A. Perhitungan /Tablet
Asam Mefenamat = 500 mg Magnesium Stearat = 1
100 x 800 mg = 8 g
Talk = 2
100 x800
mg
= 16 g Sodium Benzoat = 0,5100 x 800 mg = 4 g
CMC = 5
100 x 800 mg = 40 g
PVP = 2
100 x 800 mg = 16 g
Avicel = 3 0
100 x 800 mg = 240 g Laktosa ad 100% = ad 800 mg
W3
/1000 Tablet
Asam Mefenamat = 500 mg x 1000 tab = 50.000 mg = 500 g Magnesium Stearat = 8 g x 1000 tab = 8000 g
Talk = 16 g x 1000 tab = 16.000 g
Sodium Benzoat = 4 g x 1000 tab = 4.000 g
PVP = 2 g x 1000 tab = 2.000 g
CMC = 40 g x 1000 tab = 40.000 g
Avicel = 240 g x 1000 tab = 240.000 g Laktosa ad 100% = ad 800 x 1000 tab = 800.000 g
Laktosa = 800.000 g – (500 + 8.000 + 16.000 + 4.000 + 2.000 + 40.000 + 240.000) gram
= 800.000 g – 310.500 g
= 489.500 g 1. Fase dalam (97%)
Asam mefenamat = 500 mg x 1000 tab = 500.000 mg = 500 g
Sodium benzoat = 0,5% x 800 mg x 1000 tab = 4.000 mg = 4 g Croscarmellose = 2% x 800 mg x 1000 tab = 16.000 mg = 16 g Avicel PH 101 = 20% x 800 mg x 1000 tab = 160.000 mg = 160 g PVP = 2% x 800 mg x 1000 tab = 16.000 mg = 16 g
= 97% x 800 mg x 1000 tab = 776.000 mg = 776 g Laktosa = 776 g – (500 + 4 + 16 + 160 + 16) gram
= 776 g – 696 g
= 80 g Granul yang diperoleh = 700g
776g x 1000 tab = 902 tablet 2. Fase Luar (3%)
Talk = 2
97 x 700 g = 14,43 g Mg. Stearat = 1
97 x 700 g = 7,21 g Bobot tablet yang diperoleh
= 700g+(7,21+14,43)gram 902tab
