16/02/18 17.43 Asian Journal of Pharmaceutical and Clinical Research
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Impact (Cites per
doc)
- 0.40
(
SCImago, SJR
2016
)
ICV 2016
= 104.84
Print ISSN-
0974-2441
Online ISSN-
2455-3891
Asian Journal of Pharmaceutical and Clinical
Research
AJPCR (Asian J Pharm Clin Res) is peer reviewed, Monthly (Onward Jan 2017) open access
Journal. This journal publishes original research in the field of Pharmaceutical and Clinical
Sciences. The Journal has been designed to cover all the fields of research, which has any
correlation and impact on Pharmaceutical Science. It aims to publish all the original research in
field of science so a correlation can be made between these researches. Knowledge gained by
such researches can be exposed to all and it can be brought in real utilization as all the
branches of science are correlated and will assist all the researchers to potentiate their research
capabilities.
Abstracting and Indexing
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,
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Knowledege Resource Integrated Database)
, CAS, CASSI (American Chemical Society), ICAAP,
Scientific commons, PSOAR, Open-J-Gate, Indian Citation Index (ICI), Index Medicus for WHO
South-East Asia (IMSEAR), OAI, LOCKKS, OCLC (World Digital Collection Gateway), UIUC.
UGC Listed Journal
Innovare Academic Sciences
Vision:
Impart in quality knowledge and innovation is most important radical for human welfare.
Mission:
IAS contribute to human development through support to organization in getting
accreditation/approval for quality education, quality research dissemination, research to
innovations and finally to IPR and extension activities.
Goals:
The goals of innovare academics sciences are:
To provide support to industry and academic institute to enhance their intellectual
property.
To spread knowledge for innovations.
To help in getting organization accreditation/approvals status.
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16/02/18 17.43 Asian Journal of Pharmaceutical and Clinical Research
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M O S T
D O W N L O A D E D A R T I C L E S
PREGELATINIZED CASSAVA STARCH...
ANTIBACTERIAL ACTIVITY OF HYDROLYZED...
ANTI-CANCER ACTIVITY OF DATURA METEL...
BUCCAL PENETRATION ENHANCERS-AN OVERVIEW
DIPEPTIDYL PEPTIDASE-IV INHIBITORY...
TURMERIC: NATURE’S PRECIOUS MEDICINE.
ANTIBACTERIAL ACTIVITY OF THE...
To provide business designs in pharma and others.
To join hands with various organizers of the conference to provide a common platform for
experts, researchers, educational managers, policy makers and industrialists.
To keep a record of the state-of-the-art research and to promote study, patents, design for
business, accreditation and approval within its various specialities.
Assoiciate Conferences
Recent Trends in Biomedical Sciences-2018 (Visit Here)
Department of Medical Laboratory Sciences (LSPPS) at Lovely
Professional University is going to organize a national conference on
Recent Trends in Biomedical Sciences 2018 (RTBS-2018) on 16th
March 2018.
J O U R N A L M E T R I C S
Source Normalized Impact
per Paper (SNIP): 0.567
Impact per Publication (IPP): 0.588
SCImago Journal Rank (SJR): 0.277
Cite Score: 0.51
Print ISSN: 0974– 2441 Online ISSN:
16/02/18 17.43 Asian Journal of Pharmaceutical and Clinical Research
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A REVIEW: LOVASTATIN
PRODUCTION AND... TRADITIONAL HERBAL BASED DISEASE...
ETHNOBOTANICAL STUDIES ON
SELECTED...
Our Journals || Open Access Policy || Publication Ethics
The publication is licensed under a Creative Commons License (CC BY) . View Legal Code
16/02/18 17.44 Editorial Board
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Impact (Cites per
doc)
- 0.40
(
SCImago, SJR
2016
)
ICV 2016
= 104.84
Print ISSN-
0974-2441
Online ISSN-
2455-3891
Editorial Board
Editorial Board
AJPCR is committed to have dynamic and potential advisory-editorial board. Those established
in the field can directly send their resume. New people are first needed to serve as referee
before being considered member of advisory-editorial board. Email your resume to
editor@ajpcr.com
Editor-in-Chief
Dr. Anurekha Jain
Dept. of Pharmaceutical Sciences, Jyoti Mahila Vidyapeeth University, Jaipur, Rajasthan
Email: editor@ajpcr.com
Associate Editor
Dr. Neeraj Upmanyu
Peoples Institute of Pharmacy & Research Center, Bhopal, MP, India
Email: drneerajupmanyu@gmail.com
Dr. Vikas Sharma
Shri Rawatpura Sarkar Institute of Pharmacy, Datiya, MP, India
Email: vikassharma15@gmail.com
Assistant Editor
Dr. Vimal Kumar Jain
Institute of Pharmacy, Nirmal University, Ahemdabad, Gujarat, India
Email: cognosy@gmail.com
Dr. Rupesh Kumar Gautam
ADINA Institute of Pharmaceutical Sciences, Sagar, MP, India
Email: drrupeshgautam@gmail.com
Editorial Board Members
Dr. Debasish Maiti
Suryamaninagar, Tripura West, Agartala, Tripura, India
Dr. Rashad Mohammed Musleh
University of Thamar, Yemen
Home > Editorial BoardHome About Login Register Search Current Archives Editorial Board
16/02/18 17.44
Dept. of Pathology & Microbiology, Mahesh Bhattacharyya Homeopathic Medical College
& Hospital, Govt. of West Bengal, India
Mohd Abdul Hadi
Bhaskar Pharmacy College Affiliated To Jawaharlal Nehru Technological University,
Hyderabad, India
Dr. Amer A. Taqa
Department of Dental Basic Science, College of Dentistry, Mosul University, Iraq
Mr. Atul Kabra
Department of Pharmacy, Manav Bharti University, Solan (H.P.), India
Mr. Siddharth Kaushal Tripathi
Doctoral Research Associate National Center For Natural Products Research, School of
Pharmacy, University of Mississippi, India
Dr. Brajesh Kumar
Escuela Politécnica Del Ejército, Sangolqui, Ecuador, Latin America
Dr. Farhan Ahmed Siddiqui
Faculty of Pharmacy, Federal Urdu University Arts, Science And Technology
Karachi, Sindh, Pakistan
Dr. Deepak Kumar Mittal
Iasca Department of Itm-Universe, Gwalior, India
Dr. Jesse Joel Thathapudi
Karunya University (Deemed To Be University), Coimbatore, Tamil Nadu, India
Dr. Kumaran Shanmugam
Analytical Chemistry, Academic Faculty, (Senior Scale) & International Co-Ordinator,
Department of Biotechnology, Periyar Maniammai University, Vallam, Thanjavur-613 403,
India
Dr. Javad Sharifi Rad
Department of Pharmacognosy, Faculty of Pharmacy, Zabol University of Medical
Sciences, P.O. Box 61615-585 Zabol, Iran
Dr. Rajesh Mohanraj
Dept. of Pharmacology, CMHS, UAE
Dr. P. Thillai Arasu
Department of Chemistry, Kalasalingam University, Srivilliputhur 626190, India
Ms Vasundhra Saxena
Gautam Buddha Technical University Lucknow, India
Ms Vinit Dattatray Chavhan
Sinhgad Technical Education Society’S Smt. Kashibai Navale College of Pharmacy,
Kondhwa-Saswad Road, Kondhwa (BK), India
Dr. Sami Saqf El Hait
Junior Executive - Quality Control At Jamjoom Pharmaceuticals Company Limitedjeddah,
Saudi Arabia
Md. Moklesur Rahman Sarker
16/02/18 17.44 Editorial Board
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A REVIEW: LOVASTATIN
PRODUCTION AND... TRADITIONAL HERBAL BASED DISEASE...
ETHNOBOTANICAL STUDIES ON
SELECTED...
Dr. Ahmed Hashim Mohaisen Al-Yasari
Department of Physics, College of Education For Pure Science, University of Babylon,
Hilla, Iraq
Dr. Arun Kumar
Director & Dean, Faculty of Marine Sciences Faculty of Marine Sciences Cas In Marine
Biology Cas In Marine Biology, Parangipettai- 608502 Parangipettai- 608502 Tamil Nadu,
India
Dr. Ashraf Ahmed
Dept. of Chemistry, Aligarh Muslim Uneversity, Uttar Pradesh 202001, India
Dr. S. Bala Murugan
Dept. of Biotechnology, Bharathiar University, Coimbatore-641046, Tamil Nadu, India
Dr. Sukhen Som
Department of Pharmaceutical Chemistry, M.M.U College of Pharmacy, K.K.Doddi,
Ramadevara Betta Road, Ramanagara- 562159State- Karnataka India
Dr. Sheikh Shoib
Department of Psychiatry, Institute of Mental Health And Neurosciences Kashmir (Imhans
K), Srinagar, India
Dr. Hao Wu
Postdoctoral Fellow At Ngm Biopharmaceuticals, Inc,South San Francisco, CA 94080,
USA
Dr. Payal Bhaskar Joshi
Assistant Professor Department of Chemical Engineering, Mukesh Patel School of
Technology Management & Engineering (Mumbai Campus), Svkm’S Nmims
(Deemed-To-Be-University), India
Dr. Nagarajan Kayalvizhi
Assistant Professor Department of Zoology, Periyar University, Salem, Tamilnadu, India
Dr. Madhu Bala
Scientist ‘F’ And Joint Director, Institute of Nuclear Medicine And Allied Sciences (INMAS),
India
Prof. Dr. Mamdouh Moawad Ali
Biochemistry Department, Genetic Engineering And Biotechnology, India
Dr. Mohanraj Rathinavelu
Department of Pharmacy Practice, Raghavendra Institute of Pharmaceutical Education &
Research, Riper, India
Dr. (Mrs.) Neeru Nathani
Dept. of Swasthavritta And Yoga, Faculty of Ayurveda, Institute of Medical Sciences,
Banaras Hindu University, India
Dr. Rohini Karunakaran
Unit of Biochemistry, Faculty of Medicine, Aimst University Batu 3 1/2, Bukit Air Nasi, Jalan
Semeling, 08100 Bedong Kedah Darul Aman, Malaysia
Dr. Imran Ahmad Khan
Royal Institute of Medical Sciences Multan, Pakistan
16/02/18 17.44 Editorial Board
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Sper Timer (Publication Committee ) Regional Head U.P. State, India
Dr. Kamal A. Badr
Lecturer of Pharmaceutics And Industrial Pharmacy & Member of Quality Assurance
Unit-Faculty of Pharmacy- Delta University For Science And Technology, India
Mr. Gurpreet Singh
Department of Pharmaceutical Sciences Guru Nanak Dev University, Amritsar, Punjab
(India) 143005
Dr. Pranav Kumar Prabhakar
Lovely Faculty of Applied Medical Sciences, Lovely Professional University,
Jalandhar-Delhi G.T. Road
Dr. Raj Mohan Raja Muthiah
Research Fellow (Harvard Medical School) 172 Hosmer Street, Apt 7. Marlborough, Ma
01752
Dr. Sandip Narayan Chakraborty
Research Asst Ii, Translational Molecular Pathology, Ut Md Anderson Cancer Center, Life
Sciences Plaza, Houston, TX 77030
Dr. Anup Naha
Dept. of Pharmaceutics “Swarna Kutir ”, Ramnagar Road No.4, Mcops, Manipal-576 104,
Karnataka, India
Dr. Tushar Treembak Shelke
Vice Principal , Head of Department of Pharmacology And Research Scholar, In
Jspms Charak College of Pharmacy & Research, Gat No. - 720(1&2), Pune, India
Anindya Banerjee
Indian Pharmacopoeia Commission, Ministry of Health & Family Welfare
Govt of India
Dr. Vijay Mishra
Lovely Institute of Technology (Pharmacy), Lovely Professional University, Phagwara,
Punjab, India
Dr. Praveen Kumar Sharma
Department of Chemistry, Lovely Professional University, Punjab (India)-144411
Deepansh Sharma
School of Bioengineering & Biosciences Lovely Professional University, Phagwara Punjab,
India
Sai Prachetan Balguri
ORISE Research Fellow at U.S. FDA
Dr. Mohd Abdul Hadi
Department of Pharmaceutics, Bhaskar Pharmacy college, Yenkapally (V), Moinabad (M),
R.R (Dt), Hyderabad-500 075, Telangana, India
Tanay Pramanik
Department of Chemistry in Lovely Professional University, Punjab, India
Editorial office
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E-mail:
editor@ajpcr.com
Our Journals || Open Access Policy || Publication Ethics
The publication is licensed under a Creative Commons License (CC BY) . View Legal Code
16/02/18 17.42 Vol 10 Issue 9 September 2017
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Impact (Cites per
doc)
- 0.40
(
SCImago, SJR
2016
)
ICV 2016
= 104.84
Print ISSN-
0974-2441
Online ISSN-
2455-3891
Pages: 1-2 | Share
Pages: 3-4 | Share
Pages: 5-9 | Share
Pages: 10-14 | Share
Vol 10 Issue 9 September 2017
Table of Contents
Case Study(s)
VALPROIC ACID TOXICITY INDUCED BY LACOSAMIDE: A RARE CASE REPORT
Karthika Ashok Kumar, Chanshi Chandran, Remya Reghu
Abstract || View PDF || Download PDF || DOI: 10.22159/ajpcr.2017.v10i9.18820
LAMOTRIGINE INDUCED DRESS SYNDROME
Saurab Agarwal, Balaji Ommurugan, Amita Priya, Mohan Amberkar, Meena Kumari Kamalkishore
Abstract || View PDF || Download PDF || DOI: 10.22159/ajpcr.2017.v10i9.18876
Review Article(s)
NATURAL PERMEATION ENHANCER FOR TRANSDERMAL DRUG DELIVERY SYSTEM AND PERMEATION EVALUATION: A REVIEW
Asha Das, Abdul Baquee Ahmed
Abstract || View PDF || Download PDF || DOI: 10.22159/ajpcr.2017.v10i9.19389
FECAL CARRIAGE OF EXTENDED-SPECTRUM BETA-LACTAMASESPRODUCING ESCHERICHIA COLI IN HOSPITALS AND COMMUNITY SETTINGS: A REVIEW
Neha Sharma, Anania Arjuna
Abstract || View PDF || Download PDF || DOI: 10.22159/ajpcr.2017.v10i9.19126
A NOVEL APPROACH FOR FINDING DIABETIC MELLITUS USING ENSEMBLE MODEL FOR AN OPTIMIZED CLASSIFICATION
Sekar Kr, Kamaladevi M, Sethuraman J, Ravichandran Ks Home > Archives > Vol 10 Issue 9 September 2017
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16/02/18 17.42 Vol 10 Issue 9 September 2017
Page 2 of 11
Abstract || View PDF || Download PDF || DOI: 10.22159/ajpcr.2017.v10i9.19563
THE EMERGING ROLE OF BOTULINUM TOXIN IN THE TREATMENT OF OROFACIAL DISORDERS: LITERATURE UPDATE
Santhosh Kumar
Abstract || View PDF || Download PDF || DOI: 10.22159/ajpcr.2017.v10i9.16914
A COMPREHENSIVE STUDY ON LITERATURE EVIDENCE, CLINICAL STUDIES AND PRACTICES OF HERBAL DRUGS FOR DIABETIC NEUROPATHY AND CARDIOMYOPATHY
Arshiya Shamim, Hefazat Hussain Siddiqui, Tarique Mahmood, Paramdeep Bagga, Ranjan Kumar
Abstract || View PDF || Download PDF || DOI: 10.22159/ajpcr.2017.v10i9.18785
A REVIEW ON ARTIFICIAL BLOOD: A SOURCE WE NEED
Krishna Veni R, Brindha Devi P, Ivo Romauld S
Abstract || View PDF || Download PDF || DOI: 10.22159/ajpcr.2017.v10i9.18960
A COMPARATIVE STUDY OF ANTIMICROBIAL PROFILE HAVING BROAD SPECTRUM BACTERIOCINS AGAINST ANTIBIOTICS
Sabiha Imran, Twinkle Gupta, Aarti Arora, Nilanjan Das
Abstract || View PDF || Download PDF || DOI: 10.22159/ajpcr.2017.v10i9.19447
Original Article(s)
COMPARISON BETWEEN THERAPEUTIC ULTRASOUND AND SCAR MOBILIZATION OVER PERSISTENT POSTNATAL DYSPAREUNIA
Mariyam Farzana Sf, Ponmathi P, Sivakumar Pvr
Abstract || View PDF || Download PDF || DOI: 10.22159/ajpcr.2017.v10i9.18757
ANTI-ATHEROSCLEROTIC ACTIVITY OF ETHANOLIC EXTRACT OF CHRYSANTHEMUM INDICUM L. FLOWERS AGAINST HIGH-FAT DIET-INDUCED ATHEROSCLEROSIS IN MALE WISTAR RATS
Sravanthi P, Shakir Basha S
Abstract || View PDF || Download PDF || DOI: 10.22159/ajpcr.2017.v10i9.19463
TOXICOLOGICAL EVALUATION OF AYURVEDIC FORMULATION: GOKSHURADI GUGGULU
Gamit Kanan G, Raval Manan A
Abstract || View PDF || Download PDF || DOI: 10.22159/ajpcr.2017.v10i9.19295
SUPPLEMENTATION OF VITAMIN E 400 IU DECREASES MALONDIALDEHYDE LEVEL OF OBESE WOMEN STAFF AT SCHOOL OF MEDICINE UDAYANA UNIVERSITY
Luh Putu Ratna Sundari, Nyoman Adiputra, Made Krisna Dinata
16/02/18 17.42 Vol 10 Issue 9 September 2017
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A REVIEW: LOVASTATIN
PRODUCTION AND... TRADITIONAL HERBAL BASED DISEASE...
ETHNOBOTANICAL STUDIES ON
SELECTED...
Pages: 61-63 | Share
Pages: 64-69 | Share
Pages: 70-73 | Share
Pages: 74-77 | Share
Pages: 78-81 | Share
Pages: 82-84 | Share
Pages: 85-87 | Share
Pages: 88-91 | Share
Pages: 92-95 | Share
GAS CHROMATOGRAPHY-MASS SPECTROSCOPY ANALYSIS OF ROOT OF AN ECONOMICALLY IMPORTANT PLANT, CENCHRUS CILIARIS L. FROM THAR DESERT, RAJASTHAN (INDIA)
Sunita Arora, Ganesh Kumar
Abstract || View PDF || Download PDF || DOI: 10.22159/ajpcr.2017.v10i9.19259
COLISTIN RESISTANCE IN CARBAPENEM-RESISTANT KLEBSIELLA PNEUMONIAE STRAINS
Beena Hosdurg Bhaskar, Shalini Shenoy Mulki, Sangeeta Joshi, Ranjeeta Adhikari, Bhavana Malavalli Venkatesh
Abstract || View PDF || Download PDF || DOI: 10.22159/ajpcr.2017.v10i9.18369
ASSESSMENT OF LOW BONE MASS USING PERIPHERAL DUAL X-RAY ABSORPTIOMETRY (PDXA) IN DIFFERENT ETHNIC GROUPS
Ashok Kumar, Muhammed Javad, Snekhalatha Umapathy
Abstract || View PDF || Download PDF || DOI: 10.22159/ajpcr.2017.v10i9.19615
CYTOTOXIC ACTIVITY OF ALKALOIDS EXTRACTED FROM THREE IRAQI PLANTS AGAINST BREAST CANCER CELL LINE
Farah A Al-Marzook, Rabab Omran
Abstract || View PDF || Download PDF || DOI: 10.22159/ajpcr.2017.v10i9.19134
MORTALITY PATTERN OF UNDER-FIVE CHILDREN – A HOSPITAL-BASED CROSS-SECTIONAL STUDY IN A TERTIARY CARE HOSPITAL OF INDIA
Rachita Sarangi, Lipilekha Pattnaik, Saroj Kumar Satpathy, Mahesh Chandra Sahu
Abstract || View PDF || Download PDF || DOI: 10.22159/ajpcr.2017.v10i9.17895
BELL’S PALSY AMONG INFANTS - OUR EXPERIENCES IN A TERTIARY CARE HOSPITAL OF EASTERN INDIA
Santosh Kumar Swain, Ishwar Chandra Behera, Mahesh Chandra Sahu
Abstract || View PDF || Download PDF || DOI: 10.22159/ajpcr.2017.v10i9.19388
THE ROLE OF SYNAPSIN I IN INTRACELLULAR SIGNALING MECHANISMS UNDERLIES EXERCISE-INDUCED IMPROVEMENT IN SOCIAL MEMORY: A SYSTEMATIC REVIEW
Ria Margiana, Akmal Primadian Suprapto
Abstract || View PDF || Download PDF || DOI: 10.22159/ajpcr.2017.v10i9.19111
KNOWLEDGE AND HEALTH SEEKING BEHAVIOR RELATED TO KALA-AZAR IN RURAL COMMUNITIES OF EAST CHAMPARAN DISTRICT, BIHAR
Navin Kumar, Singh T B, Meena L P
Abstract || View PDF || Download PDF || DOI: 10.22159/ajpcr.2017.v10i9.19110
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Pages: 100-111 | Share
Pages: 112-116 | Share
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Pages: 134-137 | Share
NEURONAL DYSFUNCTION: AN IN SILICO APPROACH
Niraj Kumar Jha, Pravir Kumar
Abstract || View PDF || Download PDF || DOI: 10.22159/ajpcr.2017.v10i9.19466
ALLIUM SATIVUM LINN. CONTAINS LINEAR ALKYLBENZENE SULFONATES THAT ALTER MEMBRANE FLUIDITY FOR THE INHIBITION OF MYCOBACTERIUM TUBERCULOSIS H37RA
Rajiniraja Muniyan, Sabareesh Varatharajan, Saba Naz, Vinay K Nandicoori, Jayaraman Gurunathan
Abstract || View PDF || Download PDF || DOI: 10.22159/ajpcr.2017.v10i9.18693
ANTIMICROBIAL ACTIVITY OF STREPTOMYCES VARIABILIS STRAIN-VITUMVB03 ISOLATED FROM KANYAKUMARI MARINE SEDIMENTS
Shubha M, Ushashi B, Veena S, Bhaskara Rao Kv
Abstract || View PDF || Download PDF || DOI: 10.22159/ajpcr.2017.v10i9.19250
THE UNEXPLORED ROLES OF PROBIOTIC BACTERIA: IN VITRO ANTI-INFLAMMATORY AND ANTHELMINTIC ACTIVITY OF ENTEROCOCCUS FAECIUM BM10 KY788342 AND
LACTOBACILLUS CASEI GM10 KY794586
Neha Jain, Archana Mehta
Abstract || View PDF || Download PDF || DOI: 10.22159/ajpcr.2017.v10i9.19413
ANALYSIS OF 6-MERCAPTOPURINE AND 6-METHYLMERCAPTOPURINE IN DRIED BLOOD SPOTS USING LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY AND ITS APPLICATION IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS
Supandi Supandi, Yahdiana Harahap, Harmita Harmita, Rizka Andalusia, Marlina Ika
Abstract || View PDF || Download PDF || DOI: 10.22159/ajpcr.2017.v10i9.19790
A TBX5 NONSENSE MUTATION IN SIBLINGS WITH DIVERGENT PHENOTYPES ASSOCIATED WITH ISOLATED SEPTAL DEFECTS
Yashvanthi Borkar, Krishnananda Nayak, Ranjan K Shetty, Rajasekhar Moka
Abstract || View PDF || Download PDF || DOI: 10.22159/ajpcr.2017.v10i9.19628
ANTIMICROBIAL ACTIVITY OF A PROTEASE INHIBITOR ISOLATED FROM THE RHIZOME OF CURCUMA AMADA
Sangeetha R, Padmini R
Abstract || View PDF || Download PDF || DOI: 10.22159/ajpcr.2017.v10i9.18257
THERMAL, PASTING AND RHEOLOGICAL PROPERTIES OF PROCESSED BUCKWHEAT (FAGOPYRUM ESCULENTUM) FLOUR
Munish Siwatch, Ritika B Yadav, Baljeet S Yadav
Abstract || View PDF || Download PDF || DOI: 10.22159/ajpcr.2017.v10i9.18174
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Pages: 164-168 | Share
KARAD
Dhanraj Prakash Kharat, Prabhuswami Hiremath, Samir K Choudhari
Abstract || View PDF || Download PDF || DOI: 10.22159/ajpcr.2017.v10i9.19231
A STUDY ON THE EFFECTS OF AGOMELATINE ON FOOD INTAKE AND BODY WEIGHT IN RESTRAINT STRESS MODEL IN ADULT SWISS ALBINO MICE
Shanmuga Priya, Nivedhithaa S, Huvaneswari K
Abstract || View PDF || Download PDF || DOI: 10.22159/ajpcr.2017.v10i9.19506
ASSESSMENT OF HEMATOLOGICAL INDICES AMONG WORKERS IN SILVER JEWELRY UNITS
Shalini Kv, Ayyappa Das Mp
Abstract || View PDF || Download PDF || DOI: 10.22159/ajpcr.2017.v10i9.19809
IMMUNOMODULATORY EFFECTS OF ETHANOL EXTRACT OF CURCUMA MANGGA RHIZOMES IN MICE
Yuandani Yuandani, Edy Suwarso
Abstract || View PDF || Download PDF || DOI: 10.22159/ajpcr.2017.v10i9.18398
DETERMINATION OF SENSITIVITY AND SPECIFICITY OF ULTRASONOGRAPHY IN ACUTE APPENDICITIS: COMPARISON WITH PER-OPERATIVE FINDINGS AND HISTOPATHOLOGICAL REPORT
Sasmita Parida, Bibekananda Nayak, Jayashree Mohanty
Abstract || View PDF || Download PDF || DOI: 10.22159/ajpcr.2017.v10i9.18873
EVALUATION OF ANTIOXIDANT AND ANTIBACTERIAL ACTIVITIES OF FRESH AND FREEZE-DRIED SELECTED FRUIT JUICES
Naritsara Toobpeng, Pannapa Powthong, Pattra Suntornthiticharoen
Abstract || View PDF || Download PDF || DOI: 10.22159/ajpcr.2017.v10i9.19099
MODULATORY ACTIVITY OF BEE POLLEN AGAINST THE TOXICITY OF ANTITUBERCULOSIS DRUGS RIFAMPICIN AND ISONIAZID IN TESTIS OF SPRAGUE DAWLEY RATS
Umesh Bharti, Neelima R Kumar, Jaspreet Kaur
Abstract || View PDF || Download PDF || DOI: 10.22159/ajpcr.2017.v10i9.19701
EVALUATION OF PRESCRIBING PATTERN OF FIXED DOSE COMBINATIONS OF ANTIHYPERTENSIVES AND ANTIDIABETIC AGENTS
Niyati Devangkumar Vyas, Alpa P Gor, Jalpa V Suthar
Abstract || View PDF || Download PDF || DOI: 10.22159/ajpcr.2017.v10i9.18966
EVALUATION OF PHYTOCHEMICAL CONSTITUENTS AND ANTIMICROBIAL PROPERTIES OF MANGIFERA INDICA L. LEAVES AGAINST URINARY TRACT INFECTION-CAUSING PATHOGENS
Gyanranjan Mahalik, Sabuj Sahoo, Kunja Bihari Satapathy
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EXTRACTION OF GUM FROM ABELMOSCHUS ESCULENTUS: PHYSICOCHEMICAL PECULIARITY AND ANTIOXIDANT PREPATENT
Meenu Nagpal, Geeta Aggarwal, Upendrea K Jain, Jitender Madan
Abstract || View PDF || Download PDF || DOI: 10.22159/ajpcr.2017.v10i9.19260
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The publication is licensed under a Creative Commons License (CC BY) . View Legal Code
Vol 10, Issue 9, 2017
Online - 2455-3891 Print - 0974-2441
EXCLUSIVE BREASTFEEDING ABLE TO REDUCE THE DEVELOPMENT OF CHILDHOOD ASTHMA
SARMA NURSANI LUMBANRAJA*
Department of Obstetrics and Gynecology, University of Sumatera Utara, Medan, Indonesia. Email: sarmalumbanraja@yahoo.com
Received: 08 September 2016, Revised and Accepted: 26 September 2016
ABSTRACT
Objective: To determine the association between maternal characteristics, maternal obstetrics history, fetal chacteristics and development of childhood asthma in offspring.
Methods: This was a case control study that enrolled children visiting the pediatric polyclinic of Rumah Sakit TNI-AD Padangsidimpuan, Indonesia starting from June to December 2015. Childhood asthma was diagnosed by spirometry. Breastfeeding history were taken by history taking. Data were analyzed by SPSS with p<0.05 as significant value.
Results: A total of 130 children were included in this study. The children analyzed in both groups had similar age (p=0.232), 20.5±12.2 months and 25.4±13.9 months. No differences were found in maternal characteristics, maternal obstetrics history, and fetal characteristics between both groups, except the history of breastfeeding (p=0.002).
Conclusion: Of all maternal characteristics, maternal obstetrics history, and fetal characteristics, only exclusive breastfeeding was associated for development of childhood asthma in offspring.
Keywords: Breastfeeding, Childhood asthma, Allergy, Exclusive, Children.
INTRODUCTION
The prevalence of childhood asthma was consistently rising in worldwide. Asthma is the most chronic disease of childhood and the leading cause of morbidity with the high inpatient care, emergency department visit, and days of missed school [1]. Asthma is a heterogeneous disease of the airways that is characterized by increased responsiveness of the tracheobronchial tree to a variety of stimuli and airway obstruction that is partially or completely reversible [2]. Asthma could also be defined as at least one attack of wheeze and/or dyspnea and/or prescription of inhalation steroids in the last year [3]. Many studies used symptoms such as wheezing and shortness of breath, as main indicator of asthma in children [4].
Although the development of asthma and allergic diseases has a strong genetic component, the rise in the prevalence of these diseases indicates that environmental factors play an important role as well. Barker hypothesized that pre-natal maternal-fetal interactions might influence disease later in life in fetal. Therefore, this early life programming during intrauterine life could be associated to the development asthma in later life [5]. Many risk factors of asthma have been proposed including age, gender (male), low birth weight, maternal asthma, parental smoking, and family history of asthma. Another risk factors such as risk factors in early life for asthma-related symptoms include gestational age, parental socioeconomic status, and ethnicity [6].
The aim of the present study was to assess whether maternal characteristics, maternal obstetric history, and fetal characteristics were associated with the development of childhood asthma in offspring. In this study, we did not analyzed how family history contributed to asthmatic children. However, Subbarao et al. (2009) showed that nearly 100 genes have been found to be associated with asthma or asthma-related phenotypes [7]. We did want to know the results of asthma development in offspring induced by mother and fetal characteristics regardless of knowing the family history of asthma. This was because the high recall bias that could be occurred.
METHODS
This was an analytical, case-control study that analyzed how maternal characteristics, obstetric history, and fetal characteristics predicting offspring childhood asthma. This study was conducted at Rumah Sakit TNI-AD Padangsidimpuan, Indonesia. This hospital was geographically located at the cross section between highway roads of Sumatera-Java. This place represented the portrait of underserved area in Indonesia. This study has been approved by the Ethical Committee of University of Sumatera Utara.
This study enrolled consecutive children visiting the pediatric polyclinic starting from June to December 2015. We only included children who born in this hospital, no other pulmonary diseases, no congenital malformation, no malignancy, and no endocrine disorder. Exclusion criteria were children whose parents had psychiatric disorders, not complete data, and obese mother. In this study, we also excluded obese maternal. Many studies had positively showed the associated of obesity with asthma, due to elevated levels of pro-inflammatory cytokines (tumor necrosis factor-alpha, interleukin [IL]-6, and transforming growth factor [TGF]-beta1). Children were divided into two groups, children with childhood asthma, and children without childhood asthma. We restricted the samples to children aged below 5 years old [8].
Written informed consents were taken from all parents. Mother characteristics such as maternal age at the time of delivery, maternal ethnicity, maternal education, and maternal education were taken by history taking. We also asked their obstetric history such as parity, mode of delivery, and the presence of preterm labor, pre-eclampsia, or premature rupture of membrane in the time they delivered the children that included in this study. The information given were being cross-check with the medical records. Any discordance was found, did we ask the mother again for confirmation. If conclusion could not be reached, we excluded the participant from this study. Fetal characteristics such as fetal age, birth weight, and history of breastfeeding were taken from the medical records.
© 2017 The Authors. Published by Innovare Academic Sciences Pvt Ltd. This is an open access article under the CC BY license (http://creativecommons. org/licenses/by/4. 0/) DOI: http://dx.doi.org/10.22159/ajpcr.2017.v10i9.15118
315 Asian J Pharm Clin Res, Vol 10, Issue 9, 2017, 314-317 Lumbanraja
Diagnosis of asthma in children is often difficult. Spycher et al. defined asthma as the presence of wheezing, included viral or multiple trigger wheeze, and presence of allergic sensitization. Asthma can be diagnosed above 6 years old after the airway had been matured [9]. In this study, spirometry was also performed to diagnosis of asthma.
Data were analyzed by SPSS (Statistical Product and Service Solutions, Chicago, IL, USA) 22.0 for Windows. Categorical data were expressed as number and continuous data as mean±standard deviation. Chi-square test (Fisher’s exact test) was used to examine the relation between qualitative variables. T-independent was used to evaluate quantitative variables. Significant value was take 95% and p<0.05 was considered significant.
RESULTS
From June to December 2015, there were 1197 children visiting pediatric polyclinic in our institution. As many as 130 children eligible for this study, 50 children with childhood asthma and 50 children without childhood asthma. Maternal characteristics, obstetric history, and fetal characteristics in childhood asthma were shown in Table 1.
The children analyzed in both groups had similar age (p=0.232), 20.5±12.2 and 25.4±13.9 months. In children both suffered or not from childhood asthma, mostly mothers were 20-35 years old while giving birth (66% and 71.3%), Bataknese (56% and 50%), educated until senior high school (38% and 38.8%), and housewives (46% and 46.3%). No differences were found in maternal characteristics between both groups.
Regarding of obstetric history, no differences were found in maternal obstetric history between both groups. In both groups’ mothers, mostly were nulligravida (40% and 36.3%), had spontaneous delivery (54% and 50%), no preterm labor (80% and 93.7%), no pre-eclampsia 18% and 26.3%), and no premature rupture of membrane (88% and 93.7%).
Child characteristics were also not associated with the development of childhood asthma, except exclusive breastfeeding. Both groups had dominance of male gender (58% and 63.8%). Birth weight was found lower in asthmatic group, but the proportion was slightly similar between all samples. As mentioned, only exclusive breastfeeding differed in both groups. Children that were breastfed exclusively were more likely to develop childhood asthma (p=0.002).
(Contd...) Characteristics Childhood asthma (n=65) No childhood
asthma (n=65)
p value*
Children age 20.5 12.2 25.4 13.9 0.232
Maternal characteristics Maternal age
<20 years old 6 12.0 11 13.8 0.593
20-35 years old 33 66.0 57 71.3
>35 years old 11 22.0 12 15.0
Ethnicity
Javanese 12 24.0 23 28.8 0.782
Bataknese 28 56.0 40 50.0
Others 10 20.0 17 21.3
Maternal education
Secondary school 5 10.0 8 10 1.000
Junior high school 16 32.0 25 31.3
Senior high school 19 38.0 31 38.8
Diploma/University 10 20.0 16 20.0
Maternal employment
Housewife 23 46.0 37 46.3 0.287
Employee 11 22.0 11 13.8
Businesswoman 12 24.0 17 21.3
Honorary worker 4 8.0 15 18.8
Maternal obstetric history Parity
Nulligravida 20 40.0 29 36.3 0.714
Secundigravida 10 20.0 14 17.5
Multigravida 14 28.0 30 37.5
Grand multigravida 6 12.0 7 8.8
Mode of delivery
Spontaneous delivery 27 54.0 40 50.0 0.886
Assisted delivery 8 16.0 15 18.8
Vaginal delivery 15 30.0 25 31.3
Preterm labor
Male 21 42.0 29 36.3 0.512
Female 29 58.0 51 63.8
Birth weight (g)
316 Asian J Pharm Clin Res, Vol 10, Issue 9, 2017, 314-317 Lumbanraja
DISCUSSION
Theory of perinatal programming had been proposed that intrauterine environmental stimuli influenced the fetal development both in pre-natal and post-pre-natal. It induced permanent changes in gene expression and body metabolism function [10].
In previous study, maternal age at delivery was inversely associated with the risk of asthma [11]. McKeever et al. (2001) found the same results, but this association attenuated in children diagnosed at older ages [12]. Ethnicity brought out variation of innate immune response, but no association was found in this study [13]. In another study by Victorino et al., they found that children in families with a higher education were more likely to have allergies [14]. In this study, no differences were found in maternal age (p=0.593), ethnicity (p=0.782), senior high school (p=1.000), and housewife (p=0.287) in children with and without childhood asthma. These findings were contradicted to those of previous studies.
The number of maternal previous deliveries was also inversely associated with childhood asthma, especially in grand multigravida [15]. Meta-analysis by Bager et al. (2008) reports that delivery by cesarean section was associated with an increase in the childhood asthma development. Preterm birth might lead to unmatured airways and impaired lung function, which predispose the participant to asthma and chronic obstructive pulmonary disease in childhood and adulthood [16]. Voort et al. showed that preterm birth was associated with higher risks of preschool-age asthma (odds ratio [OR]=4.47; p<0.05) [17]. Meta-analysis by Voort et al. (2012) even showed the increased risk of asthma development until 24 years of age [18]. Pre-eclampsia has remained a bad contributor to maternal and perinatal morbidity and mortality globally [19]. Pre-eclampsia is associated with unbalance of Th1/Th2 balance [20] which could potentially skew the child’s cytokine balance after birth in the same direction and thereby protect against the development of atopic disease, including asthma [21]. Pro-inflammatory cytokines, chemokines, and adhesion molecules that increase during pre-eclampsia could contribute for asthma development in offspring [22]. Byberg et al. showed that severe maternal pre-eclampsia was associated with high-level allergic sensitization but not associated with atopic dermatitis, asthma, or altered lung function in late childhood [23]. Liu et al. showed positive association between maternal pre-eclampsia and asthma. The incidence rate ratios for asthma according to early- and late-onset pre-eclampsia were 1.88 (95% confidence interval [CI]=1.67-2.11) and 1.14 (95% CI=1.10-1.19) [24]. Getahun et al. (2010) showed that premature rupture of membranes with infection 1.66 times increased risk of asthma [25]. However, regarding of obstetric history, no differences were also found in maternal obstetric history such as parity (p=0.714), mode of delivery (p=0.886), history of preterm labor (p=0.064), pre-eclampsia (p=0.277), and premature rupture of membrane (p=0.252) between both groups in this study.
Child characteristics were also not associated with the development of childhood asthma, except exclusive breastfeeding (p=0.002). Voort et al. (2012) showed that preschoolchildren who were not breastfed for 6 months or non-receiving breastfed had increased risk of asthma. This happened the same for the presence of shortness of breath, dry
cough, and persistent phlegm during the first 4 years (OR=1.44 (95% CI=1.24-1.66), 1.26 (1.07–1.48), 1.25 (1.08–1.44), and 1.57 (1.29–1.91), respectively) [26]. Oddy et al. showed that exclusive breastfeeding for at least 4 months was associated with a decreased risk of asthma at age 6 years, regardless of maternal history of asthma [27]. Scholtens et al. showed that breastfeeding for >3 months had been showed reduced risk of developing asthma in children 3-8 years old. However, the result was not significant, and there was no association observed for bronchial hyper-responsiveness [28]. In a large-scale study, Takemura et al. (2000) showed that breastfeeding was related to the higher prevalence of asthma during pre-adolescence (OR=1.198; p<0.01) after adjustment for age, gender, parental smoking status, and parental history of asthma [28]. However, Bjorksten et al. (2011) in 206, 453 children from 32 countries report a lack of association between breastfeeding and mild-moderate allergic disease, but there was inverse association between in severe allergic disease [29].
Many studies have claimed that breastfeeding is highly protective against asthma regardless of family history of asthma. Breast milk had bioactive enzymes, hormones, growth factors, cytokines and immunological agents, that played important role in the allergy development [30,31]. The most important component was the presence of TGF-beta in breast milk. TGF-beta was induced by regulatory CD4+ T lymphocytes and could be transferred to children. TGF-beta played important role as antigen-specific protection from allergic airway disease [32,33]. Guilbert et al. also found that a longer duration of breastfeeding favorably influenced lung growth in children [34]. Other clinicians hypothesized the contrast effect. Fat-soluble chemicals and foreign protein antigens in breast milk might provoke hypersensitivity. However, some clinicians proved that glycans in breast milk might induce innate immune system of anti-inflammatory mechanism [35].
CONCLUSION
Of all maternal characteristics, maternal obstetric history, and fetal characteristics, only exclusive breastfeeding was associated for the development of asthma in offspring.
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