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Web appendix: Framing air pollution epidemiology in terms of population interventions, with applications to multi-pollutant modeling.

Jonathan M. Snowden, Colleen E. Reid, Ira B. Tager

This appendix contains the remaining plots that graphically depict the days which satisfy Conditions 1 and 2. Condition 1 stipulates that the absolute value-daily differences of the index pollutant exceed the daily concentration IQR. Condition 2 requires Condition 1 as well as stipulating that the absolute value of the co-pollutant’s daily difference is in the lower tertile of daily difference absolute values.

For each city-season, sub-figure A represents NO2 as the index pollutant and sub-figure B represents PM2.5 as the index pollutant.

Contents:

Complete figures

Page 2: eFigure 1. Ambient NO2 and PM2.5 daily differences during winter in Burbank, California, 2010 – 2012

Page 3: eFigure 2. Ambient NO2 and PM2.5 daily differences during summer in Houston, Texas, 2010 – 2012

Page 4: eFigure 3. Ambient NO2 and PM2.5 daily differences during winter in Houston, Texas, 2010 – 2012

Page 5: eFigure 4. Ambient NO2 and PM2.5 daily differences during summer in Pittsburgh, Pennsylvania, 2010 – 2012

Sensitivity analyses of Condition 2

Page 6: eTable 1. Number and percent of days fulfilling Condition 2, with sensitivity analyses varying the definition of “low concentration change in co-pollutant”

Page 7, eFigure 5. Sensitivity analyses of pollutant changes during summer in Burbank, varying the Condition 2 definition of “low concentration change in co-pollutant”

Page 8, eFigure 6. Sensitivity analyses of pollutant changes during winter in Pittsburgh, varying the Condition 2 definition of “low concentration change in co-pollutant”

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eFigure 1. Ambient NO2 and PM2.5 daily differences during winter in Burbank, California, 2010 – 2012

A. NO2 as index pollutant

B. PM2.5 as index pollutant

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eFigure 2. Ambient NO2 and PM2.5 daily differences during summer in Houston, Texas, 2010 – 2012

A. NO2 as index pollutant

B. PM2.5 as index pollutant

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eFigure 3. Ambient NO2 and PM2.5 daily differences during winter in Houston, Texas, 2010 – 2012

A. NO2 as index pollutant

B. PM2.5 as index pollutant

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eFigure 4. Ambient NO2 and PM2.5 daily differences during summer in Pittsburgh, Pennsylvania, 2010 – 2012

A. NO2 as index pollutant

B. PM2.5 as index pollutant

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eTable 1. Number and percent of days fulfilling Condition 2,a with sensitivity analyses b varying the definition of “low concentration change in co-pollutant”

Index pollutant: NO2 Index pollutant: PM2.5

Burbank n (%)

Houston n (%)

Pittsburgh n (%)

Burbank n (%)

Houston n (%)

Pittsburgh n (%) Summer

Condition 2 2 (0.9) 17 (6.4) 1 (0.4) 8 (3.7) 17 (6.4) 14 (5.6) Condition 2 [SA1] 2 (0.9) 19 (7.2) 1 (0.4) 8 (3.7) 22 (8.3) 18 (7.2) Condition 2 [SA2] 2 (0.9) 11 (4.2) 0 (0) 6 (2.8) 11 (4.2) 8 (3.2) Winter

Condition 2 5 (2.5) 16 (6.0) 4 (1.7) 9 (4.5) 13 (4.9) 2 (0.8) Condition 2 [SA1] 7 (3.5) 19 (7.2) 6 (2.5) 10 (5.1) 21 (7.9) 2 (0.8) Condition 2 [SA2] 1 (0.5) 7 (2.6) 2 (0.8) 8 (4.0) 6 (2.3) 1 (0.4) a: Condition 2 requires Condition 1 as well as stipulating that the absolute value of the co-pollutant’s daily difference is <33rd percentile of daily difference absolute values.

b: Sensitivity analysis 1 of Condition 2 requires that the absolute value of the co-pollutant’s daily difference is <40th percentile of daily difference absolute values;

Sensitivity analysis 2 of Condition 2 requires that the absolute value of the co-pollutant’s daily difference is <20th percentile of daily difference absolute values.

Abbreviations:

NO2, nitrogen dioxide; PM2.5, particulate matter with aerodynamic diameter ≤2.5μm; SA, sensitivity analysis

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eFigure 5. Sensitivity analyses of pollutant changes during summer in Burbank, varying the Condition 2 definition of “low concentration change in co-pollutant”

A. NO2 as index pollutant

B. PM2.5 as index pollutant

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eFigure 6. Sensitivity analyses of pollutant changes during winter in Pittsburgh, varying the Condition 2 definition of “low concentration change in co-pollutant”

A. NO2 as index pollutant

B. PM2.5 as index pollutant

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