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Studies on Effect of Small Molecules on Protein Folding, Misfolding and Amyloidogenesis

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Figure 1.2 Model of Goldberg and coworkers showing intramolecular interactions substituted by intermolecular ones during the process of aggregation (Adopted with permission from Eur J Biochem 1974, 47:409-415)
Figure 1.3: Proteins are synthesized by ER-associated ribosomes and co-translationally translocated across the membrane through the Sec61 complex
Figure 1.4 MTT assay showing pre fibrillar aggregates, exhibiting beaded chain-like structures, are more toxic than matured fibrils (Adopted with permission from Nature 2002, 416:
Figure 1.6 A typical growth curve of amyloid fibril showing the different stages- nucleation phase, elongation phase and mature fibrillar phase
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Scope of current research Materials & Methods .1 Materials ANS binding assay Results Materials and methods .1 Materials Summary* Bibliography

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