MEDICINE
C. CLINICAL PHARMACOLOGY AND THERAPEUTICS
1. Pharmacokinetic analysis of adrenoceptor drugs in hypertensive patients —S. N. Anavekar, M. Dynon, B. Jarrott, W. J. Louis.
2. Distribution and regulation of histamine receptors in blood vessels —B. Jarrott, A. J.
Culvenor.
149
3. Uptake distribution and metabolism of centrally acting antihypertensive drugs—E. L. Con- way, B. Jarrott.
4. Pharmacokinetics of theophylline in asthmatic patients—P. Trembath, D. Thorsborne- Palmer.
5. Distribution and regulation of dopamine receptors in the central nervous system —P. M . Beart, A. L. Gundlach.
6. Interaction between GABAergic and dopaminergic pathways in the brain-P. iM. Beart, A.
L. Gundlach.
7. Central actions of drugs modulating GABAergic neurotransmission — P. M. Beart, L.
Howes.
8. Development of radioligands for a adrenoceptors —R. J. Summers, B. Jarrott.
9. Radioligand studies of a adrenoceptors in kidney—R. J. Summers, G. A. McPherson.
10. a adrenoceptors in lymphocytes —R. J. Summers, G. A. McPherson.
11. Adrenoceptors in uterus —R. J. Summers, K. G. Digges.
12. Studies of different beta adrenoceptor blockers in experimental epilepsy in rats —J.
Papanicolaou, F. J. E. Vajda, W. J.. Louis.
13. Studies of brain adrenoceptors in chemically and electrically induced seizures —J.
Papanicolaou, R. J. Summers, F. J. E. Vajda.
14. Fluorouracil pharmacokinetics in relation to clinical drug toxicity — I . Lucas, F. J. E. Vajda, N. Christophidis, W. J. Louis.
15. Studies of cis-plaiinum in man — I . Lucas, F. J. E. Vajda, W. J. Louis.
16. Bioavailability of two preparations of fluorouracil — I . Lucas, F. J. E. Vajda, W. J. Louis.
17. Gastric and intestinal absorption of sodium valproate—N. Yeomans, F. J. E. Vajda.
18. Hepatic metabolism of methotrexate —A. Proudfoot, G. Mihaly, F. J. E. Vajda.
19. Pharmacokinetics of angiotensin converting enzyme inhibitors in hypertensive patients —P.
Miach, A. Anderson, B. Jarrott, W. J. Louis.
D.PSYCHIATRY 1. Studies of mother-infant interaction —R. A. Meares.
2. Studies of cortical evoked potentials in mental illness —R. A. Meares, J. Milgrom-Fricdman.
3. The cerebral effects of tobacco smoking —R. A. Meares, J. Milgrom-Friedman.
4. Interface of philosophy and psychiatry —E. Harari.
PUBLISHED WORK Books
1. DOYLE, A. E., MENDELSOHN, F. A. O. and MORGAN, T. O.-Pharmacological and Therapeutic Aspects of Hypertension, CRC Press (1980).
2. CUMMING, I . A., FUNDER, J. W. and MENDELSOHN, F. A. O. (eds.)-Endocrinology 1980, Australian Academy of Science, Canberra (1980).
Articles
3. A D A M , W. R. — Aldosterone and dopamine receptors in the kidney: Sites for pharmacologic manipulation of renal function. Kidney Int., 18: 623-628 (1980).
4. ALLEN, R., MENDELSOHN, F. A. O., CSICSMANN, J., WELLER, R. F., HURLEY, T.
H. and DOYLE, A. E. — A clinical evaluation of serum angiotensin converting enzyme in sarcoidosis. Aust. N.Z. J. Med., 10: 496-501 (1980).
5. ATKINS, D., WALLER,, P. C. and MARTIN, T. J . - R a t osteogenic sarcoma cells:
Modulation of hormone stimulated cyclic AMP production by prostaglandin antagonists and biosynthesis inhibitors. Clin. Exp. Pharm. & Phys., 7: 31-44 (1980).
6. BEART, P. M . and MeDONALD, D. —Neurochemical studies of the mesolimbic dopaminergic pathway: somatodendritic mechanisms and GABAergic neurones in the rat ventral tegmentum. J. Neurochem., 34: 1622-1629 (1980).
7. BEART, P. M . and GUNDLACH, A. L. — 3,4-Dihydroxyphenylacetic acid (DOPAC) and the mesolimbic dopaminergic pathway: drugs effects and evidence for somatodendritic mechanisms. Br. J. Pharmacol., 69: 241-247 (1980).
8. CHAPPLE, D. J., DUSTING, G. J., HUGHES, R. and VANE, J. R.-Some direct and reflex cardiovascular actions of prostacyclin (PGI2) and PGE2 in anaesthetized dogs. Bri. J.
Pharmacol., 68: 437-447 (1980).
9. CLARK, S„ LARKINS, R. G., deLUISE, M . and MELICK, R. A . - T h e effects of trypsin and phospholipase C on insulin binding and action in the isolated adiposyte. Biochem. J., 186: 535-540 (1980).
10. CLARK. S., LARKINS, R. G. and MELICK, R. A. — Negative cooperativity induced by desoctapeptide insulin unmasked by phospholipase C treatment. Biochem. Biophys. Pes.
Commun., 95: 1543-1549 (1980).
11. COWLING, P., EBRINGER, R., CAWDELL, D., ISHII, M . and EBRINGER, A . -
MEDICINE (AUSTIN AND REPAT. GEN. HOSPITALS) 151 C-reaclive prolcin, ESR, and Klebsiella in ankylosing spondylitis. Annals of the Rheumatic Diseases. 39: 45-49 (1980).
12. COWLING, P., EBRINGER, R. and EBRINGER, A. —Association of inflammation with raised scrum IqA in ankylosing spondylitis. Annals of the Rheumatic Diseases., 39: 545-549 (1980).
13. DAWSON, R. M . and JARROTT, B. — Regional distribution of the muscarinic cholinocep- tor and acetylcholinesterase in guinea pig brain. Neurochem. Res., 5: 809-815 (1980).
14. DEN1SON, D. fvl., DAVIES, N. J. H., MEYER, M . , PIERCE, R. J. and SCHEID, P . - Single-inhalation method for study of labar and segmental lung function by mass spec- trometry in man. Respiration Physiology, 42: 87-99 (1980).
15. DEN1SON, D. M . , BELLAMY, D. and PIERCE, R. J.-Some observations on lung func- tion in scoliosis. Scoliosis 1979, Academic Press, London: 137-147 (1980).
16. DAVIS, W. C. and McKENZIE, 1. F. C. — Immunological enhancement can bc mediated by anti-la and anti-K, D, antibodies. Transplantation, 29: 11-19 (1980).
17. DAVIS, W. C , McKENZIE, I . F. C. and MELVOLD, R. W . - A comparison of skin and heart graft rejection patterns in H-2 mutant mice. Transplantation. 29: 189-192 (1980).
18. DOYLE, A. E. —Errors in the treatment of hypertension. Current Therapeutics February:
181: 19 (1980).
19. DOYLE, A. E. —Government funding for medical research (Point of View). Med. J. Aust., I : 181-183 (Feb. 23, 1980).
20. DOYLE, A. E. and DUFFY, S. —Sodium balance and plasma renin activity during thc development of two-kidnev Goldblatl hypertension in rats. Clin. Exp. Pharmacol. Phvsiol.:
293-304 (19S0).
21. DRUMMER, O. H. O., CULVENOR", A. J., JARROTT, B. and LOUIS, W. J.-Alpha- and beta-adrenoceptor activities of norepinephrine analogues in isolated tissues of the rat.
Circulation Research, 45, Supl. I : 133-137 (1980).
22. DUNN, E. C , EBRINGER, R. and ELL, P. J.-Quantitative scintigraphy in the early diagnosis of sacroilitis Rheumatology and Rehabilitation. 19: 62-75 (1980).
23. DUSTING, G. J., MULLINS, E. M . and NOLAN, R. D.-Stimulation of prostacyclin generation by angiotensins in isolated mesenteric vasculature of rats. Microvasc. Res., 19:
246 (1980).
24. DUSTING, G. J. — Prostacyclin: the prostaglandin of physiological importance in the car- diovascular system. Clin. Exp. Pharmacol. Physiol., 7: 98 (1980).
25. DUSTING, G. J. and MULLINS, E. M.-Stimulation by angiotensin of prostacyclin biosynthesis in rats and dogs. Clin. Exp. Pharmacol. Phvsiol.. 7: 545-550 (1980).
26. DUSTING, G. J., MULLINS, E. M. and DOYLE, A. E.-Angiolcnsin-induced pro- stacyclin (PGI;) release may contribute to thc hypotensive action of converting enzvme in- hibitors. Adv. Prostaglandin Thromboxane Res.. 7: 815-819 (1980).
27. DUSTING, G. J. and VANE, J. R. —Some cardiovascular properties of prostacyclin (PGI,) which are not shared by PGE2. Circ. Res., 46 (Suppl 1.): 1-183-187 (1980).
28. DYNON, M . K., JARROTT, B., DRUMMER, O. H . O. and LOUIS, W. J.-Phar- macokinetics of prazosin in normotensive subjects after low oral doses. Clinical Phar- macokinetics, 5: 583-590 (1980).
29. EBRINGER, R., COLTHORPE, D., YOUNG, A. and CORBETT, M.-Increased in- cidence of faecal Klebsiella pneumoniae in patients with HLA B7 CRECi antigen and men with rheumatoid arthritis, lirit. Med. J., ii: 583-585 (1980).
30. EBRINGER, R.— (Editorial review) HLA B27 and thc link with rheumatic diseases: recent developments. Clinical Science, 59: 405-410 (1980).
31. EISMAN, J. A., MARTIN, T. J., MacINTYRE, 1., FRAMPTON, R. J., MOSELEY, J. M . and WHITEHEAD, R. — 1,25-dihydroxvvitamin D3 receptor in a cultured human breast cancer cell line (MCE 7 cells). Biochem.'Biophvs. Res. Comm.. 93 : 9-15 (1980).
32. EISMAN, J. A. MacINTYRE, I . , MARTIN, T. J., ERAMPTOM, R. .1. and KING, R. J. B. —Normal and malignant breast tissue is a target organ for l,25(OH), vitamin D j . Clin. Endocrinol.. 13: 261-212 (1980).
33. FINDLAY, D. M . , dcI.UISE, M., MICHELANGELI, V. P., ELLISON, M. and MARTIN, T. J. — Properties of a calcitonin receptor and adenylate cyclase in BEN cells, a human cancer cell line. Cancer Res. 40: 1311-1317 (1980).
34. FRIEDMAN, J. and MEARES, R. A. — Tobacco smoking and cortical evoked potentials: an opposite clfcct on auditory and visual svstems. Clin. Exp. Pharmacol. Phvsiol. 7(6): 609-615 (1980).
35. FRIEDMAN, J., McCALLUM, P. and MEARES, R. A.-Stimulus intensity control in depression: a studv of the comparative effect of doxepin and amitriptyline on cortical evoked potentials. Aust. N.Z. J. Psvchiat.. 14 (2): 115-120 (1980).
36. FUNDER, J. W., MERCER, J. E., ULICK, S., MARVER, D. and ADAM, W. R . - Towards more specific aldosterone antagonists: a radio-receptor assay approach. Circ. Res., 46: 1-10 (1980).
37. GREAVES, M . , IBBOTSON, K. J., ATKINS, D. and MARTIN, T. J. - Prostaglandins cx-
traded from tumours and produced by cultures of renal cortical carcinoma and benign and malignant breast tumours: relation to bone resorption. Clin. Sci., 58: 201-210 (1980).
38. GRINVVALD, P. iM., HEARSE, D. J. and SEGAL, M . B . - A possible mechanism ol glycolytic impairment after adenosine triphosphate depletion in the perfused rat heart. J.
Physiol., 301: 337-347 (1980).
39. GIRAUD, A. S. and YEOMANS, N. D.-Phylogeny of the mucous cells in vertebrate gastric mucosa. C//>i. Exper. Pharmacol. Phvsiol. 7: 82-83 (1980).
40. GIRAUD, A. S. and YEOMANS, N. D.-Ultrastructure of thc pvloric cecal epithelium.
Micron, //.-(Suppl. I): 17 (1980).
41. GIRAUD, A. S. and YEOMANS, N. D. —Ultrastructure of the pvloric cecal epithelium.
Micron I I : 489-490 (1980).
42. GUNDLACH, A. L. and BEART, P. M. —Effect of muscimol on dopamine metabolism of the rat hypothalamus. Experientia, 36: 1312-1313 (1980).
43- HALLIDAY, VV. J., BUTTON, C. J., KOPPI, T., McKENZIE, 1. F. C. and NOONAN, F.
P. — Identification of l-J antigenic determinants: a Hapten-Spccific scrum blocking factor.
Immunology Letters, I : 325-327 (1980).
44. HEAD, R. J., HJELLE, J. T., JARROTT, B., BERKOVV1TZ, B., CARD1NATE, G. and SPECTOR, S. — Isolated brain microvessels: preparation, morphology, histamine and catecholamine contents. Blood Vessels, 17: 173-186(1980).
45. HEALE, VV. P.—The management of hypertension in children. Aus. Fam. Phvsic. 9:
849-850 (1980).
46. HEYMA, P., LARKINS, R. G. and CAMPBELL, D. G. - Inhibition of propranolol of 3,5,3-triiodothyronine formation from thyroxine in isolated rat renal tubules: an effect in- dependent of beta adrenergic blockade. Endrocrinolozv, 106: 1437-1442 (1980).
47. HEYMA, P., LARKINS, R. G. and CAMPBELL, D. G. -Effects of propranolol on T3 for- mation from T4 in vitro and i7i vivo studies, in Thvroid Research VIII, eds. J. R. Stockigl and S. Nagataki, Aust. Acad. Sci.: 420-432 (1980).'
48. HEYMA, P. LARKINS, R. G., HIGGINBOTHAM, L. and NG, K. W.-D-propranolol and DL-propranolol both decrease conversion of thyroxine to triiodothyronine in man. Brit.
Med. J., 2: 24-25 (1980).
49. HEYMA, P., LARKINS, R. G. and CAMPBELL, D. G. -The effect of iodothyronines on thc conversion of thyroxine to 3,5,3'-triiodolhyronine in isolated rat renal tubules. Biochem.
J., 190: 239-242 (1980).
50. HIGGINS, T. J., PARISH, C. R., HOGARTH, P. M . , McKENZIE, 1. F. C. and HAM- MERLING, G. J. — Demonstration of carbohydrate and protein determined la antigens by
monoclonal antibodies. Immunogenetics, I I : 467-482 (1980). ' 51. HOGARTH, P. M . , POTTER, T. A., CORNELL, F. N . , McLACHLAN, R. and McKEN-
ZIE, I . F. C — Monoclonal antibodies to murine cell surface antigens. I . Lyi-1-11. J. Im- munol., 125: 1618-1624 (1980).
52. HOGARTH, P. M . , CRUISE, K. M . , McKENZIE, I . F. C. and MITCHELL, G. F.-Sur- face markers of a purified peritoneal eosinophil population from mesocestoides corti- infectcd BALB/c male mice. J. Immunol., 124: 406-411 (1980).
53. HOGARTH, P. M . , CRAIG, J. and McKENZIE, I. E. C . - A monoclonal antibody delect- ing the Ly-9.2 (LglOO) cell membrane alloantigen. Immunogenetics, 11: 65-74 (1980).
54. HOROWITZ, J. D., HOWES, L. G., CHRISTOPHIDIS, N . , LOUIS, W. J., LANG, VV.
J., GENNESSY, M . R. and RAND, M . J. - Hypertensive, responses induced by phenylpropanolamine in anorectic and decongestant preparations.' Lancet, I : 60-61 (1980).
55. HUNT, N. H. and MARTIN, T. J. — Hormone receptors and cyclic nucleotides. Significance for growth and function of tumours. Mol. Aspecis of Med., 3: 59-118 (1980).
56. HUTCHINSON, J. S. and MENDELSOHN, F. A. O. - Hypertensive effects of captopril ad- ministered centrally in intact conscious SHR and peripherally in ancphric anaesthetized SHR. Clin. Exp. Phvsiol. Pharmacol., 7: 555-558 (1980).
57. HUTCHINSON, J. S., DiNlCOLANTONIO, R., L I M , A. and FUNDER, J . - I m - munoreactivc bela-endorphin levels in plasma and pituitary tissue from hypertensive and normotensive rats.
58. HUTCHINSON, J. S., MENDELSOHN, F. A. O. and DOYLE, A. E. - Hypotensive action of captopril and saralasin in intact and anephric spontaneous^ hypertensive rats. Hyperten- sion, 2:119-124 (1980).
59. HUTCHINSON, J. S., MENDELSOHN, F. A. O. and DOYLE, A. E . - B l o o d pressure responses, of conscious normotensive and spontaneously hypertensive rats to in- . tracerebroventricular and peripheral administration of the angiotensin concerting enzyme in-
'hibitor, captopril. Hvpertension, 2: 546-550 (1980).
60. HUTCHINSON, J. S. and DOYLE, A. E. —Hypotensive effects of captopril, saralasin and bromocriptine in spontaneously hypertensive rats. Clinical Science (Suppl. 6): 79S-82S (1980).
61. JARROTT, B. SUMMERS, R. J., CULVENOR, A. J. and LOUIS, W. J.-Characteriza-
MEDICINE (AUSTIN AND REPAT. GEN. HOSPITALS) 153 tion of alpha-adrenoceptors in rat and guinea pig tissues using radiolabeled agonists and an- tagonists. Circ. Res.. 46 (Suppl. 1): 115-120 (1980).
62. JERUMS, G. — The Effect of gliclazide on the evolution of diabetic nephropathy in insulin dependent and non insulin dependent subjects. Royal Societv of Medicine: International Congress Series No. 20: 225-230 (1980).
63. KINSELLA, P., EBRINGER, R. and CORBETT, M. - Levamisolc in severe rheumatoid ar- thritis: a double blind studv. Journal of Rheumatology 7: 288-292 (1980).
64. LANGDON, W. Y., SHELLAN, G., MORGAN, G. M . and McKENZIE, I . E. C.-The augmentation of endogenous murine leukaemia virus antibodies following lymphocyte alloantigen immunisation. Immunogenetics 10: 150 (1980).
65. LARKINS, R. G., SIMEONOVA, L. and VERONI, M.-Glucose utilization in relation to insulin secretion in NZO and C57B1 mouse islets. Endocrinology 107: 1634-1638 (1980).
66. LARKINS, R. G., MARTIN, F. I . R. and TAIT, B. D . - T h e HLA system and diabetic com- plications, in Immunology of Diabetes, ed. W. J. Irvine Tcviot, Scientific Publications Ltd:
337-344 (1980).
67. LEUNG, K. N . , ADA, G. L. and McKENZIE, I . F. C . - T h c specificity Ly phenotype and H-2 compatibility requirements of effector cells in DTH responses in murine influenza virus infection. J. Exp. Med., 151: 815-826 (1980).
68. LEVY, J. P. and McKENZIE, I . F. C. — Genetic control of sensitivity to moloney leukaemia virus in mice. IV. Variability in organ involvement in cell surface markers of leukaemic cells.
J. Immunol.. 125: 1415-1420 (1980).
69. LOUIS, W. J., McNEIL, J. J., ANDERSON, A. and JARROTT, B.-Use of adrenoceptor blocking drugs in hypertension. Cardiology, 66: 28-35 (1980).
70. LUDBROOK, A., DYNON, M . , MENDELSHOHN, F. A. O. and LOUIS, W. J. - A com- parison of single and twice a day spironolactone therapy in mild hypertension. Med. J.
Aust., I : 124-125 (1980).
71. MARSHALL, A. W., MIHALY, G. W., SMALLWOOD, R. A., BALDAS, J., PHILLIPS, J. and VAJDA, F. — Hepatic elimination of thc anticpilcptic agent sodium valproate.
Gastroenterology, 78: 1313 (1980).
72. MARSHALL, A. W. MIHALY, G. W., MORGAN, D. J., STEPHENS, D. A., SMALLWOOD, R. A. and HARDY, K. J. —Propranolol disposition and biliary excretion in the pregnant sheep and fetus. Gastroenterology, 77: A25 (1980).
73. MARTIN, T. J., FINDLAY, D. M . , MacINTYRE, I . , EISMAN, J. A., MICHELANGELI, V. P., MOSELEY, J. M and PARTRIDGE. N. C.-Calcitonin receptors in a cloned human breast cancer cell line (MCF 7) Biochem. Biophys. Res. Comm., 96: 150-156 (1980).
74. MARTIN, T. J. and PARTRIDGE. N. C. - Prostaglandins, cancer and bone: phar- macological considerations. Metabolic Bone Disease and Rel. Res., 2:167-171 (1980).
75. MAS-OLIVA, J., WILLIAMS, A. J. and NAYLER, W. G . - T w o orientations of isolated cardiac sarcolemmal vesicles separated by affinity chromatography. Analyt. Biochem., 103:
222-236 (1980).
76. MENDELSOHN, F. A. O. and KACHEL, C. D . - A c t i o n or angiotensins, I , I I and HI on aldosterone • production by isolated rat adrenal zona glomerulosa cells. Importance of metabolism and conversion of" peptides in vitro. Endocrinology, 106: 1760-1768 (1980).
77. MENDELSOHN, F. A. O., HUTCHINSON, J. S. and CSICSMANN, J.-Angiotensin converting enzyme in thc brain or spontaneously hypertensive rats. Clin. Exp. Physiol. Phar- macol., 7: 551-554 (i980).
78. MENDELSOHN, F. A. O., DOYLE, A. E. and GRAY, G. W . - L a c k or response ol" the sympathetic nervous system to angiotensin inrusion. Lancet, March 1: 492-493 (1980).
79. MENDELSOHN, F. A. O —Measurement or blood pressure. Aust. Family Phvsician, 9:
652-654 (1980).
80. MENDELSOHN, F. A. O. - Different potencies of Asp1, I l es- a n d Asn' Val5-angiotensin II is stimulating aldosterone production from rat adrenal zona glomcrulosa cells />J vitro.
Clin. Exp. Physiol. Pharmacol., 7: 199-203 (1980).
81. MENDELSOHN, F. A. O. — Failure ot suppression ol" intrarenal angiotensin II in thc con- tralateral kidney one-clip two kidney hypertensive rats. Clin. Exp. Phvsiol. Pharmacol., 7:
219-223 (1980).
82. MENDELSOHN, F. A. O. and SMITH, E. A. - Intrarenal renin and angiotensin 11 and plasma renin in rats with uranvl nitrate and glvcerol-induced acute renal failure. Kidnev In- ternational, 17: 465-472 (1980).
83. MEARES, R. A., FRIEDMAN, J. and HORVAT H, T. - Attention in hvstcria: a studv of habituation and arousal. Amer. J. Psychiat.. 137 (2): 217-220 (1980),
84. MEARES, R. A. —Body feeling in human relations: the possible examples of Brancusi and Giacometti. Psychiatry, 43: 160-167 (1980).
85. MIACH, P. .1. and LOUIS, VV. .1. — Evaluation of guanfacine and clonidine in patients with essential hypertension: a single blind cross-over study. Med. J. Aust., 2: 395-395 (1980).
86. MIHALY, G. W., DRUMMER, O. H. O., MARSHALL, A., SMALLWOOD, R. A. and
F
L O U I S , W. J . — High pressure liquid chromatographic determination of Ranitidine, a new H2-receptor antagonist, in plasma and urine. J. Pharmac. Sci. 69: I I 5 5 - H 5 8 (1980).
87. M I H A L Y , G., M A R S H A L L , A . , S M A L L W O O D , R. A . , M c N E I L , J . , A N D E R S O N , A . and L O U I S , W . J. — Pharmacokinetics of the H,-receptor antagonist Ranitidine in man.
Gastroenterology, 78: I222 (19S0).
88. M I T C H E L L , G. F., D U R T I S , J. M . . H A N D M A N , E. and M c K E N Z I E , I. I'. C . - Cutaneous leishmaniasis in mice: disease patterns with Leishmania tropica. Aust. J. Exp.
Biol. Med. Sci., 58: 521-532 (1980).
89. M O R G A N . T . O., A D A M , W . R., H O D G S O N , M . and GII3BERD, R. W . - F a i l u r e of therapv to improve prognosis in elderlv males with hvpertension. Med. J. Aust., 2: 27 (1980).
90. M O R G A N , G. M . , D E L L O S , 11., M c K E N Z I E , I. F. C , M E L V O L D , R. W. and B A I L E Y , D . - S t u d i e s of two H - 2 Db mutants: C 5 7 B L / 6 - H - 2b m l 3 and C 5 7 B L / 6 - H - 2b m l 4. Immuno- genetics. 11: 341-349 (1980).
9 1 . M O R G A N , G. M . , M c K E N Z I E , I. F. C. and M E L V O L D . R. W . - T h e definition o f a new- la antigenic specificity using the C 5 7 B L / 6 . C - H - 2h m 1 2 I region mutant strain. Immuno- genetics, I I : 1-6 (1980).
92. M O R G A N , G. M . , M c K E N Z I E , I. F. C. and M E L V O L D , R. W . - S t u d i e s of H - 2 Kb mutants. I I . Definition of four new H-2 specificities using C 5 7 B L / 6 - H - 2b m , n. Immuno- genetics. 11: 434-453 (1980).
93. M O R G A N , G. M . , M c K E N Z I E . I. F. C. and M E L V O L D , R. W . - S t u d i e s of H - 2 Kb mutants. 1. Description and serological studies of C 5 7 B L / 6 - H - 2b m 9, H - 2b" " ° , H - 2b m" . I m - munogenetics. I I : 31-41 (1980).
94. M O R G A N , G. M . , M c K E N Z I E , I. F. C . G O D I N G , .1. and M E L V O L D , R. W . - / r g e n e testing in H-2 mutants. ./. Immunogenetics., 7: 421-425 (1980).
95. M O R G A N , G. M . and M c K E N Z I E . 1. F. C. —Cell membrane alloantigenic determinants of several unusual mouse strains. ./. Immunogenetics, 7: 393-399 (1980).
96. M O S E L E Y , J. M . , B E A T T Y , E. A . and M A R C H A L O N I S , .1. J . - M o l e c u l a r properties of T-lymphoma immunoglobulin I I . Peptide composition of thc heavy chain. ./. I m - munogenetics, 6: 1-18 fl980).
97. M c K E N Z I E , 1. F. C , H E N N I N G , M . and M O R G A N , G. M . - S k i n graft enhancement studies with antigenic differences arising from thc H-2K, H-2D and H-2L Loci. Transplanta- tion, 29: 439-433 (1980).
98. M c K E N Z I E , I. F. C , S A N D R I N , M . S., M O R G A N , G. M . , H E N N I N G . M . and M E L V O L D , R. W . —Mutation in the IA subrcgion of the murine H-2 complex. I m - munogenetics, 11: 103-106(1980).
99. N A Y L E R , W. Ci. —The use o f co-en/vme Q10 to protect ischaemic heart muscle. Biomedical and Clinical Aspecis o f Co-Enzvme Q I 0 , 2: 409-425 (1980).
100. N A Y L E R , W . G . , F E R R A R I , R. and S L A D E , A . - C a r d i o p r o t e c t i v e actions of calcium an- tagonists in myocardial angina and ischaemia. Calcium Antagonists, cd. A . Fleckcnstcin:
119-137 (1980).
101. N A Y L E R , W. G . - C a l c i u m antagonists. European Heart J . , I. 225-237 (1980).
107 N A Y L E R , W . G . , MAS-OI.1VA. J. and W I L L I A M S , A . J . - C a r d i o v a s c u l a r receptors and calcium. Circ. Pes., 46 (Suppl. 1): 161-166 (1980).
103. N A Y L E R , W. G. and F E R R A R I , R. —The pharmacological protection o f the ischaemic heart. A m . J . Cardiol., 46: 242-249 (1980).
104. N A Y L E R , W . G. and M A S - O L I V A , J . - T h c effect of verapamil on i h e C aJ+ transporting activity of cardiac sarcolemmal vesicles. Brit. J. Pharmacol., 70: 617-624 (1980).
105. N O L A N , R. D., D U S T I N G , G. J. and M A R T I N , T. J. - Inhibition o f prostacyclin ( P G I2) generation in rat mesenteric vasculature. Clin. Exp. Pharmacol. Physiol., 7: 427 (1980).
106. O ' N E I L L , H. C. and M c K E N Z I E , I. F. C . - Q u a n t i t a t i v e variation in H-2 antigen ex- pression. I. Estimation of H-2K and H-2D expression in different strains of mice. Immuno- genetics, 11: 225-239 (1980).
107. O L I V E R , L. E., H O R O W I T Z , .1. D., D Y N O N , M . K., J A R R O T T , B., B R E N N A N , .1. G., G O B L E , A . J. and L O U I S , W. J. —Use of dopamine and prazosin combined in thc treat- ment o f cardiogenic shock. Med. J. A u s i . (Suppl. 2): 42-45 (1980).
108. P A R I S H , C. R., O ' N E I L L , H. C. and M c K E N Z I E , I. F. C . - A new procedure for analysing the relationship between different cell surface antigens. J. Immunol. Methods., 39: 223-232 (1980).
109. P A R R , E. L., L A I T E R T Y , K. J . , B O W E N , K. M . and M c K E N Z I E , I. F. C . - T h e survival of allografts after culture in vitro. I I . Immunofcrritin labelling o f H-2 complex in la antigens on cells dissociated from mouse thyroid glands and islets o f langcrhans. Transplantation, 30:
142-148 (1980).
110 P A R T R I D G E , N. C , F R A M P T O N , R. J . , E I S M A N , J . A . , M I C H E L A N G E L I , V. P., E L M S , E., B R A D L E Y , T. R. and M A R T I N , T. J . - R c c e p i o r s for l , 2 5 ( O H )2 vitamin D3 enriched in cloned ostcoblast-likc rat osteogenic sarcoma cells. PEBS Letters, 115: 139-142 (1980).
111. P E R R Y - K E E N E , D. A . , L A R K I N S , R. G . , H E Y M A , P., PETER, C. T . , ROSS, D. and
M E D I C I N E (AUSTIN A N D REPAT. G E N . H O S P I T A L S ) 155
S L O M A N , J. G.—Thc effect of long-term diphcnyl-hydamoin therapy on glucose tolerance and insulin section: a controlled trial. Clinical Endocrinology. 12: 575-580 (1980).
112. P I E R C E , R. J. and T U R N E R - W A R W I C K , M . — Delayed skin tests to C. Albicans, Trichophyton and P.P.D in cryptogenic fibrosing alveolitis and asbestos related lung disease.
Clinical Allergv. 10: 229-237 (1980).
113. P I E R C E , R. J . , B R O W N , D. .1. and D E N I S O N , D. A . - Radiographic, scintigraphic and gas-dilution estimates of individual lung and lobar volume in man. Thorax, 35: 773-780 (1980).
114. P O T T E R , T. A . , M c K E N Z I E , I. F. C , Morgan, G. M . and C H E R R Y , M . — Murine lym- phocyte alloantigens. I. Thc Lv-6 locus. J. Immunology, 125: 541-545 (1980).
115. POTTER, T. A . , M O R G A N , G. M . and M c K E N Z I E , 1. E. C. Murine lymphocyte alloan- tigens. 2. The Ly-7 locus. J. Immunology, 125: 546-550 (1980).
116. R A F F , J . , M c K E N Z I E , I. F. C. and C L A R K E , A . E. — Antigenic determinants of primus avium are associated with the protoplast surface. /.. Pflunzenphysiol.. l i d . 98.S.: 225-234 (1980).
117. S E W E L L , R. B., H O F F M A N , N. E., S M A L L W O O D , R. A . and C O C K B A I N , S. — Bile acid structure and bile formation: a comparison of hydroxy and keto bile acids. A m . J . P h v s i o l , 238: G10 (1980).
118. S H A W , J . , C A P L A N , B., D E L O V I T C H , T. I,., M c K E N Z I E , I. F. C , P1LARSKI, L. M . and P A E T K A U , V. —Cellular origins of costimulator (IL2) and its activity in cytotoxic T lymphoevtc responses. J. Immunol., 124: 2231-2239 (1980).
119. S T A S Z E W S K A - B A R S C A K , J . , D U S T I N G , G. J . , M A Y , D. E. and N O L A N , P. N . - E f f e c t of prostacyclin on the sympathetic and vagally-mcdiatcd chcmorctlcxcs elicited from the heart with bradykinin or nicotine. Proc. Aust. Phvsiol. Pharmacol. S o c , I I : 194 (1980).
120. S U M M E R S , R. J . , J A R R O T T , B. and L O U I S , W . J.-Selectivity of a scries of clonidine like drugs for alpha 1 and alpha 2 adrenoceptors in rat brain. Neuroscience Letts.. 20:
347-350 (1980).
121. S U M M E R S , R. J . , J A R R O T T , B. and L O U I S , W. J. — Displacement o f ' H clonidine bind- ing bv clonidine analogues in membranes from rat cerebral cortex. Europ. J. Pharmacol., 66:
233-241 (1980).
122. S U M M E R S , R. J. — 3 l-l Clonidine binding to alpha adrenoceptors in membranes prepared from regions of guinea pig kidney: alteration bv monovalent and divalent cations. Pr. .1.
Pharmacol., 71: 57-65 (1980).
123. T A Y L O R , H. R. and l.OUIS, W. J . - T h c significance of tear function test abnormalities.
Annals o f Ophthalmology, 12 (5) 531-535 (May 1980).
124. T R E C H S E L , U., E I S M A N , J. A . , R1SHER, J. A . , B O N J O U R , J-P. and F L E I S C H , H - Calcium-dependent, parathyroid hormone-independent regulation of 1,25-dihydroxyvitamin D. Amer. J. Phvsiol.. 239: 119-124 (1980).
125. T H O M P S O N , C. H., P O T T E R , T . A . , M c K E N Z I E , I. F. C. and P A R I S H , C. R - Phcnotype of the D T H suppressor cell. Immunology. 40: 87-96 (1980).
126. V A J D A , F. J. E. - Principles of pharmacology. Aust. Family Phvsician. 9: 134-141 (1980).
127. V A U G H A N , H. A . , S A N D R I N , M . S., M c K E N Z I E , I. F. C , T A I T , B. D. and T I N G , A . —Cross reaction of la antigens between mouse and man. Human Immunology, 279:
639-641 (1980).
128. W E L S H , J . , A V A K J A N , 1-1., C O W L I N G , P., E B R I N G E R , A . , W O O I . E Y , P., P A N A J I , G. and t B R i N o h R , K. —Ankylosing spondylitis, H L A B27 and Klebsiella. I. Cross- reactivity studies with rabbit antisera. l i r i t . ./. o f Exper. Pathol.. 61: 85-91 (1980).
129. W I L E Y , J. S., H U T C H I N S O N , J. S., M E N D E L S O H N I-. A . O. and D O Y L E , A . E. — In- creased sodium permeability o f erythrocytes in spontaneously hypertensive rats. Clin. Exp.
Phvsiol. Pharmacol., 7: 527-530 (1980).'
130. W O R D S W O R T H , P. E B R I N G E R , R., JONES D. and BED1, S . - T h y r o i d antibodies in synovial effusions. Lancet, i: 660 (1980).
131. Y E O M A N S , N. D . - G E Medical Manpower. Ausi. N.Z. J. M e d . , 10: 372 (1980).
132. Y E O M A N S , N. D., W I L L I A M S , D. R., M a c K I N N O N , M. A . and M c L E I S H , A . R - Cigarelte smoking and duodenogastric reflux. Aust. N.Z. J. Med.. 10: 363-364 (19S0).
133. Y E O M A N S , N. D. and M I L L A R , S. J. —Mechanism of mucus secretion in rat and mouse gastric mucosa. Clin. Exp. Pharmacol. Physiol., 7: 414-415 (1980).
134. Y E O M A N S , N. D . - G l u c a g o n in gastroenterology. C7/>7. Exp. Pharmacol. Phvsiol.. 7: 700 (1980).
135. Y E O M A N S , N. D., V A J D A . F. J. E and B A L D A S , J. - G a s t r i c absorption o f valproate in rats. Clin. Exp. Pharmacol. Physiol., 7: 676-677 (1980).
136. Y E O M A N S , N. D. and M I L L A R , S. J . - E f f e c t of tobacco smoke condensate on mucus, protein and D N A synthesis in cultured antral mucosa. Ausi. N.Z. J. M e d . , 10: 590 (1980).
137. Y E O M A N S , N. D. and M I L L A R . S. J. —Synthesis and secretion of glycoproteins by mucosa of rat gastric antrum in organ culture. Dig. Dis. Sci.: 295-301 (1980).
118 Y E O M A N S , N. D. Cometidine vs. antacids for treatment o f peptic ulcers. Aust. Prescriber, 4: 33-34 (1980).
139. YEOMANS, N. D. and GIRAUD, A. S. — Non-glvcoprotcin "cores" in gastric mucus granules. Gastroenterology, 78: 1658-1659 (1980).
140. YEOMANS, N. D. and ST. JOHN, D. J. B.-Familial mediterranean fever in Australia.
Med. J. Aust., 1: 334-335 (1980).
T HESES PASSED FOR HIGHER DEGREES Doctor oj Philosophy
1. CHRISTOPHIDIS, N. - 77ie pharmacokinetics of cytotoxic drugs.
2. GI RAUD, A. S. — The phylogeny of the gastric mucosa.
3. McQUEEN, A. —Central nervous system effects of amines on behaviour.
4. POTTER, T. — Murine lymphocyte surface alloantigens.
5. SANDRIN, M. — la antigens in man and mouse.
6. WARK, J. D.- Vitamin D metabolism.
Master of Science
7. MORGAN, G. — H-2 mutations: The serological analysis of several H-2 mutant strains.
8. RIGLAR, A . - Detection of circulating immune complexes.
THESES IN PROGRESS
MEDICINE-AUSTIN HOSPITAL MD Theses in Progress
1. DONNAN, G. A. — Lacumar syndromes in a stroke population.
2. MARSHALL, A. W. — Hepatic transport of endogenous and xenobiotic organic com- pounds.
PhD Theses in Progress
3. BETTS, R. — Immunogenetics of Ihe human major histocompatibility complex.
4. CAMPBELL, D. i. —Control of aldosterone secretion.
5. DUFFY, S. — Exchangeable sodium and experimental hypertension.
6. HOGARTH, M. — Hybridoma production as a source of alloantibodies.
7. LOVELAND, B. — Cellular interactions during graft rejection in Ihe mouse.
8. MICHAELIDES, M. — Functional studies with Ly antigens in the mouse.
9. TAKATA, Y. — Angiotensin converting enzyme in hypertension.
10. THOMPSON, C. — Monoclonal antibodies recognizing human tumour specific antigens.
11. THURLOW, P. — The production of monoclonal antibodies to antigens of leukaemias lym- phomas, human tumours and the HLA system.
MSc Theses in Progress 12. Di NICOLANTONIO, R.-Mechanisms of hypertension.
13. HILL, J. S. — Studies on genetic defects of the red cell membrane.
14. LONG, J. G. — Cations and hypertension.
15. REID, M. — The effectiveness of an exercise training programme following myocardial in- farction compared with the standard rehabilitation programme as measured by maximal ex-
ercise capacity measured in mets at three months after myocardial infarction.
BSc Theses in Progress
16. SUTTON, V'. — Monoclonal antibodies to urine cell surface antigens.
17. TEW, C. — Mouse T lymphocytes sub-population in health and disease.
REPATRIATION GENERAL HOSPITAL PhD Theses in Progress
1. FINDLAY, D. M. — Calcitonin receptors in cancer cells.
2. HEANEY, T. P. — Regulation on insulin secretion in pancreatic islets.
3. NOLAN, R. D. — The regulation of prostaglandin synthesis in various tissues.
4. SHER, E. — Properties of the receptor for 1,25-dihydroxyvitamin D.
5. ROGERS, S. — Prostaglandins and diabetic vascular complications.
MSc Thesis in Progress 6. DANKS, J. M. — Renal sodium handling.
CLINICAL PHARMACOLOGY AND THERAPEUTICS MD Thesis in Progress
1. ANDERSON, A. — The pharmacokinetics of antihypertensive drugs.
MEDICINE (AUSTIN A N D REPAT. GEN. HOSPITALS) 157 PhD Theses in Progress
2. DRUMMER, O. H. O. — Structure-activity relationships on adrenoceptors.
3. DYNON, Wl.—Studies on the metabolism and mode of action of beta-blocking drugs.
4. GUNDLACH, A. —Neurotransmitter interactions in brain.
5. HOWES, L. — Mechanism of drug action on receptor and membranes.
6. MacPHERSON, G. — Characterization of adrenoceptors by ligand binding techniques.
7. McNEIL, J. J. — Pharmacokinetics of antihypertensive drugs.
8. MIACH, P. —Catecholamine receptors in brain.
9. PAPANICOLAOU, J. — Pharmacological basis of epilepsy.
10. PROUDFOOT, A. — Pharmacokinetic and clinical cisplalin and vinca alkaloids.
MSc Theses in Progress 11. LUCAS, I.—Pharmacokinetics of cytotoxic drugs.
12. THORSBORNE-PALMER, D. - Pharmacology or bronchodilator drugs.
SUBSTANTIAL GRANTS RECEIVED Grams have been received as follows:
NH & MRC: The role of tissue angiotensin formation in experimental and genetic hypertension.
NH & MRC: Studies in transplantation immunity.
NH & MRC: Cell surface immunogenetics.
NH & MRC: Production of monoclonal antibodies to lymphocyte antigens in man and mouse.
NH & MRC: Cortical evoked potentials in anxiety, depression and psychogenic pain.
NH & MRC: The hepatic transport of endogenous and xenobiotic organic compounds.
NH & MRC: Transport and excretory function of foetal liver.
NH & MRC: The control of vitamin D metabolism.
NH & MRC: The mucus-secreting cells of thc stomach: their role in health and disease.
NH & MRC: Isolation and identification of core material in exocrine secretion granules of alimen- tary tract.
NH & MRC: Calcium regulation in normoxic, ischaemic and re-oxygenated heart muscle.
NH & MRC: Modulation of lymphocyte function in hypothyroidism.
NH & MRC: Sites and mechanisms of action of centrally acting antihypertensive drugs.
NH & MRC: Identification and characterisation of a adrenoceptors by radioligand binding.
NH & MRC: Effect of antihypertensive drugs on circulating and vascular catecholamines in animal models of hypertension.
NH & MRC: The pharmacology of dopamine-GABA interactions and their clinical relevance.
Australian Tobacco Research Foundation: Production of monoclonal anticarcinoma of the lung antibodies for the early detection of displasia and neoplasia in cigarette smokers.
Australian Tobacco Research Foundation: A study of thc effect of tobacco smoking on an in- dividual's interrelationship with his sensory and social environment.
Australian Tobacco Research Foundation: Effects of smoking on prostaglandin production by vascular endothelium and blood platelets.
National Heart Foundation of Australia: Role of arachidonatc metabolites in the circulation.
National Heart Foundation of Australia: Assessment of thc role of brain angiotensin in hyperten- sion.
National Heart Foundation of Australia: Mechanism of calcium entry during post ischaemic reperfusion.
National Heart Foundation of Australia: Alpha adrenoceptors in lymphocytes.
National Heart Foundation of Australia: Distribution and regulation of adreno receptors in blood vessels.
National Heart Foundation of Australia: The influence of genetic factors on catecholamine abnor- malities in hypertension.
Medical Research Committee: Regulation of prostaglandin biosynthetic pathways in the lung and its relationship to pathogenesis of asthma and hypertension.
Medical Research Committee: Production of monoclonal antibodies to cell membrane and soluble antigens.
Austin Hospital Medical Research Foundation: An investigation into the effects of drugs and hor- mones on vitamin D metabolism and their relevance to thc treatment of uremic bone disease.
Austin Hospital Medical Research Foundation: Production of specific, monoclonal antibodies by the cell fusion hybridisation technique lo (a) human globulin; (b) bacteria; (c) human hormones.