PEMANFAATAN PATI KULIT PISANG KEPOK
(Musa
paradisiaca linn)
SEBAGAI BAHAN PENGISI TABLET
PARACETAMOL 500 Mg
ABSTRAK
Telah dilakukan penelitian Pemanfaatan Pati Kulit Pisang kepok (Musa paradisiaca linn) Sebagai Bahan Pengisi Tablet Paracetamol 500 mg. Pati kulit pisang diisolasi dari kulit pisang dengan rendemen 5%. Pati kulit pisang digunakan sebagai bahan pengisi pada tablet paracetamol dan tablet dengan pengisi Pati jagung sebagai pembanding. Granul kemudian diuji preformulasi dan dicetak dengan mesin pencetak tablet single punch lalu dilakukan uji sifat fisik pada kedua tablet tersebut. Hasil uji fisik tablet dengan pengisi pati jagung diperoleh bobot rata rata 607,429 mg, kekerasan 51,1 N, keregasan 0,886%, waktu hancur tablet 05:43 menit, uji disolusi 97,44% dan kadar zat aktif 101,453% dan tablet dengan pengisi pati kulit pisang diperoleh hasil bobot rata-rata 591,696 mg, kekerasan 32,5 N, keregasan 2,913%, waktu hancur 01:36 menit, uji disolusi 86,73% dan kadar zat aktif 99.798%. Hasil penelitian menunjukkan tablet dengan pengisi pati kulit pisang menghasilkan tablet dengan kekerasan lebih rendah dan lebih rapuh serta lebih cepat hancur.
Kata kunci : Pati kulit pisang,tablet paracetamol,uji fisik,kulit pisang
APPLICATION OF BANANA PEEL STARCH
(Mussa paradisiaca
linn)
AS FILLER OF PARACETAMOL TABLET 500 Mg
ABSTRACT
Application of banana peel starch (Mussa paradisiaca linn) as filler of paracetamol tablet 500 mg has been studied. Banana peel starch isolated from banana pell with rendemen 5%. Banana peel starch compared with corn starch as filler of paracetamol tablet. Preformulation studies had been conducted toward produced granules before compression was performed with single punch tableting machine. Result of tablet with corn starch are average weight 607,429 mg, Hardness of 51,1 N, Friabilty of 0,886%, disintegration of 05:43 minute, Dissolution of 97,44% and Assay of 101,453% and result of tablet with banana pell starch as filler are average weight 591,696 mg, Hardness of 32,5 N, Friability of 2,913%, disentegration of 01:36 minute, disolution of 86,73% and assay of 99.798%. This studies show that tablet with banana peel starch as filler make tablet with low hardness, more friability and fast disentegration.
Keyword : Banana pell starch, paracetamol tablet, physical characteristic, banana peel
