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Title: Fabrication and characterization of hybrid PCL/PEG 3D scaffolds for potential tissue engineering applications
Author(s): Hoque, ME (Hoque, M. Enamul); Meng, TTH (Meng, Terrence Teh Hooi); Chuan, YL (Chuan, Y. Leng); Chowdhury, M (Chowdhury, Moniruddin); Prasad, RGSV (Prasad, R. G. S. V.)
Source: MATERIALS LETTERS Volume: 131 Pages: 255-258 DOI: 10.1016/j.matlet.2014.05.111 Published: SEP 15 2014 Times Cited in Web of Science Core Collection: 5
Total Times Cited: 5
Usage Count (Last 180 days): 0 Usage Count (Since 2013): 26 Cited Reference Count: 10
Abstract: This research aims to fabricate hybrid 3D scaffolds for potential tissue engineering (TE) applications. The 3D scaffolds were fabricated with the hybrid polymeric materials of polycaprolactone (PCL) and polyethylene glycol (PEG) using an in-house built desktop robot based rapid prototyping (DRBRP) system. The fabricated scaffolds were characterized morphologically and mechanically investigating the effects of process parameters such as, extrusion pressure, liquefier temperature and dispensing speed on scaffolds' properties. The increase of temperature from 60 degrees C to 70 degrees C resulted in increase of filament diameter from 416.7 +/- 21.7 mu m to 508.0 +/- 25.5 mu m and thus elastic modulus from 276 +/- 1.90 MPa to 293 +/- 1.49 MPa. Similarly, the increase of pressure from 5 bars to 7 bars increased the filament diameter from 387.5 +/- 18.5 mu m to 416.7 +/- 21.7 mu m and consequently, elastic modulus from 276 +/- 1.90 MPa to 293 +/- 1.49 MPa. However, the increase in deposition speed from 3 mm/s to 5 mm/s unlikely decreased the filament diameter from 508.3 +/- 25.5 mu m to 304.6 +/- 15.8 mu m, and as a result the elastic modulus decreased from 293 +/- 2.10 MPA to 275 +/- 5.67 MPa. The results evidenced the efficacy of the PCL/PEG hybrid material to be processed into 3D scaffolds via DRBRP system for potential TE applications. (C) 2014 Elsevier B.V. All rights reserved.
Accession Number: WOS:000340141800071 Language: English
Document Type: Article
Author Keywords: Hybrid; Scaffold; Tissue engineering; Rapid prototyping; Polycaprolactone (PCL); Polyethylene glycol (PEG)
Addresses: [Hoque, M. Enamul; Meng, Terrence Teh Hooi] Univ Nottingham, Dept Mech Mat & Mfg Engn, Bioengn Res Grp, Semenyih, Malaysia.
[Chuan, Y. Leng] Taylors Univ, Dept Mech Engn, Selangor, Malaysia.
[Chowdhury, Moniruddin] Univ Tunku Abdul Rahman, Dept Med, Bandar Sungai Long, Malaysia.
[Prasad, R. G. S. V.] Biomed & Pharmaceut Technol Res Grp, Bangalore, Karnataka, India.
Reprint Address: Hoque, ME (reprint author), Univ Nottingham, Dept Mech Mat & Mfg Engn, Bioengn Res Grp, Malaysia Campus, Semenyih, Malaysia.
E-mail Addresses: [email protected] Author Identifiers:
Author ResearcherID Number ORCID Number
Hoque, Md Enamul 0000-0003-0393-6771
Publisher: ELSEVIER SCIENCE BV
Publisher Address: PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS Web of Science Categories: Materials Science, Multidisciplinary; Physics, Applied Research Areas: Materials Science; Physics
IDS Number: AM8QJ ISSN: 0167-577X eISSN: 1873-4979
29-char Source Abbrev.: MATER LETT ISO Source Abbrev.: Mater. Lett.
Source Item Page Count: 4 Funding:
Funding Agency Grant Number
Faculty of Engineering, University of Nottingham Malaysia Campus
The authors would like to thank the Faculty of Engineering, University of Nottingham Malaysia Campus for the financial support to conduct this research.
Output Date: 2018-01-02
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