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Supplemental Digital Content Table 1: Demographic, preoperative and postoperative characteristics of cases undergoing DSAEK after TASS

Cas e No.

Age (yea rs )

Se x

Preo p UDV A

Preo p IOP (mm Hg)

CCT (µm )

Duration betwee n TASS and DSAEK (months )

Preop Donor endothe lial cell count (cells/m m2)

Postop UDVA (at last follow up)

Postop CDVA (at last follow up)

Postop IOP (mm Hg) (at last follow up)

Anatom ical Outcom e (at last follow up)

Additional surgical procedures

Postop CCT ( µm) (at last follow up)

Postop donor thickness ( µm ) (at last follow up)

Postop specular (cells/mm2 ) (at last follow up)

% Endot helial cell loss (per year)

Follow up (mont hs)

1. 62 F HMC

F

18* 740 2 2550 PL PL 21** Failed

graf

Repeat DSAEK, penetrating keratoplasty, trabeculecto my

1340 - CNV - 24

2. 58 M 1/60 19 710 2.5 2750 FCCF FCCF 18* Failed

graf

Penetrating keratoplasty, trabeculecto my

1250 - CNV - 20

3. 68 F 1/60 15* 690 6 2880 6/36 6/18 18** GC 4+ None 580 122 1225 31.3% 22

4. 71 F FCCF 10 780 12 2670 6/24 6/12 16 GC 4+ None 555 121 1945 18.1% 18

5. 59 M 3/60 8 750 9 2700 6/12 6/9 14 GC 4+ None 565 114 1650 25.9% 18

6. 65 F FCCF 14 650 7 2430 6/18 6/9 17 GC 4+ None 575 94 1560 28.6% 15

7. 66 F FCCF 13 680 8 2510 6/18 6/12 18* GC 4+ None 580 87 1440 34.1% 15

8. 73 M 1/60 18* 720 10.5 2650 6/12 6/9 15** GC 4+ None 560 75 1880 21.8% 16

9. 55 M 2/60 16* 690 11 2450 6/24 6/18 12* GC 4+ None 540 110 1350 44.9% 12

10. 60 M 3/60 20 675 15 2300 6/12 6/12 13* GC 4+ None 550 90 1810 19.7% 13

11. 72 F HMC

F

12 680 12 2690 6/18 6/12 16 GC 4+ None 575 120 1980 22.6% 14

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12. 75 M 1/60 17* 640 13 2720 6/12 6/9 15** GC 4+ None 590 60 1765 35.1% 12

13. 69 M 2/60 15 750 8 2320 6/9 6/9 14 GC 4+ None 535 66 1195 48.5% 12

14. 59 M 4/60 11 700 10 2820 6/12 6/9 10 GC 4+ None 564 53 2090 25.9% 12

Me an

± SD

65.1

±6.4

14.7

± 3.6

703.

9 ± 40.2

9.0 ± 3.8 2602.9

± 179.6

15.5 ± 2.8

668.5

± 266.5

92.7 ± 25 1657.5 ± 303.1

29.7 ± 9.6

15.9 ± 4.0

DSAEK-Descemet Stripping Automated Endothelial Keratoplasty, TASS- Toxic Anterior Segment Syndrome, UDVA- Uncorrected distance visual acuity, IOP- intraocular pressure, CCT- central corneal thickness, CDVA- corrected distance visual acuity, M- male, F- female, HMCF- perception of hand movements close to face, FCCF- counting fingers close to face, PL- perception of light, GC- graf clarity, CNV- counts not captured, * IOP controlled on two topical antiglaucoma medications

(Timolol+Brimonidine), **IOP controlled on three topical antiglaucoma medications (Timolol+Brimonidine+Brinzolamide)

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