BAB V KESIMPULAN DAN SARAN
5.2 Saran
Adapun saran yang dapat diberikan dalam penelitian ini adalah :
1. Penelitian ini dapat dilanjutkan dengan penelitian polimorfisme gen IL-10 dengan sampel yang besar.
2. Pengukuran kadar IL-10 serum dapat dijadikan parameter derajat keparahan akne vulgaris.
DAFTAR PUSTAKA
1. Zaenglein AL, Graber EM, Thiboutot D. Acne vulgaris and acneiformis eruptions. In:
Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, Wolff K, editors.
Fitzpatrick’s Dermatology in General Medicine. 8th ed. New York: McGraw Hill Companies; 2012. p.897-917
2. Dawson AL, Dekkavalle RP. Clinical review : Acne vulgaris. British Medical Journal.
2013; 346:f2634. doi: 10.1136/bmj.f2634
3. Barratt H, Hamilton F, Car J, Lyons C, Layton A, Majeed A. Outcomes measures in acne vulgaris: systematic review. British Journal of Dermatology. 2009; 160(3):132-6.
doi:10.111/j.1365-2133.1008.08819.x.
4. Kraft J, Freiman A. Management of acne. Can Med Assoc J. 2011; 183(7):430-5 5. JK Tan, K Bhate. A global perspective on the epidemiology of acne. Br J Dermatol.
2015; 172(sup1):3-12. doi:10.111/bjd.13462
6. SZ Ghodsi, H Orawa, CC Zouboulis. Prevalence, severity and severity risk factors of acne in high school pupil : a community-based study. J Inves Dermatol. 2009;
129(9):2136-41. doi:10.1038/jid.2009.47.
7. Nobukazu H et al. An epidemiological study of acne vulgaris in Japan by questionnaire. Japanese Journal of Dermatology. 2001;111(9): 1347-55
8. Hanisah A, Omar K, Shah SA. Prevalence of acne and its impact on quality of life in school-aged adolescents in Malaysia. J Primary Health Care. 2009; 1(1):20-5
9. Tan HH, Tan AW, Barkham T, Yan XY, Zhu M. Community-based study of acne vulgaris in adolescents in Singapore. Br J Dermatol. 2007; 157(3):547-51
10. Wasitaatmadja SM, Arimuko A, Norawati L, Bernadette I, Legiawati L, editors.
Pedoman tata laksana akne di Indonesia. 2th ed. Jakarta: Centra communications;
2016
11. Tjekyan RMS. Kejadian dan faktor resiko akne vulgaris. MMI. 2008; 43(1):37-43.
Available from: http://ejournal.undip.ac.id/index.php/mmi/article/view/3810
12. Anggrenni O, Jusuf NK, Simanungkalit R. Studi retrospektif pasien akne vulgaris di RSUP H. Adam Malik Medan periode tahun 2010-2012. 2014. Available from:
http://repository.usu.ac.id/handle/123456789/41300
13. Baran R, Chivot M, Shalita AR, Lewis A, Wechsler A. Acne. Baran R, Maibach HI editors. Textbook of Cosmetic Dermatology. 3th Edition. London: Taylor & Francis;
2005; p.423-34
14. Koreck A, Pivarcsi A, Dobozy A, Kemeny L. The role of innate immunity in the pathogenesis of acne. Dermatology. 2003; 206(1):96-105
15. Ingham E, Eady EA, Goodwin CE, Cove JH, Cunliffe WJ. Pro-inflammatory levels of interleukin-1 alpha-like bioactivity are present in the majority of open comedones in acne vulgaris. J Invest Dermatol. 1992; 98(6) An Abstract
16. Tanghetti EA. Literature review : The Role of Inflammation in the Pathology of Acne.
J of Clinical Aesthetic Dermatol. 2013; 6(9): 27-35
17. Jeremy AH, Holland DB, Roberts SG, Thomson KF, Cunliffe WJ. Inflammatory Events are Involved in Acne Lesion Initiation. J Invest Dermatol. 2003; 121:20-7 18. Mosser DM, Zhang X. Interleukin-10: new perspectives on an old cytokine. Immunol
Rev. 2008; 226:205-18
19. Moore KW, Malefyt RdW, Coffman RL, O’Garra A. Interleukin-10 and the Interleukine-10 receptor. Annu Rev Immunol. 2001; 19: 683-765
21. Kang S, Cho S, Chung JH, Hammerberg C, Fisher GJ, Voorhees JJ. Inflammation and extracellular matrix degradation mediated by activated transcription factors nuclear factor-κB and activator protein-1 in inflammatory acne lesions in vivo. Am J of Pathol. 2005; 166(6):1691-99
22. Caillon F, O’Connell M, Eady EA, Jenkins G, Cove JH, Layton AM, Mountford AP.
Interleukin-10 secretion from CD14+ peripheral blood mononuclear cells is downregulated in patients with acne vulgaris. Br J Dermatol. 2010; 162(2):296-303 23. Lynn DD, Umari T, Dunnick CA, Cellavalle RP. The epidemiology of acne vulgaris
in late adolescence. Adolescent Health, Medicine and Therapeutics. 2016; 7: 13-25 24. Bagatin E, Timpano DL, Guadanhim LRS, Nogueira VMA, Terzian LR, Steiner D et
all. Acne vulgaris: prevalence and clinical forms in adolescents from Sao Paulo, Brazil. An Bras Dermatol. 2014; 89(3): 428-35
25. Afriyanti RN. Tinjauan literatur : Akne vulgaris pada remaja. J Majority. 2015; 4(6):
102-9
26. Williams C, Layton AM. Persistent acne in women : implications for the patient and for therapy. Am J Clin Dermatol. 2006; 7(5): 281-90
27. Yentzer BA, Hick J, Reese EL, Uhas A, Feldman SR, Balkrishnan R. Acne vulgaris in the United States: a descriptive epidemiology. Cutis. 2010; 86(2): 94-9 An abstract 28. Zeichner JA, Baldwin HE, Cook-Bolden FE, Eichenfield LF, Fallon-Friedlander SF,
Rodriguez DA. Emerging issues in adult female acne. J Clin Aesthet Dermatol. 2017;
10(1): 37-46
29. Baumann L, Keri J. Acne (type 1 sensitive skin). In: Baumann L, Saghari S, Weissberg E, editors. Cosmetic Dermatology Principles and Practice. 2nd edition.
New York: McGraw Hill; 2009. p.121-7
30. Layton AM. Disorders of the sebaceous glands. In: Burns T, Breathnach S, Cox N, Griffiths C, editors. Rook’s Textbook of Dermatology. 8th edition. United Kingdom:
Wiley-Blackwell; 2010. p.42.17-37
31. Moreno-Arrones OM, Boixeda P. The Importance of Innate Immunity in Acne. Actas Dermosifiliogr. 2016. http://dx.doi.org/10.1016/j.ad.2016.07.005
32. Chen WC, Zouboulis CC. Hormones and The Pilosebaceous Unit.
Dermatoendocrinol. 2009; 1: 81-6
33. Thiboutot D. Regulation of Human Sebaceous Glands. J Invest Dermatol. 2004; 123:
1-12
34. Deplewski D, Rosenfield R. Growth Hormone and Insulin-like Growth Factors Have Different Effects on Sebaceous Cell Growth and Differentiation. Endocrinology.
1999: 140; 4089-94
35. Ganceviciene R et all. Involvement of The Corticotropin-releasing Hormone System in The Pathogenesis of Acne Vulgaris. Br J Dermatol. 2009; 160 (2): 345-52
36. Kistowska M, Meier B, Proust T, Feldmeyer L, Cozzio A, Kuendig T et all.
Propionibacterium acnes promotes Th17 and Th17/Th1 Responses inAcne Patients. J Inves Dermatol. 2015; 135: 110-8
37. Qin M, Pirouz A, Kim M-H, Krutzik SR, Garban HJ, Kim J. Propionibacterium acnes induces IL-1β Secretion Via the NLRP3 Inflammasome in Human Monocytes. J Invest Dermatol. 2014; 134: 381-8
38. Jeremy AH, Holland DB, Roberts SG, Thomson KF, Cunliffe WJ. Inflammatory Events are Involved in Acne Lesion Initiation. J Invest Dermatol. 2003; 121:20-7 39. Do TT, Zarkhin S, Orringer JS, Nemeth S, Hamilton T, Sachs D, et al.
Computer-assisted Alignment and Tracking of Acne Lesions Indicate That Most Inflammatory
59
40. Suh DH, Kwon TE, Youn JI. Changes of comedonal cytokines and sebum secretion after UV irradiation in acne patients. Eur J Dermatol. 2002; 12(2):139-44 An Abstract 41. Picardo M, Eichenfield LF, Tan J. Acne and Rosacea. Dermatol Ther. 2017; 7(1):
S43-52
42. Sitohang ISS, Wasitaatmadja SM. Akne Vulgaris. Dalam: Menaldi SLSW, Bramono K, Indriatmi W, editor. Ilmu Penyakit Kulit dan Kelamin. Edisi ke-7. Jakarta: Balai Penerbit FKUI; 2016. h288-92
43. Mahto A. Acne vulgaris. Medicine. 2017. Available from http://dx/doi.org/10.1016/j.mpmed.2017.03.003
44. Witkowski JA, Parish LC. The Assessment of Acne: an Evaluation of Grading and Lesion Counting in the Measurement of Acne. Clinics in Dermatology. 2004;23:394-97
45. Adatyan B, Kumari R, Thappa DM. Scoring Systems in Acne Vulgaris. Indian J Dermatol Venereol Leprol. 2009;75: 323-26
46. Thiboutot D. Acne: Hormonal Concepts and Therapy. Clinics in Dermatology. 2004;
22: 419-28
47. Wasitaatmadja SM. Erupsi Ekneiformis. Dalam: Menaldi SLSW, Bramono K, Indriatmi W, editor. Ilmu Penyakit Kulit dan Kelamin. Edisi ke-7. Jakarta: Balai Penerbit FKUI; 2016. h.293-94
48. Pelle MT. Rosacea. In: Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, Wolff K, editors. Fitzpatrick’s Dermatology in General Medicine. 8th ed. New York:
McGraw Hill Companies; 2012. p.918-25
49. Lawley LP & Parker SRS. Perioral Dermatitis. In: Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, Wolff K, editors. Fitzpatrick’s Dermatology in General Medicine. 8th ed. New York: McGraw Hill Companies; 2012. p.925-8
50. Mirmirani P & Rogers M. Keratosis Pilaris and Other Inflammatory Follicular Keratotic Syndromes. In: Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, Wolff K, editors. Fitzpatrick’s Dermatology in General Medicine. 8th ed. New York: McGraw Hill Companies; 2012. p.973-8
51. Weiss E, Mamelak AJ, La-Morgia S, Wang B,Feliciani C, Tulli A et al. The Role of Interleukin 10 in the Pathogenesis and Potential Treatment of Skin Diseases. J Am Acad Dermatol. 2004;50(5): 657-75
52. Iyer SS & Cheng GH. Role of Interleukin 10 Transcriptional Regulation in Inflammation and Autoimmune Disease. Crit Rev Immunol. 2012; 32(1): 23-63 53. Nagy I, Pivarcsi A, Koreck A, et al. Distinct strains of Propionibacterium acnes
Induce Selective Human Beta-Defensin-2 and Interleukine-8 Expression in Human Keratinocytes Through Toll-Like Receptors. J Invest Dermatol. 2005. 124: 931-8 54. Trinchieri G. Interleukin-12 and the Regulation of Innate Resistance and Adaptive
Immunity. Nat Rev Immunol. 2003; 3:133-46
55. Yutrishia L, Simanungkalit R, Jusuf NK. Hubungan Resistensi Insulin dan Akne Vulgaris [thesis]. Medan: Universitas Sumatera Utara; 2016
56. Manurung MSF, Lubis SR. Faktor Risiko Akne Vulgaris di Kalangan Mahasiswa Fakultas Kedokteran Universitas Sumatera Utara [karya tulis ilmiah]. 2013. Available from: http://repository.usu.ac.id/handle/123456789/59143
57. Aprilia F. Wahyuni DD, Yosi A. Prevalensi Pemakaian KOsmetik Pekerja yang Memiliki Akne Vulgaris dibeberapa Restoran Kota Medan. [karya tulis ilmiah]. 2016.
Available from: http://repository.usu.ac.id/handle/123456789/67897
58. El-Hamd MA, Nada EEA, Moustafa MAK, Mahboob-Allah RA. Prevalence of Acne
59. Li D, Chen Q, Liu Y, Liu T, Tang W, Lie S. The Prevalence of Acne in Mainland China: a Systematic Review and Meta-Analysis. BMJ Open. 2017; 7:e015354
60. Suppiah TSS, Sundram TKM, Tan ESS, Lee CK, Bustami NA, Tan CK. Acne Vulgaris and its Association with Dietary Intake: a Malaysian Perspective. Asia Pac J Clin Nutr. 2018; 27(5): 1141-5.
61. Al Robaee AA. Prevalence, Knowledge, Beliefs and Psychosocial Impact of Acne in University Students in Central Saudi Arabia. Saudi Med J. 2005; 26(12): 1958-61 62. Ascenso A, Marques HC. Acne in the Adult. Mini Rev Med Chem. 2009; 9(1):1-10 63. Khunger N, Kumar C. A Clinico-Epidemiological Study of Adult Acne : is it
Different from Adolescent Acne?. Indian J Dermatol Venereol Leprol. 2012; 78: 335-41
64. Vilar GN, dos Santos LA, Filho JFS. Quality of Life, Self-esteem and Psychosocial Factors in Adolescents with Acne Vulgaris. An Bras Dermatol. 2015; 90(5): 622-9 65. Okoro E, Ogunbiyi A, George A. Prevalence and Pattern of Acne Vulgaris among
Adolescents in Ibadan, South-west Nigeria. Journal of the Egyptian Women’s Dermatologic Society. 2016; 13:7-12
66. Fachry MN, Putra IB. Kualitas Hidup Pasien Akne Vulgaris pada Mahasiswi Angkatan 2011 Fakultas Kedokteran Universitas Sumatera Utara. [karya tulis ilmiah].
2015. Available from: http://repository.usu.ac.id/handle/123456789/54285
67. Jappe U. Pathological Mechanism of Acne with Special Emphasis on Propionibacterium acnes and Related Therapy. Acta Derm Venereol. 2003;83; 241-8 68. Miura Y, Ishige I, Soejima N, Suzuki Y, Uchida K, Kawana S, Eishi Y. Quantitative
PCT of Propionibacterium acnes DNA in Samples Aspirated from Sebaceous Follicles on the Normal Skin of Subjects with or without Acne. J Mes Dent Sci. 2010;
57:65-74
69. Demina OM, Kartelishev AV, Karpova EI, Danischuk OI. Role of Cytokines in the Pathogenesis of Acne. International Journal of Biomedicine. 2017; 7(1):37-40
70. Poveshchenko A, Orlov N, Kazakov O, Poveshchenko O, Kim I, Bondarenko N et al.
Age and Gender Differences in Cytokine Profile of Lymph and Blood Serum.
Advances in Aging Research. 2014; 3:216-21
71. Kleiner G, Marcuzzi A, Zanin V, Monasta L, Zauli G. Cytokine Levels in Serum of Healthy Subjects. Hindawi Publishing Corporation. 2013. Available from:
http://dx.doi.org/10.1155/2013/434010
72. Al-Shobaili HA, Salem TA, Alzolibani AA, Al Robaee A, Settin AA. Tumor Necrosis Factor-α -308 G/A and Interleukin 10 -1082 A/G Gene Polymorphisms in Patients with Acne Vulgaris. Journal of Dermatological Science. 2012; 68:52-5