SUPPLEMENTAL DIGITAL CONTENT
Low Medication Adherence is Associated with Decline in Health-Related Quality of Life among Older Women and Men with Hypertension
Erin Peacock PhD, MPH, Cara Joyce PhD, MS, Leslie Craig, PhD, MPH, Zachary Lenane MD, MPH, Elizabeth W. Holt PhD, MPH, Paul Muntner PhD, MHS, Marie Krousel-Wood MD, MSPH
Table S1. Adjusted prevalence ratios and 95% confidence intervals for decline in health-related quality of life (full model results) Mental Component Summary Physical Component Summary PR (95% CI) PR (95% CI) PR (95% CI) PR (95% CI)
Low K-Wood-MAS-4 adherence 1.32** (1.08, 1.62) -- 0.95 (0.79, 1.16) --
Low PDC adherence -- 1.17 (0.94, 1.47) -- 1.10 (0.90, 1.35)
Age ≥75 1.19 (0.97, 1.48) 1.20 (0.97, 1.48) 1.02 (0.84, 1.23) 1.02 (0.84, 1.24)
Female 1.10 (0.87, 1.39) 1.12 (0.89, 1.42) 1.11 (0.91, 1.37) 1.11 (0.91, 1.37)
Black 0.99 (0.78, 1.26) 1.00 (0.79, 1.27) 0.84 (0.67, 1.05) 0.83 (0.66, 1.04)
Married 1.15 (0.93, 1.44) 1.17 (0.94, 1.47) 0.90 (0.74, 1.09) 0.89 (0.73, 1.09) High school education or greater 0.73** (0.57, 0.92) 0.73* (0.58, 0.94) 1.01 (0.79, 1.29) 1.01 (0.79, 1.30) Low hypertension knowledge 1.15 (0.92, 1.43) 1.17 (0.94, 1.46) 0.94 (0.76, 1.16) 0.94 (0.76, 1.15) Depressive symptoms 1.04 (0.79, 1.38) 1.09 (0.83, 1.44) 0.95 (0.71, 1.27) 0.94 (0.70, 1.24) Low social support 0.97 (0.78, 1.20) 0.99 (0.80, 1.22) 1.13 (0.93, 1.36) 1.13 (0.93, 1.36) Low coping 1.10 (0.90, 1.35) 1.10 (0.90, 1.35) 0.94 (0.78, 1.13) 0.94 (0.78, 1.13) 2+ alcoholic drinks per week 0.90 (0.69, 1.18) 0.89 (0.68, 1.16) 1.18 (0.96, 1.45) 1.18 (0.96, 1.46) 2+ healthy lifestyle modifications 1.23 (0.94, 1.60) 1.21 (0.93, 1.57) 0.83 (0.67, 1.02) 0.83 (0.67, 1.02) 6+ visits to healthcare provider, past year 1.25* (1.01, 1.54) 1.26* (1.02, 1.56) 1.06 (0.86, 1.30) 1.05 (0.86, 1.29) Charlson Comorbidity Index ≥2 1.02 (0.83, 1.26) 1.03 (0.83, 1.28) 1.03 (0.85, 1.25) 1.03 (0.85, 1.24) Uncontrolled blood pressure 0.97 (0.78, 1.20) 0.97 (0.78, 1.21) 1.07 (0.89, 1.30) 1.06 (0.88, 1.29) 3+ classes of antihypertensive
medications
0.91 (0.74, 1.11) 0.91 (0.75, 1.12) 0.92 (0.76, 1.10) 0.92 (0.76, 1.10)
PR – prevalence ratio; CI – confidence interval; PDC – proportion of days covered; K-Wood-MAS-4 – Krousel-Wood medication adherence scale
***p<0.001, **p<0.01, *p<0.05
