1. Dari hasil penelitian ini disarankan untuk menggunakan klonidin 2µg/kg intravena atau lidokain 2% 1.5 mg/kg intravena sebelum laringoskopi dan intubasi endotrakheal untuk mengendalikan tekanan intra okuler (TIO) dan menumpulkan respon hemodinamik akibat tindakan laringoskopi dan intubasi endotrakheal.
2. Pada hasil penelitian diperoleh bahwa kedua obat memiliki kemampuan yang sama dalam menurunkan dan mencegah kenaikan tekanan intra okuler selama tindakan laringoskopi dan intubasi endotrakheal, namun dengan pertimbangan cost and benefit: (1) cara pemberian yang lebih mudah, (2) mula kerja obat lebih cepat, (3) ketersediaan obat, dan (4) harga yang lebih murah, maka peneliti lebih menyarankan untuk menggunakan lidokain 2% 1.5 mg/kg intravena 2 menit sebelum laringoskopi dan intubasi endotrakheal.
DAFTAR PUSTAKA
1. Stead, SW. Complications in ophthalmic anesthesiology. Seminars in Anesthesia. 1996;15(2):171-82.
2. Quigley, HA. Mortality associated with ophthalmic surgery. A 20-year expreience at the Wilmer institute. Am J Ophthalmol. 1974;77:517-24. 3. Lobo E, Pelegrini F, Chiu T. Ophthalmology and Otolaryngology. Miller RD
Stoelting RK. Basic of Anesthesia. Fifth Edition. Philadelphia : Churchill Livingstone Elsevier; 2007: 463-8.
4. Schafer R, et al. Intraocular Pressure More Reduce During Anesthesia with Propofol than with Sevoflurane: Both Combined with Remifentanil. Acta Anaesthesiol Scand. 2002; 46: 703-6.
5. Murgatroyd H, Bembridge J. Intraocular Pressure. Critical Care & Pain. 2008; 8(3):100-3.
6. Morgan GE, Mikhail MS, Murray MJ. Clinical Anesthesiology. 4th Edition: McGraw-Hill. 2006; 38: 826-33.
7. Lamb K, James MFM, Janicki PK. The Laryngeal Mask Airway for Intraocular Surgery: Effects on Intraocular Pressure and Stress Responses. British Journal of Anaesthesia. 1992; 69: 143-47.
8. Abbott MA, Samuel JR. The Control of Intra-ocular Pressure During Induction of Anaesthesia for Emergency Eye Surgery. Anaesthesia. 1987; 42: 1008- 12.
9. Bharti N, Mohanty B, Bithal PK, Dash M, Dash HH. Intra-ocular pressure changes associated with intubation with the intubating laryngeal mask airway compared with conventional laryngoscopy. Anaesth Intensive Care. 2008; 36: 431-5.
10. Kovac, AL. Controlling the hemodynamic response to laryngoscopy and endotracheal intubation. Journal of Clinical Anesthesia. 1996; 8: 63-79. 11. Sator-Katzenschlager SM, Oehmke MJ, Deusch E, Dolezal S, Heinze G,
Wedrich A. Effects of remifentanil and fentanyl on intraocular pressure during the maintenance and recovery of anaesthesia in patients undergoing non-ophthalmic surgery. European Journal of Anaesthesiology. 2004; 21: 95-100.
12. Georgiiou M, Parlapani A, Argiriadou H, Papagiannopoulou P, Katsikis G, Kaprini E. Sufentanil or Clonidine for Blunting the Increase in Intraocular
Pressure During Rapid-Sequence Induction. Sixth Edition. European Journal of Anaesthesiology. 2002; 19: 819-22.
13. Kudlak, TT. Open-Eye Injury. Yao FF. Anesthesiology Problem-Oriented Patient Management. Sixth Edition. Philadelphia : Lippincott Williams & Wilkins; 2008: 1007-24.
14. Mahajan RP, Grover VK, Sharma SL, Singh H. Intranasal nitroglycerin and intraocular pressure during general anesthesia. Anesthesia Analgesia. 1988; 67: 631-6.
15. Indu B, Batra YK, Puri GD, Singh H. Nifedipine attenuates the intraocular pressure response to intubation following succinylcholine. Can J Anaesth. 1989; 36: 269-72.
16. Mirakhur RK, Shepherd WF, Darrah WC. Propofol or thiopentone: effects on intraocular pressure associated with induction of anaesthesia and tracheal intubation (facilitated with suxamethonium). Br J Anaesth. 1987; 59: 431-6. 17. Sweeney J, Underhill S, Dowd T, Mostafa SM. Modification by fentanyl and
alfentanil of the intraocular pressure response to suxamethonium and tracheal intubation. Br J Anaesth. 1989: 63: 688-91.
18. Robinson R, White M, McCann P, et al. Effect of anaesthesia on intraocular blood flow. Br J Ophthalmol. 1991;75: 92-3.
19. Moeini HA, Soltani HA, Gholami AR, Masoudpour H. The effect of lidocaine and sufentanil in preventing intraocular pressure increase due to succinylcholine and endotracheal intubation. European Journal of Anaesthesiology. 2006; 23: 739-42.
20. Miller, RD. Miller's Anesthesia. 6th edition. Churchill Livingstone. 2005; 65: 2531-37.
21. Whitford AM, Hone SW, O'hara B, et al. Intra-ocular pressure changes following laryngeal mask airway insertion: a comperative study. Anaesthesia. 1997; 52: 794-6.
22. Vinik HR. Intraocular pressure changes during rapid sequence induction and intubation: a comparison of rocuronium, atracurium, and succinylcholine. Journal of Clinical Anesthesia. 1999; 11: 95-100.
23. Kubitz JC, Motsch J. Eye surgery in the elderly. Best Practice & Research Clinical Anaesthesiology. 2003; 17(2): 245-57.
24. Derbyshire DR, Chmielewski A, Fell D, Vater M, Achola K, Smith G. Plasma catecholamine response to tracheal intubation. British Journal Anaesthesia. 1983; 55: 855-60.
25. Tomori Z, Widdicombe JG. Muscular, bronchomotor and cardiovascular reflexes elicited by mechanical stimulation of respiratory tract . Journal of Physiology. 1969; 200: 25-49.
26. Dahlgren N, Messeter K. Treatment of stress response to laryngoscopy and intubation with fentanyl. Anaesthesia. 1981; 36: 1022-26.
27. King BD, Harris LC Jr, Breifenstein FE, et al. Reflex circulatory responses to direct laryngoscopy and tracheal intubation performed during general anesthesia. Anesthesiology. 1951; 12: 556-66.
28. Shribman AJ, Smith G, Achola KJ. Cardiovascular and catecholamine responses to laryngoscopy with or without tracheal intubation. British Journal Anaesthesia.1987; 59: 295-99.
29. Murphy, DF. Anesthesia and intraocular pressure. Anesthesia Analgesia. 1985; 64: 520-30.
30. Pathak D, Slater RM, Ping SS. Effects of alfentanil and lidocaine on the hemodynamic responses to laryngoscopy and tracheal intubation. J Clin Anesth. 1990; 2: 81-5.
31. Denlinger JK, Ellison N, Ominsky AJ. Effects of intratracheal lidocaine on circulatory responses to tracheal intubation. Anesthesiology. 1974; 41: 409- 12.
32. Abou-Madi MN, Keszler H, Yacoub JM. Cardiovascular reactions to laryngoscopy and tracheal intubation following small and large intravenous dose of lidocaine. Can Anaesth Soc J. 1977; 24: 12-9.
33. Tam S, Chung F, Campbell M. Intravenous lidocain: optimal time of injection before tracheal intubation. Anesth Analg. 1987; 66: 1036-8.
34. Wilson IG, Meiklejohn BH, Smith G. Intravenous lignocaine and sympatoadrenal responses to laryngoscopy and intubation. 1991; 177-80. 35. De Vault M, Greifenstein FE, Harris LC. Circulatory responses to
endotracheal intubation in light general anesthesia-the effect of atropin and phentolamine. Clin. Anesth. 1960; 8: 360-2.
36. Safwat AM, Fung Dl, Bilton DC. The use of propanolol in rapid sequence anaesthetic induction. Can Anaesth Soc J. 1984; 31: 638-41.
37. Kindler CH, Schumacher PG, Schneider MC, Urwyler A. Effects of intravenous lidocain and or esmolol on hemodynamic responses to laryngoscopy and intubation: a double-blind,controlled clinical trial. Journal of clinical anesthesia. 1996: 8; 492-6.
38. Warner LO, Bremer LD, Davidson PJ, Rogers GL, Beach TP. Effects of lidocain,succinylcholine,and tracheal intubation on intraocular pressure in children anesthetized with halothane-nitrous oxide. Anesthesia & analgesia. 1989; 69: 687-90.
39. Zimmerman AA, Funk KJ, Tidwell JL. Propofol and alfentanil prevent the increase in intraocular pressure caused by succinylcholin and endotracheal intubation during a rapid sequence induction of anesthesia. Anesthesia & analgesia. 1996; 83:814-7.
40. Mowafi HA, Al-Ghamdi A, Rushood A. Intraocular pressure changes during laparoscopy in patients anesthetized with propofol total intravenous anesthesia versus isoflurane inhaled anesthesia. Anesthesia & analgesia. 2003; 97: 471-4.
41. Yavascaoglu B, Kaya FN, Bozkurt M, Korkmaz S. A comparison of esmolol and dexmedetomidine for attenuation of intraocular pressure and haemodynamic responses to laryngoscopy and trachea intubation. European journal of anaesthesiology. 2007; 25: 517-8.
42. Bedford, RF. Circulatory responses to tracheal intubation. [book auth.] Kirby RB, Brown DL (eds) Eichhorn JH. Problems in Anesthesia. Philadelphia : JB Lippincott. 1988; 2: 203-10.
43. Derbyshire DR, Chmielewski A, Fell D, VAter M, Achola K, Smith G. Plasma catecholamine responses to tracheal intubation. Br J Anaesth. 1983; 55: 855-60.
44. Derbyshire DR, Smith G, Achola KJ. Effect of tropical lignocaine on the sympathoadrenal responses to tracheal intubation. Br J Anaesth. 1987; 59: 300-4.
45. Prys-Roberts, C. Hypertension and anesthesia: 50 years on. Anesthesiology. 1979; 50: 281-4.
46. Ovassapian A, Yelich SJ, Dykes MH, Brunner EE. Blood pressure and heart rate changes during awake fiberoptic nasotracheal intubation. Anesth Analg. 1983; 62: 951-4.
47. Finfer SR, MacKenzie SI, Saddler JM, Watkins TG. Cardiovascular responses to tracheal intubation: a comparison of direct laryngoscopy and fiberoptic
48. Guyton AC, Hall JE. The autonomic nervous system. Text book of medical physiology . 7th edition. Elsevier saunders. 2006; 60: 757-8.
49. Singh, M. Stress response aand anaesthesia atering the peri and post-operative management. Indian J Anaesth. 2003; 47(6): 427-34.
50. Keith, I. Anaesthesia and blood loss in total hip replacement. Anaesthesia. 1977; 32: 444-50.
51. Stoelting RK, Hillier SC. Local Anesthetics. Hillier SC, editors Stoelting RK.
Pharmacology and physiology in anesthetic practice. 4th edition.
Philadelphia : Lippincott Williams; 2006: 182-3.
52. Longnecker DE, Tinker JH, Morgan GE. Toxicity of Local Anesthetics. Tinker JH, Morgan GE editor Longnecker DE. Principles and Practice of Anesththesiology. 2nd edition. Philadelphia: New York. 1998: 1350-3. 53. Cousins MJ, Bridenbaugh PO. Clinical Pharmacology of Local Anesthetic
Agents, Neural Blockade. Wildsmith, editors Covino BG. Clinical Anesthesia and Management of Pain. 3rd edition. Philadelphia, New York : Lippincott-Raven. 105-21.
54. Miler RD, Katzung BG. Anestesi Lokal. BG Katzung. Farmakologi dasar dan klinik. Edisi 8. Salemba Medika; 2002:167.
55. Carfero F, Laird JM. Local Anesthetics plus Anticonvulsant. C Bountra. Pain Current Understanding Emerging Therapies and Novel to Drug iscovery. 2nd edition. New York : 2003.
56. Tsai PS, Buerkle H, Huang LT, Lee TC, Yang LC, Lee JH. Lidocaine concentrations in plasma and cerebrospinal fluid after systemic bolus administration in human. Anesthesia Analgesia. 1998; 87: 601-4.
57. Buttermann AE, Maze M. Alpha-2 adrenergic agonists in anesthesiology. Seminars in anesthesia. 1996; 15(1): 27-40.
58. Stoelting RK, Hillier SC. Antihypertensive drugs. Pharmacology & physiology in anesthetic practice. 4th edition. Lippincott williams & wilkins. 2006; 15: 338-44.
59. Kamibayashi T, Maze M. Clinical uses of alpha2-adrenergic agonists. Anesthesiology. 2000; 93(5): 1345-9.
60. Nelson LE, Lu J, Guo T, et al. The alpha-2 adrenoreceptor agonist dexmedetomodine converges on an endogenous sleep-promoting pathway to exert its sedative effects . Anesthesiology. 2003; 98(2): 428-36.
61. Correa-sales C, Rabin BC, Maze M. A hypnotic response to dexmedetomidine, an alpha2 agonist, is mediated in the locus coeruleus in rats. Anesthesiology. 1992; 76: 948-52.
62. deSarro GB, Ascioti C, Froio F, et al. Evidence that locus coeruleus is the site where clonidine and drugs acting at alpha 1 and alpha 2 adrenoceptors afect sleep and arousal mechanisme. British Journal Pharmacology. 1987; 90: 675-85.
63. Carabine UA, Milligan KR, Moore JA. Adrenergic modulation of preoperative anxiety: a comparison of temazepam, clonidine and timolol. Anesthesia & Analgesia. 1991; 73: 633-7.
64. Wright RMC, Carabine UA, Orr DA, et al. Preanesthetic medication with clonidine. British Journal of Anesthesia. 1990; 65: 628-35.
65. Kubo T, Misu Y. Pharmacologycal characterization on the a-adrenoceptor responsible for a decrease of blood pressure in the nucleus tractus solitari of rat. Archieves pharmacology. 1981; 317: 120-25.
66. Svensson TH, Bunney BS, Aghajanian GK. Inhibition of both noradrenergic and serotonergic neurons in brain by the alpha-adrenergic agonist clonidine. Brain research. 1975; 92: 291-306.
67. Ross CA, Ruggiero DA, Reis DJ. Projection from the nucleus tractus solitarii to the rostal ventrolateral medulla. J comp neurol. 1985; 242: 511-34.
68. Unnerstall J, Kopajtic, Kuhar MJ. Distribution of alpha-2 agonist binding sites in the rat and human central nervous nervus system. Analysis of some functional, autonomic correlates of the pharmacology effects of clonidine and related adrenergic agents. Brain research rev. 1984; 7: 69-101.
69. Ernsberger P, Guiliano R, Willette N, et al. Role of imidazole receptors in the vasodepressor response to clonidine analogs in the rostal ventrolateral medulla. J pharmacol Exp. 1990; 253: 408-18.
70. Tibirica E, Feldman J, Mermet C, et al. Selectivity of rilmenidine for the nucleus reticularis lateralis, a ventrolateral medullary structure containng immidazole-prederring receptor. Euro J Pharmacologi. 1991; 209: 213-21. 71. Bernard JM, Lagarde D, Souron R. Balanced postoperative analgesia: effect of
intravenous clonidine on blood gases and pharmacokinetics of intravenous fentanyl. Anesthesia & analgesia. 1994; 79: 1126-31.
72. Bailey PL, Sperry RJ, Johnson GK, et al. Respiratory effects of clonidine alone and combined with morphine in humans. Anesthesiology. 1991; 74: 43-48.
73. Lange, SV. Presynaptic regulation of catecholamine release. Biochem pharmacol. 1974; 23: 1793-1800.
74. Stamper RL, Lieberman MF, Drake MV. Aqueous humor dynamics. Becker- shaffer's diagnosis and therapy of the glaucomas. 7th edition. Mosby. 1999: 20-82.
75. Skuta GL, Cantor LB, Weiss JS. Basic and clinical science course. American academy of ophthalmology. 2008: 17-26.
76. Nema HV, Nema N. Tonometry. Diagnostic procedures in ophthalmology. New Delhi : Jaypee brothers medical publishers. 2002; 4: 44-9.
77. Kanski, JJ. Glaucoma. Clinical ophthalmology. New York : Lippincott williams and wilkins. 2000: 188-90.
78. Tasman, W. Tonometry. Duane's clinical ophthalmology. New York : Lippincott williams and wilkins. 2004; 3 (47): 1-7.
79. Drenger B, Peer J, Benezra D, Kazenelson R, Davidson JT. The effect of intravenous lidocain on the increase in intraocular pressure induced by tracheal intubation. Anesthesia & analgesia. 1985; 64: 1211-3.
80. Hasslinger C. Catapresan (2-(2,6-dichlorophenylamino)-2-imidazoline- hydrochloride)-a bew drug lowering intraocular pressure. Klin Monatsbl Augenheilkd. 1969; 154: 95-105.
81. Macri FJ, Cervario SJ. Clonidine. Arch Ophthalmol. 1978; 96: 2111-13.