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Supplemental data
Comparisons of women according to pregnant BP status and present BP
Women with previous PE and still hypertensive (group 1), were slightly older than women with previous PIH (groups 3 and 4) (p = 0,049). Age did not significantly differ between any other groups. Although not
statistically significant, women with a current diagnosis of HT (groups 1, 3 and 5) had the highest mean values of BMI and WC. No significant differences were found in any BP levels between any groups whether examined with office, ambulatory readings or central measurements (table 1). Laboratory measures for the metabolic parameters P-glucose, P-HbA1c and S-leptin levels were highest in group 1. S-ApoB/ApoA1 did not differ (table 2). Neither neurohumoral parameters nor structural variables (RWT, LVH and IMT) differed between groups 1 - 6 (data not shown).
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Table 1: Descriptive results of characteristics and BP, group 1 – 6.
Group
n
BP during pregnancy
Present BP
1
13
PE
HT
2
18
PE
NT
3
12
PIH
HT
4
7
PIH
NT
5
17
NTP
HT
6
38
NTP
NT
Age; years 67 (5) 63 (6) 61 (6) 61 (5) 62 (5) 64 (4)
BMI; kg/m2 28 (6) 26 (5) 29 (7) 27 (5) 28 (5) 26 (4)
WC; cm 94 (15) 91 (11) 91 (13) 86 (17) 94 (13) 86 (12)
BP; mmHg 145/86 143/85 144/89 147/90 145/87 140/84
ABPM; mmHg 125/70 122/73 132/79 129/75 128/75 121/72
Ao BP; mmHg 138/85 130/84 138/90 123/77 132/86 128/81
BP: blood pressure, PE: preeclampsia, PIH: pregnancy induced hypertension, NTP: normotensive pregnancy, HT: current diagnosis of hypertension, NT: normotensive, BMI: body mass index, WC: waist circumference, BP: blood pressure, ABPM: ambulatory blood pressure measurement, Ao BP: aortic (central) blood pressure
Results presented as mean (SD) for age, BMI and WC for and as mean for BP measurements
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Table 2. Descriptive results of metabolic laboratory analyses, group 1 – 6.
Group
n
BP pregnancy
BP during study
1
13
PE
HT
2
18
PE
NT
3
12
PIH
HT
4
7
PIH
NT
5
17
NTP
HT
6
38
NTP
NT
Reference values
P-glucose; mmol/L 6,1a (1,4) 5,3 (0,5) 6,0 (1,7) 5,5 (0,7) 5,6 (0,4) 5,1 (0,6) 4,2 – 6,3
P-HbA1c; % 4,8b (0,6) 4,2 (0,3) 4,6 (0,4) 4,2 (0,3) 4,3 (0,3) 4,2 (0,3) 4 – 5,3
S-leptin; µg/L 31,7c (21,5)
17,1 (9,4)
24,1 (13,5)
22,3 (11,0)
24,6 (13,1)
16,1 (10,5)
3,7 – 11,1 *
S-ApoB/ApoA1;
ratio
0,64 (0,23)
0,74 (0,3)
0,62 (0,19)
0,60 (0,13)
0,49 (0,16)
0,64 (0,27)
< 0,7
S-hsCRP; mg/L 4,0 (4,2) 2,2 (2,7) 4,0 (4,2) 1,1 (0,5) 3,2 (4,9) 2,3 (4,0) 2 – 3**
P-noradrenaline;
nmol/L
2,60 (0,57)
2,04 (0,62)
2,77 (1,29)
2,66 (0,65)
2,31 (1,08)
2,02 (0,65)
0,18 – 2, 36
P-renin; mIU/L 23,8 (23,0)
10,8 (6,4)
22,8 (15,9)
8,4 (5,5) 24,6 (32,3)
12,9 (11,0)
2,8 – 40
S-aldosterone;
pmol/L
320 (416) 171 (115)
233 (148)
142 (49) 192 (171)
177 (92) 30 - 444
PE: preeclampsia, PIH: pregnancy induced hypertension, NTP: normotensive pregnancy, HT: current diagnosis of hypertension, NT: normotensive
a: significantly higher compared to group 6 (p = 0,036)
b: significantly higher compared to groups 2, 4, 5 and 6 (p = 0,015)
c: significantly higher compared to group 2 (p = 0,039)
*if normal weight, ** intermediate cardiovascular risk [40]
Results presented as mean (SD).
