MEDICINE
F. OTHER
1. Australian Twin Registry —J. D. Mathews, J. B. Gibson, N. G. Martin.
2. In vitro immune response to viral antigens-genetics and disease study —J. D. Mathews, B. D.
Tait.
3. Genetic studies of the immune response — .!. D. Mathews.
4. Causes of variation in blood lead levels in Melbourne families —J. D. Mathews.
PUBLISHED WORK Book
1. d'APlCE, A. J. F., BECKER, G. J., KINCAID-SMITH, P. (eds.)-ClinicalNephrology, A Lecture Series on, Boehringer Ingelheim Pty. Ltd., Sydney, for the Department of Nephrology, The Royal Melbourne Hospital (1980).
Chapters of Books
2. d'APlCE, A. J. F. — Immunopathogenesis of glomerulonephritis, in A Lecture Series on Clinical Nephrology, eds. A. J. F. d'Apicc, G. J. Becker and P. Kincaid-Smith, Boehringer Ingelheim, Sydney: 45 (1980).
3. d'APlCE, A. J. F. — Acute Renal Failure, in A Lecture Series on Clinical Nephrology, eds.
A. J. F. d'Apice, G. J. Becker and P. Kincaid-Smith, Boehringer Ingelheim, Sydney: 96 (1980).
4. KINCAID-SMITH, P. —The Treatment of Hypertension, in A Lecture Series on Clinical Nephrology, eds. A. J. V. d'Apice, G. J. Becker and P. Kincaid-Smith, Boehringer In- gelheim, Sydney: 15-22 (1980).
5. KINCAID-SMITH, P.—Analgesic Nephropathy, in A Lecture Series on Clinical Nephrologv, eds. A. J. F. d'Apice, G. J. Becker and P. Kincaid-Smith, Boehringer In- gelheim, Sydney: 86-95 (1980).
6. LOVELL, R. R. H . and the Australian Blood Pressure Study Management Commit- tee—Controlled Therapeutic Trial in Mild Hypertension, in A I hero-Sclerosis V, Proc. of the Fifth International Symposium, Workshop: Hypertension, eds. A. M . Gotto, Jr., L. C.
Smith and B. Allen, Springer-Verlag, New York: 707-711 (1980).
M E D I C I N E (ROYAL M E L B . HOSP.) 161
Articles
7. BECKER, G. J . , W A L K E R , R. C , D Z U I K A S , L. J . , H A R V E Y , K. J . , V A L E N T I N E , R.
and K I N C A I D - S M I T H , P. — Renal infection with Mycobacterium chelonci. A U S T . N.Z. J.
Med.. 10: 44-47 (1980).
8. B E N N E T T , N. M c K . , C U N N I N G H A M , A . L., ERASER, J. R. E. and SPEED, B. R.
— Epidemic polyarthritis acquired in Fiji. Med. J. Aust., 1: 316-317 (1980).
9. C O G H L A N , J . P., B U T K U S , A . , D E N T O N , D. A . , G R A H A M , W . F., H U M P H R E Y , T . J., SCOGGINS, G. A . and W H I T W O R T H , J. A . - S t e r o i d receptors in hypertension. Cir- culation Research. 4 6 ( 6 ) : 1/88-1/93, Part II (1980).
10. C O G H L A N , J. P., D E N T O N , D. A . , G R A H A M , W. F., H U M P H R E Y , T . J . , M A S O N , R. T \ , S C H N E I D E R , E. G . , SCOGGINS, B. A . and W H I T W O R T H , J. A . — Efleet of A C T H administration on the haemodvnamic response to arigininc-vasoprcssin in sheep.
Clin. & Exp. Pharmacol. & Phvsiol.. 7: 559-562 (1980).
11. C L A R K , S., L A R K I N S , R. G., de LUISE, M . and M E L L I C K , R. A . - T h e effects of trypsin and phospholipasc C on insulin binding and action in the isolated adipocyte. Biochem. J . ,
186: 535-540 (1980).
12. C L A R K , S., L A R K I N S , R. G. and M E L L I C K , R. A . — Negative coopcrativity induced by desoctapeptide insulin unmasked by phospholipasc C. Biochem. Biophvs. Research Comm., 95: 1543-1549 (1980).
13. D U M B L E , L. J . . M A C D O N A L D , I. M. and K I N C A I D - S M I T H , P. — Human renal allograft rejection is predicted by serial determinations of antibody dependent cellular cytotoxicity. Transplantation, 29 (1): 30-34 (1980).
14. D Z U I K A S , L. .1., D O U G L A S . S. M . , C A R T E R , P. M . , C A M P B E L L , D. C , A N D R E W S , J. T . , d ' A P l C E , A . J. F. and K I N C A I D - S M I T H , P . - E v a l u a t i o n o f t h e gambro lundia ma- jor l . 3 6 m; disposable parallel plate dialyzer. J. Dialysis. 3 (4): 309-325 (19S0).
15. E N G L A N D , .1. I-'.—The influence of beta blockers upon Plasma Cvclic A M P levels. Ausi.
N.Z. J. Med., 10: 180-181 (1980).
16. F A I R L E Y , K. F. — Haematuria. Med. A u s i . , 25 (2): 1781-1784 (I9S0).
17. F A I R L E Y , K. F. and W H I T W O R T H , J. A . - P r o b l e m s in thc treatment of urinary tract in- fections. Drugs, 19: 190-194 (1980).
18. FRASER, J. R. E. and C U N N I N G H A M , A . L. — Incubation time o f epidemic polyarthritis.
Med. .1. A u s i . . I: 550-551 (1980).
19. FRASER, J. R. E., T A I T , B., A A S K O V , .1. G. and C U N N I N G H A M , A . L . - P o s s i b l e genetic determinants in epidemic polyarthritis caused by Ross River virus infection. Aust.
N.Z. J. Med.. 10: 597-603 (1980).
20. G R A H A M , W. F., A L L E N , K. J. !•'., C O G H L A N . J. P., D E N T O N , D. A . , H U M P H R E Y . T. J . , SCOGGINS, B. A . , and W H I T W O R T H , J. A. - Haemodynamic changes in A C T H - induced hypertension in sheep. Clin. & Exp. Pharmacol. & Phvsiol.. 7: 569-572 (1980).
21. H I G G 1 N B O T H A M , I..., M A R T I N , F. I. R., B U C H A N A N , M . R. C , B U T K U S , A . and WHIT W O R T H , J. A . - Cushing's syndrome due to an ACTH-secrcting adrenal medullary tumour. Ausi. N.Z. J . Med.. 10: 654-656 (1980).
22. H U A , A . S. P., K A L O W S K I , S., W H I T W O R T H , J. A . A N D K I N C A I D - S M I T H , P . - Acebutolol in mild to moderate hypertension. A double blind crossover studv. Med. J.
Ausi.. I : 226-22S (1980).
23. J U N O R , B. J. F., d ' A P l C E , A . J. F. and K I N C A I D - S M I T H , P. —Circulating immune com- plexes after renal transplantation. Transplantation, 30 (2): 111-113 (1980).
24. K I N C A I D - S M I T H , P. — Analgesic abuse and the kidney. Kidnev International. 17: 250-260 (1980).
25. K I N C A I D - S M I T H , P.— Assessment of the hypertensive. Ausi. Eainilv Phvsician, 9 (4):
222-227 (I9S0).
26. K I N C A I D - S M I T H , P.-Glomerulonephritis. Med. Australia. 24 Part I I : 1795-1804 (1980).
27. K I N C A I D - S M I T H , P. — Hypertension. Med. Australia, I: 1479-1495 (1980).
2S. K I N C A I D - S M I T H , P. — Malignant hypertension: mechanisms and management. Phar/nu.
Ther.. 9: 245-269 (1980).
29. K I N C A I D - S M I T H , P. — Renal biopsy. Med. Australia. 26: 1872-1873 Part 3 (1980).
30. K I N C A I D - S M I T H , P. —The kidneys in hypertension. Current Concepts in Hypertension and Cardiovascular Disorders, I (2): 5-8 (1980).
31. K I N C A I D - S M I T H , P . - T h e treatment of glomerulonephritis. A u s i . N.Z. J . Med., 10:
340-345 (1980).
32. K I N C A I D - S M I T H , P. — Treatment of renal hypertension. Drugs. 19: 312-316 (1980).
33. K I N C A I D - S M I T H , P. and D A V I E S , B. — Lithium and the kidney: research and clinical im- plications. Advances in Human Psvchopharmacologv. I: 141-155 (1980).
34. K I N C A I D - S M I T H . P., W H I T W O R T H , J. A . , and F A I R L E Y , K. F . - M e s a n g i a l IgA nephropathy in pregnancy. Clin. & Exp. Hvperiension: 821-838 (1980).
35. K I N C A I D - S M I T H , P. and W H I T W O R T H . J. A. — Renal diseases-advances in treatment.
Current Therapeutics, 21 (9): 193-199 (1980).
36. L A W , 11. Y., B O D M E R , W. F., M A T H E W S , I. D., SKEGG, D. C . - T h c immune response to vasectomy and its relation to H L A system. Tissue Antigens, 14: 115-139 (1979).
37. L I F E , E., M E D C A L F , R., I W A N O V , V. and M O U L D S , R. F. W . - A comparison of the effects of endrallazinc and hydralazine on isolated human arteries and veins. Clin. & Exp.
Pharmacol. & Phvsiol., 7 (Abstract 78) 685 (1980).
38. L I F E , S. and M O U L D S , R. E. W. - S t u d i e s on thc mechanism o f thc effect of hydralazine on isolated human arteries and veins. Proc. A.S.C.E.P., 10: 180 (1980).
39. M A C D O N A L D , I., H U A , A. S. P., T H O M A S , G. W., W O O , K. T . . W H I T W O R T H , J. A . and K I N C A I D - S M I T H , P . - U s e of labetalol in moderate to severe hypertension. Med. J.
A n s l . . 1: 325-327 (1980).
40. M A C R A E , E. A . , ST. J O H N , D. .1. 13. - Detection of colo-rcctal tumours by Hacmoccult:
influence of patterns of bleeding and slide sensitivity. A n s l . N.Z. J . M e d . , 10: 589 (1980).
41. M A C R A E , F. A . , ST. J O H N , D. J. B. —Spontaneous bacterial peritonitis: reversible cause of deterioration in patients with cirrhosis. Med. J. Aust.. 2: 209-211 (1980).
42. M A T H E W S , J. D. — Interaction o f genetic and environmental factors causing atherosclerosis by immunologic mechanisms, in Atherosclerosis V: Proc. o f ilie F i f t h Inter- national Svmposium on Atherosclerosis: eds. A. M . G o t t o , L. C. Smilh, B. Allen, Sprinecr- Verlag, New Y o r k : 324-329 (1980).
43. M A T H E W S , J. D., M A T H I E S O N , I. D., T A I T , G. D . - E v a l u a t i n g ihc importance o f im- munological and immunogenelic factors in atherosclerosis, in Immunity and Atherosclerosis:
Proc. o f Ihe Serona Svmposia, ed. P. Consianlinides, Academic Press, London, 24: 57-67 (1980).
44. M O U L D S , R. I7. W . —Reduced responses lo noradrenaline of isolated digital arteries from hypertensives. Clin. & Exp. Pharmacol. & Phvsiol., 7: 505-508 (1980).
45. M O U L D S , R. F. W. R I T T 1 N G H A U S E N , R. E. and S H A W , J. - Prejunctional receptors in human digital arteries. Cir. Pes.. 46 ( I I ) : 180-182 (1980).
46. M O U L D S , R. F. W . and W O R L A N D , P. J. - Potentiation of human vascular smooth mus- cle contraction by angiotensin. J. Cardiovasc. Pharmacol.. 2: 377-386 (1980).
47. M U I R D E N , K. D. — Anti-arihritic drugs in ihe treat mem of rheumatoid arthritis. Australian Prescriber. 4 (2): 38-39 (1980).
48. M U I R D E N , K. D. —The evolution o f chronic inflammation in joint disease. Indian Rheumatism Association Bulletin, 2: 2-8 (1979).
49. M U I R D E N , K. D. — Treatment o f osteoarthritis. Current Therapeutics. 2 1 : 59-63 (1980).
50. M U I R D E N , K. D. — Rheumatic diseases: future treatment prospects. Current Therapeutics, 2 1 : 215-220 (1980).
51. M U I R D E N , K. D. and R O B I N S O N , A . D . - C e l l u l a r immunity to possible synovial antigens in rheumatoid arthritis. A n n . Rheum. Dis., 3 9 ( 6 ) : 539-544 (1980).
52. N A N K E R V 1 S , A . , F A I R L E Y , K. F., S H A W , P. G., W H I T W O R T H , J. A . , M I L E S , H . . G R A H A M , I., and P A V I L L A R D , R.—Treatment of urinary tract infection with multiple- dose administered iiitra-muscular cefamandole. Med. J. A u s i . , 1: 427-428 (1980).
53. R I C H M O N D , .1. M . , d ' A P l C E , A . J. F., M U I R D E N , K. D., W H I T W O R T H , J. A . and K I N C A I D - S M I T H , P. — Scleroderma crisis — response to therapy. Med. J. A u s i . , I: 545-547 (1980).
54. R I C H M O N D . J. M . , d ' A P l C E , A . J. F., W H I T W O R T H , .1. A . , and K I N C A I D - S M I T H , P.— Thrombotic thrombocytopaenic purpura and anuria: response lo plasma exchange Aust. N.Z. J. Med.. 10: 48-50 (1980).
55. R I T T I N G H A U S E N , R. E. and M O U L D S , R. I7. W . - T h e use of isolated digital arteries lo studv factors influencing adrcncrgic-transniiller release in man. C77/I. Sci., 58: 373-378 (1980).
56. S H A W , P., F A I R L E Y , K. F. and W H I T W O R T H , J. A . — Treatment of urinary tract infec- tion wilh single dose intramuscular administration ccfcmandole. Med. J. A u s i . . I : 489 (1980).
57. ST. J O H N , D. J. 13.-Gastritis and duodenitis: the role o f drugs. A u s i . N.Z. J. Med., 10:
591 (I9S0).
58. STEVENS. M . J. and M O U L D S , R. F. W . —Are neuronal uptake mechanisms responsible for the difference in sensitivity to noradrenaline between human arlcrics and veins? Clin. <£
Exp. Pharmacol. & Phvsiol.. 7: 139-145 (1980).
59. W A L K E R , R. G., W H I T W O R T H , J. A . , and K I N C A I D - S M I T H , P . - A c u t e interstitial nephritis in a patient taking licnilic acid. Brit. Med. J . . 280 (6225): 1212 (1980).
60. W A L K E R , R. G., Y E U N G , C. K.. H U A , A . S. P., T H O M A S , G. W . , W H I T W O R T H , J.
A . and K I N C A I D - S M I T H , P.—Tienilic acid in thc treatment o f mild to moderate hyperten- sion. Clin. <« Exp. Pharmacol. & Phvsiol.. 7 (5): 473-477 (1980).
61. W A L T E R . N. M. A . , W H I T W O R T H , J. A . and K I N C A I D - S M I T H , P . - C a p t o p r i l in mild and severe hypertension. Clin. <£ Exp. Pharmacol. <£ Phvsiol.. 7 ( 5 ) : 477 (1980).
62. W H I T T I N G H A M . S.. M A T H E W S . J. D., S C H A N E I E L D , M . S., M A T T H E W S , J. V., T A I T , B. D., M O R R I S , P. .1., and M A C K A Y , 1. R. — Interactive ell'ects o f Gin allotypes and
MEDICINE (ROYAL MELB. HOSP.) 163 HLA-B locus antigens on the human antibody response to a bacterial antigen. Clin. Exp. Im- munol.. 40: S-l5 (I9S0).
63. WHIT WORTH, J. A. and FAIRLEY, K. F.-Urinary tract infection. Med. Australia, 25:
1806-1813 (1980).
64. WOO, K. T., JUNOR, B. .1. R., SALEM, I I . , d'APlCE, A. J. F., WHITWORTH, J. A. and KINCAID-SMITH, P. — Bcta-thromboglobulin and platelet aggregates in glomerulo- nephritis. Clin. Nephrologv, 14 (2): 92-95 (1980).
65. YEOMANS, N. D., ST. JOHN, D. G. J.-Familial Mediterranean fever in Australia. Med.
J. Aust.. I : 334-335 (1980).
66. WRIGHT, P. A., REED, P. I . , DAVIES, W. A., ST. JOHN, D. J. B., YOUNG, G. P., HOUSE, F. R., GRIBBLE, R. .1. N. and BARON, J. II.-Scrum carbenoxolone: Ulcer heal- ing and metabolic effects. Scandinavian J. of Gastroenterology, 15, (Supp. 65): 41-46 (1980).
Reports and Notes
67. BAXTER, E., ERASER, J. R. E. and HOLMES, M . - A n i o n acceleration-a potentially useful artefact of gel chromatography in small-pore polvacrvlamide gels. Connect. Tissue lies.. 7: 198-199 (1980).
68. BAXT ER, E., FRASER, J. R. E. and CLARRIS, B. J. - Modulation of the functional behaviour of cultured human svnovial cells via membrane receptors. Ausi. N.Z. ./. Med., 10:
272 (1980).
69. BAXTER, E., FRASER, J. R. E and CLARRIS, B. J.-Thc ell'ect of adenosine on hyaluronic biosynthesis in human svnovial cells. Proc. Ausi. liiochein. Soc, 13: 50 (1980).
70. BULLEN, M . U., WHITWORTH, J. A. and KINCAID-SMITH, P.-Comparison of single-dose and twice daily timolol therapv in mild hypertension Med. J. Ausi., 2 (9): 514-515 (1980) (Letter).
71. CLARRIS, B. J., ERASER, I . R. E. and MICHELANGELI, V. P.-Cholera cnteroioxin induces "dendritic" cells and increases adenylate cyclase activity in cultures of non- rheumatoid synovium. Ausi. N.Z. J. Med., 10: 272 (1980).
72. CUNNINGHAM, A. L. and ERASER, J. R. E.-Rubella arthritis —a study of joint pathologv and pathogenesis in a single case. Aust. N.Z. ./. Med., 10: 272 (1980).
73. DUDLES', F. J., ALFORD, F. and YOUNG. G. P. - Hypcrglucagonaemia in cirrhosis: Im- paired clearance or increased secretion? Sixth World Congress of Gastroenterology, Madrid:
(June 1978).
74. DUMBLE, L. J., MACDONALD, I . M . , CLUNIE, G. J. A. and KINCAID-SMITH, P.
— The ell'ects of antibody dependent cellular cytotoxicity in renal transplantation. Abstract:
Australasian Societv of Nephrology Annual Scientific Meeting, 1980. Aust. N.Z. J. Med., 19 (4): 480 (1980).
75. FRASER, J. R. E., CUNNINGHAM, A. L., CLARRIS, B. J. and LEACH, R. — Long-term studies of epidemic polyarthritis. Aust. N.Z. J. Med.. 10: 483 (1980).
76. KINCAID-SMITH, P., WHITWORTH, J. A., WALTER, N. M . A. and DOWLING, J. P.
— Immune complex glomerulopathy and captopril. Lancet, 2: 37 (1980) (Letter).
77. MOK, J. S. L. and MOULDS, R. F. W . - A comparison of ihc ell'ects of diazoxide, chlorothiazide, ethacrvnic acid and frusemide on human vascular smooth muscle. Abstract, 17-19 December, A.S.C.E.P., Canberra: (1980).
78. RICHMOND, J. M . , KINCAID-SMITH, P. and WHITWORTH. .1. A. — Familial nephropathy and gout. Abstract: Australasian Society of Nephrology Annual Scientific Meeting, 1980. Aust. N.Z. J. Med., KJ (4): 487 (1980).
79. WOO, K. T\, JUNOR. B. J. R , SALEM, H., d'APlCE, A. J. F., WHITWORTH, I . A. and K I N C A I D - S M I T H , P . - B e t a thromboglobulin and platelet aggregates in glomerulonephritis. Aust. N.Z. J. Med.. 10: 127-128 (1980) (Abstract).
THESES PASSED FOR HIGHER DEGREES Doctor of Philosophy
1. HEYMA, P. — The regulation of triiodothyronine formation.
Doctor of Medicine
2. BURDON, J. G. W.- Ventilatory drive during loaded breathing.
Master of Science 3. TAY, S. K. — Sperm antibody measurement.
Master of Applied Science [P.M.I. TJ 4. CLARK, S. — Effects of enzymes on ihe insulin receptor.
Bachelor of Science (Hons)
5. MOK, J. — A study of direct relaxant effects of diuretic drugs on human vascular smooth muscle.
6. SANDIG, D. — Antigenicity of ureaptasma.
Bachelor of Medical Science
7. FINLAY, R. 1. — Immunogenetic studies in sudden infant death syndrome (SIDS).
THESES IN PROGRESS PhD Theses in Progress
1. BRAZIER, B. — Mechanisms of production of hypercalciuria by high protein diets.
2. CLARK, S. — Regulation of insulin binding and action.
3. DE LUISE, M. — Characteristics of polypeptide hormone receptors.
4. HUA, A. S. P. —Hypertension and drugs: clinical and experimental studies.
5. L1PE, S. — Investigation of altered nervous control of vascular smooth muscle in hyperten- sion.
6. MACDONALD, I . M.— Clinical and experimental studies in glomerulonephritis (Submiued).
7. MEDCALF, R. — Immunological mechanisms in pre-eclampsia.
8. STEVENS, M. — Comparison of the nervous control of human isolated arteries and veins.
MD Theses in Progress 9. CUNNINGHAM, A. L.-Studies in virus arthritis.
10. DZUIKAS, L. — Experimental pylonephritis in relation to focal nyalinosis.
11. HOFFMAN, L. — The metabolic effects of transplantation of foetal mouse pancreatic islets.
12. JAUERNIG, R. — 77ie development and use of isolated human vascular preparations.
13. MACRAE, 1". A. —Studies on early detection of colorectal cancer.
14. R1TTINGHAUSEN, R. — Studies in presynaptic receptors in human blood vessels.
15. WALKER, R. G. —Lithium nephrotoxicity.
16. YOUNG, G. P.- Inter-relationship of soluble and membranous forms of intestinal alkaline phosphatase.
MSc Theses in Progress
17. IWANOV, V. — The role of endogenous vasoactive agents in producing contractile effects in isolated human blood vessels.
18. PICKERING, W. J.—Ascending Ureaptasma urealyticum infection of the rat kidney—an immunopalhological study of the hosl-parasile interaction and its relationship to progressive renal disease.
19. QUELCH, K. —Studies on the proteins of human bone.
MPharm Theses in Progress
20. STEVENS, M . J. — A pharmacological comparison of human digital arteries and metacarpal veins. (Submitted).
SUBSTANTIAL GRANT'S R E C E I V E D Grants have been received as follows:
Anti-Cancer Council of Victoria: Studies on the early detection of colorectal cancer.
Australian Kidney Foundation: Lithium nephrotoxicity in animals.
Australian Kidney Foundation: Suppressor cell activity in patients with glomerulonephritis.
Australian Kidney Foundation: Blood pressure, haemodynamic, renal and metabolic effects of ACTH in man.
Australian Arthritis and Rheumatism Foundation: The role of alpha-2-macroglobulin in rheumatoid arthritis.
Australian Tobacco Research Foundation: The influence of smoking on the genesis of malignant phase hypertension.
Country Women's Association of Victoria: Arthritis research.
Life Insurance Fund: Steroids and hypertension.
Mental Health Research Fund: Lithium nephrotoxicity in animals.
NH & MRC: Enzyme inhibitors and the pathogenesis of rheumatoid arthritis.
NH & MRC: A comparison of arterial sympathetic neurotransmitter mechanisms in normotensive and hypertensive patients.
NH & MRC: Lithium nephrotoxicity.
MEDICINE (ROYAL MELB. HOSP.) 165 NH & MRC: The significance of HLA-DR and associated antigen systems in renal transplantation.
NH & MRC: Thc mechanism of the beneficial effect of blood transfusion on renal transplantation.
NH & MRC: Metabolism of hyaluronic acid.
NH & MRC: Programme grant —B. J. Clarris, National Health and Medical Research Council Fellow.
NH & MRC: Australian Twin Registry.
NH & MRC: In vilro immune response to viral antigens —genetic and disease study.
NH & MRC: lmmunogenctic and family studies of coronary heart disease.
National Heart Foundation: Twin studies of cardiovascular risk factors.
Clive and Vera Ramiciotti Foundation: Immunological complications of vasectomy.
Rheumatism and Arthritis Association of Victoria: Cell induced immunity studies in rheumatoid arthritis.
Royal Australian Navy: Study of cardiovascular risk factors in naval recruits.
University of Melbourne Floral Group: Arthritis research.
Victor Hurley Medical Research Fund: Lithium nephrotoxicity in animals.
Victor Hurley Medical Research Fund: The significance of Ureaplasma urealyticum in renal disease.
Victor Hurley Medical Research Fund: Steroids in hypertension.
MEDICINE
ST. V I N C E N T ' S H O S P I T A L I N T R O D U C T I O N
During 1980 experimental haematology remained the major research interest of thc Depart- ment. While studies on the structure and function of platelet release proteins has continued, an ex- pansion in the study o f heterogeneity of platelets was achieved with thc arrival o f Dr J . F. Martin from Sheffield. Improvements in technique resulted in new and important findings and these studies will form part o f the discussions held by a newly-formed working party o f the International Committee on Thrombosis and Haemostasis which meets in mid 1981. The Cytogenetic Depart- ment has also expanded its activities and Dr O. M . Garson is thc Australian representative on a regular International Workshop to study chromosomes in leukaemia. Dr F. Firkin is developing new techniques in long-term human bone marrow culture which he has been studying in O x f o r d during thc last six months o f 1980.
In Ihc fields of gastroenterology and nutrition the effects of alcohol and related areas of drug metabolism in the presence of liver disease have continued and will be enhanced by the appoint- ment o f Dr P. V. Desmond to Clinical Pharmacology. A n objective measure o f the efficiency o f various teaching methods and ihe ell'ects o f observer subjectivity in clinical medicine are important areas in a Clinical School and Dr G. Whelan is continuing to perform these studies. T he Depart- ment o f Endocrinology is maintaining an active research inlercst into several aspects of diabetes mellitus and ihc Cardiac Investigation Unit is continuing its studies in the use of echocardiography and exercise testing.
R E S E A R C H T O P I C S IN P R O G R E S S A . E X P E R I M E N T A L H A E M A T O L O G Y
D. G. Pcnington, C. N. Chcslernian, F. C. Firkin, O. M . Garson, J. F. M a r t i n , F. J. Morgan, W.
Beswick.
1. Investigation of synthesis of platelet factor 4 and /3-thromboglobulin in platelets and in megakaryocytes (with St. Vincent's School o f Medical Research).
2. Purification and chemistry of platelet specific mitogenic factors (with St. Vincent's School of Medical Research).
3. Platelet kinetics in coronary artery disease ( w i l h St. Vincent's School o f Medical Research and the Royal Melbourne Hospilal).
4. The effect of /3-thromboglobulin on endothelial cell prostacyclin production (wilh Prof. T. J.
M a r t i n , Repatriation General Hospital, Heidelberg and St. Vincent's School of Medical Research).
5. Investigation of platelet and coagulation abnormalities in diabetes mellitus, their relationship to small vessel disease and the etl'ccts o f treatment (with Dr F. P. A l f o r d ) .
6. Mechanisms in the production of vascular spasm secondary to limb trauma (with Microsurgery Research Unit, St. Vincent's Hospilal).
7. A n investigation of platelet volume, density, immunoglobulin content and diagnostic methods in immune thrombocytopenia (with Department of Medicine, Monash Medical School).
8. Investigation of a new antileukacmic drug: meta-AMSA.
9. Combination chemotherapy in lymphoma (with Australian Lymphoma Group).
10. Development and application o f short and long-term human bone marrow culture to study mechanisms and treatment of bone marrow depression and malignancy.
11. Estimation of erythropoietin levels in human blood disorders by a simplified tissue culture bioassay.
12. Studies in neutrophil kinetics—mechanisms of neutropenia.
13. Comparison o f methods of density separation o f platelet populations.
14. Relationship of platelet age and density studies using 7 5Se-mcthioninc cohort labelling.
15. The whole distribution and survival of 5 1C r and 1 1 1 In-labelled platelet density-defined sub- population in the monkey.
16. Volume and density of "stress" platelets produced after thrombocytopenia.
17. Nature o f the thrombocytosis produced by vinca alkaloids.
18. Investigation of thc ultrastructure and function of platelet density defined subpopulations and "stress" platelets.
19. Megakaryocyte ultrastructure in stimulated platelet production.
20. Role o f nutrition in the regeneration o f bone marrow during therapy for acuic leukaemia.
21. Chromosome studies in acute leukaemia.
22. Chromosome studies of patients wilh therapy-induced remission of lymphoma (with the Haematology Research Unit, Cancer Institute).
MEDICINE (ST. VINCENT'S HOSP.) 167 23. Cytogenetic identification of human tumour cell lines (with the Biological Research Unit,
Cancer Institute).
24. Chromosome studies in multiple myeloma and C-banding studies in patients with chronic granulocytic leukaemia.
25. Chromosome banding studies in cats (with Department of Biology, Melbourne State College).
26. Collating of clinical and cytogenetic data on patients wilh acute lymphoblastic leukaemia for participation in thc Third International Workshop on Chromosomes in Leukaemia.
27. In vitro culture of megakaryocytes.
B. CARDIOLOGY I . G. McDonald, M . J. V. Jelinek 1. Stratified risks early after uncomplicated myocardial infarction.
2. Objective and integrated clinical diagnosis using echocardiography as a model.
3. Ambulatory monitoring: comparison of 24 hour continuous and 5 day intermittent sampling technique (with the Royal Melbourne Hospilal).
4. Prognostic significance of test angina early after myocardial infarction.