يﺮﻴﮔدﺎﻳ لﻼﺘﺧا يور ﺮﺑ ﺲﻧاﺮﺗ و ﺲﻴﺳ بﺮﭼ يﺎﻫﺪﻴﺳا ﻲﻛارﻮﺧ ﺰﻳﻮﺠﺗ ﺮﺛا
ﺲﻴﺳ بﺮﭼ يﺎﻫﺪﻴﺳا ﻲﻛارﻮﺧ ﺰﻳﻮﺠﺗ ﺮﺛا هﺪﺷ دﺎﺠﻳا يﺮﻴﮔدﺎﻳ لﻼﺘﺧا يور ﺮﺑ ﺲﻧاﺮﺗ و
ﺮﻧ ﻲﻳاﺮﺤﺻ يﺎﻬﺷﻮﻣ رد ﻲﻳﺎﻴﻤﻴﺷ ﮓﻨﻴﻟﺪﻨﻴﻛ ﺮﺛا رد
ناوﺰﻴﻟﺎﭘ ﺎﺿرﺪﻤﺤﻣ ﺮﺘﻛد *
Iﻲﻋاﺰﺧ ﺎﺿردﻮﻤﺤﻣ
IIﺮﺘﻛد ﻲﻌﺨﻧ ﺎﺿردﻮﻤﺤﻣ
IIIنﺎﺴﺣا يﻮﻧﺰﻏ ﻪﻟا
IV
دار
ﻪﻣﺪﻘﻣ
نورﻮﻧ دﺮﻜﻠﻤﻋ رد لﻼﺘﺧا ﻲﻋﻮﻧ ﻊﻗاو رد ،عﺮﺻ يﺰـﻐﻣ يﺎﻫ
ﻲﻣ
هرود ﻲﺠﻨﺸﺗ يﺎﻫرﺎﺘﻓر ترﻮﺻ ﻪﺑ ﻪﻛ ﺪﺷﺎﺑ
ﻞـﺑﺎﻗﺮﻴﻏ و يا
ﺶﻴﭘ
ﻲـﻣ اﺪﻴﭘ زوﺮﺑ دﺮﻓ رد ﻲﻨﻴﺑ
ﺪـﻨﻛ . نﺎﺸـﻧ ﻲﻨﻴﻟﺎـﺑ تاﺪﻫﺎﺸـﻣ
ﺳا هداد ـ ﻛ ﺖ ـ ﻋﺮﺻ نارﺎﻤﻴﺑ ﻪ ـ
و ﻪﻈﻓﺎﺣ رد ار ﻲﺼﻗاﻮﻧ ﺐﻠﻏا ﻲ
ﻲﻣ نﺎﺸﻧ دﻮﺧ زا يﺮﻴﮔدﺎﻳ
)ﺪﻨﻫد
1
ﺎﻣا ،(
ﺖﺧﺎﻨـﺷ مﺪـﻋ ﻞـﻴﻟد ﻪـﺑ
ﻓﺎﻛ ـ
ﺐﻴﺳآ زا ﻲ
ﻲﻳاز ) ﺰﻧژﻮﺗﺎﭘ ( ﻲﻌﻄﻗ ﻲﻫار نﻮﻨﻛﺎﺗ ،يرﺎﻤﻴﺑ ﻦﻳا
ﺖـﻓﺎﻳ يرﺎـﻤﻴﺑ ﻦـﻳا ﻲﺒﻧﺎـﺟ ضراﻮـﻋ ﺶﻫﺎﻛ ﺎﻳ و نﺎﻣرد ﺖﻬﺟ ﺸﻧ ــ ﺳا هﺪ ــ ﺖ . ﻘﻴﻘﺤﺗ ﺎ ت ﻫﺎﮕﺸﻳﺎﻣزآ يﺎﻬﻟﺪﻣ يور ﺮﺑ ـ
ﺠﻳا ﻲ ـ دﺎ
هﺪﻴﻜﭼ
فﺪﻫ و ﻪﻨﻴﻣز :
و ﻚـﻳژﻮﻟﻮﻳﺰﻴﻓ يﺎـﻫدﺮﻜﻠﻤﻋ يور ﺮـﺑ يروﺮﺿ بﺮﭼ يﺎﻫﺪﻴﺳا فﺮﺼﻣ ﺖﻴﻤﻫا ﻪﻨﻴﻣز رد يدﺎﻳز تﺎﻘﻴﻘﺤﺗ
نﺎﺴﻧا رد يرﺎﺘﻓر
ﺖﺳا ﻪﺘﻓﺮﮔ مﺎﺠﻧا تﺎﻧاﻮﻴﺣ و ﺎﻫ .
هداد نﺎﺸﻧ ﻲﻫﺎﮕﺸﻳﺎﻣزآ تﺎﻘﻴﻘﺤﺗ
ﻼﺘـﺧا دﺎﺠﻳا ﺐﺒﺳ ،ﮓﻨﻴﻟﺪﻨﻴﻛ ﻪﻛ ﺪﻧا رد ل
ﻲﻣ يﺮﻴﮔدﺎﻳ و ﻪﻈﻓﺎﺣ
ددﺮﮔ . ﻦﻴـﺣ رد و ﻞـﺒﻗ ،ﺲﻧاﺮـﺗ و ﺲﻴـﺳ بﺮـﭼ يﺎﻫﺪﻴـﺳا ﻲﻛارﻮـﺧ ﺮـﺛا ﻲﺳرﺮﺑ ،ﻪﻌﻟﺎﻄﻣ ﻦﻳا زا فﺪﻫ
لوزاﺮﺘﺗ ﻦﻠﻴﺘﻨﭘ ﺎﺑ ﻲﻳﺎﻴﻤﻴﺷ ﮓﻨﻴﻟﺪﻨﻴﻛ
، ﺖﺳا ﺮﻧ ﻲﻳاﺮﺤﺻ يﺎﻬﺷﻮﻣ رد يﺮﻴﮔدﺎﻳ تﻻﻼﺘﺧا يور ﺮﺑ .
ﺑ شور ﺮ ﻲﺳر : ﻪﻠﺧاﺪﻣ عﻮﻧ زا ﻪﻌﻟﺎﻄﻣ ﻦﻳا ﺖﺳا ﻲﺑﺮﺠﺗ ـ يا
. ﻪﻌﻟﺎﻄﻣ ﻦﻳا داﺪﻌﺗ يور ﺮﺑ 18
داﮋـﻧ ﺮـﻧ ﻲﻳاﺮﺤـﺻ شﻮـﻣ ﺮﺳ
ﺖﺳا ﻪﺘﻓﺮﮔ مﺎﺠﻧا رﺎﺘﺴﻳو .
ﺪﻧﺪﺷ ﻢﻴﺴﻘﺗ هوﺮﮔ ﻪﺳ ﻪﺑ تﺎﻧاﻮﻴﺣ ،ﻪﻌﻟﺎﻄﻣ ﻦﻳا رد .
دراﺪﻧﺎﺘـﺳا ياﺬﻏ ،لﺮﺘﻨﻛ هوﺮﮔ يﺎﻬﺷﻮﻣ )
ﻪـﻴﻬﺗ
سرﺎﭘ ماد ﺪﻴﻟﻮﺗ ﺖﻛﺮﺷ زا هﺪﺷ (
ﺪﻧدﺮﻛ ﺖﻓﺎﻳرد ار .
هوﺮﮔ ياﺬﻏ ﻪﺑ
و ﺲﻴـﺳ بﺮـﭼ يﺎﻫﺪﻴـﺳا ﺐـﻴﺗﺮﺗ ﻪﺑ ،ﺲﻧاﺮﺗ و ﺲﻴﺳ يﺎﻫ
ا ﺲﻧاﺮﺗ ﺪﺷ ﻪﻓﺎﺿ .
ﮓﻨﻴﻟﺪـﻨﻴﻛ نﺎـﻳﺎﭘ زا ﺲـﭘ ﻪـﺘﻔﻫ ﻚـﻳ و ﺪـﺷ زﺎﻏآ ﮓﻨﻴﻟﺪﻨﻴﻛ ،تﺎﻧاﻮﻴﺣ ﻪﻳﺬﻐﺗ عوﺮﺷ زا ﺲﭘ هﺎﻣ ﻚﻳ ﻲﻳﺎـﻧاﻮﺗ ،
رد تﺎﻧاﻮﻴﺣ يﺮﻴﮔدﺎﻳ shuttle box
ﺖﻓﺮﮔ راﺮﻗ ﻲﺑﺎﻳزرا درﻮﻣ .
هداد ﻞـﻴﻠﺤﺗ و ﻪـﻳﺰﺠﺗ ياﺮـﺑ ﺲﻧﺎـﻳراو ﺰﻴﻟﺎـﻧآ نﻮـﻣزآ زا ،ﺎـﻫ
ﻜﻳ نﻮﻣزآ و ﻪﻓﺮﻄ Tukey
ﺪﺷ هدﺎﻔﺘﺳا .
ﻪﺘﻓﺎﻳ ﺎﻫ : ﺎﺘﻧ
هوﺮﮔ ﻪﻛ داد نﺎﺸﻧ ﻖﻴﻘﺤﺗ ﻦﻳا ﺞﻳ
يﺮﻴﮔدﺎـﻳ رد لﻼﺘـﺧا ،ﺲﻧاﺮـﺗ و لﺮﺘﻨﻛ يﺎﻫ نﺎﺸـﻧ دﻮـﺧ زا ار ﺲﻛﺎـﺑ ﻞﺗﺎـﺷ
؛ﺪﻧداد هوﺮـﮔ رد ﻪـﻛ ﻲﻟﺎﺣ رد ،داﺪﻧ نﺎﺸﻧ قﻮﻓ هوﺮﮔ ود رد هﺪﺷ دﺎﺠﻳا يﺮﻴﮔدﺎﻳ ناﺰﻴﻣ رد ار ﻲﻓﻼﺘﺧا ،يرﺎﻣآ ﻞﻴﻠﺤﺗ و ﻪﻳﺰﺠﺗ
ﻲﻨﻌﻣ ﻞﻜﺷ ﻪﺑ يﺮﻴﮔدﺎﻳ ناﺰﻴﻣ ،ﺲﻴﺳ ﺑ ﺮﮕﻳد هوﺮﮔ ود زا يراد
ﺶﻴ دﻮﺑ ﺮﺗ .
ﻪﺠﻴﺘﻧ يﺮﻴﮔ :
ﻲﻣ دﺎﻬﻨﺸﻴﭘ ،ﻪﻌﻟﺎﻄﻣ ﻦﻳا زا ﻞﺻﺎﺣ ﺞﻳﺎﺘﻧ لﺪـﻨﻴﻛ يﺎﻬـﺷﻮﻣ ﻪـﺑ ﺲﻴﺳ بﺮﭼ يﺎﻫﺪﻴﺳا ﻲﻛارﻮﺧ ﺰﻳﻮﺠﺗ ﻪﻛ ﺪﻨﻨﻛ
ﻲﻣ لوزاﺮﺘﺗ ﻦﻠﻴﺘﻨﭘ ﺎﺑ ﻲﻳﺎﻴﻤﻴﺷ ﮓﻨﻴﻟﺪﻨﻴﻛ ﻂﺳﻮﺗ هﺪﺷ دﺎﺠﻳا يﺮﻴﮔدﺎﻳ لﻼﺘﺧا ناﺰﻴﻣ ﺶﻫﺎﻛ ﺐﺒﺳ ،هﺪﺷ ددﺮﮔ
.
هژاوﺪﻴﻠﻛ ﺎﻫ : 1 زاﺮﺘﺗ ﻦﻠﻴﺘﻨﭘ– لو
2 ﮓﻨﻴﻟﺪﻨﻴﻛ – 3 ﻲﻃﺮﺷ– ﻪﻓﺮﻃ ود يزاﺮﺘﺣا نﺪﺷ 4
ﺲﻴﺳ بﺮﭼ ﺪﻴﺳا –
–5
ﺲﻧاﺮﺗ بﺮﭼ ﺪﻴﺳا
85/9/5:شﺮﻳﺬﭘ ﺦﻳرﺎﺗ ،84/9/5 :ﺖﻓﺎﻳرد ﺦﻳرﺎﺗ
(I و رﺎﻳدﺎﺘﺳا ﻮﻳﺰﻴﻓ PhD
ناﺮﻳا ،كارا ،كارا ﻲﻧﺎﻣرد ـ ﻲﺘﺷاﺪﻬﺑ تﺎﻣﺪﺧ و ﻲﻜﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد ،ﺲﻳدﺮﭘ ﺞﻴﺴﺑ ناﺪﻴﻣ ،ﻲﻜﺷﺰﭘ هﺪﻜﺸﻧاد ،يژﻮﻟ
*) لوﺆﺴﻣ ﻒﻟﺆﻣ (.
(II ﺖﺴﻳز سﺎﻨﺷرﺎﻛ
،ﻲﺳﺎﻨﺷ ناﺮﻳا ،كارا ،كارا ﻲﻧﺎﻣرد ـ ﻲﺘﺷاﺪﻬﺑ تﺎﻣﺪﺧ و ﻲﻜﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد ،ﺲﻳدﺮﭘ ﺞﻴﺴﺑ ناﺪﻴﻣ ،ﻲﻜﺷﺰﭘ هﺪﻜﺸﻧاد .
(III و رﺎﻳدﺎﺘﺳا ﺗ PhD
ﻪﻳﺬﻐ ناﺮﻳا ،كارا ،كارا ﻲﻧﺎﻣرد ـ ﻲﺘﺷاﺪﻬﺑ تﺎﻣﺪﺧ و ﻲﻜﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد ،ﺲﻳدﺮﭘ ﺞﻴﺴﺑ ناﺪﻴﻣ ،ﻲﻜﺷﺰﭘ هﺪﻜﺸﻧاد ، .
(IV بوﺮﻜﻴﻣ ﺪﺷرا سﺎﻨﺷرﺎﻛ و ﻲﻤﻠﻋ تﺄﻴﻫ ﻮﻀﻋ ناﺮﻳا ،كارا ،كارا ﻲﻧﺎﻣرد ـ ﻲﺘﺷاﺪﻬﺑ تﺎﻣﺪﺧ و ﻲﻜﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد ،ﺲﻳدﺮﭘ ﺞﻴﺴﺑ ناﺪﻴﻣ ،ﻲﻜﺷﺰﭘ هﺪﻜﺸﻧاد ،ﻲﺳﺎﻨﺷ
.
ﻫﺪﻴﺳا ﻲﻛارﻮﺧ ﺰﻳﻮﺠﺗ ﺮﺛا يﺮﻴﮔدﺎﻳ لﻼﺘﺧا يور ﺮﺑ ﺲﻧاﺮﺗ و ﺲﻴﺳ بﺮﭼ يﺎ
ناﺮﻳا ﻲﻜﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد ﻪﻠﺠﻣ
هرود رﺎﻬﭼ ﻢﻫد / هرﺎﻤﺷ 56 / ﺰﻴﻳﺎﭘ 1386
ﻲﻜﻳﺮﺘﻜﻟا ﮓﻨﻴﻟﺪﻨﻴﻛ لﺎﺒﻧد ﻪﺑ ﻪﻛ ﺖﺳا هداد نﺎﺸﻧ ﺰﻴﻧ عﺮﺻ
) 2
و (
ﺎﻴﻤﻴﺷ ﮓﻨﻴﻟﺪﻨﻴﻛ
)ﻲﻳ
3
(
ﻲﻣ ﺎﺳرﺎﻧ يﺮﻴﮔدﺎﻳ ﺪﻨﻳاﺮﻓ ،
ددﺮﮔ . ﻦـﻳا ﻪـﺑ
رد يﺮﻴﮔدﺎـﻳ لﻼﺘـﺧا ﺶﻫﺎﻛ ﻪﻨﻴﻣز رد ﻲﻧاواﺮﻓ تﺎﻘﻴﻘﺤﺗ ﺐﻴﺗﺮﺗ ﺖﺳا مﺎﺠﻧا لﺎﺣ رد ﻲﻋﺮﺻ نارﺎﻤﻴﺑ .
ﺖـﻴﻤﻫا ﻲـﻌﻴﺒﻃ ﻞـﻣﺎﻜﺗ و ﺪـﺷر ياﺮﺑ ﺲﻴﺳ بﺮﭼ يﺎﻫﺪﻴﺳا
ﺪﻧراد
).
4
بﺮـﭼ يﺎﻫﺪﻴـﺳا ﻪـﺑ ،يروﺮـﺿ بﺮـﭼ يﺎﻫﺪﻴـﺳا ﻦﻳا (
ــﺳا ﻪــﻛ ﻞــﻳﻮﻃ هﺮــﻴﺠﻧز ﺎــﺑ عﺎﺒــﺷاﺮﻴﻏ يﺎﺸــﻏ نﺎﻤﺘﺧﺎــﺳ سﺎ
نورﻮﻧ
ﻲﻣ ﻞﻴﻜﺸﺗ ار ﺎﻫ
ﺪﻨﻫد
، ﺮﺒﻣﺎـﻴﭘ ناﻮـﻨﻋ ﻪـﺑ و هﺪـﺷ ﻞﻳﺪﺒﺗ
نورﻮﻧ رد ﻪﻳﻮﻧﺎﺛ
ﻲﻣ ﻞﻤﻋ ﺎﻫ
ﺪﻨﻨﻛ . ﻪـﻛ ﺖـﺳا هﺪـﺷ هداد نﺎﺸـﻧ
رد لﻼﺘﺧا ﺐﺒﺳ ،تﺎﻧاﻮﻴﺣ رد يروﺮﺿ بﺮﭼ يﺎﻫﺪﻴﺳا دﻮﺒﻤﻛ بﺮــﭼ يﺎﻫﺪﻴــﺳا ﺐــﻴﻛﺮﺗ رد ﺮــﻴﻴﻐﺗ و ﻲﺘﺧﺎﻨــﺷ لﺎــﻤﻋا ﻞــﻣﺎﻜﺗ
ﻲـﻣ ءﺎﺸﻏ يﺎﻫﺪﻴﭙﻴﻟﻮﻔﺴﻓ رد دﻮﺟﻮﻣ
ددﺮـﮔ
) 5 و 6
ﻪـﻛ ﻲﻟﺎـﺣ رد ،(
عﺎﺒـﺷاﺮﻴﻏ بﺮـﭼ يﺎﻫﺪﻴﺳا فﺮﺼﻣ n-3)
( زا يﺮﻴﮔﻮـﻠﺟ ﺐﺒـﺳ
ﺮﻤﻳاﺰﻟآ يرﺎﻤﻴﺑ ﻲﻧاﻮﻴﺣ يﺎﻬﻟﺪﻣ رد تﻻﻼﺘﺧا
) 7
ﺶﻳاﺰﻓا ﺐﺒﺳ و (
ناﺰـﻴﻣ
ﺰـﻐﻣ زا ﻖﺘﺸـﻣ ﻚـﻴﻓوﺮﺗورﻮﻧ رﻮﺘﻛﺎـﻓ BDNF)
Brain =
derived neurotrofic factor (
تﻻﻼﺘــﺧا زا يﺮﻴﮔﻮــﻠﺟ ﺰــﻴﻧ و
ﺐﻴــﺳآ لﺎــﺒﻧد ﻪــﺑ يﺮﻴﮔدﺎــﻳ رد يﺰــﻐﻣ يﺎــﻫ
ﻲﻳاﺮﺤــﺻ شﻮــﻣ
ﻲﻣ ددﺮﮔ
).
8
يﺎﻫﺪﻴـﺳا زا هدﺎﻔﺘﺳا ﻪﻛ ﺖﺳا هداد نﺎﺸﻧ تﺎﻘﻴﻘﺤﺗ (
يرﺎﻤﻴﺑ ﻪﺑ ﻼﺘﺑا ﻚﺴﻳر ﺶﻳاﺰﻓا ﺐﺒﺳ ،ﺲﻧاﺮﺗ بﺮﭼ
قوﺮـﻋ يﺎﻫ
ﺮﻧوﺮﻛ
) 9
(
ﮓﻨﺳ ﺪﻴﻟﻮﺗ ﺶﻳاﺰﻓا و
ﻲـﻣ اﺮﻔـﺻ ﻪﺴﻴﻛ يﺎﻫ
دﻮـﺷ
).
10 (
شﻮـﻣ رد ﻪـﻛ ﺖـﺳا هﺪـﺷ شراﺰﮔ ﻦﻴﻨﭽﻤﻫ B6D2f
ﻪـﭼ ﺮـﮔا ،
ﮕﻠﻣﺎـﺣ نارود رد ﺲﻧاﺮـﺗ بﺮﭼ يﺎﻫﺪﻴﺳا فﺮﺼﻣ ﺮـﺑ يﺮـﺛا ﻲ
ناﺰـﻴﻣ لﻼﺘـﺧا ﺐﺒﺳ ،دراﺪﻧ ﻲﺒﺼﻋ ﻢﺘﺴﻴﺳ ﻞﻣﺎﻜﺗ ناﺰﻴﻣ يور زﺎﻣ رد نادازﻮﻧ ﻲﻳﺎﻀﻓ يﺮﻴﮔدﺎﻳ T
ﻲﻣ ﻞﻜﺷ دﻮﺷ
).
11
ﻦﻳاﺮﺑﺎﻨﺑ (
بﺮـﭼ يﺎﻫﺪﻴـﺳا فﺮﺼﻣ ﺮﺛا ﻲﺳرﺮﺑ ،ﺮﺿﺎﺣ ﻪﻌﻟﺎﻄﻣ زا فﺪﻫ هﺪـﺷ دﺎـﺠﻳا يﺮﻴﮔدﺎـﻳ لﻼﺘﺧا ﺶﻫﺎﻛ يور ﺮﺑ ﺲﻧاﺮﺗ و ﺲﻴﺳ ﺖﺳا لوزاﺮﺘﺗ ﻦﻠﻴﺘﻨﭘ ﺎﺑ ﻲﻳﺎﻴﻤﻴﺷ ﮓﻨﻴﻟﺪﻨﻴﻛ ﻂﺳﻮﺗ .
ﻲﺳرﺮﺑ شور
ﻪﻠﺧاﺪﻣ عﻮﻧ زا ﻪﻌﻟﺎﻄﻣ ﻦﻳا ﺖﺳا ﻲﺑﺮﺠﺗ ـ يا
. ،ﻪﻌﻟﺎﻄﻣ ﻦﻳا رد
داﮋـﻧ ﺮﻧ ﻲﻳاﺮﺤﺻ يﺎﻬﺷﻮﻣ زا wistar
) ﻮﺘﻴﺘﺴـﻧا زا هﺪـﺷ ﻪـﻴﻬﺗ
ناﺮﻬﺗ رﻮﺘﺳﺎﭘ (
نزو ﺎﺑ 300 - 250
ﺪﺷ هدﺎﻔﺘﺳا مﺮﮔ .
تﺎـﻧاﻮﻴﺣ
تراﺮﺣ ﺎﺑ ﻲﻗﺎﺗا رد 24
ﻲﺘﻧﺎﺳ ﻪﺟرد
يرﻮـﻧ ﻂﻳاﺮﺷ و داﺮﮔ 12
و ﻲﻳﺎﻨﺷور ﺖﻋﺎﺳ 12
ﺗ ﺖﻋﺎﺳ ﺪﻧﺪـﺷ يراﺪﻬﮕﻧ ﻲﻜﻳرﺎ و بآ و
رﺎﻴﺘﺧا رد دازآ رﻮﻃ ﻪﺑ اﺬﻏ
ﺖﺷاد راﺮﻗ ﺎﻬﻧآ .
ﻪـﺑ تﺎـﻧاﻮﻴﺣ ﻞـﻛ
ﺪﻧﺪﺷ ﻢﻴﺴﻘﺗ هوﺮﮔ ﻪﺳ :
1 - رد و ﮓﻨﻴﻟﺪـﻨﻴﻛ عوﺮـﺷ زا ﻞـﺒﻗ هﺎـﻣ ﻚﻳ زا ﻪﻛ ﻲﺗﺎﻧاﻮﻴﺣ ﻪـﺑ ﺲﻴـﺳ بﺮـﭼ ﺪﻴﺳا ﺎﻬﻧآ دراﺪﻧﺎﺘﺳا ياﺬﻏ ﻪﺑ ،ﮓﻨﻴﻟﺪﻨﻴﻛ ﻦﻴﺣ
راﺪﻘﻣ 3 رد مﺮﮔ 100 دﻮﺑ هﺪﺷ ﻪﻓﺎﺿا اﺬﻏ مﺮﮔ .
2 - رد و ﮓﻨﻴﻟﺪـﻨﻴﻛ عوﺮـﺷ زا ﻞـﺒﻗ هﺎـﻣ ﻚﻳ زا ﻪﻛ ﻲﺗﺎﻧاﻮﻴﺣ ﻪـﺑ ﺲﻧاﺮـﺗ بﺮﭼ ﺪﻴﺳا ﺎﻬﻧآ دراﺪﻧﺎﺘﺳا ياﺬﻏ ﻪﺑ ،ﮓﻨﻴﻟﺪﻨﻴﻛ ﻦﻴﺣ
راﺪﻘﻣ 3 رد مﺮﮔ 100 دﻮﺑ هﺪﺷ ﻪﻓﺎﺿا اﺬﻏ مﺮﮔ .
3 - رد و ﮓﻨﻴﻟﺪـﻨﻴﻛ عوﺮـﺷ زا ﻞـﺒﻗ هﺎـﻣ ﻚﻳ زا ﻪﻛ ﻲﺗﺎﻧاﻮﻴﺣ
ﻲﻣ هدﺎﻔﺘﺳا دراﺪﻧﺎﺘﺳا ياﺬﻏ زا ﻂﻘﻓ ،ﮓﻨﻴﻟﺪﻨﻴﻛ ﻦﻴﺣ ﺪﻧدﺮﻛ
.
ﻴﺳا ــ بﺮـﭼ ﺪﻴـﺳا ،ﻖـﻴﻘﺤﺗ ﻦـﻳا رد هدﺎﻔﺘـﺳا درﻮـﻣ بﺮﭼ ﺪ
لﻮﻧﺎﻛ ﻦﻏور زا هﺪﻣآ ﺖﺳﺪﺑ )
ﻲﺗﺎـﺒﻧ ﻦﻏور ﺖﻛﺮﺷ زا هﺪﺷ ﻪﻴﻬﺗ
ﻪﭽﻨﻏ ( دﻮﺑ . ،ﻦﻏور ﻦﻳا رد 6
% ،هﺪـﺷ عﺎﺒـﺷا بﺮـﭼ ﺪﻴـﺳا 26
%
ﺪﻴﺳا ﻚﺌﻴﻟﻮﻨﻴﻟ ω-6)
( ، 10 %
ﺪﻴـﺳا ﻚـﻴﻨﻟﻮﻨﻴﻟ ﺎﻔﻟآ ω-3)
( و 58 % زا
بﺮـــﭼ يﺎﻫﺪﻴـــﺳا ﻪـــﻧﺎﮔود ﺪـــﻧﻮﻴﭘ ﻚـــﻳ ﺎـــﺑ عﺎﺒـــﺷاﺮﻴﻏ
MUFA) Monounsaturated fatty acid=
( ﺖﺷاد دﻮﺟو .
ياﺮﺑ
دوﺪﺣ ،ﺲﻧاﺮﺗ بﺮﭼ ﺪﻴﺳا دﺎﺠﻳا 3
/ 33 % ﺲﻴـﺳ يﺎـﻫﺮﻣوﺰﻳا زا
رد ﻲـﺋﺰﺟ نﻮﻴـﺳﺎﻧژورﺪﻴﻫ شور ﻪـﺑ ﻻﻮﻧﺎﻛ ﻦﻏور رد دﻮﺟﻮﻣ يﺎـﻫﺮﻣوﺰﻳا ﻪـﺑ هﺎﺸـﻧﺎﻣﺮﻛ ﺖـﺷد ﻲﻫﺎﻣ ﻲﺗﺎﺒﻧ ﻦﻏور ﻪﻧﺎﺧرﺎﻛ ﺪﻧﺪﻳدﺮﮔ ﻞﻳﺪﺒﺗ ﺲﻧاﺮﺗ .
ﺎـﺑ تﺎـﻧاﻮﻴﺣ ،ﻪـﻳﺬﻐﺗ عوﺮـﺷ زا ﺲـﭘ هﺎﻣ ﻚﻳ ﻞـﺧاد ﻖـﻳرﺰﺗ
لوزاﺮﺘﺗ ﻦﻠﻴﺘﻨﭘ ﻲﻗﺎﻔﺻ )
ﺎﻤﮕﻴﺳ ﺖﻛﺮﺷ زا هﺪﺷ ﻪﻴﻬﺗ (
زود ﺎﺑ 45
ﻲﻠﻴﻣ ﺮـﻫ ،ناﻮـﻴﺣ نزو مﺮﮔﻮـﻠﻴﻛ ﺮـﻫ يازا ﻪﺑ مﺮﮔ 48
ﺖﻋﺎـﺳ
ﺪﻧﺪﺷ لﺪﻨﻴﻛ ،رﺎﺒﻜﻳ
).
12
(
ــﺻ زا لﺪــﻣ ﻦــﻳا رد ﺞﻨﺸــﺗ ﻞــﺣاﺮﻣ تﺎــﻘﻴﻘﺤﺗ سﺎــﺳاﺮﺑ ،عﺮ
)ﻲﻠﺒﻗ
13
ﻲﻣ ﻢﻴﺴﻘﺗ ﻪﻠﺣﺮﻣ ﺞﻨﭘ ﻪﺑ (
زا ﺪﻨﺗرﺎﺒﻋ ﻪﻛ ﺪﻧﻮﺷ :
ﻪﻠﺣﺮﻣ 0
= ﺪﻋ ﺦﺳﺎﭘ م
لوا ﻪﻠﺣﺮﻣ =
ﺎﻬﺷﻮﮔ و ترﻮﺻ تﻼﻀﻋ ضﺎﺒﻘﻧا
مود ﻪﻠﺣﺮﻣ =
نﺪﺑ ﻲﺿﺎﺒﻘﻧا جﻮﻣ
ﺳ ﻪﻠﺣﺮﻣ ـ
مﻮ = ﻬﺷﺮﭘ ـ
ـﻴﻧﻮﻠﻛﻮﻴﻣ يﺎ ـ
ود يور ندﺎﺘﺴـﻳا و ﻚ
ﺎﭘ مرﺎﻬﭼ ﻪﻠﺣﺮﻣ =
ﻮﻠﻬﭘ ﻪﺑ ندﺎﺘﻓا
ﻢﺠﻨﭘ ﻪﻠﺣﺮﻣ =
و ﻚـﻴﻧﻮﺗ ﻲﻣﻮـﻤﻋ تﻼـﻤﺣ و ﺖﺸﭘ ﻪﺑ ندﺎﺘﻓا
ﻚﻴﻧﻮﻠﻛ .
يﺮﻴﮔدﺎﻳ لﻼﺘﺧا يور ﺮﺑ ﺲﻧاﺮﺗ و ﺲﻴﺳ بﺮﭼ يﺎﻫﺪﻴﺳا ﻲﻛارﻮﺧ ﺰﻳﻮﺠﺗ ﺮﺛا
ﺖــﻴﻟﺎﻌﻓ لﻮــﻃ رد ﻲﺠﻨﺸــﺗ يﺎــﻫ
20 ﻖــﻳرﺰﺗ زا ﺲــﭘ ﻪــﻘﻴﻗد
)PTZ Pentylentetrazol (
ﺪﻧﺪﺷ ﻲﺑﺎﻳزرا .
هوﺮﮔ ﺮﻫ رد تﺎﻘﻳرﺰﺗ
ناﻮﻴﺣ ﺮﻫ ﺎﺗ هدﺮﻛ اﺪﻴﭘ ﻪﻣادا 2
ﻢﺠﻨـﭘ ﻪﻠﺣﺮﻣ ،ﻢﻫ ﺮﺳ ﺖﺸﭘ رﺎﺑ
ﺪﻫد نﺎﺸﻧ دﻮﺧ زا ار ﺞﻨﺸﺗ
، ناﻮﻨﻋ ﻪﺑ ناﻮﻴﺣ ﻦﻳا ﺐﻴﺗﺮﺗ ﻦﻳا ﻪﺑ
ﻲﻣ ﻪﺘﻓﺮﮔ ﺮﻈﻧ رد لﺪﻨﻴﻛ ناﻮﻴﺣ ﺪﺷ
.
ـﻴﻣ ،ﮓﻨﻴﻟﺪﻨﻴﻛ نﺎﻳﺎﭘ زا ﺲﭘ ﻪﺘﻔﻫ ﻚﻳ تﺎـﻧاﻮﻴﺣ يﺮﻴﮔدﺎـﻳ ناﺰ
ﻲﻣ راﺮﻗ ﻲﺑﺎﻳزرا درﻮﻣ
ﻞﺗﺎـﺷ هﺎﮕﺘـﺳد زا رﺎﻛ ﻦﻳا ياﺮﺑ ،ﺖﻓﺮﮔ
ﺪﺷ هدﺎﻔﺘﺳا ﺲﻛﺎﺑ .
ﻪـﺒﻌﺟ ﺲﻛﺎـﺑ ﻞﺗﺎـﺷ ﻲﺴـﻛﻼﻓ ﺲﻨـﺟ زا يا
دﺎﻌﺑا ﺎﺑ و سﻼﮔ 18
× 18
× 60 ﻲﺘﻧﺎﺳ ﺮﺘﻣ ﻲـﻣ ﻂـﺳﻮﺗ ﻪـﻛ ﺪـﺷﺎﺑ
هراﻮﻳد ﻦﻴـﺑ رد و ﺖـﺳا هﺪـﺷ ﻢﻴﺴﻘﺗ يوﺎﺴﻣ ﺖﻤﺴﻗ ود ﻪﺑ يا
ﻪﭽﻳرد ،ﺖﻤﺴﻗ ود ﻦﻳا
دراد دﻮﺟو يا
ﻲـﻣ ناﻮـﻴﺣ ﻪـﻛ
زا ﺪـﻧاﻮﺗ
ددﺮــﮔ ﺮــﮕﻳد ﺖﻤﺴــﻗ دراو ﺖﻤﺴــﻗ ﻚــﻳ زا نآ ﻖــﻳﺮﻃ .
ﺮــﻫ رد
،ﻲﻜﻳﺮﺘﻜﻟا نﺎﻳﺮﺟ ﻂﺳﻮﺗ ناﻮﻴﺣ يﺎﭘ ﻒﻛ ﻚﻳﺮﺤﺗ ياﺮﺑ ،ﺖﻤﺴﻗ ﻪﻠﻴﻣ
ﺎﺟ ﻪـﺒﻌﺟ ﻒـﻛ رد نﺰـﻧ ﮓـﻧز دﻻﻮﻓ ﺲﻨﺟ زا ﻲﻳﺎﻫ يزﺎـﺳ
ﺖﺳا هﺪﺷ .
ﻪﻠﻴﻣ ﻦﻴﺑ ﻪﻠﺻﺎﻓ
ﺎﻫ ﻳ ـ ﻲﺘﻧﺎﺳ ﻚ ﺘﻣ ـ نآ ﭗـﻣﻻ ،ﺖﺳا ﺮ
5 و تاو 12
ﻲﻣ ﺖﻟو
ا نآ دﻮﻳد ،ﺪﺷﺎﺑ ﺰﻣﺮﻗ نودﺎﻣ ﻪﻌﺷا عﻮﻧ ز
ﻪﻛ هدﻮﺑ ﺰﻣﺮﻗ نودﺎﻣ رﻮﻧ ﻪﺑ سﺎﺴﺣ عﻮﻧ زا ،نآ رﻮﺘﻜﺗد ،ﺖﺳا ﻪﻠﺻﺎﻓ رد 5
ﻲﺘﻧﺎﺳ ﺎـﺑ و ﺖـﺳا ﻪـﺘﻓﺮﮔ راﺮﻗ ﺲﻔﻗ ﻒﻛ زا يﺮﺘﻣ
ﺲﻧﺎﻛﺮﻓ 400
ﻲﻣ رﺎﻛ ﺰﺗﺮﻫ
ﺪﻨﻛ . ﻢﻴﻫاﻮـﺧ ردﺎـﻗ ﺐـﻴﺗﺮﺗ ﻦـﻳا ﻪﺑ
ﻲﻃﺮﺷ ﺦﺳﺎﭘ عوﺮﺷ ﻲﻧﺎﻣز ﺮﻴﺧﺎﺗ ﺎﺗ دﻮﺑ CONDITIONAL )
RESPONSE LATENCY (
اﻮﻴﺣ رد ار هزاﺪﻧا ن
،ﻢﻴـﻨﻛ يﺮـﻴﮔ
ﻞـﺑﺎﻗ ﻪـﻨﻣاد ﺎـﺑ يزﺎﻓ ﻚﺗ ﻲﻌﺑﺮﻣ جﻮﻣ ﻚﻳ ﻞﻣﺎﺷ ﻲﻜﻳﺮﺤﺗ جﻮﻣ ﻢﻴﻈﻨﺗ 150 - 0
ﻲﻣ ﺖﻟو ﺮﻫ ﺶﻳاﺰﻓا ﺎﺑ ﺐﻴﺗﺮﺗ ﻦﻳا ﻪﺑ ﻪﻛ ﺪﺷﺎﺑ 15
ﻼﺘــﺧا ﺖــﻟو ف
،ﻞﻴﺴــﻧﺎﺘﭘ 1
/ 0 ﻲــﻠﻴﻣ ﻪــﺑ يدورو نﺎــﻳﺮﺟ ﺮــﭙﻣآ
،جﻮـﻣ ضﺮـﻋ ،ﺪـﺷ ﺪـﻫاﻮﺧ هدوﺰـﻓا هﺪﻨﻫد كﻮﺷ ﻢﺘﺴﻴﺳ 180
،نآ ﺲﻧﺎﻛﺮﻓ و ﻪﻴﻧﺎﺛوﺮﻜﻴﻣ 80
ﻮﺑ ﺰﺗﺮﻫ د .
ﻣزآ ﺶﻳﺎ
ﺪـﻨﺘﻓﺮﮔ ترﻮـﺻ ﻦـﺷور ﻞﺤﻣ ﻚﻳ رد ﺎﻫ زا ﻞـﺒﻗ و
تﺪﻣ ﻪﺑ ناﻮﻴﺣ ،ﻖﺑﺎﻄﺗ دﺎﺠﻳا ياﺮﺑ ،عوﺮﺷ 5
ﭻﻴـﻫ نوﺪـﺑ ﻪﻘﻴﻗد
ﻲــﻣ راﺮــﻗ هﺎﮕﺘــﺳد ﻞــﺧاد رد ﻲــﻛﺮﺤﻣ ﺖــﻓﺮﮔ
Adaptation) .(
ﺮﻫ تﺎﺸﻳﺎﻣزآ 48
ﻲـﻣ مﺎـﺠﻧا رﺎـﺒﻜﻳ ﺖﻋﺎـﺳ
ﺮـﻫ رد و ﺪـﻨﺘﻓﺮﮔ
ﺎﻳ شزﻮﻣآ ﻪﺴﻠﺟ Learning session
، 40 ﺎﻳ ﺖﺴﺗ Trial اﺮـﺑ ي
ﺮﻫ رد و ﺪﺷ مﺎﺠﻧا ناﻮﻴﺣ ﺮﻫ ﻪـﻛ نﺪـﺷ ﻲﻃﺮﺷ كﺮﺤﻣ ،ﺖﺴﺗ
دﻮﺑ اﺪﺻ تﺪﻣ ﻪﺑ ، 10
ﻲﻣ ﻦﺷور ﻪﻴﻧﺎﺛ
هزﺎﺟا نﺎﻣز تﺪﻣ و ﺪﺷ
ﺎﻳ ناﻮﻴﺣ راﺮﻓ ياﺮﺑ Warning period
تﺪـﻣ ﻪـﺑ 5
دﻮـﺑ ﻪـﻴﻧﺎﺛ .
ﻪـﻈﻔﺤﻣ ﻒـﻛ ﻪـﺑ ،تﺪﻣ ﻦﻳا زا ﺲﭘ
راﺮـﻗ نآ رد ناﻮـﻴﺣ ﻪـﻛ يا
ﺖﺷاد
،
ﺪﺷ ﻲﻣ دراو كﻮﺷ .
كﻮﺷ نﺎﻣز 5
ﻲﻣ لﻮﻃ ﻪﻴﻧﺎﺛ ﻴﺸﻛ
ﺪ
زا ﺲﭘ ﺐﻴﺗﺮﺗ ﻦﻳﺪﺑ و 10
اﺪـﻴﭘ ﻪﻤﺗﺎﺧ ﻢﻫ ﺎﺑ كﻮﺷ و اﺪﺻ ﻪﻴﻧﺎﺛ
ﻲﻣ ﺪﻧدﺮﻛ ) هرﺎﻤﺷ ﻞﻜﺷ 1
.(
هرﺎﻤﺷ ﻞﻜﺷ 1
- و ﻲﻃﺮﺷ كﺮﺤﻣ ضﺮﻌﻣ رد شﻮﻣ يﺮﻴﮔراﺮﻗ هﻮﺤﻧ
ﺲﻛﺎﺑ ﻞﺗﺎﺷ رد ﻲﻃﺮﺷﺮﻴﻏ
ﻞﺗﺎـﺷ ﺮـﮕﻳد ﺖﻤﺴـﻗ ﻪـﺑ ،كﻮـﺷ ﻦﺘﻓﺮـﮔ زا ﻞﺒﻗ ناﻮﻴﺣ ﺮﮔا ﻲﻣ ﺲﻛﺎﺑ ،ترﻮـﺻ ﻦـﻳا ﺮـﻴﻏ رد و ﺖـﺳرد ﺦﺳﺎﭘ ،ﺖﻓر ﺦـﺳﺎﭘ
ﻲـﻣ ﻪـﺘﻓﺮﮔ ﺮﻈﻧ رد ناﻮﻴﺣ ياﺮﺑ ﻂﻠﻏ
زا ﺲـﭘ و ﺪـﺷ 20
،ﻪـﻴﻧﺎﺛ
ﻲﻣ زﺎﻏآ يﺪﻌﺑ ﺖﺳ
ﺪﺷ . ﺶﻳﺎﻣزآ اﺪـﻴﭘ ﻪـﻣادا ترﻮـﺻ ﻦﻳﺪـﺑ ﺎﻫ
ﻲﻣ رد ،شزﻮـﻣآ ﻪﺴـﻠﺟ ﻚـﻳ رد ﺪـﻧاﻮﺘﺑ ناﻮـﻴﺣ ﺎـﺗ ﺪﻧدﺮﻛ 80
%
ﺪﻳﺎﻤﻧ ﻪﻳارا دﻮﺧ زا ﺢﻴﺤﺻ ﺦﺳﺎﭘ دراﻮﻣ .
ﻦﻴﮕﻧﺎﻴﻣ ترﻮﺻ ﻪﺑ ﻞﺻﺎﺣ ﺞﻳﺎﺘﻧ
ﻦﻴﮕﻧﺎـﻴﻣ رﺎـﻴﻌﻣ يﺎـﻄﺧ ±
ﻪﻳارا ﺖﺳا هﺪﻳدﺮﮔ .
ﺖـﻴﻤﻛ ﻪﺴـﻳﺎﻘﻣ ياﺮـﺑ ،ﻪﻌﻟﺎﻄﻣ ﻦﻳا رد
يﺎـﻫ
ﻣزآ زا ،ﻒﻠﺘﺨﻣ
ﻜﻳ ﺲﻧﺎﻳراو ﺰﻴﻟﺎﻧآ نﻮ نﻮـﻣزآ و ﻪـﻓﺮﻄ
Tukey
ﺖﺳا هﺪﺷ هدﺎﻔﺘﺳا .
ﻪﺘﻓﺎﻳ ﺎﻫ يﺎﻫﺪﻴـﺳا فﺮﺼـﻣ ﻪـﻛ ﺖﺳا نآ زا ﻲﻛﺎﺣ ﻪﻌﻟﺎﻄﻣ ﻦﻳا ﺞﻳﺎﺘﻧ ﮓﻨﻴﻟﺪـﻨﻴﻛ دﺎـﺠﻳا ﺪﻧور يور ﺮﺑ يﺮﺛا ،ﺲﻧاﺮﺗ ﺎﻳ و ﺲﻴﺳ بﺮﭼ
وزاﺮﺘﺗ ﻦﻠﻴﺘﻨﭘ ﺎﺑ ﻲﻳﺎﻴﻤﻴﺷ ﺪﻧراﺪﻧ ل
) هرﺎﻤـﺷ ﻞﻜﺷ 2
ﻲـﺳرﺮﺑ ﺎـﻣا ،(
ﺮـﺑ بﺮـﭼ يﺎﻫﺪﻴﺳا ﻦﻳا فﺮﺼﻣ ﺮﺛا يزاﺮـﺘﺣا يﺮﻴﮔدﺎـﻳ يور
ود نﺎﺸـﻧ ،ﻪـﺘﻓﺮﮔ راﺮـﻗ ﻲـﺳرﺮﺑ درﻮﻣ ﻖﻴﻘﺤﺗ ﻦﻳا رد ﻪﻛ ﻪﻓﺮﻃ
ﻲﻣ
ﻲﻨﻌﻣ فﻼﺘﺧا ﻪﭼ ﺮﮔا ﻪﻛ ﺪﻫد
يﺮﻴﮔدﺎـﻳ ناﺰﻴﻣ ﺮﻈﻧ زا يراد
ﻲﻃﺮﺷ ﺮﻴﻏ كﺮﺤﻣ )
رﻮﻧ (
ﻲﻃﺮﺷ كﺮﺤﻣ )
كﻮﺷ (
5 ﻪﻴﻧﺎﺛ ﻲﻠﻴﻣ ) راﺮﻓ نﺎﻣز تﺪﻣ (
ﻫﺪﻴﺳا ﻲﻛارﻮﺧ ﺰﻳﻮﺠﺗ ﺮﺛا يﺮﻴﮔدﺎﻳ لﻼﺘﺧا يور ﺮﺑ ﺲﻧاﺮﺗ و ﺲﻴﺳ بﺮﭼ يﺎ
ناﺮﻳا ﻲﻜﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد ﻪﻠﺠﻣ
هرود رﺎﻬﭼ ﻢﻫد / هرﺎﻤﺷ 56 / ﺰﻴﻳﺎﭘ 1386
هوﺮﮔ ﻦﻴﺑ
ﺖﺷاﺪﻧ دﻮﺟو ﻢﺸﺷ زور ﺎﺗ ﻒﻠﺘﺨﻣ يﺎﻫ زور زا ﺎﻣا ،
ﺰـﻴﻣ ،ﺪﻌﺑ ﻪﺑ ﻢﺘﻔﻫ بﺮـﭼ ﺪﻴـﺳا ﻪـﻛ ﻲﻳﺎﻬـﺷﻮﻣ رد يﺮﻴﮔدﺎـﻳ نا
ﻲـﻨﻌﻣ ﻞﻜـﺷ ﻪﺑ ،ﺪﻧدﻮﺑ هدﺮﻛ ﺖﻓﺎﻳرد ﺲﻴﺳ ﻲﻳﺎﻬـﺷﻮﻣ زا يراد
هدﺮـﻛ ﺖـﻓﺎﻳرد دراﺪﻧﺎﺘـﺳا ياﺬـﻏ ﺎـﻳ و ﺲﻧاﺮـﺗ بﺮﭼ ﺪﻴﺳا ﻪﻛ ﺶﻴﺑ ،ﺪﻧدﻮﺑ
دﻮﺑ ﺮﺗ . ﺞﻳﺎﺘﻧ ﻞﻴﻠﺤﺗ و ﻪﻳﺰﺠﺗ ﺰﻴﻟﺎـﻧآ زا هدﺎﻔﺘـﺳا ﺎﺑ
ﻜﻳ ﺲﻧﺎﻳراو ،فﻼﺘـﺧا ﻦـﻳا ﻪـﻛ داد نﺎﺸﻧ ﻲﻛﻮﺗ نﻮﻣزآ و ﻪﻓﺮﻄ
ﻲﻨﻌﻣ راد ﺖﺳا ) 05 / p<0 ( ) هرﺎﻤﺷ ﻞﻜﺷ 3
.(
ﺖـﻓﺎﻳرد ﺲﻧاﺮـﺗ بﺮـﭼ ﺪﻴﺳا ﻪﻛ ﺎﻬﺷﻮﻣ زا ﻲﻫوﺮﮔ ﻪﺴﻳﺎﻘﻣ
ﻲﻨﻌﻣ فﻼﺘﺧا ،لﺮﺘﻨﻛ هوﺮﮔ ﺎﺑ ﺪﻧدﻮﺑ هدﺮﻛ
ود ﻦـﻳا ﻦﻴﺑ ار يراد
داﺪﻧ نﺎﺸﻧ شزﻮﻣآ ﻒﻠﺘﺨﻣ يﺎﻫزور رد هوﺮﮔ )
هرﺎﻤﺷ ﻞﻜﺷ 3
.(
هرﺎﻤﺷ ﻞﻜﺷ 2
- و ﺲﻧاﺮﺗ ،ﺲﻴﺳ بﺮﭼ يﺎﻫﺪﻴﺳا فﺮﺼﻣ ﺮﻴﺛﺎﺗ ﻪﺴﻳﺎﻘﻣ
وﺮﮔ يور ﺮﺑ لوزاﺮﺘﺗ ﻦﻠﻴﺘﻨﭘ ﺎﺑ ﻲﻳﺎﻴﻤﻴﺷ ﮓﻨﻴﻟﺪﻨﻴﻛ ﻦﻴﺣ رد و ﻞﺒﻗ ،لﺮﺘﻨﻛ ه
ﺎﻬﺷﻮﻣ رد هﺪﺷ دﺎﺠﻳا ﺞﻨﺸﺗ
هرﺎﻤﺷ ﻞﻜﺷ 3
- و ﺲﻧاﺮﺗ ،ﺲﻴﺳ بﺮﭼ يﺎﻫﺪﻴﺳا فﺮﺼﻣ ﺮﻴﺛﺎﺗ ﻪﺴﻳﺎﻘﻣ
ﺘﺗ ﻦﻠﻴﺘﻨﭘ ﺎﺑ ﻲﻳﺎﻴﻤﻴﺷ ﮓﻨﻴﻟﺪﻨﻴﻛ ﻦﻴﺣ رد و ﻞﺒﻗ ،لﺮﺘﻨﻛ هوﺮﮔ يور ﺮﺑ لوزاﺮ
ود يزاﺮﺘﺣا يﺮﻴﮔدﺎﻳ ﻪﻓﺮﻃ
ﺚﺤﺑ
ﺎﺘﻧ
ﻲـﻣ دﺎﻬﻨﺸـﻴﭘ ﻖـﻴﻘﺤﺗ ﻦـﻳا زا ﻞﺻﺎﺣ ﺞﻳ
ﺰﻳﻮـﺠﺗ ﻪـﻛ ﺪـﻨﻛ
ﺐﺒﺳ ،هﺪﺷ لﺪﻨﻴﻛ يﺎﻬﺷﻮﻣ ﻪﺑ ﺲﻴﺳ بﺮﭼ يﺎﻫﺪﻴﺳا ﻲﻛارﻮﺧ ﮓﻨﻴﻟﺪـﻨﻴﻛ ﻂـﺳﻮﺗ هﺪـﺷ دﺎـﺠﻳا يﺮﻴﮔدﺎـﻳ لﻼﺘﺧا ناﺰﻴﻣ ﺶﻫﺎﻛ
ﻲـﻣ لوزاﺮـﺘﺗ ﻦﻠﻴـﺘﻨﭘ ﺎﺑ ﻲﻳﺎﻴﻤﻴﺷ
ﺰﻳﻮـﺠﺗ ﻪـﻛ ﻲﻟﺎـﺣ رد ،ددﺮـﮔ
ﺲﻧاﺮﺗ بﺮﭼ يﺎﻫﺪﻴﺳا
، ﻦـﻳا رد يﺮﻴﮔدﺎـﻳ ناﺰﻴﻣ يور ﺮﺑ يﺮﺛا
اﺪﻧ ﺎﻬﺷﻮﻣ ﺖﺷ
.
ﻞــﻣﺎﻜﺗ يور ﺮــﺑ ﺲﻴــﺳ بﺮــﭼ يﺎﻫﺪﻴــﺳا ﺶــﻘﻧ درﻮــﻣ رد ؛ﺖـﺳا ﻪـﺘﻓﺮﮔ مﺎـﺠﻧا يدﺎﻳز تﺎﻘﻴﻘﺤﺗ ،يﺰﻛﺮﻣ بﺎﺼﻋا ﻢﺘﺴﻴﺳ ﻲﻧﻮـﺧ ﺪـﺳ زا ،بﺮـﭼ يﺎﻫﺪﻴـﺳا ﻦﻳا ﻪﻛ ﺖﺳا هﺪﺷ هداد نﺎﺸﻧ
هدﺮﻛ رﻮﺒﻋ ﺰﻐﻣ
) 14
ءﺎﺸﻏ نﺎﻤﺘﺧﺎﺳ رد و هﺪﺷ هﺮﻴﺧذ ﺰﻐﻣ رد ،(
نورﻮﻧ ﻲﻟﻮﻠﺳ
ﻲﻣ رﺎﻜﺑ ﺎﻫ
ﺪﻧور
).
15
(
ا عﻮـﻧ ﻦـﻳا ﺶـﻘﻧ ﻦﻴﻨﭽﻤﻫ ز
و ءﺎﺸـﻏ ﻪـﺑ ﻪﺘﺴـﺑاو ﻲﺒﺼـﻋ مﺎـﻴﭘ لﺎـﻘﺘﻧا رد بﺮﭼ يﺎﻫﺪﻴﺳا ﻲﺠﻧﺎﻴﻣ ﻢﺴﻴﻟﻮﺑﺎﺘﻣ
ﺖـﺳا هﺪﻳدﺮﮔ تﺎﺒﺛا ﺰﻴﻧ ﻲﺒﺼﻋ يﺎﻫ
).
16
رد (
نﺎﺸـﻧ يﺮﻴﮔدﺎﻳ و ﻪﻈﻓﺎﺣ رد ﺲﻴﺳ بﺮﭼ يﺎﻫﺪﻴﺳا ﺶﻘﻧ درﻮﻣ نارود رد ﺲﻴـﺳ بﺮـﭼ يﺎﻫﺪﻴـﺳا دﻮـﺒﻤﻛ ﻪﻛ ﺖﺳا هﺪﺷ هداد يﺎﻬـﺷﻮﻣ رد ﻲﻳﺎﻀـﻓ يﺮﻴﮔدﺎـﻳ ﻲﻳﺎـﻧاﻮﺗ ﺶﻫﺎـﻛ ﺐﺒﺳ ﻲﻨﻴﻨﺟ ﻲﻳاﺮﺤﺻ ﻲﻣ
ددﺮﮔ
).
17 و 18
ﻲﻳاﺮﺤـﺻ يﺎﻬـﺷﻮﻣ رد ﺞﻳﺎﺘﻧ ﻦﻴﻤﻫ(
ﺎﻫﺪﻴﺳا ﻪﻛ ﻲﻐﻟﺎﺑ
ـﺑ هﺪـﺷ فﺬﺣ ﺎﻬﻧآ ياﺬﻏ زا ﺲﻴﺳ بﺮﭼ ي دﻮ
ﺖـﺳا هﺪﻣآ ﺖﺳﺪﺑ ﺰﻴﻧ
).
17
ﺰـﻴﻧ ﻪـﻌﻟﺎﻄﻣ ﻦـﻳا زا ﻞـﺻﺎﺣ ﺞﻳﺎـﺘﻧ (
ﻲـﻣ بﺮـﭼ يﺎﻫﺪﻴـﺳا زا عﻮـﻧ ﻦـﻳا فﺮﺼﻣ ﻪﻛ داد نﺎﺸﻧ ﺪـﻧاﻮﺗ
ﻦﻠﻴـﺘﻨﭘ ﺎـﺑ ﻲﻳﺎﻴﻤﻴـﺷ ﮓﻨﻴﻟﺪﻨﻴﻛ زا ﻲﺷﺎﻧ يﺮﻴﮔدﺎﻳ لﻼﺘﺧا ناﺰﻴﻣ اﺮﺘﺗ
ﺪﻫد ﺶﻫﺎﻛ ار لوز .
ﻞـﻤﻋ ﻢﺴﻴﻧﺎﻜﻣ درﻮﻣ رد ﻦـﻳا ﻲﻟﺎـﻤﺘﺣا
،يﺮﻴﮔدﺎـﻳ رد لﻼﺘـﺧا ناﺰﻴﻣ ﺶﻫﺎﻛ رد بﺮﭼ يﺎﻫﺪﻴﺳا زا عﻮﻧ تﻻﺎــﻤﺘﺣا زا ﻲــﻜﻳ
، ﻢــﻳژر رد دﻮــﺟﻮﻣ يﺮﻟﺎــﻛ ناﺰــﻴﻣ ﺶﻳاﺰــﻓا
هﺮـﻴﺟ ﻪـﺑ ﺲﻴـﺳ بﺮـﭼ ﺪﻴـﺳا ﺶﻳاﺰـﻓا ﺮﺛا رد ﻪﻛ ﺖﺳا ﻲﻳاﺬﻏ
ﻲﻣ دﺎﺠﻳا هوﺮﮔ ﻦﻳا يﺎﻬﺷﻮﻣ ﻲﻳاﺬﻏ ددﺮﮔ
. ﻞـﻴﻟد ﻪـﺑ لﺎﺣ ﻦﻳا ﺎﺑ
ا بﺬـﺟ ،ﺮـﮕﻳد هوﺮـﮔ ﻪـﺑ ﺲﻧاﺮـﺗ بﺮﭼ ﺪﻴﺳا زا يﺮﺑاﺮﺑ ﺶﻳاﺰﻓ
هدور ﺲﻴــﺳ و ﺲﻧاﺮــﺗ بﺮــﭼ يﺎﻫﺪﻴــﺳا ﺮــﺑاﺮﺑ يا
) 19
مﺪــﻋ و (
ﺮـﻈﻧ ﻪـﺑ ،لﺮـﺘﻨﻛ هوﺮـﮔ ﻪﺑ ﺖﺒﺴﻧ يﺮﻴﮔدﺎﻳ لﻼﺘﺧا رد يدﻮﺒﻬﺑ ﻲﻣ
ﻲﻤﻧ ﻲﺘﻓﺎﻳرد يﺮﻟﺎﻛ ناﺰﻴﻣ ﺶﻳاﺰﻓا ﺪﺳر
ﺶﻫﺎـﻛ ﺖـﻠﻋ ﺪﻧاﻮﺗ
ﺪﺷﺎﺑ ﺎﻬﺷﻮﻣ ﻦﻳا رد يﺮﻴﮔدﺎﻳ و ﻪﻈﻓﺎﺣ رد لﻼﺘﺧا .
Rauca
هداد نﺎﺸﻧ ﺶﻧارﺎﻜﻤﻫ و
ﮓﻨﻴﻟﺪـﻨﻴﻛ لﺎـﺒﻧد ﻪـﺑ ﻪﻛ ﺪﻧا
لﺎـﻜﻳدار ناﺰـﻴﻣ ،لوزاﺮﺘﺗ ﻦﻠﻴﺘﻨﭘ ﺎﺑ ﻲﻳﺎﻴﻤﻴﺷ
ﻞـﻛ رد دازآ يﺎـﻫ
0 1 2 3 4 5 6
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
تﺎﻘﻳرﺰﺗ داﺪﻌﺗ
ﻪﻠﻤﺣﻪﻠﺣﺮﻣ
Control Cis Trans
0 10 20 30 40 50 60 70 80
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
شزﻮﻣﺁ يﺎه زور داﺪﻌﺗ
ﺖﺳرديﺎهﺦﺳﺎﭘﺪﺻرد
لﺮﺘﻨﻛ هوﺮﮔ
ﺪﻧا هدﺮﻛ ﺖﻓﺎﻳرد ﺲﻧاﺮﺗ بﺮﭼ ﺪﻴﺳا ﻪﻛ ﻲﻫوﺮﮔ ﺪﻧا هدﺮﻛ ﺖﻓﺎﻳرد ﺲﻴﺳ بﺮﭼ ﺪﻴﺳا ﻪﻛ ﻲﻫوﺮﮔ
*
* *
*
*
*
*
يﺮﻴﮔدﺎﻳ لﻼﺘﺧا يور ﺮﺑ ﺲﻧاﺮﺗ و ﺲﻴﺳ بﺮﭼ يﺎﻫﺪﻴﺳا ﻲﻛارﻮﺧ ﺰﻳﻮﺠﺗ ﺮﺛا
ﻲﻣ ﺶﻳاﺰﻓا ﺰﻐﻣ
ﺪﺑﺎﻳ
).
20
زﺎﺗﻮﻤﺳد ﻲﺴﻛا ﺮﭘﻮﺳ ﺖﻴﻟﺎﻌﻓ ﺶﻳاﺰﻓا (
ﺖـﺳا هﺪـﺷ شراﺰـﮔ ﺰﻴﻧ ﮓﻨﻴﻟﺪﻨﻴﻛ لﺎﺒﻧد ﻪﺑ
).
21
ﻦـﻳا فﻼﺧﺮـﺑ (
هزاﺪﻧا ؛ﻪﺘﻓﺎﻳ يﺮﻴﮔ
Vesna Erakoric ﺶﻧارﺎـﻜﻤﻫ و
هداد نﺎﺸـﻧ
ناﺰـﻴﻣ ،لوزاﺮـﺘﺗ ﻦﻠﻴـﺘﻨﭘ ﺎـﺑ ﻲﻳﺎﻴﻤﻴـﺷ ﮓﻨﻴﻟﺪـﻨﻴﻛ لﺎـﺒﻧد ﻪﺑ ﻪﻛ
ﺎﻛ زﺎﺗﻮﻤﺳد ﺪﻴﺴﻛاﺮﭘﻮﺳ ﻢﻳﺰﻧآ ﺖﻴﻟﺎﻌﻓ ﻲﻣ ﺶﻫ
ﻦـﻳا ﻪـﺑ و ﺪـﺑﺎﻳ
عﻮﻧ ﻚﻳ ﺐﻴﺗﺮﺗ ﺮـﺛا رد ﺞﻨﺸـﺗ دﺎـﺠﻳا ﻪـﻴﻠﻋ ﺮـﺑ ﻲـﺗاذ ﻢﺴـﻴﻧﺎﻜﻣ
ﻲﻣ دﺎﺠﻳا لوزاﺮﺘﺗ ﻦﻠﻴﺘﻨﭘ ﻖﻳرﺰﺗ
ﺪﻨﻛ
).
22
ﺺﺨﺸـﻣ لﺎـﺣ ﺮـﻫ ﻪﺑ (
لﺎﻜﻳدار فﺬﺣ ﻪﻛ هﺪﺷ
ﺐﺒﺳ دازآ يﺎﻫ و گﺮـﻣ ناﺰـﻴﻣ ﺶﻫﺎـﻛ
نآ لﺎﺒﻧد ﻪﺑ و ﻲﻧورﻮﻧ ﺮﻴﻣ
، يﺮﻴﮔدﺎـﻳ رد لﻼﺘﺧا ناﺰﻴﻣ ﺶﻫﺎﻛ
ﻲﻣ ددﺮﮔ . ،ﺎﺘﺳار ﻦﻴﻤﻫ رد Singh
هداد نﺎﺸـﻧ ﺶﻧارﺎﻜﻤﻫ و
ﺪـﻧا
ندﺮـﺑ رﺎـﻜﺑ ،لوزاﺮﺘﺗ ﻦﻠﻴﺘﻨﭘ ﺎﺑ ﻲﻳﺎﻴﻤﻴﺷ ﮓﻨﻴﻟﺪﻨﻴﻛ لﺎﺒﻧد ﻪﺑ ﻪﻛ ﻞـــﻴﺒﻗ زا يداﻮـــﻣ tracrolimus)
FK506( هﺪـــﻨﻨﻛ رﺎـــﻬﻣ ﻪـــﻛ
ﺖﺳا زاﺪﻴﺴﻛاﺮﭘﻮﭙﻴﻟ
،
ﻬﻣ ﺐﺒﺳ ﻦﻠﻴـﺘﻨﭘ ﺎـﺑ ﻲﻳﺎﻴﻤﻴـﺷ ﮓﻨﻴﻟﺪﻨﻴﻛ رﺎ
ﻲـﻣ لوزاﺮﺘﺗ
ددﺮـﮔ
).
23
رﺎـﻬﻣ رد ﺲﻴـﺳ بﺮـﭼ يﺎﻫﺪﻴـﺳا ﺮـﺛا (
لﺎﻜﻳدار هﺪـﺷ هداد نﺎﺸـﻧ ﻒـﻠﺘﺨﻣ تﺎـﻌﻟﺎﻄﻣ رد ﺰـﻴﻧ دازآ يﺎﻫ
ﺖﺳا
).
24
(
ﻴﺗﺮﺗ ﻦﻳا ﻪﺑ ـ
ﺑ ﺐ ـ ﻈﻧ ﻪ ـــ ﻲـﻣ ﺮ ـﻛ ﺪـﺳر ـ
ـﭼ يﺎﻫﺪﻴـﺳا ﻪ ـ
بﺮ
ﻲـﺘﻧآ ﺪـﺳ ﺶﻳاﺰـﻓا ﺎـﺑ ﺲﻴﺳ
سﺮﺘـﺳا رﺎـﻬﻣ و ﺰـﻐﻧ ناﺪﻴﺴـﻛا
ﻓا ﺐﺒﺳ ،ﻮﻴﺗاﺪﻴﺴﻛا
نورﻮـﻧ ﺖـﻣوﺎﻘﻣ ﺶﻳاﺰ
گﺮـﻣ ﺮـﺑاﺮﺑ رد ﺎـﻫ
رد لﻼﺘـﺧا ناﺰـﻴﻣ زا و هﺪـﺷ لوزاﺮـﺘﺗ ﻦﻠﻴﺘﻨﭘ ﻖﻳرﺰﺗ زا ﻲﺷﺎﻧ ﻲﻣ يﺮﻴﮔدﺎﻳ
ﻲﻣ ﺮﻈﻧ ﻪﺑ ﻦﻴﻨﭽﻤﻫ و ﺪﻨﻫﺎﻛ
ﻦـﻳا فﺮﺼﻣ ﻪﻛ ﺪﺳر
ﻲـﻣ عﺮﺻ ﻪﺑ ﻼﺘﺒﻣ نارﺎﻤﻴﺑ رد بﺮﭼ يﺎﻫﺪﻴﺳا زا عﻮﻧ ﺎـﺗ ﺪـﻧاﻮﺗ
نارﺎــﻤﻴﺑ ﻦــﻳا رد هﺪــﺷ دﺎــﺠﻳا يﺮﻴﮔدﺎــﻳ لﻼﺘــﺧا زا يدوﺪــﺣ ﺪﻨﻛ يﺮﻴﮔﻮﻠﺟ .
ﻳدوﺪﺤﻣ زا ﺎﻬﺘﻧا رد ﺖ
ﻲﻣ ،ﻪﻌﻟﺎﻄﻣ ﻦﻳا ﻢﻬﻣ يﺎﻫ
ﻪﺑ ناﻮﺗ مﺪﻋ
هزاﺪـﻧا ﻢﻴﻘﺘﺴـﻣ نﺎﻜﻣا
ﺲﻧاﺮـﺗ بﺮـﭼ يﺎﻫﺪﻴـﺳا ناﺰـﻴﻣ يﺮـﻴﮔ
ﻢﻴﻘﺘﺴـﻣ ژاوﺎـﮔ مﺪـﻋ ﺰـﻴﻧ و هﺪﺷ ﻪﻧژورﺪﻴﻫ ﻦﻏور رد دﻮﺟﻮﻣ ﺎﻬﺷﻮﻣ هﺪﻌﻣ ﻞﺧاد ﻪﺑ ﺲﻧاﺮﺗ بﺮﭼ يﺎﻫﺪﻴﺳا دﺮﻛ هرﺎﺷا
.
ﻪﺠﻴﺘﻧ يﺮﻴﮔ
اﺮـﺘﺗ ﻦﻠﻴـﺘﻨﭘ ﺎﺑ ﻲﻳﺎﻴﻤﻴﺷ ﮓﻨﻴﻟﺪﻨﻴﻛ
يزاﺮـﺘﺣا يﺮﻴﮔدﺎـﻳ ،لوز
ود لﺎﻌﻓ
ﻲـﻣ ﻞـﺘﺨﻣ ﺲﻛﺎـﺑ ﻞﺗﺎـﺷ رد ار ﻪﻓﺮﻃ
ﺪـﻳﺎﻤﻧ . فﺮﺼـﻣ
ﺲﻴـﺳ بﺮـﭼ يﺎﻫﺪﻴـﺳا ﻲﻛارﻮﺧ
،
ﮓﻨﻴﻟﺪـﻨﻴﻛ ﻦﻴـﺣ رد و ﻞـﺒﻗ
،
ﻲﻣ ار ﺎﻬـﺷﻮﻣ رد هﺪـﻣآ دﻮـﺟﻮﺑ يﺮﻴﮔدﺎـﻳ لﻼﺘﺧا ناﺰﻴﻣ ﺪﻧاﻮﺗ يﺮﺛا ﺲﻧاﺮﺗ بﺮﭼ يﺎﻫﺪﻴﺳا فﺮﺼﻣ ﻪﻛ ﻲﻟﺎﺣ رد ،ﺪﻫد ﺶﻫﺎﻛ
دراﺪﻧ يﺮﻴﮔدﺎﻳ ناﺰﻴﻣ يور ﺮﺑ .
و ﺮﻳﺪﻘﺗ ﺮﻜﺸﺗ
مﻮــﻠﻋ هﺎﮕﺸــﻧاد ﻲﻟﺎــﻣ ﺖــﻳﺎﻤﺣ زا هدﺎﻔﺘــﺳا ﺎــﺑ ﻖــﻴﻘﺤﺗ ﻦــﻳا
حﺮـﻃ ﺐـﻟﺎﻗ رد كارا ﻲﻧﺎـﻣرد ـ ﻲﺘـﺷاﺪﻬﺑ تﺎﻣﺪـﺧ و ﻲﻜـﺷﺰﭘ
ﻪﻟﺎﻘﻣ نﺎﮔﺪﻨﺴﻳﻮﻧ ﻪﻠﻴﺳو ﻦﻳﺪﺑ ﻪﻛ ﺖﺳا هﺪﻳدﺮﮔ مﺎﺠﻧا ﻲﺗﺎﻘﻴﻘﺤﺗ زاﺮـﺑا ﺰـﻛﺮﻣ نآ ﻦﻴﻟوﺆﺴـﻣ زا ار دﻮـﺧ ﺮﻜﺸـﺗ و ﺮﻳﺪـﻘﺗ ﺐﺗاﺮﻣ ﻲﻣ ﺪﻧراد .
ﻊﺑﺎﻨﻣ ﺖﺳﺮﻬﻓ
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Hippocampus 1993; 3: 123-5.
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ﻫﺪﻴﺳا ﻲﻛارﻮﺧ ﺰﻳﻮﺠﺗ ﺮﺛا يﺮﻴﮔدﺎﻳ لﻼﺘﺧا يور ﺮﺑ ﺲﻧاﺮﺗ و ﺲﻴﺳ بﺮﭼ يﺎ
ناﺮﻳا ﻲﻜﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد ﻪﻠﺠﻣ
هرود رﺎﻬﭼ ﻢﻫد / هرﺎﻤﺷ 56 / ﺰﻴﻳﺎﭘ 1386
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Pentylenetetrazol-induced seizures and kindling: changes in free fatty acids, superoxide dismutase, and glutathione peroxide dismutase, and glutathione peroxidase activity.
Neurochem Int 2003; 42: 173-8.
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75: 853-60.
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يﺮﻴﮔدﺎﻳ لﻼﺘﺧا يور ﺮﺑ ﺲﻧاﺮﺗ و ﺲﻴﺳ بﺮﭼ يﺎﻫﺪﻴﺳا ﻲﻛارﻮﺧ ﺰﻳﻮﺠﺗ ﺮﺛا
Effect of Dietary administration of Cis and Trans Fatty acids on Learning Impairment Induced by Pentylenetetrazol Kindling in Male
Rats
I II III
*M.R. Palizvan, PhD M.R. Khazaee, BSc M.R. Nakhaee, PhD IV
E. Ghaznavi Rad, MSc
Abstract
Background & Aim: Impressive research demonstrates the importance of essential fatty acids for many physiological and behavioral mechanisms in both humans and animals. Experimental research showed that deficit in learning and memory is induced after kindling. The objective of this study was to investigate whether dietary cis and trans fatty acids, pre and during pentylenetetraxol(PTZ) kindling would effect learning deficits in male rats.
Materials and Methods: This is an experimental research. Eighteen Wistar rats were assigned in three groups. The control group received standard diet. The cis and trans groups received cis and trans fatty acids respectively. The kindling process was initiated one month after the start of the experiment, and the shuttle box learning ability was assessd one week after kindling. Data were analyzed using one way ANOVA and Tukey test.
Results: Results showed control and trans groups had impairment in shuttle box learning and no considerable differences were found between these two groups. However on the other hand administration of dietary cis fatty acid reduced impairment in shuttle box learning in pentylenetetrazol kindled rats.
Conclusion: The results of this experiment suggest that dietary treatment of kindled rats with cis fatty acids reduced learning deficits induced by PTZ kindling in rats.
Key Words: 1) Pentylenetetrazol 2) Kindling 3) Two Way Active Avoidance Learning 4) Cis Fatty Acid 5) Trans Fatty Acid
I) PhD, Assistant Professor of Physiology, Faculty of Medicine, Baseej Pardees Sq., Arak University of Medical Sciences and Health Services, Arak, Iran. (*Corresponding Author)
II) Bsc in Biology, Faculty of Medicine, Baseej Pardees Sq., Arak University of Medical Sciences and Health Services, Arak, Iran.
III) PhD, Assistant Professor of Nutrition, Faculty of Medicine, Baseej Pardees Sq., Arak University of Medical Sciences and Health Services, Arak, Iran.
IV) Msc in Microbiology, Instructor, Faculty member of Arak University of Medical Sciences and Health Services, Arak, Iran.
