Online Figure and Table Legend
Online Figure 1. Distribution of post-DOACs-initiation systolic blood pressure in CPRD patients on DOACs.
Online Figure 2. Distribution of the number of days between DOACs initiation and post-DOACs initiation systolic blood pressure measurements by blood pressure measurements in CPRD patients on DOACs.
Online Figure 3. Distribution of the year of DOACs initiation by type of DOACs in CPRD patients on DOACs.
Online Figure 4. Adjusted Cox proportional hazard ratios of a bleeding event in CPRD patients on DOACs (reference 160mmHg and 140mmHg).
Online Figure 5. Adjusted Cox proportional hazard ratios of an event, all-cause mortality, and cardiovascular mortality in CPRD patients on DOACs with and without a history of stroke/ischaemic heart disease (reference 140mmHg).
Online Table 1. Read and ICD-10 codes for atrial fibrillation.
Online Table 2. Product codes for DOACs.
Online Table 3. Read and ICD-10 codes for events.
Online Table 4. Read and ICD-10 codes for medical history conditions.
Online Table 5. Incidence rate for an event, all-cause, and cardiovascular mortality by post-DOAC initiation systolic blood pressure groups and history of stroke and/or ischaemic heart disease in CPRD patients on DOACs.
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Online Figure 1. Distribution of post-DOACs-initiation systolic blood pressure in CPRD patients on DOACs.
Online Figure 2. Distribution of the number of days between DOACs initiation and post-DOACs initiation systolic blood pressure measurements by blood pressure measurements in CPRD patients on DOACs.
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Online Figure 3. Distribution of the year of DOACs initiation by type of DOACs in CPRD patients on DOACs.
Three patients (0.03%) were prescribed two DOACs on the same date. They were included in only one DOACs group for the first listed DOACs.
Online Figure 4. Adjusted Cox proportional hazard ratios of a bleeding event in CPRD patients on DOACs (reference 160mmHg and 140mmHg).
Adjusted for sex, age, dementia, liver disease, and current alcohol use.
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Online Figure 5. Adjusted Cox proportional hazard ratios of an event, all-cause mortality, and cardiovascular mortality in CPRD patients on DOACs with and without a history of stroke/ischaemic heart disease (reference 140mmHg).
Adjusted for sex, age, dementia, liver disease, and current alcohol use.
Online Table 1. Read and ICD-10 codes for atrial fibrillation.
Read code ICD-10 code
Atrial fibrillation G573000, G573.00, G573z00, 212R.00 I48.0, I48.1, I48.2, I48.3, I48.4, I48.9
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Online Table 2. Product codes for DOACs.
DOAC Product code
Rivaroxaban 47353, 71303, 54451, 48966, 47207, 39119, 62150
Apixaban 47566, 54066
Dabigatran 39444, 46632, 39503
Edoxaban 64678, 65247, 65876
Online Table 3. Read and ICD-10 codes for events.
Event Read code ICD-10 code
Intracerebral Haemorrhage
G61..12 I60, I61, I62
Ischaemic Stroke G64..13 I63.0, I63.1, I63.2, I63.3, I63.4, I63.5, I63.6,
I63.8, I63.9 Unspecified Stroke G66..00, G66..12 G65z100, G66..00, G66..11,
G66..12, G66..13, G667.00, G668.00, G669.00 I64 Stroke in Puerperium L440.12
Myocardial Infarction G300.00, G301.00, G301000, G301100, G301z00, G380.00, G30..00, G30..11, G30..12, G30..13, G30..14, G30..15, G30..16, G30..17, G302.00, G303.00, G308.00, G30yz00, G381.00, G309.00, G30X.00, G30X000, G383.00, Gyu3400, G307.00, G307000, G307100, G30y100
I21.0, I21.1, I21.2, I21.3, I21.4, I21.9, I22.0, I22.1, I22.8, I22.9, I25.2, I25.8
Bleeding (GI) J110111, J121111, J111111, J510900, J573.11, G848000
I85.01, I85.11, K22.11, K29.91 K29.81, K29.71, K29.61, K29.51, K29.21, K29.01, K22.11, K28.0, K27.3, K27.2, K26.2, K26.0, K25.0, K25.6, K26.3
Bleeding events were identified as events with codes for Intracerebral Haemorrhage or Bleeding (GI).
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Online Table 4. Read and ICD-10 codes for medical history conditions.
Medical history event Read code ICD-10 code
Stroke/IHD 504, 569, 1298, 1433, 1469, 1895, 3149, 3535, 5051, 5185, 5363, 5602, 6116, 6155, 6253, 6960, 7780, 7912, 8443, 8837, 9985, 10504, 12833, 13564, 15019, 15252, 15788, 16507, 16517, 16956, 17322, 18604, 18689, 19201, 19260, 19280, 19354, 23671, 24446, 25615, 26424, 27975, 28314, 30045, 30202, 31060, 31595, 33499, 33543, 34758, 36717, 39344, 40338, 40758, 44765, 46316, 47642, 50594, 51767, 53745, 55247, 57315, 62342, 90572, 91627, 92036, 94482, 96630, 101251 241, 732, 737, 1204, 1344, 1414, 1430, 1431, 1655, 1676, 1677, 1678, 2155, 2491, 2901, 3159, 3704, 3999, 4017, 4656, 5030, 5254, 5387, 5413, 5674, 5703, 5744, 5904, 6182, 6331, 6336, 6980, 7134, 7137, 7320, 7347, 7442, 7609, 7634, 7696, 8312, 8568, 8679, 8935, 8942, 9276, 9413, 9414, 9507, 9555, 10209, 10562, 10603, 11048, 11610, 11983, 12139, 12229, 12734, 12804, 12986, 13566, 13571, 14658, 14897, 14898, 15661, 15754, 16408, 17133, 17307, 17464, 17689, 17872, 18118, 18125, 18249, 18643, 18670, 18842, 18889, 18913, 19046, 19193, 19402, 19413, 19655, 20095, 20903, 21844, 22020, 22383, 22647, 22828, 23078, 23579, 23708, 23892, 24126, 24540, 24888, 25842, 26863, 27484, 27951, 27977, 28138, 28554, 28736, 28837, 29421, 29553, 29643, 29758, 29902, 30330, 30421, 31519, 31540, 31556, 31571,
G45, G45.8, G45.9, I61, I61.0, I61.2, I61.3, I61.4, I61.5, I61.6, I61.8, I61.9, I62.9, I63, I63.0, I63.1, I63.2, I63.3, I63.4, I63.5, I63.6, I63.8, I63.9
45370, 45809, 45886, 46017, 46112, 46166, 46276, 47788, 48206, 48767, 48822, 50372, 51507, 51515, 51702, 52938, 54251, 54535, 55092, 55137, 55598, 56905, 56990, 57062, 57241, 57634, 58198, 58256, 58401, 59189, 59193, 59423, 59940, 60067, 60753, 61208, 61248, 61310, 62608, 62626, 63153, 63467, 64923, 66236, 66388, 66583, 66664, 66921, 67087, 67554, 67591, 67761, 68123, 68139, 68357, 68748, 69247, 69474, 70111, 70755, 72562, 72780, 74092, 74151, 74336, 74379, 74480, 74618, 74634, 74650, 74803, 75123, 75840, 76830, 76831, 77092, 77280, 77374, 77984, 79034, 79268, 79499, 80024, 81779, 83376, 84228, 84273, 84291, 84418, 84951, 85001, 85947, 86071, 86094, 87849, 87937, 88735, 89513, 89832, 90211, 91358, 91532, 91774, 92233, 92419, 92927, 93618, 93706, 93828, 95382, 96804, 96838, 97953, 99991, 101569, 105250, 105479, 106812, 109035 Liver disease 1638, 1641, 1754, 1755, 2834, 2860, 3450, 4743, 5129, 5638, 6015, 6800, 6863, 7602, 7943, 7957, 8206, 8363, 9029, 9494, 10539, 10636, 10797, 11431, 11960, 15424, 15489, 16455, 16725, 16759, 16766, 17219, 18652, 18739, 19512, 20233, 20912, 21713, 22841, 23578, 24220, 24813, 24989, 25383, 25589, 26037, 26319, 26367, 27438, 27663, 28703, 28798, 28929, 30586, 30655, 30729, 31008, 31897, 32277, 33597, 34642, 39351, 40567, 40963, 41096, 41237, 42843, 43404, 44120, 44424, 44676, 46647, 47214, 47257, 48102, 48928, 50245, 53480, 53704, 53877, 55454, 58184, 58630, 60104, 62582, 64750, 65050, 66534, 68376, 69053, 69204, 69313, 71453, 73139, 73482, 91591, 92909, 96085, 96664, 96756, 98148, 99898, 100253, 100474, 100592, 102922, 104572, 105611, 108800
K70, K70.0, K70.1, K70.2, K70.3, K70.4, K70.9, K71, K71.0, K71.1, K71.2, K71.3, K71.4, K71.5, K71.6, K71.7, K71.8, K71.9, K72.0, K72.1, K72.9, K73, K73.0, K73.1, K73.2, K73.8, K73.9, K74.0, K74.1, K74.2, K74.3, K74.4, K74.5, K74.6, K75, K75.4, K75.8, K75.9, K76.0, K76.1, K76.2, K76.3, K76.5, K76.6, K76.9
Dementia 1350, 1916, 1917, 4357, 4693, 5931, 6578, F00, F00.0, F00.1, F00.2, F00.9, F01, F01.0, 11
7323, 7664, 8195, 8634, 8934, 9509, 9565, 11136, 11175, 11379, 12621, 15165, 16797, 18386, 19393, 19477, 21887, 25386, 25704, 26323, 27342, 27677, 27759, 28402, 29386, 30032, 30706, 31016, 32057, 33707, 34944, 37014, 37015, 38438, 38678, 41089, 41185, 42279, 42602, 43089, 43292, 43346, 44674, 46488, 46762, 48501, 49263, 49513, 53446, 54106, 54505, 55313, 55467, 55838, 56912, 59122, 60059, 61528, 64267
F01.1, F01.2, F01.3, F01.8, F01.9, F02.0, F02.1, F02.2, F02.3, F02.4, F02.8, F03
Online Table 5.
Incidence rate for an event, all-cause, and cardiovascular mortality by post-DOAC initiation systolic blood pressure groups and history of stroke or ischaemic heart disease in CPRD patients on DOACs.
Blood pressure
(mmHg)
No history of stroke/IHD History of stroke/IHD
Person- years
Event* All-cause mortality Cardiovascular mortality
Person-
years Event* All-cause mortality
n
Rate
(95% CI) n
Rate
(95% CI) n
Rate
(95% CI) n
Rate
(95% CI) n
Rate (95% CI) 90-120 2,191 109 49.7 (41.2-60.0) 218 99.5 (87.1-113.6) 40 18.3 (13.4-24.9) 1,816 118 65.0 (54.2-77.8) 204 112.3 (97.9-128.8) 121-140 3,957 158 39.9 (34.2-46.7) 200 50.5 (44.0-58.1) 34 8.6 (6.1-12.0) 2,806 214 76.3 (66.7-87.2) 209 74.5 (65.0-85.3)
141-160 1,527 77 50.4 (40.3-63.0) 74 48.5 (38.6-60.9) 16 10.5 (6.4-17.1) 1,076 95 88.3 (72.2-107.9) 69 64.1 (50.6-81.2)
161-210 453 30 66.2 (46.3-94.7) 15 33.1 (20.0-54.9) <5 6.6 (2.1-20.5) 320 31 96.7 (68.0-137.5) 24 74.9 (50.2-111.7)
Total 8,128 374 46.0 (41.6-50.9) 507 62.4 (57.2-68.0) 93 11.4 (9.3-14.0) 6,019 458 76.1 (69.4-83.4) 506 84.1 (77.1-91.7)
Rate=per 1,000 person-years. Cell values <5 cannot be reported per CPRD regulations.
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