Supplementary table 1: List Immune-related adverse events
Organ system Specific complication ICD-10 code
Cardiac Acute pericarditis, Acute myocarditis,
Cardiomyopathy, I30.0/8/9, I40.0-9, I42.0-5/8-9
Pulmonary Pneumonitis, unspecified (drug- induced),
Post-inflammatory pulmonary fibrosis, Acute interstitial pneumonitis,
Unspecified pneumopathy
J69, J70, J84, J84.10/114, J94.0-9
Endocrine Panhypopituitarism or other pituitary disorders, Iatrogenic or other/unspecific hypothyroidism, Thyroiditis,
Thyrotoxicosis, Adrenal insufficiency, Hypoparathyroidism, Hypogonadism
E23.0/1/7, E03.2, E06.0/1/4/9, R94.6/7, E05.90, E27.0-9, E20.0/1/8/9, E23.1
Neurological Guillain Barre syndrome and neuropathies, Myasthenia Gravis, Myoneural disorders
G61.0-9, G70.0/1/8/9
Gastrointestinal Enterocolitis, Complications with enterocolitis, altered liver enzymes, Hepatitis (autoimmune and other), Pancreatic dysfunction
K50.0-9, K51.0-9, R94.5, K754, K86.81
Supplementary table 2: 25 most common autoimmune diseases in the U.S.16 with respective ICD-10 codes
Autoimmune disease U.S. Prevalence per 100.000 people
ICD - 10 code
Rheumatoid arthritis 860.00 M05, M06
Hashimoto’s thyroiditis 791.70 E06.3
Celiac disease 750.00 K90.0
Graves’ disease 629.00 E05.00
Diabetes mellitus, type 1 480.00 E10.0-9
Vitiligo 400.20 L80
Rheumatic fever 250.00 I00, I01.0-9, I02.0-9
Pernicious anemia/atrophic gastritis 150.90 D51.0
Alopecia areata 150.00 L63.0-9
Immune thrombocytopenic purpura 72.00 D69.3
Multiple sclerosis 58.30 G35.0-9
Systematic Lupus Erythematosus 32.00 M32.0-9
Temporal arteritis 30.00 M31.6
Ulcerative colitis 30.00 K51.0-9
Crohn’s disease 25.00 K50.0-9
Scleroderma 24.00 M34.0-9
Antiphospholipide syndrome 21.50 D68.61
Autoimmune hepatitis type 1 16.10 K75.4
Primary biliary cirrhosis 14.60 K74.3
Sjogren’s Syndrom 14.40 M35.0
Addison’s disease 14.00 E27.1
Dermatitis herpetiformis 11.20 L13.0
Kawasaki disease 10.00 M30.3
Sympathetic ophthalmia 9.00 H44.1
HLA-B27 associated acute anterior uveitis
8.70 H20.019
Supplementary table 3: Pre-existing autoimmune diseases of patients diagnosed with cutaneous melanoma
Autoimmune disease ICI+pAID
N = 106 (2.9%)
Non-ICI+pAID N = 2706
(73.1%)
Rheumatoid arthritis 28 656
Hashimoto’s thyroiditis ** 134
Celiac disease ** 61
Graves’ disease ** 79
Diabetes mellitus, type 1 16 536
Vitiligo ** 38
Rheumatic fever ** **
Pernicious anemia/atrophic gastritis 31 676
Alopecia areata ** 27
Immune thrombocytopenic purpura ** 54
Multiple sclerosis ** 47
Systematic lupus erythematosus ** 78
Temporal arteritis ** 88
Ulcerative colitis ** 151
Crohn’s disease ** 64
Scleroderma ** 111
Antiphospholipide syndrome ** **
Autoimmune hepatitis type 1 ** 13
Primary biliary cirrhosis ** **
Sjogren’s syndrom ** 93
Addison’s disease ** 64
Dermatitis herpetiformis ** **
Kawasaki disease ** **
Sympathetic ophthalmia ** **
HLA-B27 associated acute anterior uveitis ** 26
**Due to the CMS (Center for Medicare & Medicaid Services) cell size suppression policy, numbers<11 cannot be reported directly.
pAID=pre-existing autoimmune disease
