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Study on leakage of sesame (Sesamum indicum L.) and coconut (Cocos nucifera L.) liposomes

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Department of Chemistry, Faculty of Science and Mathematics, Diponegoro University, Semarang, Indonesia Department of Chemistry, Faculty of Mathematics and Natural Sciences, Gadjah Mada University, Yogyakarta, Indonesia

Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia

Abstract

Leakage phenomena on sesame (Sesamum indicum L.) and coconut (Cocos nucifera L.) liposomes has been studied to evaluate their ability as drug delivery materials. Permeation of carboxyﬂuorescein through the liposomes with and without added cholesterol was examined. Sesame liposomes release carboxyﬂuorescein less than coconut liposomes in all circumstances. Sesame liposomes save about 50% of payload after 17 hours of storage while coconut liposomes only 10%. Addition of cholesterol has increase storage capability of all liposomes. The sesame-cholesterol and coconut-cholesterol liposomes save greater amount of payload compare to the original. Sesame liposomes have better potency as drug delivery systems.

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Cholesterol Coconut Drug delivery Leakage Liposome Sesame

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Oriental Journal of Chemistry

Volume 31, Issue 1, 1 March 2015, Pages 435-439

Hudiyanti, D.^a  Raharjo, T.J.^b Narsito, N.^b Noegrohati, S.^c 

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Colorectal Neoplasms | Risk | Rectal cancer

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ISSN: 0970020X CODEN: OJCHE Source Type: Journal Original language: English

DOI: 10.13005/ojc/310152 Document Type: Article

Publisher: Oriental Scientiﬁc Publishing Company

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Encapsulation of Vitamin C in Sesame Liposomes:

Computational and Experimental Studies

Hudiyanti, D. Hamidi, N.I.

Anugrah, D.S.B.

Cholesterol implications on coconut liposomes encapsulation of beta-carotene and vitamin C Hudiyanti, D. Aminah, S.

Hikmahwati, Y.

Simultant encapsulation of vitamin C and beta-carotene in sesame (Sesamum indicum l.) liposomes

Hudiyanti, D. Fawrin, H.

Siahaan, P.

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6/9/2020 Yahoo Mail - confirmation of paper

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confirmation of paper

Dari: Oriental Journal ([email protected]) Kepada: [email protected]

Tanggal: Selasa, 23 Desember 2014 18.18 GMT+7

Dear,

Dr. Dwi HUDIYANTI

I thankfully acknowledge the receipt of your valuable research paper en tled Study on Leakage of Sesame (Sesamum indicum L.) and Coconut (Cocos nucifera L.) Liposomes (OJC-9607-14)

We are proceeding your paper for review, soon we will inform you accordingly.

Dr. Dwi HUDIYANTI Kindly send us the complete contact emails and Addresses of five senior Researchers’ and pioneer workers related to your field of research, for review purpose, out of these five reviewers at least two must be out of your university and two must be from other countries.

Thanks

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Re: confirmation of paper

Dari: Dwi Hudiyanti ([email protected]) Kepada: [email protected]

Tanggal: Selasa, 23 Desember 2014 21.24 GMT+7

Dear Editor of Oriental Journal of Chemistry, Thank you for your confirmation of the paper.

For review purpose, I suggest the following researchers:

1. Prof. Vladimir P. Torchilin

Department of pharmaceutical Sciences School of Pharmacy

Northeastern University

Massachusetts 02115, United States E-mail: [email protected]

2. Prof. Yuri N. Antonenko

A.N. Belozersky Institute of Physico-Chemical Biology M.V. Lomonosov Moscow State University

Moscow 119991, Russia

E-mail: [email protected]

3. Prof. Peter J. Quinn

Department of Biochemistry King's College London

150 Stamford Street, London SE1 9NH, UK E-mail: [email protected]

4. Prof. Daryono Hadi Tjahjono

School of Pharmacy

Bandung Institute of Technology Bandung, West Java, Indonesia E-mail: [email protected]

5. Prof. Mudasir Mudasir

Chemistry Department, FMIPA Gadjah Mada University Yogyakarta, Indonesia E-mail: [email protected]

Your consideration of the paper is greatly appreciated.

Looking forward to hearing from you soon.

Best regards, Dwi

--- Dr. Dwi Hudiyanti, MSc.

[email protected] Physical Chemistry Laboratory Chemistry Department Diponegoro University Semarang INDONESIA

On Tuesday, December 23, 2014 6:18 PM, Oriental Journal <[email protected]> wrote:

Dear,

Dr. Dwi HUDIYANTI

I thankfully acknowledge the receipt of your valuable research paper entitled Study on Leakage of Sesame (Sesamum indicum L.) and Coconut (Cocos nucifera L.) Liposomes (OJC-9607-14)

We are proceeding your paper for review, soon we will inform you accordingly.

(23)

6/9/2020 Yahoo Mail - Re: confirmation of paper

2/2 Dr. Dwi HUDIYANTI Kindly send us the complete contact emails and Addresses of five senior Researchers’ and pioneer

workers related to your field of research, for review purpose, out of these five reviewers at least two must be out of your university and two must be from other countries.

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Pls find the pdf proof of your article, if you have any change or correction, pls intimate urgently.

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INTRODUCTION

Liposomes are important in medicinal, biotechnological, cosmetic, and industrial applications. They are used as delivery vehicles for drug or other active materials in their compartments.

They have ability to encapsulate hydrophilic compounds within their interior cavity and carrying hydrophobic compounds in their membranes^1,2. Since the discovery until 2008, there are some

ORIENTAL JOURNAL OF CHEMISTRY

www.orientjchem.org

An International Open Free Access, Peer Reviewed Research Journal

ISSN: 0970-020 X CODEN: OJCHEG 2015, Vol. 31, No. (1):

Pg.

Study on Leakage of Sesame (Sesamum indicum L.) and Coconut (Cocos nucifera L.) Liposomes

DWI HUDIYANTI¹*, TRI JOKO RAHARJO², NARSITO NARSITO² and SRI NOEGROHATI³

1Department of Chemistry, Faculty of Science and Mathematics, Diponegoro University, Semarang, Indonesia.

2Department of Chemistry, Faculty of Mathematics and Natural Sciences, Gadjah Mada University,Yogyakarta, Indonesia

3Faculty of Pharmacy, Gadjah Mada University,Yogyakarta, Indonesia

*Corresponding author E-mail: [email protected] (Received: November 12, 2014; Accepted: December 04, 2014)

ABSTRACT

Leakage phenomena on sesame (Sesamum indicum L.) and coconut (Cocos nucifera L.) liposomes has been studied to evaluate their ability as drug delivery materials. Permeation of carboxyfluorescein through the liposomes with and without added cholesterol was examined.

Sesame liposomes release carboxyfluorescein less than coconut liposomes in all circumstances.

Sesame liposomes save about 50% of payload after 17 hours of storage while coconut liposomes only 10%. Addition of cholesterol has increase storage capability of all liposomes. The sesame- cholesterol and coconut-cholesterol liposomes save greater amount of payload compare to the original. Sesame liposomes have better potency as drug delivery systems.

Key words: coconut; cholesterol; drug delivery; leakage; liposome; sesame.

drugs have been approved for use in a liposomal delivery system¹. There are also some cosmetics preparation that contain liposomes to encapsulate and carry the active ingredients to specific cells in the skin^3-5. The potential use of liposomes as carriers of active ingredients has attract a lot of attention and has been explored tremendously. This is because they are biodegradable, biocompatible, have low toxicity and do not activate the immune system². It is also because of their ability to bring

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2

active material directly to the active site, known as targeted delivery⁶. Research on liposomes from natural phospholipid that were derived from soybeans has been widely reported^7-10 but research on liposomes of coconut and sesame phospholipids so far only a few ¹¹.

The most important property of liposomes that will influence their efficacy is permeability and leakage of liposomes. Leakage is a condition when liposomes release some of their payload to the environment spontaneously after they are produced.

Leakage or permeability properties of phospholipid membranes of liposomes is key element in the the ability of liposomes to store their payload in their cavity. It is also critical to drug transport across the cell membrane and the ability of drug to reach the target in intracellular sites¹².

Membrane permeability and leakage are affected by cholesterol^{13, 14}. Cholesterol molecules is known as lipid with small head and large and rigid tail. It is an amphiphilic molecule and easily merges into the phospholipid bilayer. Cholesterol reduces water and ion permeability ^15-17, regulate CO₂ permeability of cell membranes ¹⁸ and other functions as well ^{19, 20}.

The ability of liposomes to store their payload is indicated by the amount of leakage after certain time. 5-Carboxyfluorescein (CF) was used as payload ^21-23. The release of CF from liposomes was calculated by the following equation:

% = − 0

∞− ₀ × 100%

L% : Liposomes leakage.

I_t: intensity of CF in liposomes at t second.

I₀: intensity of CF in liposomes at 0 second.

I_”: intensity of CF in liposomes after the liposomes were broken down.

This study investigate the potency of liposomes made from natural phospholipids, i.e., coconut meat (Cocos nucifera L.) and sesame seeds (Sesamum indicum L.) to be used as carrier for active substances in drug delivery system. These resources have been used as basic ingredients in Indonesian traditional medicine. These resources

are quite abundant and empirically known as save materials and never cause any health problem for users. Soybean (Glycine max) phospholipids that have been used as basic ingredient of liposomes in various applications were selected as positive control.

MATERIAL AND METHODS Material and equipments

Phospholipids of coconut and sesame were obtained in house from coconuts and sesame endosperm²⁵. Soybean phospholipid (30% L-±- phosphatydilcholine, Cat no. P3644), Triton X-100 (cat no. X-100), cholesterol (cat no. 86826) and 5- Carboxyfluorescein (cat no. C8667) were obtained from Sigma-Aldrich. Phosphate buffer solution (PBS) 10 mM pH 7.41 was prepared from Na₂HPO₄•2H₂O (Merck) and NaH₂PO₄•2H₂O (Merck). Sephadex G 50 was from Pharmacia, Uppsala, Sweden.

Mini extruder was obtained from Avanti Polar Lipids. A polycarbonate membrane with pore size of 100 nm was placed inside the extruder.

Leakage analysis was conducted on spectrofluorometer SPEX Fluorolog 2, Model F212, with computer system DMlB from SPEX Industries Inc., Edison, NJ.

Liposomes preparation

Liposomes of coconut, sesame and soybean were prepared by lipid hydration process as described by Hudiyanti et al.¹¹. Sesame phospholipid (1 mmol) was diluted in 1 mL of chloroform / methanol (1:1 v/v) in a test tube. The solvent was evaporated under flow of nitrogen gas to form thin film. Opened tube with thin layer was stored in a drying oven for 1 night. After 1 night the tube was taken from the drying oven, filled with nitrogen gas then covered and sealed with parafilm.

The tube was deposited in a freezer until used.

To prepare liposomes 1 mL of PBS was added to the tube and agitated in 30 seconds. The tube then was immersed in liquid nitrogen until all the solution has been frozen. Subsequently the tubes was soaked in a water bath with temperature 50 ºC until all the solution melt. The tube was frozen back in liquid nitrogen. The procedure was repeated

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3 several times until thin film was completely

dispersed. The phospholipid dispersion obtained was passed through an extruder. A Clear dispersion of liposomes was obtained. Dispersion of liposomes were then put into a refrigerator and allowed to stand for 1 night.

Leakage analysis

To determine the ability of liposome as carriers, an analysis of leakage was performed.

Liposomes with CF payload were prepared. CF was added to the PBS solution so that the concentration was 100 mM. The solution was used as liposomes payload. CF-Liposome dispersions were prepared as above. CF-Liposome dispersions were then analysed in a spectrofluorometer. Excitation wavelength was set at 490 nm, while the emission was at 520 nm. The intensities were measured for 17 hours at temperature 25 ºC every 5 s. At the end of the analysis, the liposomes were broken down using 100 mM Triton X-100 solution to released all the payload into the PBS medium. The maximum intensity was measured. The effect of cholesterol was studied by adding cholesterol to liposomes preparation with varied concentration.

RESULTS AND DISCUSSION

In this study leakage analysis were conducted to determine the nature of liposomes that are closely linked to their function as carrier of active ingredients. Analysis was performed using CF as a model of the active ingredients. CF is a fluorescent probe that is soluble in polar medium.

Leakage of liposomes indicated by the release of CF during observation. Leakage analysis in this study was carried out continuously for 17 hours.

The amount of leakage (L %) of coconut, sesame and soybean liposomes are presented in Figure 1. Leakage pattern of coconut and sesame liposomes were similar to the soybean patterns. In general the liposomes leaked fast at the begining and became slower after 2 hours of observation. In 2 hours, coconut liposomes leaked 40% of the payload while sesame only 10%. The analysis showed that the ability to store CF of coconut liposomes lower than sesame and soy liposomes.

After 17 hours coconut liposome has released 88%

of its payload, and sesame liposome was 42%. By

comparison soybean liposome was only 38%. This results show that coconut liposomes have more defects or pores in their membrane phospholipid hence they leak more payload than sesame liposomes.

Fig. 1: Leakage of coconut, sesame and soybean liposomes during 17 hours observation

Further analysis was conducted to determine the effects of adding cholesterol to the leakage. It is known that the addition of cholesterol has effect on membrane permeability13,15,18,19,24. In turn the liposomes leakage is closely related to the permeability properties of its phospholipid bilayer membrane.

The addition of cholesterol to the coconut, sesame and soybean liposomes showed decline of the leakage of all liposomes as shown in Figure 2, 3, and 4. The cholesterol concentrations also influenced the amount of CF released. The greater the cholesterol concentration the more reduced the leakage. There is a decrease in the rate of leakage with increasing concentrations of cholesterol (Figure 5). In general, the highest liposome leakage rate occurred at cholesterol concentration less than 40%.

Fig. 2: Leakage of coconut liposomes with added cholesterol during 17 hours observation

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4

These results suggest that sesame liposomes have better potency to be used as carrier of hydrophilic substance than coconut liposomes.

Adding cholesterol to the preparation has reduced the leakage of all liposomes. Cholesterol has greater effect on coconut liposomes. Addition of cholesterol to coconut liposomes reduces the leakage more effectively than to sesame liposomes.

The molecular species in coconut phospholipids mostly are phosphatydilserine and phosphatydilethanolamine ²⁵. The presence of

Fig. 3: Leakage of sesame liposomes with added cholesterol during 17 hours observation

Fig. 4: Leakage of soybean liposomes with added cholesterol during 17 hours observation

Fig. 5: Leakage of coconut, sesame and soybean liposomes after 17 hours observation

as a function of cholesterol concentration

cholesterol might have promoted hydrogen bonding formation among the phospholipids molecular species on the bilayer surface, which could hinder the membrane pore formation.

CONCLUSION

Sesame liposomes save about 50% of payload after 17 hours of storage while coconut liposomes only 10%. Addition of cholesterol has increase storage capability of both sesame and coconut liposomes. The results above illustrate the possibility of using sesame and coconut liposomes.

Sesame liposomes have better potential application as drug delivery materials.

ACKNOWLEDGEMENTS

Dwi Hudiyanti would like to express her gratitude to Prof. K. Edwards for fruitful discussion and an opportunity to work in her laboratory, Dr. V. A.

Hernandez for his help with the SPEX. This study was supported in part by Sandwich-Like Program Dikti Indonesia.

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3. Laouini, A.; Jaafar-Maalej, C.; Limayem- Blouza, I.; Sfar, S.; Charcosset, C.; Fessi, H. J.

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4. Mehl, T. L. S.; Zaias, N. 2001, US patent 6, 183, 451

5. Guaratini, T.; Gianeti, M. D.; Campos P. M. B.

G. M. Int. J. Pharm. 2006, 327, 12–16 6. Allen, T. M.; Cullis, P. R.; Adv. Drug Deliv. Rev.

2013, 65, 36–48

7. Aisha, A. F.; Majid, A. M. S. A.; Ismail, Z. BMC

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Biotechnol. 2014, 14, 23

8. Chen, Y.; Wu, Q.; Zhang, Z.; Yuan, L.; Liu, X.;

Zhou, L. Molecules 2012, 17, 5972–5987 9. Yokota, D.; Moraes, M.; Pinho, S. C. Braz. J.

Chem. Eng. 2012, 29, 325–335

10. Imura, T.; Otake, K.; Hashimoto, S.; Gotoh, T.;

Yuasa, M.; Yokoyama, S.; Sakai, H.; Rathman, J. F.; Abe, M.; Colloids Surf. B Biointerfaces 2003, 27, 133–140

11. Hudiyanti, D.; Raharjo, T. J.; Narsito, N.;

Noegrohati, S. Indo. J. Chem. 2012 12, 57–

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12. Mouritsen, O. G.; Jørgensen, K. Pharm. Res.

1998, 15, 1507–1519

13. Papahadjopoulos, D.; Nir, S.; Ohki, S.

Biochim. Biophys. Acta BBA - Biomembr.

1972, 266, 561–583

14. De Kruyff, B.; Demel, R. A.; Deenen, L. L. M.

Biochim. Biophys. Acta BBA - Biomembr.

1972, 255, 331–347

15. Matsuoka, S.; Murata, M. Biochim. Biophys.

Acta. 2002, 1564, 429–434

16. Saito, H.; Shinoda, W.; J. Phys. Chem. B. 2011, 115, 15241–15250

17. Mathai, J. C.; Tristram-Nagle, S.; Nagle, J. F.;

Zeidel, M. L. J. Gen. Physiol. 2008, 131, 69–

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18. Itel, F.; Al-Samir, S.; Öberg, F.; Chami, M.;

Kumar, M.; Supuran, C. T.; Deen, P. M. T.; Meier, W.; Hedfalk, K.; Gros, G.; Endeward, V. FASEB J. 2012, 26, 5182–5191

19. Papahadjopoulos, D.; Cowden, M.;

Kimelberg, H. Biochim. Biophys. Acta BBA - Biomembr. 1973, 330, 8–26

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Noegrohati, S. J. Agritech. Fak. Teknol.

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6/9/2020 Yahoo Mail - Re: "OJC Proof" revision

1/2

Re: "OJC Proof" revision

Dari: Dwi Hudiyanti ([email protected]) Kepada: [email protected]

Tanggal: Kamis, 12 Maret 2015 07.07 GMT+7

Dear Dr. Meena Iqbal

I have check the final pdf and everything looks OK to me.

Thank you.

Regards,

[email protected] Physical Chemistry Laboratory Diponegoro University Semarang INDONESIA

On Thursday, March 12, 2015 2:49 AM, Dr. S.A. Iqbal <[email protected]> wrote:

Dear Dr. Dwi

Plz find the final pdf of your article Looking forward to hear from you soon.

Regards

On Thursday, February 26, 2015 7:25 AM, Dwi Hudiyanti <[email protected]> wrote:

Dear Dr. Meena Iqbal,

Please find a few corrections on page 2 of my article. I have given marks of the corrections on the pdf proof.

Best regards, Dwi

On Wednesday, February 25, 2015 2:03 PM, Dr. S.A. Iqbal <[email protected]> wrote:

Dear Dr. Dwi

(31)

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2/2

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(32)

6/9/2020 Gmail - Re: "OJC Proof" revision

https://mail.google.com/mail/u/0?ik=2320b4a19d&view=pt&search=all&permmsgid=msg-f%3A1494132405871279730&simpl=msg-f%3A14941324058… 1/1 Dwi Hudiyanti <[email protected]>

Re: "OJC Proof" revision

Dwi Hudiyanti <[email protected]> Thu, Feb 26, 2015 at 8:55 AM

Reply-To: Dwi Hudiyanti <[email protected]>

To: "Dr. S.A. Iqbal" <[email protected]>

Dear Dr. Meena Iqbal,

Please find a few corrections on page 2 of my article. I have given marks of the corrections on the pdf proof.

Best regards, Dwi

On Wednesday, February 25, 2015 2:03 PM, Dr. S.A. Iqbal <[email protected]> wrote:

Dear Dr. Dwi

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Dwi Hudiyanti rev.pdf 191K

(33)

INTRODUCTION

Liposomes are important in medicinal, biotechnological, cosmetic, and industrial applications. They are used as delivery vehicles for drug or other active materials in their compartments.

They have ability to encapsulate hydrophilic compounds within their interior cavity and carrying hydrophobic compounds in their membranes^1,2. Since the discovery until 2008, there are some

ORIENTAL JOURNAL OF CHEMISTRY

www.orientjchem.org

An International Open Free Access, Peer Reviewed Research Journal

ISSN: 0970-020 X CODEN: OJCHEG 2015, Vol. 31, No. (1):

Pg.

Study on Leakage of Sesame (Sesamum indicum L.) and Coconut (Cocos nucifera L.) Liposomes

DWI HUDIYANTI¹*, TRI JOKO RAHARJO², NARSITO NARSITO² and SRI NOEGROHATI³

1Department of Chemistry, Faculty of Science and Mathematics, Diponegoro University, Semarang, Indonesia.

2Department of Chemistry, Faculty of Mathematics and Natural Sciences, Gadjah Mada University,Yogyakarta, Indonesia

3Faculty of Pharmacy, Gadjah Mada University,Yogyakarta, Indonesia

*Corresponding author E-mail: [email protected] (Received: November 12, 2014; Accepted: December 04, 2014)

ABSTRACT

Leakage phenomena on sesame (Sesamum indicum L.) and coconut (Cocos nucifera L.) liposomes has been studied to evaluate their ability as drug delivery materials. Permeation of carboxyfluorescein through the liposomes with and without added cholesterol was examined.

Sesame liposomes release carboxyfluorescein less than coconut liposomes in all circumstances.

Sesame liposomes save about 50% of payload after 17 hours of storage while coconut liposomes only 10%. Addition of cholesterol has increase storage capability of all liposomes. The sesame- cholesterol and coconut-cholesterol liposomes save greater amount of payload compare to the original. Sesame liposomes have better potency as drug delivery systems.

Key words: coconut; cholesterol; drug delivery; leakage; liposome; sesame.

drugs have been approved for use in a liposomal delivery system¹. There are also some cosmetics preparation that contain liposomes to encapsulate and carry the active ingredients to specific cells in the skin^3-5. The potential use of liposomes as carriers of active ingredients has attract a lot of attention and has been explored tremendously. This is because they are biodegradable, biocompatible, have low toxicity and do not activate the immune system². It is also because of their ability to bring

(34)

2

active material directly to the active site, known as targeted delivery⁶. Research on liposomes from natural phospholipid that were derived from soybeans has been widely reported^7-10 but research on liposomes of coconut and sesame phospholipids so far only a few