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1- Miller RD. Anesthesia .6th ed. New York: Churchill Livingstone; 2005: 1582-1583.
2- Bilotta F, Ferri F, Giovanini F, Pinto G, Rosa G. Nefopam or clonidine in the pharmacologic prevention of shivering in patients undergoing conscious sedation for interventional neuroradiology. Anaesthesia. 2005; 60 (2): 124-128.
3- Kranke P, Eberhart LH, Rower N, Tramer M. Single-dose parenteral pharmacological interventions for the prevention of postoperative shivering: a quantitative systematic review of randomized controlled trials. Anesth Analg.
2004; 99 (3): 718-727.
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Anaesthesia. 2004; 59 (6): 559-564.
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Abstract Original Article
A survey on the effect of clonidine in prevention of shivering following general anesthesia
Z. Moodi1, Sh. Borjian2
Background and Aim: Shivering is an unpleasant complication of General Anesthesia which is seen in 40%
of cases. Shivering is a serious complication that increases oxygen consumption to several times and results in increased ventilation, cardiac output, myocardial ischemia, intraocular & intracerebral pressure and intensity of postoperative pain. Preventing this unwanted complication is necessary to reach perfect anesthesia and to decrease its hazards.
Materials and Methods: This study was performed as a double-blinded randomized clinical trial on 100 patients demanding eye surgery, aged over 18 years old, having ASA class I and II in Alzahra hospital of Zahedan. The patients were randomly divided into two groups using blocking method: Group A received Clonidine and Group B received placebo. Before anaesthesia, each of the cases and controls received 0.2 mg of clonidine and placebo with 30 ml of plain water, respectively. General anesthesia techniques were the same for both groups. In the recovery room, all the subjects were assessed for shivering and special questionnaires were filled out. The obtained data was analyzed through statistical analysis by SPSS version 13 software, using chi-square test, at the significant level of P<0.05.
Results: It was found that only 2% of the cases but 20% of the controls developed shivering; the difference was statistically significant (P=0.004).
Conclusion: This study revealed that clonidine is effective in preventing post-anesthetic shivering and could be used as a routine preoperative medication.
Key Words: General Anesthesia; Clonidine; Postoperative shivering
Journal of Birjand University of Medical Sciences. 2009; 16 (2): 5-9 Received: 16.8.2008 Last Revised: 15.2.2009 Accepted: 10.3.2009
1Corresponding Author; Assistant Professor, Department of Anesthesiology, Faculty of Medicine, Zahedan University of Medical Sciences. Zahedan, Iran [email protected]
2Assistant Professor, Department of Anesthesiology, Faculty of Medicine, Zahedan University of Medical Sciences. Khatam ol Anbia Hospital, Zahedan, Iran
