• Tidak ada hasil yang ditemukan

SIMPULAN DAN SARAN

7.1 Simpulan

Setelah dilakukan penelitian tentang faktor-faktor yang berhubungan dengan

loss to follow up pada odha yang menerima terapi ARV di Klinik Amertha

Yayasan Kerti Praja Bali Tahun 2002-2012, dapat disimpulkan bahwa dari 10 variabel yang diteliti, tiga variabel yang terbukti secara statistik berhubungan dengan loss to follow up. Loss to follow up lebih besar pada odha yang tidak memiliki PMO, odha dengan umur ≤32 tahun, dan odha pada kelompok heteroseksual sebagai pekerja seksual. Sedangkan variabel jenis kelamin, tingkat pendidikan, jenis pekerjaan, kadar CD4, berat badan, hemoglobin, dan infeksi oportunisik tidak terbukti secara statistik memiliki hubungan terhadap loss to

follow up.

7.2 Saran

Untuk mengurangi loss to follow up pada odha yang menerima terapi ARV dapat disarankan kepada provider untuk melakukan pendampingan yang lebih intensif pada mereka, terutama untuk pekerja seks. Konseling yang lebih intensif juga perlu diberikan pada odha yang berumur lebih muda sebelum memulai terapi ARV. Selain itu diperlukan penelitian lain yang menggunakan data primer seperti penelitian kualitatif untuk dapat mengetahui alasan mengapa odha loss to follow

62

DAFTAR PUSTAKA

Arikunto, S. 2006. Prosedur Penelitian Suatu Pendekatan Praktek, Edisi Revisi

VI, Jakarta : PT Rineka Cipta

Caluwaerts C., R. Mendaeanda, F. Maldonado, M. Biot, N. Ford, K. Chu. 2009. Risk factors and true outcomes for loss to follow-up individuals in an antiretroviral treatment programme in Tete, Mozambique. Int Health. 2009 Sep;1(1):97-101. doi: 10.1016/j.inhe.2009.03.002. Available from : http://www.ncbi.nlm.gov/pubmed

Charurat, M., M. Oyegunle, R. Benjamin, A. Habib, E. Eze, P. Ele, I. Ibanga, S. Ajayi, M. Eng, P. Mondal, U. Gebi, E. Iwu, M. Etiebet, A. Abimiku, P. Dakum, J. Farley, W. Blattner. 2010. Patient retention and adherence to antiretrovirals in a large antiretroviral therapy program in Nigeria: a longitudinal analysis for risk factors. PloS one, 5(5), e10584. doi:10.1371/journal.pone.0010584

Clouse K.,A. Pettifor, M. Maskew, J. Bassett, A. Van Rie, C. Gay, F. Behets, I. Sanne. 2013. Initiating antiretroviral therapy when presenting with higher CD4 cell counts results in reduced loss to follow-up in a resource-limited setting. AIDS (London, England), 27(4), pp.645–50. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23169326 [Accessed October 1, 2013].

Dahlan. 2008.Statistik untuk Kedokteran dan Kesehatan. Jakarta : Salemba Medika

Depkes RI. 2006. Situasi HIV/AIDS di Indonesia Tahun 1987-2006. Jakarta : Depkes RI

_________ 2011. Pedoman Nasional Tatalaksana Klinis Infeksi HIV dan Terapi

Antiretroviral pada Orang Dewasa. Jakarta : Depkes RI

Fu. T, Westergaard, P. Ryan, B. Lau, Celentano, D. David, D. Vlahov, H. S. Mehta, D. G.Kirk. 2012. Changes in sexual and drug-related risk behavior following antiretroviral therapy initiation among HIV-infected injection drug users. AIDS (London, England), 26(18), pp.2383–91. Available at: http://europepmc.org/articles/PMC3678983/?report=abstract [Accessed May 17, 2014]

Gerver, S.M.,T.R. Chadborn, F. Ibrahim, B. Vasta, V.C. Delpech, P.J. Easterbrook. 2010. High rate of loss to clinical follow up among African HIV-infected patients attending a London clinic: a retrospective analysis of a clinical cohort. Journal of the International AIDS Society, 13, p.29.

Available from:

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2924265&tool =pmcentrez&rendertype=abstract [Accessed October 7, 2013].

Hana, S. 2009. Faktor-faktor yang Berhubungan dengan Kesembuhan Penderita

TB Paru di Balai Pengobatan Penyakit Paru-paru (BP4) Kota Tegal

(onine). Available at:http://www.eprints.undip.ac.id

Hønge, B.L., S. Jaspersen, P.B., Nordentoft, C. Medina, D. Silva, Z.J. Silva, L. Ostergraad, A.L. Laursen, C. Wejse. 2013. Loss to follow-up occurs at all stages in the diagnostic and follow-up period among HIV-infected patients in Guinea-Bissau: a 7-year retrospective cohort study. BMJ open, 3(10),

p.e003499. Available from:

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3808780&tool =pmcentrez&rendertype=abstract [Accessed November 7, 2013].

Ioannidis, J.P., R. Bassett, M. Hughes, P.A. Volberding., H.S. Sacks, J. Lau. 1997. Predictors and impact of patients lost to follow-up in a long-term randomized trial of immediate versus deferred antiretroviral treatment.

Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 16(1), pp.22–30. Available from: http://www.ncbi.nlm.nih.gov/pubmed/9377121 [Accessed October 7, 2013].

Keiser, O.,B.Spycher, A. Rauch, A. Calmy, M. Cavassini, T. Glass, D. Nicca, B. Ledergerber, M. Egger. 2012. Outcomes of antiretroviral therapy in the Swiss HIV Cohort Study: latent class analysis. AIDS and behavior, 16(2), 245–55. doi:10.1007/s10461-011-9971-5

Kemenkes RI. 2014. Laporan Perkembagan HIV-AIDS Triwulan IV Tahun 2013. Jakarta : Kemenkes RI

Keputusan Menteri Kesehatan Nomor 451/Menkes/SK/XII/2012 tentang Rumah Sakit Rujukan Bagi Orang Dengan HIV dan AIDS

Komisi Penanggulangan AIDS. 2013. Modul Pelatihan Konseling dan Tes

Krishnan, S., K.Wu, M. Smurzynski, R.J. Bosch, C.A. Benson, A.C. Collier, M.K. Klebert, J. Feinberg, Koletar, S L. 2011. Incidence rate of and factors associated with loss to follow-up in a longitudinal cohort of antiretroviral-treated HIV-infected persons: an AIDS Clinical Trials Group (ACTG) Longitudinal Linked Randomized Trials (ALLRT) analysis. HIV clinical

trials, 12(4), pp.190–200. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3207266&tool =pmcentrez&rendertype=abstract [Accessed October 7, 2013].

Krisnawan, Upik. 2005. Peran PMO Keluarga dalam Keberhasilan Pengobatan

TBC di BP4 Semarang (onlne). Aveilable at:http://www.eprints.undip.ac.id

Lanoy, E., M. Mary-Krause, P. Tattevin, R. Dray-Spira, C. Duvivier, P. Fischer, Y. Obadia, F. Lert, D. Costagliola. 2006. Predictors identified for losses to follow-up among HIV-seropositive patients. Journal of Clinical

Epidemiology, 59(8), pp.829–835.e1. Available from: http://www.sciencedirect.com/science/article/pii/S0895435606000278 [Accessed October 16, 2013].

Lebouché, B., Y. Yazdanpanah, Y. Gérard, D. Sissoko, F. Ajana, I. Alcaraz, P. Boitte, B. Cadoré, Y. Mouton. 2006. Incidence rate and risk factors for loss to follow-up in a French clinical cohort of HIV-infected patients from January 1985 to January 1998. HIV medicine, 7(3), pp.140–5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16494627 [Accessed October 16, 2013].

Mahardining, A.B., Hubungan Antara Pengetahuan, Motivasi dan Dukungan Keluarga dengan Kepatuhan Terapi ARV ODHA. Jurnal Kesehatan

Masyarakat. Volume 5 : 131-137. Avaiable from : http://www.journal.unnes.ac.id [Accessed February 13, 2013]

Martin W.G.B., D.François, M. Landon, R.B. David, B. Andrew N. Denis, S. Mauro, L. Christian, K. Olivia, M. Margaret, S. Eduardo, E. Matthias, A. Xavier. 2008. Early loss of HIV-infected patients on potent antiretroviral therapy programmes in lower-income. Bull World Health Organ vol.86 n.7 Genebra Jul. 2008. Available from : http://www.ncbi.nlm.gov/pubmed

Maru, D.S.R., D.C. Khakha, M. Tahir, S. Basu, S.K. Sharma. 2007. Poor follow-up rates at a self-pay northern Indian tertiary AIDS clinic. International

journal for equity in health, 6, p.14. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2200646&tool =pmcentrez&rendertype=abstract [Accessed October 7, 2013].

Mimiaga, M.J. S.A.Safren, S. Dvoryak, S.L. Reisner, R. Needle, G. Woody. 2010. “We fear the police, and the police fear us”: structural and individual barriers and facilitators to HIV medication adherence among injection drug users in Kiev, Ukraine. AIDS care, 22(11), pp.1305–13. Available at: http://dx.doi.org/10.1080/09540121003758515 [Accessed April 30, 2014].

Mocroft, A., O. Kirk, P. Aldins, A. Chies, A. Blaxhult, N. Chentsova, N. Vetter, F. Dabis, J. Gatell, J.D. Lundgren. 2008. Loss to follow-up in an international, multicentre observational study. HIV medicine, 9(5), 261–9. doi:10.1111/j.1468-1293.2008.00557.x

Mosoko, J.J., W. Akam, P.J. Weidle, J.T. Brooks, A.J. Aweh, T.N. Kinge, S. Pals, P.L. Raghunathan. 2011. Retention in an antiretroviral therapy programme during an era of decreasing drug cost in Limbe, Cameroon.

Journal of the International AIDS Society, 14, p.32. Available from:

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3143073&tool =pmcentrez&rendertype=abstract [Accessed October 1, 2013].

Nasronudin. 2007. HIV & AIDS Pendekatan Biologi Molekuler, Klinis, dan

Sosial. Surabaya : AIrlangga University Press

Odafe, S., O. Idoko, T. Badru, B. Aiyenigba, C. Suzuki, H. Khamofu, O. Onyekwena, E. Okechukwu, K. Torpey, O.N. Chabikuli. 2012. Patients’ demographic and clinical characteristics and level of care associated with lost to follow-up and mortality in adult patients on first-line ART in Nigerian hospitals. Journal of the International AIDS Society, 15(2),

p.17424. Available from:

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3494164&tool =pmcentrez&rendertype=abstract [Accessed October 7, 2013].

Putri, N.A. 2010. Hubungan Kinerja Pengawas Minum Obat (PMO) dengan

Kesembuhan Pasien TB Paru Kasus Baru Stategi DOTS. Surakarta :

Universitas Sebelas Maret (online). Available from: http://www.eprints.uns.ac.id [Accessed February 13, 2013].

Rosenstock I.M., V.J. Srecher, M.H. Becker. 1988. Sosial Learning theory and

health Belief Model. Health Education Quarterly, Vol 15 (2) : 175-183

Roura, M., J. Busza, A. Wringe, D. Mbata, M. Urassa, B. Zaba. 2009. Barriers to sustaining antiretroviral treatment in Kisesa, Tanzania: a follow-up study to understand attrition from the antiretroviral program. AIDS patient care

Saka, B., D.E. Landoh, A. Patassi, S. D'Almeida, A. Singo, B.D. Gessner. 2013. Loss of HIV-infected patients on potent antiretroviral therapy programs in Togo: risk factors and the fate of these patients. The Pan African medical

journal, 15, p.35. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3758855&tool =pmcentrez&rendertype=abstract [Accessed October 2, 2013].

Sastroasmoro dan Ismael. 2011. Dasar-dasar Metodologi Penelitian Klinis. Jakarta : Sagung Seto

Surat Edaran Menteri Kesehatan Republik Indonesia Nomor : 129 Tahun 2013 tentang Pelaksanaan Pengendalian HIV-AIDS dan Infeksi Menular Seksual (IMS)

UNAIDS. 2013. Global Report. UNAIDS Report on the Global AIDS Epidemic

2013 (online). Available at : http://www.unaids.org

_______. 2013. HIV in Asia and the Pasific (online). Available at : http://www.unaids.org

USAID. 2006. Interventions to Improve Adherence to Antiretroviral Therapy: A

Review of the Evidence (online). Available at : http://pdf.usid.gov

WHO. 2013. Global Update on HIV Treatment 2013, Result, Impact, and

Opportunities. WHO

Yayasan Kerti Praja. 2013. ARV Service. (online). Available at: http://www.kertiprajafoundation.com

Zhou, J., J. Tanuma, R. Chaiwarith, C.K.C Lee, M.G. Law, N. Kumarasamy, P. Phanuphak, Y.A. Chen, S. Kiertiburanakul, F. Zhang, S. Vonthanak, R. Ditangco, S. Pujari, J.Y. Choi, T.P. Merati, E. Yunihastuti, P.C.K. Li, A. Kamarulzaman, V.K. Nguyen, T.T.T. Pham, P.L. Lim. 2012. Loss to Followup in HIV-Infected Patients from Asia-Pacific Region: Results from TAHOD. AIDS research and treatment, 2012, p.375217. Available from:

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3296146&tool =pmcentrez&rendertype=abstract [Accessed October 7, 2013].

Lampiran 1

FORMULIR PENGUMPULAN DATA PASIEN

HIV/AIDS YANG MELAKUKAN TERAPI ARV DI

KLINIK YAYASAN KERTI PRAJA BALI TAHUN

2002-2012

DATA DEMOGRAFI PASIEN

NO VARIABEL DATA 1 Nama Pasien

2 No RM

3 Tanggal Lahir / Umur (saat kunjungan pertama) 4 Nama Konselor 5 Jenis Kelamin 6 Risiko atau Paparan

(saat kunjungan pertama)

1. Risiko seksual

(Jabarkan apa risikonya: misalnya apakah ganti-ganti pasangan, bagaimana pemakaian kondom, mencari pekerja seks, mencari waria, cewek café) 2. Risiko IDU

(Jabarkan apa risikonya: misalnya apakah

menggunakan jarum suntik, menyuntik bersama)

3. Risiko lainnya (jelaskan: misal tatto, piercing, transfuse darah)

7 Pekerjaan 8 Pendidikan

9 Kadar CD4 Tanggal Test CD4 Pertama Kali: Hasil:

Jumlah CD4 %CD4 Tanggal Test Tanggal Hasil Hemoglobin Tanggal Kunjungan

Terapi ARV

Tanggal Mulai ART Pemeriksaan Fisik

Infeksi Opportunistik

Jenis IO Tanggal Diagnosis

Kunjungan Ke- Alasan Kunjungan Darah

Hubungan Berat Badan

Kadar CD4+ Hasil Test Tanggal Test Tanggal Hasil

Supervisor ART atau Pengawas Minum Obat

Lampiran 5

HASIL OUTPUT STATA

Univariat

Age 31.7792 .3317989 31.12744 32.43095 Mean Std. Err. [95% Conf. Interval] Mean estimation Number of obs = 548 . mean Age Total 548 100.00 >32 213 38.87 100.00 <=32 335 61.13 61.13 Age2cat Freq. Percent Cum. . tab Age2cat

Total 548 100.00 missing 3 0.55 100.00 PS 147 26.82 99.45 other 398 72.63 72.63 ion Freq. Percent Cum. new_occupat . tab new_occupation Total 548 100.00 female 233 42.52 100.00 male 315 57.48 57.48 sex Freq. Percent Cum. . tab sex

Total 548 100.00

dont have 175 31.93 100.00 have 373 68.07 68.07 fARV Freq. Percent Cum. Supervisoro . tab SupervisorofARV Total 548 100.00 have 87 15.88 100.00 dont have 461 84.12 84.12 V Freq. Percent Cum. nstartingAR TypeofIOwhe . tab TypeofIOwhenstartingARV Total 548 100.00 elementary,no edu 264 48.18 100.00 jun,sen,col 284 51.82 51.82 edu2cat Freq. Percent Cum. . tab edu2cat Total 548 100.00 IDU 139 25.36 100.00 homosex 103 18.80 74.64 heteroNonPS 182 33.21 55.84 heteroPS 124 22.63 22.63 NewRisk2 Freq. Percent Cum. . tab NewRisk2

Total 548 100.00

lost to follow up 77 14.05 100.00 no lost to follow up 471 85.95 85.95 outcome Freq. Percent Cum. . tab outcome

Haemoglobin 12.73682 .0850218 12.56981 12.90384 Mean Std. Err. [95% Conf. Interval] Mean estimation Number of obs = 538 . mean Haemoglobin Total 548 100.00 . 10 1.82 100.00 >12 357 65.15 98.18 <=12 181 33.03 33.03 Hb2cat Freq. Percent Cum. . tab Hb2cat, missing

Weight 55.25627 .4480319 54.37618 56.13637 Mean Std. Err. [95% Conf. Interval] Mean estimation Number of obs = 542 . mean Weight Total 548 100.00 . 6 1.09 100.00 >55 232 42.34 98.91 <=55 310 56.57 56.57 W2cat Freq. Percent Cum. . tab W2cat, missing

Total 548 100.00 . 3 0.55 100.00 >=200 180 32.85 99.45 100-<200 132 24.09 66.61 <100 233 42.52 42.52 CD4100an Freq. Percent Cum. . tab CD4100an, missing

Insiden rate

total 1493.859001 .0515444 548 6.157426 . . time at risk rate subjects 25% 50% 75% incidence no. of Survival time origin: time dateof1stdayvisitYKP

analysis time _t: (dateotthelastdayvisitingY-origin)/365.25 failure _d: outcome == 1

. stsum

Bivariat

last observed exit t = 11.30459 earliest observed entry t = 0 1493.859 total analysis time at risk, at risk from t = 0 77 failures in single record/single failure data

548 obs. remaining, representing

0 exclusions

548 total obs.

origin: time dateof1stdayvisitYKP

t for analysis: (time-origin)/365.25 exit on or before: failure

obs. time interval: (origin, dateotthelastdayvisitingY] failure event: outcome == 1

. stset dateotthelastdayvisitingY, failure( outcome==1) origin( dateof1stdayvisitYKP) scale(365.25)

JENIS KELAMIN

sex 1.605116 .368226 2.06 0.039 1.023845 2.516394 _t Haz. Ratio Std. Err. z P>|z| [95% Conf. Interval] Log likelihood = -435.52369 Prob > chi2 = 0.0386 LR chi2(1) = 4.28 Time at risk = 1493.859001

No. of failures = 77

No. of subjects = 548 Number of obs = 548 Cox regression -- Breslow method for ties

Iteration 0: log likelihood = -435.52369 Refining estimates:

Iteration 2: log likelihood = -435.52369 Iteration 1: log likelihood = -435.52419 Iteration 0: log likelihood = -437.66205 origin: time dateof1stdayvisitYKP

analysis time _t: (dateotthelastdayvisitingY-origin)/365.25 failure _d: outcome == 1

. xi: stcox sex

female 42 6.3330 6.6319 4.9011 8.9739 male 35 8.6056 4.0671 2.9202 5.6646 sex D Y Rate Lower Upper (548 records included in the analysis)

Estimated rates (per 100) and lower/upper bounds of 95% confidence intervals origin: time dateof1stdayvisitYKP

analysis time _t: (dateotthelastdayvisitingY-origin)/365.25 failure _d: outcome == 1

UMUR

_IAge2cat_2 .609908 .1585631 -1.90 0.057 .3664124 1.015216 _t Haz. Ratio Std. Err. z P>|z| [95% Conf. Interval] Log likelihood = -435.71845 Prob > chi2 = 0.0487 LR chi2(1) = 3.89 Time at risk = 1493.859001

No. of failures = 77

No. of subjects = 548 Number of obs = 548 Cox regression -- Breslow method for ties

Iteration 0: log likelihood = -435.71845 Refining estimates:

Iteration 3: log likelihood = -435.71845 Iteration 2: log likelihood = -435.71845 Iteration 1: log likelihood = -435.73007 Iteration 0: log likelihood = -437.66205 origin: time dateof1stdayvisitYKP

analysis time _t: (dateotthelastdayvisitingY-origin)/365.25 failure _d: outcome == 1

i.Age2cat _IAge2cat_1-2 (naturally coded; _IAge2cat_1 omitted) . xi: stcox i.Age2cat

>32 20 5.4147 3.6936 2.3830 5.7252 <=32 57 9.5239 5.9850 4.6165 7.7590 Age2cat D Y Rate Lower Upper (548 records included in the analysis)

Estimated rates (per 100) and lower/upper bounds of 95% confidence intervals origin: time dateof1stdayvisitYKP

analysis time _t: (dateotthelastdayvisitingY-origin)/365.25 failure _d: outcome == 1

PENDIDIKAN

edu2cat .8221985 .1883037 -0.85 0.393 .5248444 1.28802 _t Haz. Ratio Std. Err. z P>|z| [95% Conf. Interval] Log likelihood = -437.29571 Prob > chi2 = 0.3920 LR chi2(1) = 0.73 Time at risk = 1493.859001

No. of failures = 77

No. of subjects = 548 Number of obs = 548 Cox regression -- Breslow method for ties

Iteration 0: log likelihood = -437.29571 Refining estimates:

Iteration 2: log likelihood = -437.29571 Iteration 1: log likelihood = -437.29571 Iteration 0: log likelihood = -437.66205 origin: time dateof1stdayvisitYKP

analysis time _t: (dateotthelastdayvisitingY-origin)/365.25 failure _d: outcome == 1

. xi: stcox edu2cat

elementary,no edu 36 7.8458 4.5884 3.3098 6.3611 jun,sen,col 41 7.0928 5.7805 4.2563 7.8506 edu2cat D Y Rate Lower Upper (548 records included in the analysis)

Estimated rates (per 100) and lower/upper bounds of 95% confidence intervals origin: time dateof1stdayvisitYKP

analysis time _t: (dateotthelastdayvisitingY-origin)/365.25 failure _d: outcome == 1

PEKERJAAN

_Inew_occup_99 1.479216 1.499579 0.39 0.699 .2028207 10.78824 _Inew_occup_2 1.688489 .3970441 2.23 0.026 1.064977 2.677049 _t Haz. Ratio Std. Err. z P>|z| [95% Conf. Interval] Log likelihood = -435.27109 Prob > chi2 = 0.0915 LR chi2(2) = 4.78 Time at risk = 1493.859001

No. of failures = 77

No. of subjects = 548 Number of obs = 548 Cox regression -- Breslow method for ties

Iteration 0: log likelihood = -435.27109 Refining estimates:

Iteration 3: log likelihood = -435.27109 Iteration 2: log likelihood = -435.27109 Iteration 1: log likelihood = -435.29552 Iteration 0: log likelihood = -437.66205 origin: time dateof1stdayvisitYKP

analysis time _t: (dateotthelastdayvisitingY-origin)/365.25 failure _d: outcome == 1

i.new_occupat~n _Inew_occup_1-99 (naturally coded; _Inew_occup_1 omitted) . xi: stcox i.new_occupation

missing 1 0.1797 5.56359 0.78371 39.49636 PS 30 4.0864 7.34141 5.13301 10.49995 other 46 10.6724 4.31017 3.22843 5.75436 new_oc~n D Y Rate Lower Upper (548 records included in the analysis)

Estimated rates (per 100) and lower/upper bounds of 95% confidence intervals origin: time dateof1stdayvisitYKP

analysis time _t: (dateotthelastdayvisitingY-origin)/365.25 failure _d: outcome == 1

.

new_occupation 1.689914 .3973969 2.23 0.026 1.065854 2.679363 _t Haz. Ratio Std. Err. z P>|z| [95% Conf. Interval] Log likelihood = -429.27863 Prob > chi2 = 0.0292 LR chi2(1) = 4.75 Time at risk = 1475.88501

No. of failures = 76

No. of subjects = 545 Number of obs = 545 Cox regression -- Breslow method for ties

Iteration 0: log likelihood = -429.27863 Refining estimates:

Iteration 3: log likelihood = -429.27863 Iteration 2: log likelihood = -429.27863 Iteration 1: log likelihood = -429.30457 Iteration 0: log likelihood = -431.65521 origin: time dateof1stdayvisitYKP

analysis time _t: (dateotthelastdayvisitingY-origin)/365.25 failure _d: outcome == 1

. xi: stcox new_occupation if new_occupation~=99

PENGAWAS MINUM OBAT

dont have 30 3.2418 9.2542 6.4704 13.2356 have 47 11.6968 4.0182 3.0190 5.3480 Supervi~V D Y Rate Lower Upper (548 records included in the analysis)

Estimated rates (per 100) and lower/upper bounds of 95% confidence intervals origin: time dateof1stdayvisitYKP

analysis time _t: (dateotthelastdayvisitingY-origin)/365.25 failure _d: outcome == 1

_ISuperviso_2 2.042776 .4830546 3.02 0.003 1.285102 3.247163 _t Haz. Ratio Std. Err. z P>|z| [95% Conf. Interval] Log likelihood = -433.3936 Prob > chi2 = 0.0035 LR chi2(1) = 8.54 Time at risk = 1493.859001

No. of failures = 77

No. of subjects = 548 Number of obs = 548 Cox regression -- Breslow method for ties

Iteration 0: log likelihood = -433.3936 Refining estimates:

Iteration 3: log likelihood = -433.3936 Iteration 2: log likelihood = -433.39361 Iteration 1: log likelihood = -433.51158 Iteration 0: log likelihood = -437.66205 origin: time dateof1stdayvisitYKP

analysis time _t: (dateotthelastdayvisitingY-origin)/365.25 failure _d: outcome == 1

i.Supervisoro~V _ISuperviso_1-2 (naturally coded; _ISuperviso_1 omitted) . xi: stcox i.SupervisorofARV

CD4 >=200 29 4.2327 6.8513 4.7611 9.8592 100-<200 20 4.1524 4.8164 3.1074 7.4655 <100 28 6.4031 4.3729 3.0193 6.3333 CD4100an D Y Rate Lower Upper (545 records included in the analysis)

Estimated rates (per 100) and lower/upper bounds of 95% confidence intervals origin: time dateof1stdayvisitYKP

analysis time _t: (dateotthelastdayvisitingY-origin)/365.25 failure _d: outcome == 1

CD4100an 1.226311 .1646613 1.52 0.129 .9425551 1.595492 _t Haz. Ratio Std. Err. z P>|z| [95% Conf. Interval] Log likelihood = -435.82328 Prob > chi2 = 0.1291 LR chi2(1) = 2.30 Time at risk = 1478.830938

No. of failures = 77

No. of subjects = 545 Number of obs = 545 Cox regression -- Breslow method for ties

Iteration 0: log likelihood = -435.82328 Refining estimates:

Iteration 2: log likelihood = -435.82328 Iteration 1: log likelihood = -435.82348 Iteration 0: log likelihood = -436.97509 origin: time dateof1stdayvisitYKP

analysis time _t: (dateotthelastdayvisitingY-origin)/365.25 failure _d: outcome == 1

. xi: stcox CD4100an if CD4100an~=999

_ICD4100an_3 1.503239 .3994009 1.53 0.125 .8930368 2.530386 _ICD4100an_2 1.130838 .3313503 0.42 0.675 .6367768 2.00823 _t Haz. Ratio Std. Err. z P>|z| [95% Conf. Interval] Log likelihood = -435.77452 Prob > chi2 = 0.3010 LR chi2(2) = 2.40 Time at risk = 1478.830938

No. of failures = 77

No. of subjects = 545 Number of obs = 545 Cox regression -- Breslow method for ties

Iteration 0: log likelihood = -435.77452 Refining estimates:

Iteration 3: log likelihood = -435.77452 Iteration 2: log likelihood = -435.77452 Iteration 1: log likelihood = -435.77968 Iteration 0: log likelihood = -436.97509 origin: time dateof1stdayvisitYKP

analysis time _t: (dateotthelastdayvisitingY-origin)/365.25 failure _d: outcome == 1

i.CD4100an _ICD4100an_1-3 (naturally coded; _ICD4100an_1 omitted) . xi: stcox i.CD4100an

BERAT BADAN

_IW2cat_2 .8137962 .1984743 -0.84 0.398 .5045668 1.31254 _t Haz. Ratio Std. Err. z P>|z| [95% Conf. Interval] Log likelihood = -420.43852 Prob > chi2 = 0.3938 LR chi2(1) = 0.73 Time at risk = 1474.521561

No. of failures = 74

No. of subjects = 542 Number of obs = 542 Cox regression -- Breslow method for ties

Iteration 0: log likelihood = -420.43852 Refining estimates:

Iteration 2: log likelihood = -420.43852 Iteration 1: log likelihood = -420.43872 Iteration 0: log likelihood = -420.80215 origin: time dateof1stdayvisitYKP

analysis time _t: (dateotthelastdayvisitingY-origin)/365.25 failure _d: outcome == 1

i.W2cat _IW2cat_1-2 (naturally coded; _IW2cat_1 omitted) . xi: stcox i.W2cat

>55 26 5.7315 4.5363 3.0887 6.6625 <=55 48 9.0137 5.3252 4.0131 7.0664 W2cat D Y Rate Lower Upper (542 records included in the analysis)

Estimated rates (per 100) and lower/upper bounds of 95% confidence intervals origin: time dateof1stdayvisitYKP

analysis time _t: (dateotthelastdayvisitingY-origin)/365.25 failure _d: outcome == 1

W2cat .8137962 .1984743 -0.84 0.398 .5045668 1.31254 _t Haz. Ratio Std. Err. z P>|z| [95% Conf. Interval] Log likelihood = -420.43852 Prob > chi2 = 0.3938 LR chi2(1) = 0.73 Time at risk = 1474.521561

No. of failures = 74

No. of subjects = 542 Number of obs = 542 Cox regression -- Breslow method for ties

Iteration 0: log likelihood = -420.43852 Refining estimates:

Iteration 2: log likelihood = -420.43852 Iteration 1: log likelihood = -420.43872 Iteration 0: log likelihood = -420.80215 origin: time dateof1stdayvisitYKP

analysis time _t: (dateotthelastdayvisitingY-origin)/365.25 failure _d: outcome == 1

. xi: stcox W2cat if W2cat~=999

HEMOGLOBIN

_IHb2cat_2 .7845558 .1881889 -1.01 0.312 .4902852 1.255448 _t Haz. Ratio Std. Err. z P>|z| [95% Conf. Interval] Log likelihood = -412.43031 Prob > chi2 = 0.3162 LR chi2(1) = 1.00 Time at risk = 1462.548939

No. of failures = 73

No. of subjects = 538 Number of obs = 538 Cox regression -- Breslow method for ties

Iteration 0: log likelihood = -412.43031 Refining estimates:

Iteration 2: log likelihood = -412.43031 Iteration 1: log likelihood = -412.43092 Iteration 0: log likelihood = -412.93251 origin: time dateof1stdayvisitYKP

analysis time _t: (dateotthelastdayvisitingY-origin)/365.25 failure _d: outcome == 1

i.Hb2cat _IHb2cat_1-2 (naturally coded; _IHb2cat_1 omitted) . xi: stcox i.Hb2cat

Hb2cat .7845558 .1881889 -1.01 0.312 .4902852 1.255448 _t Haz. Ratio Std. Err. z P>|z| [95% Conf. Interval] Log likelihood = -412.43031 Prob > chi2 = 0.3162 LR chi2(1) = 1.00 Time at risk = 1462.548939

No. of failures = 73

No. of subjects = 538 Number of obs = 538 Cox regression -- Breslow method for ties

Iteration 0: log likelihood = -412.43031 Refining estimates:

Iteration 2: log likelihood = -412.43031 Iteration 1: log likelihood = -412.43092 Iteration 0: log likelihood = -412.93251 origin: time dateof1stdayvisitYKP

analysis time _t: (dateotthelastdayvisitingY-origin)/365.25 failure _d: outcome == 1

. xi: stcox Hb2cat if Hb2cat~=999

_IHb2cat_2 .7845558 .1881889 -1.01 0.312 .4902852 1.255448 _t Haz. Ratio Std. Err. z P>|z| [95% Conf. Interval] Log likelihood = -412.43031 Prob > chi2 = 0.3162 LR chi2(1) = 1.00 Time at risk = 1462.548939

No. of failures = 73

No. of subjects = 538 Number of obs = 538 Cox regression -- Breslow method for ties

Iteration 0: log likelihood = -412.43031 Refining estimates:

Iteration 2: log likelihood = -412.43031 Iteration 1: log likelihood = -412.43092 Iteration 0: log likelihood = -412.93251 origin: time dateof1stdayvisitYKP

analysis time _t: (dateotthelastdayvisitingY-origin)/365.25 failure _d: outcome == 1

i.Hb2cat _IHb2cat_1-2 (naturally coded; _IHb2cat_1 omitted) . xi: stcox i.Hb2cat

INFEKSI OPORTUNISTIK

_ITypeofIOw_2 .6596046 .2340774 -1.17 0.241 .3290131 1.322373 _t Haz. Ratio Std. Err. z P>|z| [95% Conf. Interval] Log likelihood = -436.89812 Prob > chi2 = 0.2164 LR chi2(1) = 1.53 Time at risk = 1493.859001

No. of failures = 77

No. of subjects = 548 Number of obs = 548 Cox regression -- Breslow method for ties

Iteration 0: log likelihood = -436.89812 Refining estimates:

Iteration 3: log likelihood = -436.89812 Iteration 2: log likelihood = -436.89813 Iteration 1: log likelihood = -436.91033 Iteration 0: log likelihood = -437.66205 origin: time dateof1stdayvisitYKP

analysis time _t: (dateotthelastdayvisitingY-origin)/365.25 failure _d: outcome == 1

i.TypeofIOwhe~V _ITypeofIOw_1-2 (naturally coded; _ITypeofIOw_1 omitted) . xi: stcox i.TypeofIOwhenstartingARV

have 9 2.5698 3.5022 1.8223 6.7310 dont have 68 12.3688 5.4977 4.3347 6.9728 TypeofI~V D Y Rate Lower Upper (548 records included in the analysis)

Estimated rates (per 100) and lower/upper bounds of 95% confidence intervals origin: time dateof1stdayvisitYKP

analysis time _t: (dateotthelastdayvisitingY-origin)/365.25 failure _d: outcome == 1

FAKTOR RISIKO PENULARAN Prob > chi2 = 0.0035 chi2( 3) = 13.61 ( 3) _INewRisk2_4 = 0 ( 2) _INewRisk2_3 = 0 ( 1) _INewRisk2_2 = 0 . testparm _INewRisk2* _INewRisk2_4 .308768 .1099012 -3.30 0.001 .1536952 .6203035 _INewRisk2_3 1.141577 .3688715 0.41 0.682 .605984 2.150549 _INewRisk2_2 .8119563 .2331612 -0.73 0.468 .4624894 1.425488 _t Haz. Ratio Std. Err. z P>|z| [95% Conf. Interval] Log likelihood = -429.46201 Prob > chi2 = 0.0009 LR chi2(3) = 16.40 Time at risk = 1493.859001

No. of failures = 77

No. of subjects = 548 Number of obs = 548 Cox regression -- Breslow method for ties

Iteration 0: log likelihood = -429.46201 Refining estimates:

Iteration 3: log likelihood = -429.46201 Iteration 2: log likelihood = -429.46272 Iteration 1: log likelihood = -429.7365 Iteration 0: log likelihood = -437.66205 origin: time dateof1stdayvisitYKP

analysis time _t: (dateotthelastdayvisitingY-origin)/365.25 failure _d: outcome == 1

i.NewRisk2 _INewRisk2_1-4 (naturally coded; _INewRisk2_1 omitted) . xi: stcox i.NewRisk2

IDU 12 5.7302 2.0942 1.1893 3.6875 homosex 16 1.7679 9.0502 5.5445 14.7727 heteroNonPS 24 3.9662 6.0511 4.0558 9.0278 heteroPS 25 3.4742 7.1959 4.8623 10.6494 NewRisk2 D Y Rate Lower Upper (548 records included in the analysis)

Estimated rates (per 100) and lower/upper bounds of 95% confidence intervals origin: time dateof1stdayvisitYKP

analysis time _t: (dateotthelastdayvisitingY-origin)/365.25 failure _d: outcome == 1

Multivariat _ICD4100an_3 1.052746 .2974222 0.18 0.856 .6051209 1.831494 _ICD4100an_2 1.013407 .3033473 0.04 0.965 .5636251 1.822123 _IAge2cat_2 .5800395 .1544525 -2.05 0.041 .3441915 .9774959 _INewRisk2_4 .4839525 .3408563 -1.03 0.303 .1216988 1.924505 _INewRisk2_3 1.628288 .9856226 0.81 0.421 .4971513 5.333028 _INewRisk2_2 1.108921 .7026314 0.16 0.870 .3203058 3.839163 _ISuperviso_2 1.824912 .4458583 2.46 0.014 1.13052 2.945815 _Inew_occup_99 1.08224 1.128272 0.08 0.940 .1402546 8.35084 _Inew_occup_2 1.071217 .5844343 0.13 0.900 .3676877 3.120871 _Isex_2 1.429216 .5020292 1.02 0.309 .7179651 2.845068 _t Haz. Ratio Std. Err. z P>|z| [95% Conf. Interval] Log likelihood = -423.05146 Prob > chi2 = 0.0019 LR chi2(10) = 27.85 Time at risk = 1478.830938

No. of failures = 77

No. of subjects = 545 Number of obs = 545 Cox regression -- Breslow method for ties

Iteration 0: log likelihood = -423.05146 Refining estimates:

Iteration 3: log likelihood = -423.05146 Iteration 2: log likelihood = -423.05232 Iteration 1: log likelihood = -423.50887

Dokumen terkait