BAB V SIMPULAN DAN SARAN
5.2. Saran
Dari hasil penelitian yang didapat, maka muncul beberapa saran dari peneliti, yaitu :
1. Perlu dilakukan pemeriksaan histokimia Giemsa ataupun imunohistokimia untuk mendeteksi keberadaan bakteri H. pylori yang merupakan salah satu indikator sebagai faktor prognosis.
2. Diharapkan pada pelaporan histopatologi dapat memberikan kerangka yang konsisten untuk pelaporan histologi rutin pada kasus gastritis dengan menggunakan klasifikasi Sydney system dan staging OLGA system sehingga klinisi dapat menegakkan diagnosis dengan lebih rinci lagi agar dapat memberikan pengobatan dan pencegahan secara dini apabila terdapat tanda-tanda lesi prekanker.
3. Diharapkan pada dokter klinisi agar memberikan informasi klinis yang jelas seperti mengenai lama menderita penyakit gastritis dan obat-obatan yang sudah diberikan untuk pengobatan karena berpengaruh terhadap gambaran histopatologi gastritis kronis.
4. Diharapkan agar dokter klinisi dapat memberikan sampel jaringan biopsi dengan lima pengambilan lokasi biopsi yang sudah ditentukan (kurvatura mayor antrum distal, kurvatura minor antrum distal, kurvatura minor incisura angularis, dinding anterior corpus proksimal, dan dinding posterior corpus proksimal) agar patolog dapat memenuhi kriteria penilaian histomorfologi gastritis kronis berdasarkan OLGA System.
DAFTAR PUSTAKA
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histologyrelevant to pathological practice. in editors : Shepherd N, Warren
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pylori Menurut Sistem Sydney. Majalah Patologi. Vol. 23 No. 2. Hal.20-6 27. Yulida E, Oktaviyanti IK, Rosida L. 2013. Gambaran derajat infiltrasi sel
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9(10). Hal.2232-35
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35. Latif MA, Batin H, Shahin R, Shawqy A, Arafa M, Shaleh G, et al. 2016.
Value of Additional Corpus Biopsi for Diagnosis of Helicobacter Pylori in Atrophic Gastritis. Clinics in Surgery - General Surgery. Hal.1-6
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68
Inflammasi Kronik Aktifitas PMN Atrofi Kelenjar Metaplasia Intestinal H. pylori Inflammasi Kronik Aktifitas PMN Atrofi Kelenjar Metaplasia Intestinal H. pylori
1 H/19/013 Benny Surbakti 49 ♂ Karo 1 0 0 0 0 1 0 0 0 0 Gastritis chemical
14 H/17/028 Andri Hatriyanto 43 ♂ Minang 1 0 0 0 0 1 0 0 0 0 Gastritis chemical 17 H/17/193 Windy Seprianto
Purba 28 ♂ Batak 1 0 0 0 0 1 0 0 0 0 Gastritis chemical
/ gastropathy 0
18 H/17/226 Suratik 59 ♀ Jawa 1 0 0 0 0 1 0 0 0 0 Gastritis chemical
/ gastropathy 0 19 H/16/001 Ahmad Dahruddin
Siregar 56 ♂ Mandailing 1 0 0 0 0 1 0 0 0 0 Gastritis chemical
70
48 H/15/237 Purnama Sari
72
84 H/14/297 Rentina Nainggolan 51 ♀ Batak 1 0 0 0 0 1 0 0 0 0 Gastritis chemical
74
101 H/12/132 Warsiyem 58 ♀ Jawa 2 0 0 0 0 2 0 0 0 0 Gastritis chemical
/ gastropathy 0
102 H/12/144 Sumarsono 54 ♀ Jawa 3 1 1 0 0 2 0 0 0 0 Gastritis
Limfositik 1
103 H/12/180 Tigor Nababan 62 ♂ Batak 2 0 0 1 0 1 0 0 0 0 Gastritis Atrofi 0
104 H/12/339 D. Sinaga 70 ♂ Batak 2 0 0 0 0 2 0 0 0 0 Gastritis chemical
/ gastropathy 0
105 H/13/340 Jiman Berutu 65 ♂ Batak 2 0 1 0 0 2 0 1 0 0 Gastritis Atrofi 1
106 H/11/005 Junaidi 39 ♂ Aceh 2 0 0 0 0 2 0 0 0 0 Gastritis chemical
/ gastropathy 0
107 H/11/009 Afrizal 48 ♂ Melayu 2 0 1 0 0 1 0 0 0 0 Gastritis chemical
/ gastropathy 1
108 H/11/069 Nuraidah 52 ♀ Jawa 2 0 1 0 0 2 0 0 0 0 Gastritis Atrofi 1
109 H/11/098 Lim Bie Eng 75 ♀ China 1 0 0 1 0 1 0 0 1 0 Gastritis chemical
/ gastropathy 0
110 H/11/145 Samin Siregar 51 ♂ Mandailing 2 0 0 0 0 0 1 0 0 0 Gastritis Kronis
aktif 0
111 H/11/163 M. Haris 31 ♂ Simalungun 1 0 1 0 0 1 0 0 0 0 gastritis Kronis
aktif 1
112 H/11/218 Erwan Arbie 61 ♂ Minang 1 0 1 0 0 0 1 0 1 0 Gastritis Atrofi 1
113 H/11/250 Harjono Saleh 34 ♂ Jawa 1 0 0 1 0 1 0 0 0 0 Gastritis Atrofi 0
114 H/11/251 Sukardi 44 ♂ Jawa 1 0 1 0 0 1 0 0 0 0 Gastritis Atrofi 1
LAMPIRAN 2.
GAMBARAN MIKROSKOPIS SAMPEL FOTO MAKROSKOPISFOTO MIKROSKOPIS
Gambar Mikroskopis gaster. A. Antrum. B. Corpus
A B
76
Gambar mikroskopis gastritis kronis. A. Infitrasi sel radang MN grade 1. D. Infitrasi sel radang MN grade 2. C. Infiltrasi inflammasi PMN. D. Atrofi pada antrum. E. Atrofi pada corpus. F. Metaplasia intestinal.
A B
C D
E F
LAMPIRAN 3. TABEL OUTPUT
LAPORAN STATISTIK
FREQUENCIES VARIABLES=Jenis_Klamin Suku DD Inflmsi_Krn_Ant Aktf_PMN_Ant Atf_Kel_Ant Met_Ints_Ant H_Plyr_Ant Inflmsi_Krn_Crp Aktf_PMN_Crp Atf_Kel_Crp Met_Ints_Crp H_Plyri_Crp Diagnosa Grd_Atr_Ant St_OLGA
/PIECHART FREQ /ORDER=ANALYSIS.
Frequencies
Notes
Output Created 10-AUG-2020 12:11:58
Comments
Input Data D:\Tulisan\Analisis SPSS\Analisis dr.
Irma Sp.PA\Deskriptif.sav
Missing Value Handling Definition of Missing User-defined missing values are treated as missing.
Cases Used Statistics are based on all cases with valid data.
Resources Processor Time 00:00:03,42
Elapsed Time 00:00:03,36
78
Frequency Percent Valid Percent
Cumulative
Frequency Percent Valid Percent Cumulative Percent
Valid Karo 2 1,8 1,8 1,8
Frequency Percent Valid Percent Cumulative Percent
Valid Susp. Ca Gaster 1 ,9 ,9 ,9
Inflammasi Kronis Antrum
Frequency Percent Valid Percent Cumulative Percent
Valid 1,00 84 73,7 73,7 73,7
2,00 20 17,5 17,5 91,2
3,00 10 8,8 8,8 100,0
Total 114 100,0 100,0
Aktifitas PMN Antrum
Frequency Percent Valid Percent Cumulative Percent
Valid ,00 95 83,3 83,3 83,3
1,00 14 12,3 12,3 95,6
2,00 5 4,4 4,4 100,0
Total 114 100,0 100,0
Atrofi Kelenjar Antrum
Frequency Percent Valid Percent Cumulative Percent
Valid ,00 91 79,8 79,8 79,8
1,00 18 15,8 15,8 95,6
2,00 5 4,4 4,4 100,0
Total 114 100,0 100,0
Metaplasia Intestianal Antrum
Frequency Percent Valid Percent Cumulative Percent
Valid ,00 103 90,4 90,4 90,4
1,00 10 8,8 8,8 99,1
2,00 1 ,9 ,9 100,0
Total 114 100,0 100,0
H.Pylori Antrum
Frequency Percent Valid Percent Cumulative Percent
Valid ,00 111 97,4 97,4 97,4
1,00 2 1,8 1,8 99,1
2,00 1 ,9 ,9 100,0
Total 114 100,0 100,0
Inflammasi Kronis Corpus
Frequency Percent Valid Percent Cumulative Percent
Valid ,00 3 2,6 2,6 2,6
Frequency Percent Valid Percent Cumulative Percent
Valid ,00 97 85,1 85,1 85,1
1,00 15 13,2 13,2 98,2
2,00 2 1,8 1,8 100,0
Total 114 100,0 100,0
80
Atrofi Kelenjar Corpus
Frequency Percent Valid Percent Cumulative Percent
Valid ,00 102 89,5 89,5 89,5
1,00 7 6,1 6,1 95,6
2,00 5 4,4 4,4 100,0
Total 114 100,0 100,0
Metaplasia Intestianal Corpus
Frequency Percent Valid Percent Cumulative Percent
Valid ,00 106 93,0 93,0 93,0
1,00 6 5,3 5,3 98,2
2,00 2 1,8 1,8 100,0
Total 114 100,0 100,0
H..Pylori Corpus
Frequency Percent Valid Percent Cumulative Percent
Valid ,00 114 100,0 100,0 100,0
Diagnosa
Frequency Percent Valid Percent
Cumulative Percent Valid Gastritis Chemical /
Gastropathy 72 63,2 63,2 63,2
Frequency Percent Valid Percent
Cumulative
Frequency Percent Valid Percent
Cumulative
/STATISTICS=STDDEV MINIMUM MAXIMUM MEAN MEDIAN SUM /ORDER=ANALYSIS.
Frequencies
Notes
Output Created 10-AUG-2020 12:20:20
Comments
Input Data D:\Tulisan\Analisis SPSS\Analisis dr.
Irma Sp.PA\Deskriptif.sav
Missing Value Handling Definition of Missing User-defined missing values are treated as missing.
Cases Used Statistics are based on all cases with valid data.
Resources Processor Time 00:00:00,00
Elapsed Time 00:00:00,00
82
LAMPIRAN 4.
SURAT TANDA BUKTI
TELAH DILAKUKAN PEMBACAAN ULANG SLAID
Judul Penelitian
Nama NIM Program Studi
:
: : :
Histomorfologi Gastritis Kronis dengan menggunakan klasifikasi Sydney system dan staging OLGA system di Laboratorium Patologi Anatomik Fakultas Kedokteran Universitas Sumatera Utara Medan
dr. Siti Aisyah 187041096
Program Magister Kedokteran Klinik Ilmu Patologi Anatomik
Telah dilakukan pembacaan ulang slaid pada : Hari / Tanggal : Selasa, 4 Agustus 2020
Didampingi oleh : 1. Dr. dr. Betty, M. Ked. (PA), Sp. PA
2. Dr. dr. Lidya Imelda Laksmi, M. Ked. (PA), Sp. PA
LAMPIRAN 5. SURAT IZIN PENELITIAN
84
LAMPIRAN 6. SURAT PERSETUJUAN KOMITE ETIK