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Supplemental Table 1. Baseline demographic and clinical characteristics of participating women.

Patient variables

age, mean (SD), years 49.50 (10.24)

Obese, no. (%), BMI ≥30 424 (22.1)

Diabetes, no (%) 72 (3.8)

Smoker

- never, no. (%) 1286 (66.9)

- previous, no. (%) 590 (30.7)

- current, no. (%) 45 (2.3)

Pre-operative patient-reported outcome data

BREAST-Q satisfaction with breast, mean (SD), 0-100 62.79 (21.16) BREAST-Q psychosocial well-being, mean (SD), 0-100 71.37 (17.72) BREAST-Q physical well-being chest and upper body, mean (SD), 0-100 79.93 (14.45) BREAST-Q physical well-being abdomen, mean (SD), 0-100 90.04 (13.39)

BREAST-Q sexual well-being, mean (SD), 0-100 57.20 (19.43)

Clinical variables Radiation

- after reconstruction, no. (%) 418 (21.75)

- before reconstruction, no. (%) 182 (9.47)

- none, no. (%) 1321 (68.77)

Mastectomy

- nipple-sparing, no. (%) 268 (13.95)

- simple, no. (%) 1643 (85.55)

- other, no. (%) 10 (0.52)

Reconstruction technique

- tissue expander (TE), no. (%) 1156 (60.18)

- direct-to-implant (DTI), no. (%) 90 (4.69)

- transverse rectus abdominis (TRAM) flap, no. (%) 123 (6.4) - deep inferior epigastric perforator (DIEP) flap, no. (%) 310 (16.1)

- latissimus dorsi (LD) flap, no. (%) 40 (2.08)

- gluteal artery perforator (GAP) flap, no. (%) 9 (0.47) - superficial inferior epigastric artery (SIEA) flap, no. (%) 55 (2.86)

- crossover flap, no. (%) 76 (3.96)

- mixed flaps, no. (%) 45 (2.34)

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- mixed implant and autologous, no. (%) 17 (0.88) Chemotherapy

- received, no. (%) 604 (31.44)

- not received, no. (%) 1317 (68.56)

Reconstruction laterality

- unilateral, no. (%) 845 (43.99)

- bilateral, no. (%) 1076 (56.01)

Mastectomy indication

- cancer, no. (%) 1693 (88.13)

- prophylactic, no. (%) 228 (11.87)

Axillary intervention

- axillary lymph node dissection (ALND), no. (%) 532 (27.69)

- sentinel lymph node biopsy (SLNB), no. (%) 929 (48.36)

- none, no. (%) 460 (23.95)

Socioeconomic and ethnic data Marital status

- single, no. (%) 156 (8.12)

- living with significant other, no. (%) 93 (4.84)

- married, no. (%) 1441 (75.01)

- separated, no. (%) 37 (1.93)

- divorced, no. (%) 153 (7.96)

- widowed, no. (%) 41 (2.13)

Education level

- some high school, no. (%) 41 (2.13)

- high school degree, no. (%) 146 (7.6)

- some college/trade school, no. (%) 276 (14.37)

- college/trade school degree, no. (%) 789 (41.07)

- some masters/doctoral, no. (%) 85 (4.42)

- masters/doctoral degree, no. (%) 584 (30.40)

Working status

- unable to work, no. (%) 38 (1.98)

- unemployed, no. (%) 32 (1.67)

- student, no. (%) 15 (0.78)

- volunteer, no. (%) 12 (0.62)

- retired, no. (%) 170 (8.85(

- homemaker, no. (%) 226 (11.76)

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- part time employed, no. (%) 257 (13.38)

- full time employed, no. (%) 1100 (57.26)

- other, no. (%) 71 (3.7)

Household income per year

- <25,000$, no. (%) 92 (4.79)

- 25,000$ to 49,999$, no. (%) 209 (10.88)

- 50,000$ to 74,999$, no. (%) 312 (16.24)

- 75,000$ to 99,999$, no. (%) 298 (15.51)

- >100,000$, no. (%) 1010 (52.58)

Ethnical background

- Caucasian, no. (%) 1740 (90.58)

- African American, no. (%) 87 (4.53)

- Asian, no. (%) 78 (4.06)

- American Indian, no. (%) 16 (0.83)

- Pacific Islander, no. (%) 0 (0)

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