BAB V KESIMPULAN DAN SARAN
B. Saran
1. Dilakukan optimasi jumlah siklus untuk pembuatan nanokrim dengan emulsifikasi energi tinggi agar dihasilkan ukuran droplet yang seragam.
2. Perlu dilakukan uji aktivitas untuk mengetahui seberapa besar daya antioksidan dari kojic acid dipalmitate yang terkandung dalam sediaan nanokrim KAD.
3. Perlu dilakukan uji penetrasi nanokrim kojic acid dipalmitate melewati kulit.
46
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LAMPIRAN
Lampiran 1. Sertifikat analisis kojic acid dipalmitate dari PT. Cortico Mulia Sejahtera
Lampiran 2. Perhitungan HLB nanokrim KAD
Lampiran 3. Data pengamatan organoleptis sediaan nanokrim KAD Formula Pengamatan Sebelum
accelerated testing Lampiran 4. Data pengukuran pH sediaan nanokrim KAD Sebelum mengalami accelerated testing
Lampiran 5. Data pengukuran ukuran droplet sediaan nanokrim KAD Sebelum mengalami accelerated testing
Diameter Frekuensi AxB C2 A2 A2 x B 10,34 582 6017,88 36214879,69 106,9156 62224,8792 11,68 4552 53167,36 2826768169 136,4224 620994,765
13,2 7295 96294 9272534436 174,24 1271080,8
14,91 7668 114329,9 13071321461 222,3081 1704658,51 16,84 6397 107725,5 11604779041 283,5856 1814097,08 19,03 4594 87423,82 7642924303 362,1409 1663675,29 21,5 3085 66327,5 4399337256 462,25 1426041,25 24,29 2242 54458,18 2965693369 590,0041 1322789,19 27,45 2060 56547 3197563209 753,5025 1552215,15 31,01 2313 71726,13 5144637725 961,6201 2224227,29 35,03 2725 95456,75 9111991121 1227,101 3343849,95 39,58 3078 121827,2 14841876406 1566,576 4821922,16 44,72 3266 146055,5 21332214922 1999,878 6531602,85 50,53 3285 165991,1 27553028680 2553,281 8387527,76 57,09 3202 182802,2 33416637013 3259,268 10436176,5 64,5 3104 200208 40083243264 4160,25 12913416 72,87 3063 223200,8 49818601585 5310,037 16264643 82,33 3114 256375,6 65728458530 6778,229 21107404,8 93,02 3251 302408 91450610560 8652,72 28129994 105,1 3438 361333,8 1,30562E+11 11046,01 37976182,4 118,74 3621 429957,5 1,84863E+11 14099,19 51053158,3 134,16 3743 502160,9 2,52166E+11 17998,91 67369903,7 151,57 3760 569903,2 3,2479E+11 22973,46 86380228 171,25 3642 623692,5 3,88992E+11 29326,56 106807341 193,48 3382 654349,4 4,28173E+11 37434,51 126603514 218,6 2986 652739,6 4,26069E+11 47785,96 142688877 246,98 2478 612016,4 3,74564E+11 60999,12 151155820 279,04 1893 528222,7 2,79019E+11 77863,32 147395268 315,27 1276 402284,5 1,61833E+11 99395,17 126828241 356,2 687 244709,4 59882690448 126878,4 87165488,3 402,44 219 88134,36 7767665413 161958 35468791,8 3422,75 100001 8077847 3,43218E+12 747318,9 1292491354 Rata-rata 80,77765962
Perhitungan rerata dan simpangan baku ukuran droplet sediaan nanokrim KAD sebelum accelerated testing.
Setelah mengalami accelerated testing
Diameter Frekuensi AxB C2 A2 A2 x B 16,84 3622 60994,48 3720326590 283,5856 1027147,043 19,03 10224 194562,72 37854652014 362,1409 3702528,562 21,5 10437 224395,5 50353340420 462,25 4824503,25 24,29 4246 103135,34 10636898357 590,0041 2505157,409 72,87 856 62376,72 3890855198 5310,0369 4545391,586 82,33 8765 721622,45 5,20739E+11 6778,2289 59411176,31 93,02 12747 1185725,94 1,40595E+12 8652,7204 110296226,9 105,1 8510 894401 7,99953E+11 11046,01 94001545,1 118,74 357 42390,18 1796927360 14099,1876 5033409,973 513,71 2843 1460477,53 2,13299E+12 263897,9641 750261911,9 580,41 9199 5339191,59 2,8507E+13 336875,7681 3098920191 655,76 12543 8225197,68 6,76539E+13 430021,1776 5393755631 740,89 10662 7899369,18 6,24E+13 548917,9921 5852563632 837,07 4989 4176142,23 1,74402E+13 700686,1849 3495723376 3881,56 100000 30589982,54 1,80969E+14 2327983,251 18876571828
rata-rata 305,8998254
Perhitungan rerata dan simpangan baku ukuran droplet sediaan nanokrim KAD sebelum accelerated testing.
Lampiran 6. Data pengukuran viskositas dan rheologi sediaan nanokrim KAD
Sebelum mengalami accelerated testing
Replikasi Rpm Shear stress Shear rate Viskositas
I 50,0 1610,149 55,554 28,98349
II 50,0 883,086 55,554 15,89599
III 50,0 1230,754 55,554 22,15419
Rata-rata 22,345±6,546
Setelah mengalami accelerated testing
Replikasi Rpm Shear stress Shear rate Viskositas
I 50,0 278,569 55,554 5,01438
II 50,0 701,819 55,554 12,63310
III 50,0 665,488 55,554 11,97912
Rata-rata 9,876±4,223
Lampiran 7. Data pengukuran daya sebar sediaan nanokrim KAD Sebelum mengalami accelerated testing
Setelah mengalami accelerated testing
Lampiran 8. Data pengukuran daya lekat sediaan nanokrim KAD Sebelum mengalami accelerated testing
Rpm Replikasi I Replikasi
II
Lampiran 9. Data perhitungan statistika uji normalitas sediaan nanokrim KAD
Keterangan :
Uji normalitas data awal formula nanokrim KAD untuk parameter pH, viskositas, daya lekat, dan daya sebar menunjukkan bahwa data terdistribusi normal yaitu p-value > 0,05.
Keterangan :
Uji normalitas data akhir formula nanokrim KAD setelah mengalami accelerated testing untuk parameter pH, viskositas, daya lekat, dan daya sebar menunjukkan bahwa data terdistribusi normal yaitu p-value > 0,05.
Lampiran 10. Data perhitungan statistika uji T berpasangan sediaan nanokrim KAD sebelum dan setelah accelerated testing
Keterangan :
Uji T berpasangan untuk data normal antara pH, viskositas, daya lekat, dan daya sebar untuk sediaan nanokrim KAD sebelum dan setelah accelerated testing menunjukkan tidak ada perbedaan signifikan yaitu dengan p-value > 0,05.
Lampiran 11. Dokumentasi
Replikasi I nanokrim KAD Replikasi II nanokrim KAD sebelum accelerated testing sebelum accelerated testing
Replikasi III nanokrim KAD pH nanokrim RI sebelum accelerated testing sebelum accelerated testing
pH nanokrim RII pH nanokrim RIII sebelum accelerated testing sebelum accelerated testing
Homogenitas sediaan nanokrim KAD sebelum accelerated testing
Replikasi I nanokrim KAD Replikasi II nanokrim KAD setelah accelerated testing setelah accelerated testing
Replikasi III nanokrim KAD Homogenitas nanokrim KAD setelah accelerated testing setelah accelerated testing
Stabilitas tipe emulsi pada fase air Stabilitas tipe emulsi pada fase minyak
Stabilitas pH sediaan nanokrim RI Stabilitas pH sediaan nanokrim RII
Stabilitas pH sediaan nanokrim RIII
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BIOGRAFI PENULIS
Penulis bernama lengkap Suzan, lahir di Pemangkat tanggal 26 Juli 1993. Penulis merupakan anak ketiga dari lima bersaudara pasangan Ha Cie Liong dan Chin Siat Ngo. Penulis menyelesaikan pendidikan di TK Amkur Pemangkat (1997-1999), SD TK Amkur Pemangkat (1999-2005), SMP Amkur Pemangkat (2005-2008), SMA Amkur Pemangkat (2008-2011), dan menempuh perguruan tinggi di Fakultas Farmasi Universitas Sanata Dharma Yogyakarta. Selama menempuh kuliah, penulis aktif dalam berbagai kegiatan organisasi dan kepanitian. Penulis pernah menjadi Sekretaris DPMF (Dewan Perwakilan Mahasiswa Fakultas) Farmasi, Bendahara PPRToS ( Pharmacy Performance and Road To School), Humas Latihan Kepemimpinan I. Penulis juga pernah menjadi Asisten Dosen pada Praktikum Bentuk Sediaan Farmasi tahun 2014 dan BioKimia 2015. Penulis mengikuti Program Kreativitas Mahasiswa bidang Kewirausahaan pada tahun 2014 dengan judul “SANSEKAI (Sabun Tangan Tipis Sekali Pakai) dan berhasil lolos hingga ke PIMNAS.