LECTURES Three lectures per week throughout the year.
TUTORIALS One 1-hour tutorial per week throughout the year.
PRACTICAL CLASSES DEMONSTRATION SEMINARS Each student will attend a 3-hours' session each fortnight throughout the year. Details will be posted on notice boards.
SYLLABUS The course will be concerned with the general principles of pharmacology and with the mechanisms of action of drugs in common use in medicine under the following headings:
The nature of receptors. The physiological basis of drug action and the kinetics of drug action. Absorption, distribution, excretion and meta- bolism of drugs. The pharmaceutical aspects of drug administration.
Pharmacogenetics. The mechanism of drug interaction. Principles of selective toxicity. Drugs affecting water and electrolyte balance. The biochemistry, physiology and pharmacology of junctional transmission in the peripheral autonomic and somatic neuroeffector systems and in the central nervous system. The effects of drugs on neurohumoural trans- mission. Local hormones and other pharmacologically active substances occurring naturally in tissues; their role in physiological and pathological processes and the modification of their actions by drugs. Drugs affect- ing the central nervous system; psychotropic drugs; centrally acting drugs to treat disorders of motor function; sedatives and hypnotics;
analgesics; and general anaesthetics. Drugs acting on the cardiovascular, 105
Faculty of Medicine
respiratory and gastrointestinal systems. Drugs affecting fertility and reproduction. Ocular pharmacology. The pharmacology of the endocrine system including hormone preparations, their synthetic analogues and antagonists and drugs which interact with hormone and endocrine glands.
Drugs affecting haematopoiesis and coagulation. Anti-inflammatory drugs.
Mechanisms of drug dependence and abuse.
BOOKS Prescribed textbooks:
Bowman W C Rand M J and West G B Text-book of Pharmacology rev 1st ed, Blackwell Scientific Pub' 1970
•Rand M J Raper C and McCulloch M W An Introduction to the Physi- ology end Pharmacology of the Autonomic Nervous System rev 1st ed, Aust Pharmaceutical 1973
•Goodman L S and Gilman A The Pharmacological Basis of Thera- peutics 4th ed, Macmillan 1970
Di Palma J R Drill's Pharmacology in Medicine 4th ed, McGraw-Hill 1971
•Goldstein A Arownow L and Kalman S M Principles of Drug Action 2nd ed, Harper & Row 1974
Meyers F H and Jawetz E and Goldfin A Medical Pharmacology, Lange 1974
Laurence D R Clinical Pharmacology 4th ed, Churchill 1973
Passmore R and Robson J S. A Companion to Medical Studies Vol 2, Pharmacology Microbiology General Pathology and Related Sub- jects, Blackwell Sclentif Pub 1970
Martindale's Extra Pharmacopeia 26th ed, Pharmaceutical 1972
EXAMINATION A 2-hours' written examination consisting of multiple choice type questions will be held after the 1st term. Marks allotted to this examination will be used in making the end of the year assess- ment. The final examination will consist of one 3-hour written paper.
Oral examinations may be required for some students, who will be notified after assessment of the written paper. A terminal test may also be given.
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032 MICROBIOLOGYA course of 71 lectures, 18 three-hour practical sessions with associated tutorials, 18 two-hour museum sessions, and a small number of hospital clinical sessions.
SYLLABUS The characteristics of pathogenic bacteria, viruses, fungi, protozoa and helminths; the properties that enable them to cause disease;
the immunological response of the host; the principles of epidemiology, chemotherapy, sterilization and immunization; and the techniques used in laboratory diagnosis of microbial diseases.
PRACTICAL WORK Lays stress on case studies that relate laboratory diagnosis to clinical data. Supplemented by museum demonstrations.
BOOKS
(a) Preliminary reading:
Burnet F M & White D O Natural History of Infectious Disease, CUP 1972
(b) Prescribed textbook:
Davis B D et al Microbiology 2nd ed, Heber 1973 or
Cruickshank R Medical Microbiology Vol 1 12th ed, Churchill Living- stone 1973
(c) Recommended for reference:
Benenson S A The Control of Communicable Disease, 11th or subse- quent ed, APIA 1970
Fenner F & White D 0 Medical Virology, Academic Press 1970 Gillies R R & Dodds T C Bacteriology Illustrated, 3rd ed Livingstone
1973
Roitt I M Essential Immunology 2nd ed, Blackwell 1974
Rubbo S D & Gardner J F A Review of Sterilization end Disinfection, 2nd ed Lloyd-Luke 1974
EXAMINATION Terminal tests plus a final 3-hour written paper, a prac- tical examination, and, in certain cases, an oral or equivalent examination.
FOURTH YEAR
500-491 MEDICINE
CLINICAL INTRODUCTORY COURSE
A systematic course in clinical methods to be conducted with small groups of students. Class demonstrations on history taking will be given.
MEDICAL CLERKING
Medical clerking involves the appointment of a small group of students to a teaching unit with Inpatient and/or Outpatient facilities. In respect of Inpatients: Patients will be allocated on admission to individual students who will clerk them. Clerking involves history taking, physical examination, following the investigation, course and treatment of the patient and recording all of this In a systematic way. In respect of Outpatients: Clerking involves initially the observation by a small group of students of an experienced doctor handling an Outpatient consultation, then gradually increasing the involvement of individual students in the process until they assume, under supervision, much of the role of the doctor.
Medical Inpatient clerking will generally be based on an allocation of not less than three patients suitable for clerking per student at any one time.
During tenure of a medical clerking appointment, students will receive daily organized instruction in small groups in wards and/or Outpatients.
MEDICAL LECTURES
Lectures will be designed as commentaries on the course. The details of the programmes will be the responsibility of Individual clinical schools.
EXAMINATION 500-492 SURGERY
From the beginning of 1976 this year will be spent entirely within the clinical schools, with Instruction in medicine and surgery and continuing teaching in the pre and para clinical subjects. Following an introductory clinical period of six weeks students will be allocated in groups to clinical units in Medicine and Surgery, where they will receive bedside instruction in clinical methods and patient care. Throughout the year the 107
Faculty of Medicine
clinical teaching will be combined with continuing instruction in Spеciat Pathology, Anatomy, Physiology, Pharmacology and Microbiology.
Emphasis will be placed on the relevance of these subjects to clinicat practice. Students will be assessed during the year in Medicine and Surgery and this may be taken into account at the time of the finak examinations in Sixth Year.
BOOKS These are listed under "General Surgery".