Table S1. Cardiac Arrest and Pupil Score
Pupil Score 0 (n=295） 1 (n=65) 2 (n=112)
P value
Cardiac arrest
<.0001
Yes 28 (45.9) 2 (3.3) 31 (50.8)
No 267 (65.0) 63 (15.3) 81 (19.7)
P value in bold is significant.
Table S2. Glasgow Coma Scale Score and the Systemic Vasospasm Score (SVS)
Glasgow Coma Scale 3 (n=169) 4 (n=65) 5 (n=52) 6 (n=74) P value
SVS score (all patients) <.011
1 148 (87.6) 48 (73.9) 43 (82.7) 53 (71.6)
2 5 (3.0) 10 (15.4) 2 (3.9) 5 (6.8)
3 4 (2.49) 3 (4.6) 2 (3.9) 5 (6.8)
4 20 (7.1) 4 (6.2) 5 (9.6) 11 (14.9)
SVS score (patients with aneurysm treatment) .10
1 74 (80.4) 34 (68.0) 30 (76.9) 47 (69.1)
2 4 (4.4) 10 (20.0) 2 (5.1) 5 (7.4)
3 4 (4.4) 3 (6.0) 2 (5.1) 5 (7.4)
4 10 (10.9) 3 (6.0) 5 (12.8) 11 (16.2)
Data are presented as the number of patients (%).
P value in bold is significant.
Table S3. Outcomes According to the Glasgow Outcome Scale for the Individual Glasgow Coma Scale Score in All Patients
Glasgow Coma Scale 3 4 5 6 P value
At discharge (n=472) (n=230) (n=88) (n=61) (n=93)
Glasgow Outcome Scale <.0001
GR 9 (3.9) 3 (3.4) 5 (8.2) 9 (9.7)
MD 10 (4.6) 15 (17.1) 8 (13.1) 10 (10.8)
SD 32 (13.9) 13 (14.8) 10 (16.4) 29 (31.2)
PVS 20 (8.7) 9 (10.2) 16 (26.2) 17 (18.3)
D 159 (69.1) 48 (54.6) 22 (36.1) 28 (30.1)
Favorable outcomes (GR or MD) 19 (8.3) 18 (20.5) 13 (21.3) 19 (20.4) .0022
At 3 months (n=454) (n=227) (n=83) (n=58) (n=86)
Glasgow Outcome Scale <.0001
GR 12 (5.3) 10 (12.1) 5 (8.6) 10 (11.6)
MD 13 (5.7) 9 (10.9) 9 (15.5) 8 (9.3)
SD 29 (12.8) 9 (10.9) 10 (17.2) 30 (34.9)
PVS 12 (5.3) 5 (6.0) 10 (17.2) 10 (11.6)
D 161 (70.9) 50 (60.2) 24 (41.4) 28 (32.6)
Favorable outcomes (GR or MD) 25 (11.0) 19 (22.9) 14 (24.1) 18 (20.9) .012 Data are presented as the number of patients (%). GR, good recovery; MD, moderate disability; SD, severe disability; PVS, persistent vegetative state; D, death; mRS, modified Rankin Scale.
P values in bold are significant.
Table S4. Outcomes According to the Glasgow Outcome Scale for Individual Glasgow Coma Scale Score in Patients with Aneurysm Treatment
Glasgow Coma Scale 3 4 5 6 P value
At discharge (n=257) (n=94) (n=51) (n=39) (n=73)
Glasgow Outcome Scale .17
GR 9 (9.6) 3 (5.9) 5 (12.8) 9 (12.3)
MD 10 (10.6) 14 (27.5) 7 (18.0) 10 (13.7)
SD 31 (33.0) 11 (21.6) 9 (23.1) 28 (38.4)
PVS 16 (31.4) 7 (13.7) 9 (23.1) 14 (19.2)
D 28 (29.8) 16 (31.4) 9 (23.1) 12 (16.4)
Favorable outcomes (GR or MD) 19 (20.2) 17 (33.3) 12 (30.8) 19 (26.0) .32
At 3 months (n=242) (n=91) (n=47) (n=37) (n=67)
Glasgow Outcome Scale .24
GR 12 (13.2) 9 (19.2) 5 (13.5) 10 (14.9)
MD 12 (13.2) 9 (19.2) 8 (21.6) 8 (11.9)
SD 29 (31.9) 9 (19.2) 8 (22.2) 29 (43.3)
PVS 10 (11.0) 4 (8.5) 7 (18.9) 8 (11.9)
D 28 (30.8) 16 (34.0) 9 (24.3) 12 (17.9)
Favorable outcome (GR or MD) 24 (26.4) 18 (38.3) 13 (35.1) 18 (26.9) .41 Data are presented as the number of patients (%). GR, good recovery; MD, moderate disability; SD, severe disability; PVS, persistent vegetative state; D, death; mRS, modified Rankin Scale.
Table S5. Outcomes According to the Glasgow Outcome Scale for individual Glasgow Coma Scale-Pupil Score in All Patients
Glasgow Coma Scale-P 1 2 3 4 5 6 P value
At discharge (n=472) (n=80) (n=45) (n=152) (n=61) (n=58) (n=76)
Glasgow Outcome Scale <.0001
GR 0 (0) 0 (0) 10 (6.6) 4 (6.6) 3 (5.2) 9 (1.9)
MD 0 (0) 1 (2.2) 14 (9.2) 10 (16.4) 8 (13.8) 10 (2.1)
SD 2 (2.5) 7 (15.6) 27 (17.8) 10 (16.4) 12 (20.7) 26 (34.2)
PVS 2 (2.5) 4 (8.9) 19 (12.5) 8 (13.1) 13 (22.4) 16 (21.1)
D 76 (95.0) 33 (73.3) 82 (54.0) 29 (47.5) 22 (37.9) 15 (19.7)
Favorable outcomes (GR or MD) 0 (0) 1 (2.2) 24 (15.8) 14 (23.0) 11 (19.0) 19 (25.0) .0007
At 3 months (n=454)） (n=80) (n=43) (n=149) (n=58) (n=55) (n=69)
Glasgow Outcome Scale <.0001
GR 0 (0) 0 (0) 14 (9.4) 10 (17.2) 3 (5.5) 10 (14.5)
MD 0 (0) 1 (2.3) 15 (10.1) 6 (10.3) 9 (16.4) 8 (11.6)
SD 2 (2.5) 6 (14.0) 24 (16.1) 8 (13.8) 11 (20.0) 27 (39.1)
PVS 1 (1.3) 3 (7.0) 12 (8.1) 3 (5.2) 9 (16.4) 9 (13.0)
D 77 (96.3) 33 (76.7) 84 (56.4) 31 (53.5) 23 (41.8) 15 (21.7)
Favorable outcomes (GR or MD) 0 (0) 1 (2.3) 29 (19.5) 16 (27.6) 12 (21.8) 18 (26.1) <.0001
Data are presented as the number of patients (%). GR, good recovery; MD, moderate disability; SD, severe disability; PVS, persistent vegetative state; D, death;
mRS, modified Rankin Scale.
P values in bold are significant.
Table S6. Outcomes Assessed Using the Glasgow Coma Scale-Pupil and the Glasgow Outcome Scale in Patients with Aneurysm Treatment.
Glasgow Outcome Scale-Pupil 1 2 3 4 5 6 P value
At discharge (n=257) (n=11) (n=18) (n=87) (n=40) (n=58) (n=76)
Glasgow Outcome Scale .046
GR 0 (0) 0 (0) 10 (13.4) 4 (10.0) 3 (8.3) 9 (13.9)
MD 0 (0) 1 (5.6) 13 (14.9) 10 (25.0) 7 (19.4) 10 (15.4)
SD 2 (18.2) 7 (38.9) 26 (29.9) 8 (20.0) 11 (30.6) 25 (38.5)
PVS 1 (9.1) 4 (22.2) 15 (17.2) 5 (12.5) 7 (19.4) 14 (21.5)
D 8 (72.7) 6 (33.3) 23(26.4) 13 (32.5) 8 (22.2) 7 (10.8)
Favorable outcomes (GR or MD) 0 (0) 1 (5.6) 23 (26.4) 14 (35.0) 10 (27.8) 19 (29.2) .079
At 3 months (n=242) (n=11) (n=16) (n=84) (n=38) (n=34) (n=59)
Glasgow Outcome Scale .014
GR 0 (0) 0 (0) 13 (15.5) 10 (26.3) 3 (8.8) 10 (17.0)
MD 0 (0) 1 (6.3) 14 (16.7) 6 (15.8) 8 (23.5) 8 (13.6)
SD 2 (18.2) 6 (37.5) 24 (28.6) 7 (18.4) 10 (29.4) 26 (44.1)
PVS 1 (9.1) 3 (18.8) 10 (11.9) 2 (5.3) 5 (14.7) 8 (13.6)
D 8 (72.7) 6 (37.5) 23 (27.4) 13 (34.2) 8 (23.5) 7 (11.9)
Favorable outcomes (GR or MD) 0 (0) 1 (6.3) 26 (31.0) 16 (42.1) 11 (32.4) 18 (30.5) .036
Data are presented as the number of patients (%). GR, good recovery; MD, moderate disability; SD, severe disability; PVS, persistent vegetative state; D, death;
mRS, modified Rankin Scale.
Table S7. Outcome at 3 Months and Prognostic Factors
Outcome by GOS P values Outcome by mRS P values
Variable GR or MD SD or VS or D Univariate Multivariate 0–2 3–6 Univariate Multivariate
Female sex 48 (16.2) 248 (83.8) .68 38 (12.8) 258 (87.2) .96
Age, years 62.9 ± 13.1 67.9 ± 13.8 .0038 .023 61.4 ± 13.3 67.9 ± 13.7 .0008 .0043
Neurological deficits 6 (8.0) 69 (92.0) .027 .078 5 (6.7) 70 (93.3) .090 .21
Pupillary dilatation <.0001 <.0001 <.0001 <.0001
Normal 68 (24.4) 211 (75.6) 53 (19.0) 226 (81.0)
Unilateral 8 (12.3) 57 (7.7) 5 (7.7) 60 (92.3)
Bilateral 0 (0) 110 (100) 0 (0) 110 (100)
Lack of corneal reflex .036 .46 .037 .068
Bilateral 1 (2.6) 37 (97.4) 0 (0) 38 (100)
Unilateral 0 (0) 3 (100) 0 (0) 3 (100)
Cardiac arrest 1 (1.7) 58 (98.3) .0003 .0023 1 (1.7) 58 (98.3) .0003 .0044
Respiratory arrest 7 (23.3) 23 (76.7) .31 5 (16.7) 25 (83.3) .57
Shock status 2 (8.7) 21 (91.3) .40 1 (4.4) 22 (95.6) .34
Pulmonary edema 3 (12.5) 21 (87.5) .78 2 (8.3) 22 (91.7) .75
Hypoxia 2 (11.8) 15 (88.2) .75 1 (5.9) 16 (94.1) .71
Sedation 25 (29.4) 60 (70.6) .015 17 (20.0) 68 (80.0) .12
Endotracheal intubation 27 (18.0) 123 (82.0) .69 20 (13.3) 130 (86.7) .82
Time after last bleeding, hrs 2 (1- 9) 2 (1-6) .61 2 (1-7.5) 2 (1-6) .99
Fisher CT group .40 .039
1 3 (33.3) 62 (66.7) 3 (33.3) 62 (66.7)
2 5 (20.0) 20 (80.0) 5 (20.0) 20 (80.0)
3 59 (14.4) 351 (85.6) 40 (9.8) 370 (90.2)
4 1 (14.3) 6 (85.7) 0 (0) 7 (100)
Aneurysm location .020 .17 .012 .095
Anterior 47 (17.7) 218 (82.3) 36 (13.6) 229 (86.4)
Posterior 21 (30.4) 48 (69.6) 18 (26.1) 51 (73.9)
Intracerebral hemorrhage .0145 .0005 .028 .017
With shift 12 (11.42) 93 (88.6) 8 (7.6) 97 (86.8)
Without shift 6 (9.5) 57 (90.5) 5 (7.9) 58 (92.1)
No 58 (21.5) 212 (78.5) 459 (16.7) 225 (83.3)
Intraventricular hemorrhage .78 .42
None 38 (18.7) 165 (81.3) 29 (14.3) 174 (85.7)
Reflux only 21 (18.1) 95 (81.9) 18 (15.5) 98 (84.5)
Packed one ventricle 5 (14.7) 29 (85.3) 2 (5.9) 32 (94.1)
Packed two or more ventricles 12 (14.1) 73 (85.9) 9 (10.6) 76 (89.4)
Aneurysm treatment
Clipping 39 (27.9) 101 (72.1) .36 30 (21.4) 110 (78.6) .36
IVR 34 (33.3) 68 (66.7) 27 (26.5) 75 (73.5)
Categorical data are presented as the number of patients (%), age is presented as mean ± standard deviation, and time after last bleeding is presented as median with interquartile ranges (IQR). GOS, Glasgow Coma Scale; mRS, modified Rankin Scale. GR, good recovery; MD, moderate disability; SD, severe disability; VS, vegetative state; D, death; IVR, interventional radiology
Table S8. Change of the Glasgow Coma Scale (GCS) Score and Outcomes
GOS P value mRS P value
GCS GR or MD SD or PVS or D 0-2 3-6
Worsened 4 (13.8) 25 (86.2) <.0001 3 (10.3) 26 (89.7) <.0001
Unchanged 50 (13.1) 331 (86.9) 36 (9.5) 345 (90.5)
Improved 21 (48.8) 22 (51.2) 18 (41.9) 25 (58.1)
GOS, Glasgow Outcome Scale; mRS, modified Rankin Scale P value in bold are significant.
Table S9. Outcome at 3 Months in the Clip and IVR Groups
Treatment methods Clip (n=139) IVR (n=102) P value
Modified Rankin Scale .38
mRS 0-2 30 (21.6) 27 (26.5)
mRS 3 -6 109 (78.4) 75 (73.5)
Glasgow Outcome Scale .38
GR or MD 39 (28.1) 34 (33.3)
SD or VS or D 100 (71.9) 68 (66.7)
Data are presented as the number of patients (%). IVR, Interventional Radiology; GR, good recovery; MD, moderate disability; SD, severe disability; PVS, persistent vegetative state; D, death; mRS, modified Rankin Scale.
