69
LAMPIRAN
Lampiran 3.
Informed consent
JUDUL PENELITIAN
: HUBUNGAN ABNORMALITAS HASIL CT-SCAN
DENGAN DEVELOPMENTAL DELAYED PADA
PASIEN SUSPEK INFEKSI CYTOMEGALOVIRUS
KONGENITAL
INSTANSI PELAKSANA
:
FAKULTAS
KEDOKTERAN
UNIVERSITAS
DIPONEGORO
Persetujuan Setelah Penjelasan
(INFORMED CONSENT)
Bapak/Ibu Yth :
Saya Wilujeng Puja Sari, mahasiswa Fakultas Kedokteran Universitas Diponegoro Semarang, Program Studi Kedokteran Umum. Saya bermaksud melakukan penelitian mengenai “Hubungan Abnormalitas Hasil CT-Scan terhadap Developmental Delayed pada Pasien Suspek Infeksi
Cytomegalovirus Kongenital”. Penelitian ini dilakukan sebagai tahap akhir dalam penyelesaian studi di Fakultas Kedokteran Universitas Diponogoro, Program Studi Kedokteran Umum. Pada penelitian ini akan dilakukan pengumpulan data pada catatan medis untuk mengetahui apakah kalsifikasi intrakranial, ventrikulomegali, atrofi cerebri, serta kelianan minor lainnya secara sendiri-sendiri atau bersama-sama merupakan faktor resiko terjadinya developmental delayed pada pasien suspek infeksi CMV kongenital. Peneliti akan menjaga kerahasiaan identitas dan informasi yang diberikan dan hanya digunakan untuk kepentingan penelitian.
Terima kasih atas kerjasama Bapak/Ibu/Sdr.
Setelah mendengar dan memahami penjelasan Penelitian, dengan ini saya menyatakan SETUJU / TIDAK SETUJU
Untuk ikut sebagai responden / sampel penelitian.
Semarang,
Saksi : Nama Terang :
Nama Terang : Alamat :
72
Lampiran 4.
Hasil Analisis
Frequencies
Jenis Kelamin
Frequency Percent Valid Percent
Cumulative Percent Valid Laki-laki 20 71.4 71.4 71.4 Perempuan 8 28.6 28.6 100.0 Total 28 100.0 100.0
Descriptives
Descriptive StatisticsN Minimum Maximum Mean Std. Deviation
Usia (bulan) 28 1 59 15.36 15.404 Valid N (listwise) 28 FREQUENCIES VARIABLES=AbnormalitasCTScan /PIECHART FREQ /ORDER=ANALYSIS. N Valid 28 Missing 0
Frequencies
Statistics Abnormalitas CT Scan N Valid 28 Missing 0 Abnormalitas CT ScanFrequency Percent Valid Percent
Cumulative Percent
Valid Ya 22 78.6 78.6 78.6
Tidak 6 21.4 21.4 100.0
Total 28 100.0 100.0
FREQUENCIES VARIABLES=Kalsifikasi Ventrikulomegali AtrofiCerebri KelMinorLain /PIECHART FREQ
/ORDER=ANALYSIS.
Frequencies
Statistics
Kalsifikasi
Intracranial Ventrikulomegali Atrofi Cerebri
Kelainan Minor Lainnya
N Valid 28 28 28 28
Frequency Table
Kalsifikasi Intracranial
Frequency Percent Valid Percent
Cumulative Percent Valid Ya 7 25.0 25.0 25.0 Tidak 21 75.0 75.0 100.0 Total 28 100.0 100.0 Ventrikulomegali
Frequency Percent Valid Percent
Cumulative Percent Valid Ya 5 17.9 17.9 17.9 Tidak 23 82.1 82.1 100.0 Total 28 100.0 100.0 Atrofi Cerebri
Frequency Percent Valid Percent
Cumulative Percent
Valid Ya 10 35.7 35.7 35.7
Tidak 18 64.3 64.3 100.0
Total 28 100.0 100.0
Kelainan Minor Lainnya
Frequency Percent Valid Percent
Cumulative Percent
Valid Ya 16 57.1 57.1 57.1
Tidak 12 42.9 42.9 100.0
Pie Chart
FREQUENCIES VARIABLES=Developmentaldelayed /PIECHART FREQ /ORDER=ANALYSIS.Frequencies
Statistics Developmental Delayed N Valid 28 Missing 0Developmental Delayed
Frequency Percent Valid Percent
Cumulative Percent Valid Ya 21 75.0 75.0 75.0 Tidak 7 25.0 25.0 100.0 Total 28 100.0 100.0 CROSSTABS /TABLES=AbnormalitasCTScan BY Developmentaldelayed /FORMAT=AVALUE TABLES /STATISTICS=CHISQ RISK /CELLS=COUNT ROW /COUNT ROUND CELL.
Crosstabs
Case Processing Summary
Cases
Valid Missing Total
N Percent N Percent N Percent Abnormalitas CT Scan *
Developmental Delayed
Abnormalitas CT Scan * Developmental Delayed Crosstabulation
Developmental Delayed
Total Ya Tidak
Abnormalitas CT Scan Ya Count 20 2 22
% within Abnormalitas CT Scan 90.9% 9.1% 100.0% Tidak Count 1 5 6 % within Abnormalitas CT Scan 16.7% 83.3% 100.0% Total Count 21 7 28 % within Abnormalitas CT Scan 75.0% 25.0% 100.0% Chi-Square Tests Value df Asymp. Sig. (2-sided) Exact Sig. (2-sided) Exact Sig. (1-sided) Pearson Chi-Square 13.859a 1 .000 Continuity Correctionb 10.182 1 .001 Likelihood Ratio 12.680 1 .000
Fisher's Exact Test .001 .001
Linear-by-Linear Association
13.364 1 .000
N of Valid Cases 28
a. 2 cells (50,0%) have expected count less than 5. The minimum expected count is 1,50. b. Computed only for a 2x2 table
Risk Estimate
Value
95% Confidence Interval Lower Upper Odds Ratio for Abnormalitas CT
Scan (Ya / Tidak)
50.000 3.741 668.350
For cohort Developmental Delayed = Ya
5.455 .907 32.803
For cohort Developmental Delayed = Tidak
.109 .028 .429
CROSSTABS
/TABLES=Kalsifikasi BY Developmentaldelayed /FORMAT=AVALUE TABLES
/STATISTICS=CHISQ RISK /CELLS=COUNT ROW /COUNT ROUND CELL.
Crosstabs
Case Processing Summary
Cases
Valid Missing Total
N Percent N Percent N Percent Kalsifikasi Intracranial *
Developmental Delayed
28 100.0% 0 .0% 28 100.0%
Kalsifikasi Intracranial * Developmental Delayed Crosstabulation
Developmental Delayed
Total Ya Tidak
Kalsifikasi Intracranial Ya Count 7 0 7
% within Kalsifikasi Intracranial 100.0% .0% 100.0% Tidak Count 14 7 21 % within Kalsifikasi Intracranial 66.7% 33.3% 100.0% Total Count 21 7 28 % within Kalsifikasi Intracranial 75.0% 25.0% 100.0% Chi-Square Tests Value df Asymp. Sig. (2-sided) Exact Sig. (2-sided) Exact Sig. (1-sided) Pearson Chi-Square 3.111a 1 .078 Continuity Correctionb 1.587 1 .208 Likelihood Ratio 4.757 1 .029
Fisher's Exact Test .141 .098
Linear-by-Linear Association
3.000 1 .083
a. 1 cells (25,0%) have expected count less than 5. The minimum expected count is 1,75. b. Computed only for a 2x2 table
CROSSTABS
/TABLES=Ventrikulomegali BY Developmentaldelayed /FORMAT=AVALUE TABLES
/STATISTICS=CHISQ RISK /CELLS=COUNT ROW /COUNT ROUND CELL
Crosstabs
Case Processing Summary
Cases
Valid Missing Total
N Percent N Percent N Percent Ventrikulomegali *
Developmental Delayed
28 100.0% 0 .0% 28 100.0%
Ventrikulomegali * Developmental Delayed Crosstabulation
Developmental Delayed Total Ya Tidak Ventrikulomegali Ya Count 5 0 5 % within Ventrikulomegali 100.0% .0% 100.0% Tidak Count 16 7 23 % within Ventrikulomegali 69.6% 30.4% 100.0% Total Count 21 7 28 % within Ventrikulomegali 75.0% 25.0% 100.0% Risk Estimate Value 95% Confidence Interval Lower Upper For cohort Developmental
Delayed = Ya
1.500 1.109 2.030
Chi-Square Tests Value df Asymp. Sig. (2-sided) Exact Sig. (2-sided) Exact Sig. (1-sided) Pearson Chi-Square 2.029a 1 .154 Continuity Correctionb .730 1 .393 Likelihood Ratio 3.224 1 .073
Fisher's Exact Test .290 .207
Linear-by-Linear Association
1.957 1 .162
N of Valid Cases 28
a. 2 cells (50,0%) have expected count less than 5. The minimum expected count is 1,25. b. Computed only for a 2x2 table
Risk Estimate
Value
95% Confidence Interval Lower Upper For cohort Developmental
Delayed = Ya 1.438 1.097 1.884 N of Valid Cases 28 CROSSTABS /TABLES=AtrofiCerebri BY Developmentaldelayed /FORMAT=AVALUE TABLES /STATISTICS=CHISQ RISK /CELLS=COUNT ROW /COUNT ROUND CELL.
Crosstabs
Case Processing Summary
Cases
Valid Missing Total
N Percent N Percent N Percent Atrofi Cerebri *
Developmental Delayed
Atrofi Cerebri * Developmental Delayed Crosstabulation
Developmental Delayed
Total Ya Tidak
Atrofi Cerebri Ya Count 10 0 10
% within Atrofi Cerebri 100.0% .0% 100.0%
Tidak Count 11 7 18
% within Atrofi Cerebri 61.1% 38.9% 100.0%
Total Count 21 7 28
% within Atrofi Cerebri 75.0% 25.0% 100.0%
Chi-Square Tests Value df Asymp. Sig. (2-sided) Exact Sig. (2-sided) Exact Sig. (1-sided) Pearson Chi-Square 5.185a 1 .023 Continuity Correctionb 3.319 1 .069 Likelihood Ratio 7.434 1 .006
Fisher's Exact Test .030 .027
Linear-by-Linear Association
5.000 1 .025
N of Valid Cases 28
a. 2 cells (50,0%) have expected count less than 5. The minimum expected count is 2,50. b. Computed only for a 2x2 table
Risk Estimate
Value
95% Confidence Interval Lower Upper For cohort Developmental
Delayed = Ya 1.636 1.132 2.366 N of Valid Cases 28 CROSSTABS /TABLES=KelMinorLain BY Developmentaldelayed /FORMAT=AVALUE TABLES /STATISTICS=CHISQ RISK /CELLS=COUNT ROW /COUNT ROUND CELL.
Crosstabs
Case Processing Summary
Cases
Valid Missing Total
N Percent N Percent N Percent Kelainan Minor Lainnya *
Developmental Delayed
28 100.0% 0 .0% 28 100.0%
Kelainan Minor Lainnya * Developmental Delayed Crosstabulation
Developmental Delayed
Total Ya Tidak
Kelainan Minor Lainnya Ya Count 14 2 16
% within Kelainan Minor Lainnya
87.5% 12.5% 100.0%
Tidak Count 7 5 12
% within Kelainan Minor Lainnya
58.3% 41.7% 100.0%
Total Count 21 7 28
% within Kelainan Minor Lainnya 75.0% 25.0% 100.0% Chi-Square Tests Value df Asymp. Sig. (2-sided) Exact Sig. (2-sided) Exact Sig. (1-sided) Pearson Chi-Square 3.111a 1 .078 Continuity Correctionb 1.750 1 .186 Likelihood Ratio 3.133 1 .077
Fisher's Exact Test .103 .093
Linear-by-Linear Association 3.000 1 .083 N of Valid Cases 28
a. 2 cells (50,0%) have expected count less than 5. The minimum expected count is 3,00. b. Computed only for a 2x2 table
Risk Estimate
Value
95% Confidence Interval Lower Upper Odds Ratio for Kelainan Minor
Lainnya (Ya / Tidak)
5.000 .767 32.574
For cohort Developmental Delayed = Ya
1.500 .898 2.505
For cohort Developmental Delayed = Tidak
.300 .070 1.291
N of Valid Cases 28
Logistic Regression
LOGISTIC REGRESSION VARIABLES Developmentaldelayed /METHOD=ENTER Kalsifikasi AtrofiCerebri KelMinorLain /PRINT=CI(95)
/CRITERIA=PIN(0.05) POUT(0.10) ITERATE(20) CUT(0.5).
Block 1: Method = Backward Stepwise (Wald)
Omnibus Tests of Model Coefficients
Chi-square df Sig. Step 1 Step 11.898 3 .008 Block 11.898 3 .008 Model 11.898 3 .008 Step 2a Step -5.259 1 .022 Block 6.639 2 .036 Model 6.639 2 .036 Step 3a Step -4.875 1 .027 Block 1.763 1 .184 Model 1.763 1 .184 Step 4a Step -1.763 1 .184 Step 5 Step 6.182 1 .013 Block 6.182 1 .013 Model 6.182 1 .013
a. A negative Chi-squares value indicates that the Chi-squares value has decreased from the previous step.
Model Summary
Step -2 Log likelihood
Cox & Snell R Square Nagelkerke R Square 1 17.199a .346 .536 2 22.458a .211 .327 3 27.333b .061 .094 4 29.096c .000 .000 5 22.915a .198 .307
a. Estimation terminated at iteration number 20 because maximum iterations has been reached. Final solution cannot be found. b. Estimation terminated at iteration number 5 because parameter estimates changed by less than .001.
c. Estimation terminated at iteration number 4 because parameter estimates changed by less than .001.
Classification Tablea Observed Predicted Developmental Delayed Percentage Correct Ya Tidak
Step 1 Developmental Delayed Ya 19 3 86.4
Tidak 2 4 66.7
Overall Percentage 82.1
Step 2 Developmental Delayed Ya 22 0 100.0
Tidak 6 0 .0
Overall Percentage 78.6
Step 3 Developmental Delayed Ya 22 0 100.0
Tidak 6 0 .0
Overall Percentage 78.6
Step 4 Developmental Delayed Ya 22 0 100.0
Tidak 6 0 .0
Overall Percentage 78.6
Step 5 Developmental Delayed Ya 22 0 100.0
Tidak 6 0 .0
Overall Percentage 78.6
Variables in the Equationc
B S.E. Wald df Sig. Exp(B)
95% C.I.for EXP(B) Lower Upper Step 1a Kalsifikasi 20.666 13741.842 .000 1 .999 944191775.979 .000 . AtrofiCerebri 20.492 11832.343 .000 1 .999 793357780.263 .000 . KelMinorLain .981 1.155 .722 1 .396 2.667 .277 25.636 Constant -83.989 36268.028 .000 1 .998 .000 Step 2a AtrofiCerebri 20.274 12629.568 .000 1 .999 638024225.546 .000 . KelMinorLain .693 1.041 .443 1 .505 2.000 .260 15.381 Constant -42.340 25259.137 .000 1 .999 .000 Step 3a KelMinorLain 1.253 .973 1.658 1 .198 3.500 .520 23.559 Constant -3.199 1.631 3.845 1 .050 .041 Step 4a Constant -1.299 .461 7.958 1 .005 .273 Step 5b AtrofiCerebri 20.510 12710.151 .000 1 .999 807737459.492 .000 . Constant -41.713 25420.301 .000 1 .999 .000 a. Variable(s) entered on step 1: Kalsifikasi, AtrofiCerebri, KelMinorLain.
b. Variable(s) entered on step 5: AtrofiCerebri.
c. Stepwise procedure stopped because removing the least significant variable results in a previously fitted model.
Variables not in the Equation
Score df Sig. Step 2a Variables Kalsifikasi 3.680 1 .055
Overall Statistics 3.680 1 .055 Step 3b Variables Kalsifikasi 2.717 1 .099
AtrofiCerebri 3.438 1 .064 Overall Statistics 7.117 2 .028 Step 4c Variables Kalsifikasi 2.545 1 .111
AtrofiCerebri 4.242 1 .039 KelMinorLain 1.768 1 .184 Overall Statistics 7.774 3 .051 Step 5c Variables Kalsifikasi 3.462 1 .063
KelMinorLain .450 1 .502 Overall Statistics 4.062 2 .131 a. Variable(s) removed on step 2: Kalsifikasi.
b. Variable(s) removed on step 3: AtrofiCerebri. c. Variable(s) removed on step 4: KelMinorLain.
Score df Sig. Step 0 Variables Kalsifikasi 3.111 1 .078
KelMinorLain .778 1 .378 AtrofiCerebri 1.867 1 .172 Overall Statistics 5.576 3 .134
