Anonimus. 2005a. Kandungan Gizi Buah Merah. http://www.trubus-online.com. (2 Oktober 2005).
[ ]. 2005b. Panduan Praktis Buah Merah Bukti Empiris dan Ilmiah. Jakarta: Penebar Swadaya. Hal: 1-50.
[ ]. 2006a. Hepatitis. http://en.wikipedi.org/wiki/Hepatitis. (6 Agustus 2006).
[ ]. 2006b. Parasetamol. http://en.wikipedi.org/wiki/Paracetamol. ( 6 Agustus 2006).
[ ]. 2007a. Buah Merah jenis merah panjang.
http://medicastore.com/buahmerah. (26 Februari 2007).
[ ].2007b. Penyakit Hati.
http://www.prodia.co.id/info_terkini/isi_hati.html. (26 Februari 2007).
Arnelia. 2002. Fitokimia Komponen Ajaib Cegah Penyakit Jantung Koroner, Diabetes Melitus dan Kanker.
Brouwer KL. 1993. Acute Phenobarbital Administration Alters the Disposition of Acetaminophen Metabolites in Rat. Drug Metabolies Disposition. 21: 1129-1133.
Carlton WW & McGavin MD. 1995. Thomson’s Special Veterinary Pathology. Ed ke-2. Mosby. St. louis. Hal: 209-245.
Cheville NF. 1999. Introduction To Veterinery Pathology. Ed ke-2. USA: Iowa State University Press. Hal: 5-25.
Cotran RS, Kumar V & Robins S. 1989. Pathologic Basic of Disesae. Philadephia: WB Saunders Company. Hal: 911-1051.
Dalimartha S. 2002. Ramuan Tradisional Untuk Pengobatan Hepatitis. Jakarta: Penerbit Swadaya. Hal: 33.
Darmansjah I. 2005. Benarkah Parasetamol Toksik Terhadap Hati?.
http://medicalarticels.com [2 Oktober 2005].
Fall. 1984. Gangguan Saluran Cerna Dalam: Patofisiologi: Konsep Klinik Proses-Proses Penyakit. Jakarta: Penerbit Buku Kedokteran EGC. Hal: 327-328.
Ganiswara SG. 1995. Farmakologi dan Terapi. Ed ke-4. Jakarta: Farmakologi Fakultas Kedokteran Universitas Indonesia. Hal: 116.
Girindra, A. 1988. Biokimiawi Patologi Hewan. Bogor: Institut Pertanian Bogor. Hal: 63-77.
Handoko IS. 2003. Organ Hati. http://www.klinikku.com. [21 Januari 2003]. Hembing W. 2005. Menjaga Kesehatan Dan Kebugaran Manusia Serta Hewan
Dengan Tanaman Obat [Seminar]. [17 September 2005].
Hinson JA. 1980. Biochemical Toxycology of Acetaminophen. Rev Biochemical Toxycology. 2: 103-129.
Jollow DJ, Thoirgeirson SS, Potter WZ. 1974. Acetaminophen Induced Hepatic Necrosis. Pharmacology. 12: 251-271.
Jubb KVP et al. 1993. Pathology of Domestic Animal. London: Academic Press. Hal: 1411-1418.
Koolman Jan. 2000. Atlas Berwarna Dan Teks Biokimia. Jakarta: Hipokrates. Hal 272-278.
Lesson CR, Leeson TS & Paparo AA. 1995. Buku Ajar Histologi. Ed ke-5. Jakarta: Penerbit Buku Kedokteran EGC. Hal: 383, 385-388, 392.
Lu FC. 1995. Toksikologi Dasar. Ed ke-2. Jakarta. Universitas Indonesia Press. Hal: 206-223.
Mac Farlene PS, Reid R & Callander. 2000. Pathology Illustrated. Toronto. Huerchill Livingstone. Hal: 342-357.
Made Budi I. 2005. Kajian Kandungan Zat Gizi dan Sifat Fisiko Kimia Berbagai Jenis Minyak Buah Merah(Pandanus conoideus. Lam) Hasil Ekstrasi Secara Tradisional Di Kabupaten Jayawijaya Propinsi Irian Jaya [Tesis]. Bogor: Program Pascasarjana Institut Pertanian Bogor.
Maronpot RR.. 1999. Pathology of Mouse. USA: Cache River Press. Hal: 119- 117.
Mitchell JR, Jollow DJ, Potter WZ. 1973. Acetaminophen Induced Hepatic Necrosis. Jurnal Pharmacology Exp Therapy. 187: 195-202.
Mohapatra D, Mishra SC, & Misra SN. 1993. Paracetamol Induced Hepatotoxicity In Broiler Birds. Indian Veteriner. J. 70: 914-916. Penn D. 1999. A House Primer.
http://www.stormy.biology.utah.edu/lab/mouse_primer.html. [3 Juni 2006].
Ressang AA. 1984. Buku Pelajaran Patologi Khusus Veteriner. Fakultas Kedokteran Hewan IPB. Hal 45-82.
Rzucidlo SJ, Bounous DI, Jones DP & Brackett BG. 2000. Acute Acetaminophen Toxicity in Transgenic with Elevated Hepatic Glutathione. Vet Human Toxicol. 42 (3): 146-150.
Smith JB & Mangkoewidjodjo S. 1988. Pemeliharaan, Pembiakan dan Penggunaan Hewan Percobaan di Daerah Tropis. Jakarta: Universitas Indonesia Press. Hal 10-12.
Susana N. 1987. Pengaruh Pemberian Seduhan Rimpang Temulawak Terhadap Hepatotoksisitas Parasetamol Pada Mencit Jantan [Skripsi]. Yogyakarta: Jurusan Kimia FMIPA UGM.
Sutanto J. Pengaruh Isoflavon Pada Resisitensi Lipoprotein Berdensitas Rendah (LDL) Terhadap Oksidasi Kimia [Skripsi]. Bogor: Jurusan Kimia FMIPA IPB.
Suyono. 2007. Sonografi Sirosis Hepatitis Di RSUD Dr Moerwardi.
http://www.kalbefarma.com/files/cdk/files. (28 Februari 2007).
Sulaksono ME, Pudjoprajitno, Yuwon SS dan Patra K. 1986. Keadaan dan Masalah Hewan Percobaan di Indonesia. Volume ke-14(3). Departemen Kesehatan Republik Indonesia. Badan Penelitian dan Pengembangan Kesehatan. Jakarta: Buletin Penelitian Kesehatan.
Wilson & Lester. 1995. Patofisiologi Konsep Klinis Proses-Proses Penyakit. Ed ke--4. Jakarta: Penerbit Buku Kedokteran EGC. Hal: 426-427,429-430. Zubairi. 2007. Sirosis Hati. http://www.republika.co.id/koran (26 Februari 2007)
LAMPIRAN
Lampiran 1 Persentase lesio hepatosit mencit uji ANOVA
One-way ANOVA: Nekrosa versus data
Analysis of Variance for Nekrosa
Source DF SS MS F P data 2 301,7 150,9 13,51 0,001 Error 12 134,0 11,2
Total 14 435,7
Individual 95% CIs For Mean Based on Pooled StDev
Level N Mean StDev ----+---+---+---+--
Kn 5 7,000 1,225 (---*---)
Kp 5 16,200 3,834 (---*---)
P 5 6,400 4,159 (---*---)
----+---+---+---+--
Pooled StDev = 3,342 5,0 10,0 15,0 20,0 One-way ANOVA: Degenerasi Lemak versus data Analysis of Variance for Degenera Source DF SS MS F P data 2 187,6 93,8 2,05 0,171 Error 12 548,8 45,7 Total 14 736,4 Individual 95% CIs For Mean Based on Pooled StDev Level N Mean StDev ---+---+---+---+-
Kn 5 3,600 1,140 (---*---)
Kp 5 3,800 2,280 (---*---)
P 5 11,200 11,432 (---*---)
---+---+---+---+-
Pooled StDev = 6,763 0,0 6,0 12,0 18,0 One-way ANOVA: Degenerasi Hidrops versus data Analysis of Variance for Degenera Source DF SS MS F P data 2 1451 726 4,07 0,045 Error 12 2138 178
Total 14 3590
Individual 95% CIs For Mean Based on Pooled StDev Level N Mean StDev ---+---+---+---
Kn 5 24,80 10,01 (---*---)
Kp 5 40,80 19,28 (---*---)
P 5 17,20 7,92 (---*---)
---+---+---+---
Pooled StDev = 13,35 15 30 45
One-way ANOVA: Normal versus data Analysis of Variance for Normal Source DF SS MS F P data 2 2543 1271 3,96 0,048 Error 12 3855 321
Total 14 6398
Based on Pooled StDev
Level N Mean StDev -+---+---+---+---
Kn 5 64,00 9,57 (---*---)
Kp 5 37,00 21,01 (---*---)
P 5 65,20 20,75 (---*---)
-+---+---+---+---
Pooled StDev = 17,92 20 40 60 80
Lampiran 2 Persentase lesio hepatosit mencit uji Duncan Nor mal The SAS Sy s t em 11: 26 Sat ur day , J anuar y 10, 1998 7
Gener al Li near Model s Pr oc edur e Dunc an' s Mul t i pl e Range Tes t f or v ar i abl e: XY NOTE: Thi s t es t c ont r ol s t he t y pe I c ompar i s onwi s e er r or r at e, not t he ex per i ment wi s e er r or r at e Al pha= 0. 05 df = 12 MSE= 11. 16667 Number of Means 2 3
Cr i t i c al Range 4. 605 4. 820 Means wi t h t he s ame l et t er ar e not s i gni f i c ant l y di f f er ent . Dunc an Gr oupi ng Mean N PLAKUAN A 16. 200 5 Kp B 7. 000 5 Kn B B 6. 400 5 P Degener as i l emak The SAS Sy s t em 11: 26 Sat ur day , J anuar y 10, 1998 10
Gener al Li near Model s Pr oc edur e Dunc an' s Mul t i pl e Range Tes t f or v ar i abl e: XY NOTE: Thi s t es t c ont r ol s t he t y pe I c ompar i s onwi s e er r or r at e, not t he ex per i ment wi s e er r or r at e Al pha= 0. 05 df = 12 MSE= 45. 73333 Number of Means 2 3 Cr i t i c al Range 9. 319 9. 754
Means wi t h t he s ame l et t er ar e not s i gni f i c ant l y di f f er ent . Dunc an Gr oupi ng Mean N PLAKUAN
A 11. 200 5 P A
A
A 3. 600 5 Kn
Degenerasi hidropik
The SAS Sy s t em 11: 26 Sat ur day , J anuar y 10, 1998 13 Gener al Li near Model s Pr oc edur e
Dunc an' s Mul t i pl e Range Tes t f or v ar i abl e: XY
NOTE: Thi s t es t c ont r ol s t he t y pe I c ompar i s onwi s e er r or r at e, not t he
ex per i ment wi s e er r or r at e Al pha= 0. 05 df = 12 MSE= 178. 2
Number of Means 2 3 Cr i t i c al Range 18. 40 19. 25
Means wi t h t he s ame l et t er ar e not s i gni f i c ant l y di f f er ent . Dunc an Gr oupi ng Mean N PLAKUAN
A 40. 800 5 Kp A B A 24. 800 5 Kn B B 17. 200 5 P Nek r os a
The SAS Sy s t em 11: 26 Sat ur day , J anuar y 10, 1998 16 Gener al Li near Model s Pr oc edur e
Dunc an' s Mul t i pl e Range Tes t f or v ar i abl e: XY
NOTE: Thi s t es t c ont r ol s t he t y pe I c ompar i s onwi s e er r or r at e, not t he
ex per i ment wi s e er r or r at e Al pha= 0. 05 df = 12 MSE= 321. 2333
Number of Means 2 3 Cr i t i c al Range 24. 70 25. 85
Means wi t h t he s ame l et t er ar e not s i gni f i c ant l y di f f er ent . Dunc an Gr oupi ng Mean N PLAKUAN
A 65. 20 5 P A
A 64. 00 5 Kn B 37. 00 5 Kp
Lampiran 3 Persentase lesio daerah vena porta dan vena sentralis uji ANOVA
One-way ANOVA: deg.lemak versus C1
Source DF SS MS F P C1 5 334.8 67.0 0.92 0.488 Error 24 1756.0 73.2
Total 29 2090.8
S = 8.554 R-Sq = 16.01% R-Sq(adj) = 0.00%
Individual 95% CIs For Mean Based on Pooled StDev
Level N Mean StDev ---+---+---+---+---
k-porta 5 3.400 2.074 (---*---) k-sentral 5 5.800 4.438 (---*---) k+porta 5 6.200 3.564 (---*---) k+sentral 5 8.000 5.612 (---*---) pportal 5 14.000 17.889 (---*---) psentral 5 9.400 7.127 (---*---) ---+---+---+---+--- 0.0 7.0 14.0 21.0 Pooled StDev = 8.554 One-way ANOVA: normal versus C1 Source DF SS MS F P C1 5 6054 1211 3.34 0.020 Error 24 8689 362 Total 29 14743 S = 19.03 R-Sq = 41.06% R-Sq(adj) = 28.79% Individual 95% CIs For Mean Based on Pooled StDev Level N Mean StDev --+---+---+---+---
k-porta 5 67.40 6.02 (---*---) k-sentral 5 60.80 15.12 (---*---) k+porta 5 38.00 22.86 (---*---) k+sentral 5 33.20 26.28 (---*---) pportal 5 66.60 19.27 (---*---) psentral 5 66.20 17.96 (---*---) --+---+---+---+--- 20 40 60 80 Pooled StDev = 19.03
One-way ANOVA: deg.hidrops versus C1
Source DF SS MS F P C1 5 3543 709 3.68 0.013 Error 24 4624 193
Total 29 8167
Individual 95% CIs For Mean Based on Pooled StDev
Level N Mean StDev --+---+---+---+---
k-porta 5 23.60 7.73 (---*---) k-sentral 5 22.20 13.01 (---*---) k+porta 5 38.40 20.90 (---*---) k+sentral 5 42.20 17.21 (---*---) pportal 5 10.40 9.61 (---*---) psentral 5 20.60 10.09 (---*---) --+---+---+---+--- 0 15 30 45 Pooled StDev = 13.88 One-way ANOVA: nekrosa versus C1 Source DF SS MS F P C1 5 619.0 123.8 9.84 0.000 Error 24 302.0 12.6 Total 29 921.0 S = 3.547 R-Sq = 67.21% R-Sq(adj) = 60.38% Individual 95% CIs For Mean Based on Pooled StDev Level N Mean StDev ---+---+---+---+--
k-porta 5 5.600 0.894 (---*---) k-sentral 5 8.600 2.408 (---*---) k+porta 5 14.800 3.834 (---*---) k+sentral 5 16.800 5.070 (---*---) pportal 5 7.000 3.873 (---*---) psentral 5 5.000 3.674 (---*---) ---+---+---+---+-- 5.0 10.0 15.0 20.0 Pooled StDev = 3.547