Certificate No. 17781-СИ Registered on July 4, 2019 at the Ministry of Information and Communications of the Republic of Kazakhstan. The assessment of quality of life in this work was based on completing special questionnaires. According to the results of the questionnaire, the question is: «How often do you visit the dentist in the last three years?'.
But the children of this region, according to the results of the survey, have encountered difficulties in eating solid foods in 86%. At the same time, a variety of high-quality foods contribute to the child's physical and mental development. QUALITY OF LIFE OF PATIENTS WITH DISEASES OF THE ORAL CAVITY (LITERATURE REVIEW) // Modern problems of science and education.
More than 85% of cervical cancer cases are registered in developing countries, where a third of all women are diagnosed at an advanced stage of the disease. The connection between cervical cancer and the chronic persistence of the human papillomavirus is unquestionable. According to the number of RTAD, Almaty city has a higher number compared to Nur-Sultan city.
There is also alcohol in the blood of the corpse, which was more likely to be male between 25 and 34 years old.
Section 2
- Cutaneous manifestations
- Musculoskeletal manifestations
- Neurological manifestations
- Renal manifestations
- Sicca symptoms
- Pulmonary manifestations
- Endocrine disorders
- Gastrointestinal and hepatic manifestations Hepatomegaly, abnormal liver function
- Cardiovascular manifestations
- Female reproductive dysfunctions
Cryoglobulinemic vasculitis associated with HCV Hepatitis C virus (HCV) is notable for its hepatic and extrahepatic manifestations (25). It can be of infectious origin, with the most common cause being hepatitis C virus (HCV) infection [32;33]. The discovery of the sensitivity of the hepatitis C virus envelope to a transmembrane protein, CD81, provided a basis for understanding the mechanisms of HCV-induced lymphoproliferation [53,54].
Furthermore, chronic antigenic stimulation can cause overexpression (favoring some clones) of B cells and support immune dysregulation mechanisms that give rise to the development of mixed cryoglobulinemia and finally to malignant transformation occasionally found in patients with chronic hepatitis C virus infection. Hepatitis C virus infection can lead to B-cell transformation in addition to stimulation of B-cell expansion and decrease in B-cell activation threshold. B cells are induced to develop a variety of autoantibodies upon chronic stimulation by hepatitis C virus infection [ 61 ].
In patients with chronic hepatitis C virus infection, clonal B cell populations are found in the liver and peripheral blood. However, only about 2% of cases of cryoglobulinemic vasculitis tend to be caused by hepatitis B virus infection [66]. Cryoglobulinemic vasculitis can sometimes be associated with HIV infection, especially in cases of hepatitis C virus coinfection [82].
Cryoglobulinemia is an autoimmune manifestation most often identified in patients with hepatitis C virus infection. Detection and distribution of hepatitis C virus-related proteins in the lymph nodes of patients with mixed cryoglobulinemia type II and neoplastic or non-neoplastic lymphoproliferation . Impaired hepatosplenic elimination of circulating cryoglobulins in patients with mixed essential cryoglobulinemia and hepatitis C virus (HCV) infection.
Binding of hepatitis C virus glycoprotein E2 to CD81 is strain-specific and modulated by a complex interplay between hypervariable regions 1 and 2. Membranoproliferative glomerulonephritis and mixed cryoglobulinemia after hepatitis C virus infection resulting from glomerular deposits of NS3 viral antigen. Detection of viral antigens in renal tissue of patients with glomerulonephritis without serological evidence of hepatitis B and hepatitis C virus infection.
Section 3
Except for one article on a possible association between ABO blood group and isolated AF (12). To fully evaluate ABO blood group and other potential risk factors for AF and types of AF, we conducted a cross-sectional study and included hypertension, CHF, IHD, diabetes mellitus (DM), and history of CVA as comorbidities. We also investigated the interaction between ABO blood group and gender on the prevalence of AF.
Based on a 2014 study that included 369 healthy Kazakh donors, blood type O is the most common blood type, followed by A, B, and AB (13). To assess the evidence for ABO blood group and gender influence on the incidence of. Multivariate logistic regression analysis was performed using a forced entry method with baseline clinical characteristics to examine the associations between the non-O and O blood groups with risk of AF as well as to examine them for any type of ABO blood group.
After comparing blood type O with non-O blood types, there was no significant difference in the number of blood types O and A. In this cross-sectional study, we found that patients with non-O blood type had a significantly higher risk of atrial fibrillation than patients with blood type O. Blood type O is the most common blood type in Kazakhstan (13). a different strategy and is targeted directly at genes that specify surface proteins.
ABO blood group genotyping by real-time PCR has several essential advantages over other PCR-based techniques, such as high speed and reliability of the analysis. Sample phenotypes included blood type A (n = 99, however, non-O blood types (mainly type A) show a strong association with atrial fibrillation according to our study results. This is what raises the red flag when taken consider a possible connection and clarification between blood type and AF.
There was no evidence between ABO blood group interaction and gender on the incidence of atrial fibrillation. Results from the study of the association between ABO blood group and AF show that non-O blood groups, especially A group, have a significant association with the risk of developing AF compared to people with O blood group. The relationship between ABO blood group and von Willebrand factor levels: From biology to clinical implications.
Section 4
One of the more common procedures for the treatment of chronic sinus diseases is functional endoscopic sinus surgery [10]. Aim of the study: To assess the incidence of nasal polyps in patients with chronic rhinosinusitis who have undergone functional endoscopic sinus surgery. Patients under 18 years of age, mucoceles and sinus cysts, as well as those who were candidates for FESS other than CRS (sinus tumors, choanal atresia) were excluded.
In all cases, a preoperative CT scan was requested to map skeletal anatomy and extent of disease. Nasal polyps affect 4 percent of the population, 7-15 percent of asthmatics and up to 36-60 percent of Samter triad patients [14]. In the EPOS (European Position Paper on Rhinosinusitis and Nasal Polyps), nasal polyps are classified as a subgroup of CRS [15].
One of the most common clinical indications for referral to an otolaryngologist is nasal congestion (NB) and is defined as a feeling of distress resulting from the perception of insufficient airflow through the nose or increased air resistance [1] [2]. Mobilization, resection/reposition, and reconstruction/fixation are the phases of the approach of the existing septoplasty process. In the existing context, this retrospective study allows us to increase the knowledge about the use of the GBI scale to assess nasal symptoms after septoplasty with turbinoplasty.
Based on the absolute and relative frequencies for the qualitative variables, a descriptive study of the variables and measurements of the central tendency and dispersion for the quantitative variables were carried out. In recent years, as part of the research results, the evaluation of the quality of life after certain surgical procedures has increasingly dominated as objective criteria that evaluate only one physical parameter. Our evaluation is based on the improvement of the initial problems related to the quality of life after nose surgery.
Patients' memory of symptoms fades over time, which may have influenced observed outcomes. This is one of the few studies in Almaty using validated subjective scales such as the GBI questionnaire to assess the change in patients' quality of life after septoplasty with turbinoplasty. Onerci, “The comparison of quality of life and intranasal edema between patients with or without nasal congestion after septoplasty,” Eur.
Section 5
The aim of the study was to learn the evaluation of cytogenetic changes in bone marrow cells in laboratory animals, treated and not treated with GMO product, in a comparative aspect. Bone marrow cells were isolated according to a standard technique from the femur bones of animals sacrificed with a euthanasia device. Red bone marrow was washed from the femur with a nutrient medium containing 0.04% colchicine in a centrifuge tube and incubated for 2-2.5 hours in a thermostat at 37 °C.
Red bone marrow was washed from a hypotonic solution of femur COP L and incubated for 40 minutes in an oven at 37 0 C. Cytogenetic changes in rat bone marrow cells were studied using the following methods: Method of directly. Red bone marrow cells were used for the analysis, in which elements of the mitotic apparatus were detected.
The analysis revealed that – the low mitotic activity of bone marrow cells in group 1 (treated with GMO-soy) only partially in the bone marrow samples revealed the metaphase plate (tab.1). Experimental studies on laboratory animals proved that the GM product used (soy) led to cytogenetic changes in the cells of very widespread tissues, such as the red bone marrow of white mice. There is a partial inhibition of the proliferation of bone marrow cells due to the cytotoxic action, which can lead to cytopenia.
The number of metaphase plates found in the bone marrow was the same in the animals of group 1. In group 3 (control group), all bone marrow samples contained only metaphase plates with a normal karyotype (Fig.). of white mongrel rats treated with genetically modified soybeans found cytogenetic changes in their red bone ohm brains that led in part to the inhibition and proliferation of bone marrow cells through the cytotoxic action, which could lead to cytopenias.
In the group of animals that did not receive soy with and without GS (3 groups - control group), all bone marrow samples contained only metaphase plates with a normal karyotype, and cells did not contain genomic abnormalities. The mitotic activity of rat bone marrow cells was higher than in the experimental groups (groups 1 and 2). The effect of diets containing genetically modified soy in the body of animals // veterinar.
