 2 4,65 4,73 4,37 4,28

Kadar air III 3 4,69 4,77 4,41 4,32 3-5 (Voigt, 1995)

(persen) X 4,67 475 4,39 4,3 SD 0,02 0,02 0,02 0,02 1 9,69 9,55 9,39 9,11 I 2 9,65 9,53 9,33 9,12 3 9,67 9,52 9,37 9,15 1 9,64 9,55 9,38 9,17 Waktu II 2 9,66 9,58 9,35 9,18

alir (detik) 3 9,63 9,57 9,34 9,11 Tidak lebih dari 1 9,69 9,54 9,38 9,15 10 detik III 2 9,68 9,55 9,36 9,14 (Banker &

3 9,67 9,59 9,37 9,13 Anderson, X 9,66 9,55 9,36 9,14 1986) SD 0,02 0,02 0,01 0,02 1 35,62 36,1 36,6 35,33 I 2 34,69 35,24 36,98 35,95 3 35,3 36,18 35,8 35,12 1 34,38 35,19 35,9 36,91 Sudut diam II 2 34,76 36,12 36,87 37,1 25-40 (derajat) 3 35,76 35,87 36,2 35,76 (Banker &

1 35,9 35,9 36,98 36,99 Anderson, III 2 34,1 36,58 35,17 35,13 1986) 3 34,96 36,97 35,67 36,96 X 35,05 36,01 36,15 36,13 SD 0,63 0,56 0,73 0,85 1 13,48 13,78 14,01 13,94 I 2 13,25 13,51 14,62 13,35 3 13,48 13,51 14,01 13,35 1 13,91 13,78 14,62 13,94 Indeks II 2 13,48 13,32 13,5 14,05 11-15 = baik Kompresibilitas 3 13,69 13,32 13,5 14,05 (persen) 1 13,25 13,78 14,79 13,9 III 2 13,48 13,51 13,89 13,35 (Siregar, 1992) 3 13,69 13,78 13,89 13,35 X 13,52 13,58 14,09 13,69 SD 0,21 0,19 0,47 0,33

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LAMPIRAN B

Hasil Uji Kekerasan Tablet Salbutamol Batch I

Batch II No

Kekerasan Tablet

Salbutamol

Formula A Formula B Formula C Formula D

1 13,6 13,4 13,9 14,0 2 13,7 14,1 14,1 14,1 3 13,3 13,8 13,9 14,2 4 13,8 13,4 14,2 14,0 5 13,9 13,7 13,8 13,9 6 13,6 14,2 13,9 13,8 7 13,4 13,9 14,1 13,9 8 13,9 14,1 14,3 13,9 9 13,8 13,3 14,0 14,1 10 13,7 13,7 13,9 14,0 X±SD 13,67±0,20 13,76±0,32 14,01±0,15 13,99±0,11 No Kekerasan Tablet Salbutamol

1 13,5 13,5 13,7 14,1 2 13,6 13,6 13,8 13,7 3 13,1 13,1 14,0 14,1 4 14,1 14,1 14,1 14,2 5 14,0 14,0 14,1 13,8 6 13,9 13,9 13,9 13,8 7 13,2 13,2 13,8 14,0 8 13,9 12,9 14,1 13,9 9 13,1 13,1 13,7 14,1 10 13,9 12,5 13,9 14,2 X±SD 13,63±0,38 13,39±0,51 13,91±0,15 13,99±0,17

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Batch III

No

Kekerasan Tablet

Salbutamol

1 13,7 13,2 13,5 13,9 2 13,5 13,8 13,7 13,8 3 13,4 14,1 13,9 14,1 4 13,7 13,7 14,0 14,2 5 13,1 13,8 14,1 14,1 6 13,9 13,2 14,1 13,9 7 13,7 13,2 13,9 13,9 8 13,0 13,6 13,8 14,1 9 13,3 14,1 14,1 14,2 10 13,8 14,0 14,0 14,0 X±SD 13,51±0,30 13,67±0,36 13,91±0,19 14,02±0,13

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LAMPIRAN C

Hasil Uji Kerapuhan Tablet Salbutamol Batch I Formula Replikasi Berat awal (gram) Berat akhir (gram) Kerapuhan (%) X±SD A 1 5,989 5,978 0,184 2 5,997 5,986 0,183 0,183±0,000215 3 5,983 5,972 0,184 B 1 5,813 5,802 0,189 2 5,815 5,804 0,189 0,189±0,000228 3 5,802 5,791 0,190 C 1 5,997 5,986 0,183 2 5,951 5,940 0,185 0,183±0,001231 3 6,031 6,020 0,182 D 1 6,023 6,012 0,183 2 5,997 5,986 0,183 0,184±0,001341 3 5,938 5,927 0,185 Batch II Formula Replikasi Berat awal (gram) Berat akhir (gram) Kerapuhan (%) X±SD A 1 5,989 5,978 0,184 2 5,997 5,986 0,183 0,183±0,000215 3 5,983 5,972 0,184 B 1 5,813 5,802 0,189 2 5,815 5,804 0,189 0,189±0,000228 3 5,802 5,791 0,190 C 1 5,997 5,986 0,183 2 5,951 5,940 0,185 0.183±0,001231 3 6,031 6,020 0,182 D 1 6,023 6,012 0,183 2 5,997 5,986 0,183 0,184±0,001341 3 5,938 5,927 0,185

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Batch III Formula Replikasi Berat awal (gram) Berat akhir (gram) Kerapuhan (%) X±SD A 1 5,989 5,978 0,184 2 5,997 5,986 0,183 0,183±0,000215 3 5,983 5,972 0,184 B 1 5,813 5,802 0,189 2 5,815 5,804 0,189 0,189±0,000228 3 5,802 5,791 0,190 C 1 5,997 5,986 0,183 2 5,951 5,940 0,185 0.183±0,001231 3 6,031 6,020 0,182 D 1 6,023 6,012 0,183 2 5,997 5,986 0,183 0,184±0,001341

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LAMPIRAN D

Hasil Penetapan Kadar Tablet Lepas Lambat Salbutamol Batch I

Formula Replikasi absorbansi Csampel Cteoritis %kadar X±SD

1 0,045 6,3056 6,2587 100,75 99,75 A 2 0,044 6,1667 6,2442 98,76 ± 3 0,044 6,2222 6,2379 99,75 0,99 1 0,043 6,0278 6,1506 98,00 98,57 B 2 0,044 6,1667 6,2379 98,86 ± 3 0,045 6,3611 6,4355 98,84 0,48 1 0,044 6,1667 6,2587 98,53 98,76 C 2 0,044 6,1667 6,2483 98,69 ± 3 0,045 6,3611 6,4210 99,07 0,27 1 0,044 6,1667 6,1526 100,23 99,82 D 2 0,046 6,4444 6,4022 100,66 ± 3 0,043 6,0833 6,1714 98,57 1,1 Batch II

Formula Replikasi absorbansi Csampel Cteoritis %kadar X±SD

1 0,045 6,3056 6,2566 100,78 100,50 A 2 0,045 6,3056 6,2421 101,02 ± 3 0,044 6,2222 6,2400 99,72 0,69 1 0,043 6,0278 6,1006 98,81 98,87 B 2 0,044 6,1667 6,2421 98,79 ± 3 0,043 6,0833 6,1443 99,01 0,12 1 0,045 6,3056 6,2670 100,61 99,60 C 2 0,043 6,0278 6,0778 99,18 ± 3 0,044 6,2222 6,2837 99,02 0,87 1 0,045 6,3056 6,2483 100,92 100,60 D 2 0,045 6,3056 6,2774 100,45 ± 3 0,044 6,2222 6,1942 100,45 0,26

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Batch III

Formula Replikasi absorbansi Csampel Cteoritis %kadar X±SD

1 0,044 6,1667 6,2171 99,19 100,39 A 2 0,045 6,3056 6,2421 101,02 ± 3 0,046 6,5000 6,4376 100,97 1,04 1 0,045 6,3056 6,2629 100,68 100,25 B 2 0,043 6,0278 6,0798 99,14 ± 3 0,046 6,5000 6,4397 100,94 0,96 1 0,043 6,0278 6,0986 98,84 99,6 C 2 0,045 6,3056 6,2504 100,88 ± 3 0,044 6,2222 6,2795 99,09 1,11 1 0,044 6,1667 6,2587 98,53 99,5 D 2 0,043 6,0278 6,0798 99,14 ± 3 0,045 6,3611 6,3086 100,83 1,19

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LAMPIRAN E

Contoh Perhitungan

Contoh perhitungan sudut diam: Formula A:

W persegi panjang = 4,28 gram W lingkaran = 0,88 gram Luas persegi panjang = 21,5 x 28

= 602 cm2 Luas lingkaran =

602

28 ,

4

88 ,

0 ×

_{= 123,78 cm}2 A = π.r2 r2 =

π

A

=

14 ,

3

78 ,

123

= 39,42 r = 6,28 cm tg α =

r

t

=

28 ,

6

5 ,

4

= 0,72 α _{= 35,62°}

Contoh perhitungan indeks kompresibilitas: Formula A :

Berat gelas = 125,89 g (W1)

Berat gelas + granul = 165,69 g (W2) V = 100 ml

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V2 = 86 ml Bj nyata = 1 1 2

)

(

V

W

W −

=

100 )

89 ,

125

69 ,

165 (

−

= 0,398 Bj mampat = 2 1 2

)

(

V

W

W −

=

87 )

89 ,

125

69 ,

165 (

−

= 0,46 % kompresibilitas =

_x

₁₀₀

_%

mampat

.

Bj

nyata

.

Bj

1 _











−

= 13,48%

Contoh perhitungan akurasi & presisi:

Absorbansi = 0,044 → y = 0,0072x – 0,0004 Konsentrasi sebenarnya = 6,1667 ppm Konsentrasi teoritis = 6,2338 ppm

% perolehan kembali = (konsentrasi sebenarnya / konsentrasi teoritis) x 100% = (6,1667 / 6,2338) x 100% = 98,92 % Untuk menghitung % KV =

x

100 %

X

SD

=

₁₀₀

_%

99,72

0,93

x

= 0,9331 % % Bahan aktif (mg) Matriks (mg) +Dapar fosfat pH 6,8 ad Pipet +Dapar fosfat pH 6,8 ad Konsent rasi (ppm) 100 9,6 290,4 100 0,65 10 6,24

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Contoh perhitungan % obat terlepas: % obat terlepas =

100 %

100 ×

× dosis

PK

Wt

Formula A replikasi 1 pada t = 30 menit

% obat terlepas =

100 %

25,02

%

6 ,

9

100 100,22

2,4072

=

×

Contoh perhitungan AUC pada disolusi: Rumus: Wtn + W tn-1 x tn – tn-1 2 Formula A batch 1 Wtn-1 = 2,4072 Wtn = 3,1779 tn = 90 menit tn-1 = 60 menit AUC = ₍₉₀ ₆₀₎ 2 1779 , 3 4072 , 2 + ₋ x =83,7765

Luas □ = 360 x penetapan kadar x dosis = 360 x 100,22% x 9,6 mg = 3463,6032

% ED Formula A batch 1= (∑ AUC / luas □) x 100% = (2268.7611/3463,6032) x 100% = 65,50 %

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Perhitungan persamaan orde satu: Rumus: ln (

X

-Ct) = ln C0 - k . t

Dari persamaan regresi ln (

X

-Ct) versus t (waktu), maka didapatkan suatu persamaan regresi dan nilai r, slope serta intersept. Nilai kdiss adalah –slope.

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LAMPIRAN F

Persamaan Formula A Persamaan Orde Nol

r = 0.980345 r tabel = 0,404 Persamaan Higuchi

r = 0,9926 r tabel = 0,404 Persamaan orde satu

r = -0,9793 r tabel = 0,404 0 5 10 15 0 200 400 Formula A Linear (Formula A) 0 10 20 0 5 10 15 20 Formula A Linear (Formula A) -2 0 2 4 0 200 400 Formula A Linear (Formula A)

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LAMPIRAN G

Persamaan Formula B Persamaan orde nol

r = 0,9859 r tabel = 0,404 Persamaan Higuchi r = 0,9988 r tabel = 0,404 Persamaan orde satu

r = -0,9909 r tabel = 0,404 0 5 10 0 100 200 300 400 Formula B Linear (Formula B) 0 5 10 0 5 10 15 20 Formula B Linear (Formula B) -2 0 2 4 0 100 200 300 400 Formula B Linear (Formula B)

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LAMPIRAN H

Persamaan Formula C Persamaan Orde Nol

r = 0,9826 r tabel = 0,404 Persamaan Higuchi

r = 0,9960 r tabel = 0,404 Persamaan Orde Satu

r = 0,9890 r tabel = 0,404 0 5 10 0 100 200 300 400 Formula C Linear (Formula C) 0 5 10 0 5 10 15 20 Formula C Linear (Formula C) -2 0 2 4 0 100 200 300 400 Formula C Linear (Formula C)

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LAMPIRAN I

Persamaan Formula D Persamaan Orde Nol

r = 0,9769 r tabel = 0,404 Persamaan Higuchi

r = 0,9888 r tabel = 0,404 Persamaan Orde Satu

r = 0,9547 r tabel = 0,404 0 5 10 0 100 200 300 400 Formula D Linear (Formula D) 0 2 4 6 8 0 5 10 15 20 Formula D Linear (Formula D) -1 0 1 2 0 100 200 300 400 Formula D Linear (Formula D)

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LAMPIRAN J

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LAMPIRAN K

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LAMPIRAN L

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LAMPIRAN M

Sertifikat Analisis Magnesium Stearat M

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LAMPIRAN N

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LAMPIRAN O

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LAMPIRAN P

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LAMPIRAN Q

Tabel Uji r LAMPIRAN Q

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LAMPIRAN

Tabel Uji HSD (0,05) LAMPIRAN R

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LAMPIRAN S

Hasil Uji Statistik Kadar Air Antar Formula Anova: Single Factor

SUMMARY

Groups Count Sum Average Variance

Column 1 3 14.01 4.67 0.0004 Column 2 3 14.25 4.75 0.0004 Column 3 3 13.17 4.39 0.0004 Column 4 3 12.9 4.3 0.0004 ANOVA Source of

Variation SS df MS F P-value F crit Between Groups 0.421425 3 0.140475 3.1875 0.1191 4.0661 Within Groups 0.0032 8 0.0004 Total 0.424625 11 PENGUJIAN HIPOTESA : a. H : Pi = 0

Yang berarti tidak ada perbedaan EFEK yang signifikan sebagai akibat perbedaan perlakuan.

b. KESIMPULAN:

Karena F hitung < F(0.05) maka H diterima.

Dengan perkataan lain perlakuan-perlakuan tidak memberikan perbedaan efek yang signifikan.

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LAMPIRAN T

Hasil Uji Statistik Waktu AlirAntar Formula Anova: Single Factor

SUMMARY

Column 1 3 29.01 9.67 0.0004 Column 2 3 28.6 9.5333 0.000233 Column 3 3 28.09 9.3633 0.000933 Column 4 3 27.38 9.1266 0.000433 ANOVA Source of Variation SS df MS F P-value F crit Between Groups 0.493667 3 0.1645 3.91111 0.0683 4.0661 Within Groups 0.004 8 0.0005 Total 0.497667 11 PENGUJIAN HIPOTESA : a. H : Pi = 0

b. KESIMPULAN:

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LAMPIRAN U

Hasil Uji Indeks Kompresibilitas Antar Formula Anova: Single Factor

SUMMARY

Groups Count Sum Average Variance Column 1 3 105.61 35.203 0.223233 Column 2 3 107.52 35.84 0.2716 Column 3 3 109.38 36.46 0.3628 Column 4 3 106.4 35.466 0.186233 ANOVA Source of Variation SS df MS F P-value F crit Between Groups 2.673292 3 0.8910 3.414602 0.0732 4.0661 Within Groups 2.087733 8 0.2609 Total 4.761025 11 PENGUJIAN HIPOTESA : a. H : Pi = 0

b. KESIMPULAN:

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LAMPIRAN V

Hasil Uji Statistik Sudut Diam Antar Formula Anova: Single

Factor SUMMARY

Groups Count Sum Average Variance Column 1 3 40.21 13.40333 0.017633 Column 2 3 40.8 13.6 0.0243 Column 3 3 42.64 14.21333 0.124033 Column 4 3 40.64 13.54667 0.116033 ANOVA Source of Variation SS df MS F P-value F crit Between Groups 1.154092 3 0.384697 3.456698 0.0695 4.0661 Within Groups 0.564 8 0.0705 Total 1.718092 11 PENGUJIAN HIPOTESA : a. H : Pi = 0

b. KESIMPULAN:

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LAMPIRAN W

Hasil Uji Statistik Kekerasan Tablet Formula A Antar Batch Anova: Single Factor

SUMMARY

Groups Count Sum Average Variance Column 1 10 136.7 13.67 0.040111 Column 2 10 136.3 13.63 0.149 Column 3 10 135.1 13.51 0.092111 ANOVA Source of Variation SS df MS F P-value F crit Between Groups 0.138667 2 0.069333 0.739629 0.4867 3.3541 Within Groups 2.531 27 0.093741 Total 2.669667 29 PENGUJIAN HIPOTESA : a. H : Pi = 0

b. KESIMPULAN:

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LAMPIRAN X

Hasil Uji Statistik Kekerasan Tablet Formula B Antar Batch Anova: Single

Factor SUMMARY

b. KESIMPULAN:

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LAMPIRAN Y

Hasil Uji Statistik Kekerasan Tablet Formula C Antar Batch Anova: Single Factor

SUMMARY

b. KESIMPULAN:

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LAMPIRAN Z

Hasil Uji Statistik Kekerasan Tablet Formula D Antar Batch Anova: Single Factor

SUMMARY

b. KESIMPULAN:

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LAMPIRAN AA

Hasil Uji Statistik Kekerasan Tablet Antar Formula Batch 1

PENGUJIAN HIPOTESA : a. H : Pi = 0

b. KESIMPULAN:

Anova: Single Factor SUMMARY

Groups Count Sum Average Variance Column 1 10 136.7 13.67 0.040111 Column 2 10 137.6 13.76 0.102667 Column 3 10 140.1 14.01 0.025444 Column 4 10 139.9 13.99 0.014333 ANOVA Source of Variation SS df MS F P-value F crit Between Groups 0.85475 3 0.284917 2.242848 0.0715 2.8662 Within Groups 1.643 36 0.045639 Total 2.49775 39

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LAMPIRAN AB

b. KESIMPULAN:

Groups Count Sum Average Variance Column 1 10 136.3 13.63 0.149 Column 2 10 133.9 13.39 0.269889 Column 3 10 139.1 13.91 0.025444 Column 4 10 139.9 13.99 0.032111 ANOVA Source of

Variation SS df MS F P-value F crit Between Groups 2.256 3 0.752 2.313433 0.07149 2.8662 Within Groups 4.288 36 0.119111

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LAMPIRAN AC

b. KESIMPULAN:

Groups Count Sum Average Variance Column 1 10 135.1 13.51 0.092111 Column 2 10 136.7 13.67 0.131222 Column 3 10 139.1 13.91 0.038778 Column 4 10 140.2 14.02 0.019556 ANOVA Source of Variation SS df MS F P-value F crit Between Groups 1.59475 3 0.531583 2.549112 0.0704 2.8662 Within Groups 2.535 36 0.070417 Total 4.12975 39

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LAMPIRAN AD

Hasil Uji Statistik Kerapuhan Tablet Formula A Antar Batch

Groups Count Sum Average Variance Column 1 3 0.567987 0.189328 5.21E-08 Column 2 3 0.567987 0.189328 5.21E-08 Column 3 3 0.567987 0.189328 5.21E-08 ANOVA Source of Variation SS df MS F P-value F crit Between Groups 0 2 -8.47E-22 -5.6E-16 1 5.1432 Within Groups 3.1259E-07 6 5.2099E-08 Total 3.1259E-07 8 PENGUJIAN HIPOTESA : a. H : Pi = 0

b. KESIMPULAN:

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LAMPIRAN AE

Hasil Uji Statistik Kerapuhan Tablet Formula B Antar Batch Anova: Single Factor

SUMMARY

Groups Count Sum Average Variance Column 1 3 0.5679 0.189328 5.21E-08 Column 2 3 0.5679 0.189328 5.21E-08 Column 3 3 0.5679 0.189328 5.21E-08 ANOVA Source of Variation SS df MS F P-value F crit Between Groups 0 2 -8.47E-22 -5.6E-16 1 5.1432 Within Groups 3.1259E-07 6 5.2099E-08 Total 3.1259E-07 8 PENGUJIAN HIPOTESA : a. H : Pi = 0

b. KESIMPULAN:

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LAMPIRAN AF

Hasil Uji Statistik Kerapuhan Tablet Formula C Antar Batch Anova: Single Factor

SUMMARY

Groups Count Sum Average Variance Column 1 3 0.550659 0.183553 1.52E-06 Column 2 3 0.550659 0.183553 1.52E-06 Column 3 3 0.550659 0.183553 1.52E-06 ANOVA Source of Variation SS df MS F P-value F crit Between Groups -1.7E-21 2 -8.5E-22 -5.6E-16 1 5.1432 Within Groups 9.09E-06 6 1.52E-06 Total 9.09E-06 8 PENGUJIAN HIPOTESA : a. H : Pi = 0

b. KESIMPULAN:

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LAMPIRAN AG

Hasil Uji Statistik Kerapuhan Tablet Formula D Antar Batch Anova: Single Factor

SUMMARY

Groups Count Sum Average Variance Column 1 3 0.5513 0.183769 1.8E-06 Column 2 3 0.5513 0.183769 1.8E-06 Column 3 3 0.5513 0.183769 1.8E-06 ANOVA Source of Variation SS df MS F P-value F crit Between

Groups 1.69E-21 2 8.47E-22

4.71E-16 1 5.1432 Within

Groups 1.08E-05 6 1.8E-06

Total 1.08E-05 8

b. KESIMPULAN:

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LAMPIRAN AH

Hasil Uji Statistik Kerapuhan Tablet Antar Formula Batch 1 Anova: Single Factor

SUMMARY

Groups Count Sum Average Variance Column 1 3 0.550949 0.18365 4.64E-08 Column 2 3 0.567987 0.189329 5.21E-08 Column 3 3 0.550659 0.183553 1.52E-06 Column 4 3 0.551306 0.183769 1.8E-06 ANOVA Source of Variation SS df MS F P-value F crit Between Groups 7.25E-05 3 2.42E-05 2.321472 0.070 4.0661 Within Groups 6.82E-06 8 8.53E-07 Total 7.93E-05 11 PENGUJIAN HIPOTESA : a. H : Pi = 0

b. KESIMPULAN:

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LAMPIRAN AI

SUMMARY

Groups Count Sum Average Variance Column 1 3 0.550949 0.18365 4.64E-08 Column 2 3 0.567987 0.189329 5.21E-08 Column 3 3 0.550659 0.183553 1.52E-06 Column 4 3 0.551306 0.183769 1.8E-06 ANOVA Source of

Variation SS df MS F P-value F crit Between Groups 7.25E-05 3 2.42E-05 2.321472 0.070 4.0661 Within Groups 6.82E-06 8 8.53E-07 Total 7.93E-05 11 PENGUJIAN HIPOTESA : a. H : Pi = 0

b. KESIMPULAN:

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LAMPIRAN AJ

SUMMARY

Groups Count Sum Average Variance Column 1 3 0.550949 0.18365 4.64E-08 Column 2 3 0.567987 0.189329 5.21E-08 Column 3 3 0.550659 0.183553 1.52E-06 Column 4 3 0.551306 0.183769 1.8E-06 ANOVA Source of Variation SS df MS F P-value F crit Between

Groups 7.25E-05 3 2.42E-05 2.321472 0.070 4.0661 Within

Groups 6.82E-06 8 8.53E-07

Total 7.93E-05 11

b. KESIMPULAN:

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LAMPIRAN AK

Hasil Uji Statistik Penetapan Kadar Tablet Formula A Antar Batch Anova: Single Factor

SUMMARY

b. KESIMPULAN:

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LAMPIRAN AL

Hasil Uji Statistik Penetapan Kadar Tablet Formula B Antar Batch Anova: Single Factor

SUMMARY

b. KESIMPULAN:

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LAMPIRAN AM

Hasil Uji Statistik Penetapan Kadar Tablet Formula C Antar Batch Anova: Single Factor

SUMMARY

b. KESIMPULAN:

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LAMPIRAN AN

Hasil Uji Statistik Penetapan Kadar Tablet Formula D Antar Batch Anova: Single Factor

SUMMARY

b. KESIMPULAN:

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LAMPIRAN AO

Hasil Uji Statistik Penetapan Kadar Tablet Antar Formula Batch 1 Anova: Single

Factor SUMMARY

b. KESIMPULAN:

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LAMPIRAN AP

Hasil Uji Statistik Penetapan Kadar Tablet Antar Formula Batch 2 Anova: Single Factor

SUMMARY

b. KESIMPULAN:

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LAMPIRAN AQ

Hasil Uji Statistik Penetapan Kadar Tablet Antar Formula Batch 3 Anova: Single Factor

SUMMARY

b. KESIMPULAN:

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LAMPIRAN AR

Hasil Uji Statistik % ED360 PERHITUNGAN ANAVA (Uji Statistik % ED360 ) Anova: Single Factor

SUMMARY

Column 1 3 196.26 65.421 0.3150 Column 2 3 155.126 51.708 0.001 Column 3 3 142.2 47.423 0.0126 Column 4 3 117.914 39.304 0.0069 ANOVA Source of Variation SS df MS F P-value F crit Between Groups 1074.162 3 358.054 4265.423 3.7E-13 4.066 Within Groups 0.671547 8 0.08394 Total 1074.834 11

keterangan: F hitung>F tabel (0,05) sehingga H ditolak dan ada perbedaan yang bermakna antar formula HSD = 0.6562 FA FB FC F D Mean 65.4216 51.7088 47.423 39.3047 formula A 65.4216 0 13.71278 * 17.998 * 26.1169 * formula B 51.7088 0 4.2855 * 12.4041 * formula C 47.4233 0 8.11861 * Formula D 39.3047 Keterangan

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LAMPIRAN AS

Hasil Uji Statistik % Obat Terlepas

Anova: Single Factor

SUMMAR Y

Column 1 3 298.48 99.493 0.1980 Column 2 3 256.16 85.387 0.1758 Column 3 3 240.59 80.197 0.0037 Column 4 3 210.58 70.193 0.0058 ANOVA Source of Variation SS df MS F P-value F crit Between Groups 1340.767 3 446.92 4662.322 3E-13 4.066181 Within Groups 0.766867 8 0.0959 Total 1341.534 11

keterangan: F hitung>F tabel (0,05) sehingga H ditolak dan ada perbedaan yang bermakna antar formula HSD = 0.701267 FA F B F C FD Mean 99.493 85.386 80.196 70.19333 formula A 99.493 0 14.106 * 19.296 * 29.3 * formula B 85.386 0 5.19 * 15.19333 * formula C 80.196 0 10.00333 * Formula D 70.193 Keterangan

* : Perbedaannya signifikan, karena selisihnya > HSD(5%) TS : Perbedaannya tidak signifikan, karena selisihnya < HSD(5%)

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LAMPIRAN AT

Uji F Kurva Baku

REPLIKASI 1 KONSENTRASI ABSORBANSI X2 _Y2 _XY 1.53 0.011 2.331 0.000121 0.0168 4.07 0.029 16.581 0.000841 0.1181 6.11 0.044 37.307 0.001936 0.2688 8.14 0.054 66.324 0.002916 0.4398 10.18 0.075 103.632 0.005625 0.7635 30.03 0.213 226.177 0.011439 1.6069 REPLIKASI 2 KONSENTRASI ABSORBANSI X2 _Y2 _XY 1.52 0.012 2.295 0.000144 0.0182 4.04 0.028 16.321 0.000784 0.1131 6.06 0.042 36.723 0.001764 0.2545 8.08 0.052 65.286 0.002704 0.4202 10.10 0.074 102.010 0.005476 0.7474 29.80 0.208 222.636 0.010872 1.5534 REPLIKASI 3 KONSENTRASI ABSORBANSI X2 _Y2 _XY 1.54 0.014 2.359 0.000196 0.0215 4.10 0.033 16.777 0.001089 0.1352 6.14 0.049 37.748 0.002401 0.3011 8.19 0.057 67.108 0.003249 0.4669 10.24 0.079 104.857 0.006241 0.8090 30.21 0.232 228.851 0.013176 1.7336 ΣX2 _Σ_XY _Σ_Y2 _N _SSi _RDF Regresi I 226.1777 1.606 0.011439 5 0.0043 4 Regresi II 222.6368 1.553 0.010872 5 0.0039 4 Regresi III 228.8517 1.733 0.013176 5 0.0056 4 677.6663 4.893 0.035487 0.0138 SSc= 0.028265 267 F= 3.2929 < Ftabel0,05(2;12) 3,89

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LAMPIRAN AU

LOD dan LOQ

y ŷ y-ŷ (y-ŷ)2 0.011 0.01128 -0.00028 0.0000001 LOD y=yB+3SB= -0.0003 0.029 0.02948 -0.00048 0.0000002 X= 0.006 0.044 0.04404 -0.00004 0.0000000 0.054 0.05860 -0.00460 0.0000212 LOQ y=yB+10SB= -0.0002 0.075 0.07316 0.00184 0.0000034 X= 0.0201 Σ(y-ŷ)2 0.0000248 SB 0.0000143 y ŷ y-ŷ (y-ŷ)2 0.012 0.01043 0.00157 0.0000025 LOD y=yB+3SB= 0.0002 0.028 0.02801 -0.00001 0.0000000 X= 0.008 0.042 0.04208 -0.00008 0.0000000 0.052 0.05614 -0.00414 0.0000171 LOQ y=yB+10SB= 0.0003 0.074 0.07020 0.00380 0.0000144 X= 0.0282 Σ(y-ŷ)2 0.0000340 SB 0.0000196 y ŷ y-ŷ (y-ŷ)2 0.014 0.00788 0.00612 0.0000375 LOD y=yB+3SB= 0.0035 0.033 0.02621 0.00679 0.0000460 X= 0.055 0.049 0.04088 0.00812 0.0000659 0.057 0.05555 0.00145 0.0000021 LOQ y=yB+10SB= 0.0044 0.079 0.07022 0.00878 0.0000770 X= 0.1842 Σ(y-ŷ)2 0.0002285 SB 0.0001319 Rata-rata LOD= 0.023 ppm LOQ= 0.077 ppm