JUDUL PENELITIAN : HUBUNGAN ASUPAN LEMAK DENGAN KETEBALAN TUNIKA INTIMA-MEDIA ARTERI KAROTIS INTERNA PADA PENDERITA PASCA STROKE ISKEMIK

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JUDUL PENELITIAN :

“HUBUNGAN ASUPAN LEMAK DENGAN

KETEBALAN TUNIKA INTIMA-MEDIA ARTERI KAROTIS INTERNA

PADA PENDERITA PASCA STROKE ISKEMIK”

INSTALASI PELAKSANA : BAGIAN NEUROLOGI RSUP Dr. KARIADI SEMARANG

Persetujuan Setelah Penjelasan

(INFORMED CONSENT)

Bapak/Ibu/Sdr Yth

Anda terpilih sebagai responden penelitian yang berhubungan dengan Faktor Risiko Gizi

(Asupan lemak) dan Gaya Hidup pada pasien stroke yang anda/keluarga anda alami. Apabila

bapak/ ibu/ saudara setuju sebagai peserta penelitian maka tindakan yang akan Bapak/Ibu/Saudara

alami :

 Dilakukan anamnesis dan pemeriksaan fisik dan klinis neurologi, dengan wawancara dan

menggunakan palu refleks serta senter.

 Pemeriksaan laboratorium dengan pengambilan darah.

 Pemeriksaan USG Dupleks Karotis untuk menilai ketebalan dinding arteri karotis interna.

 Kunjungan ke rumah untuk konfirmasi pola diet, ukuran dalam penyajian, dan hal-hal lain yang

berhubungan dengan diet, terutama diet lemak.

Penelitian ini mempunyai risiko berupa rasa sakit sewaktu dilakukan pengambilan darah.

Keuntungan Bapak/ Ibu/ Saudara ikut dalam penelitian ini adalah mengetahui dan mendapat penjelasan

tentang pola diet terutama diet lemak, dan beberapa pemeriksaan lainnya; serta ketebalan tunika intima

media arteri karotis interna sebagai faktor risiko stroke yang anda/ keluarga anda alami sehingga

dikemudian hari dapat digunakan sebagai indikator keberhasilan pengobatan yang dijalani.

Setiap data (anamnesis, pemeriksaan fisik, hasil laboratorium dan hasil USG Dupleks Karotis) dijamin

kerahasiaannya. Sebagai responden keikutsertaan dalam penelitian ini bersifat sukarela, setiap waktu

Bapak/ Ibu/ Saudara dapat mengundurkan diri dari penelitian ini tanpa mengurangi kualitas terapi yang

dijalani.

Bapak/ Ibu/ Saudara dapat menghubungi kami sebagai peneliti :

Nama

: dr. Edi Mulyanto

Alamat

: Jl. Wonosari I/41 Semarang

HP

: 081 325 451 835

Setelah mendengar dan memahami penjelasan penelitian, dengan ini saya :

Nama :...

Alamat : ...

Menyatakan

SETUJU / TIDAK SETUJU

untuk ikut sebagai responden penelitian.

Semarang, _______________

Peserta penelitian

Saksi

Peneliti

(4)

KUESIONER PENELITIAN

FAKTOR RISIKO GIZI, GAYA HIDUP DAN FAKTOR RISIKO LAIN DENGAN

DERAJAT ATEROSKLEROSIS PADA PASIEN PASCA STROKE ISKEMIK

PENELITIAN PAYUNG:

HUBUNGAN ASUPAN LEMAK DENGAN

ATEROSKLEROSIS (PENEBALAN IMT) ARTERI KAROTIS INTERNA

PADA PASIEN PASCA STROKE ISKEMIK

1. Nama

: ...

2. Tgl lahir / Umur

: ...

3. Pekerjaan

: ...

4. Alamat

: ...

Telpon Rumah/Hp...

5. No RM

: ...

(5)

KUISIONER DATA UMUM DAN KLINIK

No

Data

Jawaban

Keterangan

1 Jenis Kelamin :

1. Laki – laki

2. Wanita

1. 

2. 

2 Status Perkawinan :

1. Menikah

3. Duda

2. Janda

4. Tidak/belum menikah

1. 

2. 

3. 

4. 

3 Pendidikan :

1. SD

4. Universitas

2. SLTP

5. Tidak sekolah

3. SLTA

1. 

2. 

3. 

4. 

5. 

4 Pekerjaan :

1. PNS / ABRI

4. Pensiunan

2. Pegawai Swasta

5. Tidak bekerja

3. Wiraswasta

6. ...

1. 

2. 

3. 

4. 

5. 

6. 

5 Lama Perawatan (hari) :

1. < 7hr

2. 7- 14 hr

3. > 14 hr

1. 

2. 

3. 

MRS tgl:

KRS tgl:

6 Penggunaan kontrasepsi hormonal :

1. Ya

2. Tidak

1. 

2. 

7 Hipertensi : 1. Ya

2. Tidak

1. 

2. 

8 DM :

1. Ya

2. Tidak

1. 

2. 

9 Jantung :

1. Ya

2. Tidak

1. 

2. 

10 COPD

1. Ya

2. Tidak

1. 

2. 

11 Merokok

> 10 batang/hr

1. Ya

2. Tidak

1. 

2. 

(6)

12 Riwayat demam 3 bulan terakhir

1. Ya

2. Tidak

1. 

2. 

13 Riwayat batuk lama 3 bulan terakhir

1. Ya

2. Tidak

1. 

2. 

14 Riwayat sakit kencing 3 bulan terakhir

1. Ya

2. Tidak

1. 

2. 

15 Riwayat sakit saluran cerna 3 bulan terakhir

1. Ya

2. Tidak

1. 

2. 

16 Riwayat sakit gondok (struma/ tiroid)

1. Ya

2. Tidak

1. 

2. 

17 Riwayat sakit gangguan fungsi ginjal

1. Ya

2. Tidak

1. 

2. 

18 Riwayat sakit gangguan fungsi hati

1. Ya

2. Tidak

1. 

2. 

19 Riwayat hamil

1. Ya

2. Tidak

1. 

2. 

PEMERIKSAAN FISIK

40 Tinggi badan

41 Berat Badan

42 BMI

45 Sistolik saat kontrol di RSDK

46 Diastolik saat kontrol di RSDK

47 Nadi saat kontrol di RSDK :

48 RR saat kontrol di RSDK :

49 Suhu saat kontrol di RSDK :

50 Retinopati DM : 0. Tidak 1. Grade 1

2. Grade 2 3. Grade 3

4.Grade 4

0. 

2. 

1. 

3. 

51 Retinopati HT : 0. Tidak 1. Grade 1

(Hipertensi)

2. Grade 2 3. Grade 3

4. grade 4

0. 

2. 

1. 

3. 

4. 

(7)

PEMERIKSAAN NEUROIMEJING

53 Lokasi Hasil CT Scan (Dx Topis) : hemisfer ka

1. Kapsula interna 4. Cortex

2. putamen

5. Batang Otak

3. Thalamus

6. ...

1. 

2. 

3. 

4. 

5. 

6. 

54 Lokasi Hasil CT Scan (Dx Topis : hemisfer ki

4. Kapsula interna 4. Cortex

5. putamen

5. Batang Otak

6. Thalamus

6. ...

1. 

2. 

3. 

4. 

5. 

6. 

56 USG duplex Carotis Interna

Ketebalan IMT :

...

mm

PEMERIKSAAN LABORATORIUM

57 Kadar Hb (gr%) :

58 Jumlah Leukosit (per mm3) :

60 Jumlah Trombosit (per mm3) :

61 Nilai Hematokrit (gr%) :

62 Kadar Glukosa Darah Puasa (mg%) :

63 Kadar Glukosa 2 jam PP (mg%) :

64 Kadar HbA1C :

65 Kadar Total Kolesterol (mg%) :

66 Kadar Trigliserida (mg%) :

67 Kadar LDL (mg%) :

68 Kadar HDL (mg%) :

69 Apolipoprotein B

(8)

PEMERIKSAAN PENUNJANG

72 Elektro Kardiografi (EKG)

1. Normo Sinus Rhytm (NSR) 3.Iskemik/ Infark

2. AF

4. ...

1. 

2. 

3. 

4. 

TERAPI

79 Statin selama rawat inap: 10 mg

1. Ya

2. Tidak

1. 

2. 

80 Statin selama rawat inap: 20 mg

1. Ya

2. Tidak

1. 

2. 

81 Fibrat selama rawat inap: 100 mg.

1. Ya

2. Tidak

1. 

2. 

82 Fibrat selama rawat inap: 200 mg

1. Ya

2. Tidak

1. 

2. 

83 Fibrat selama rawat inap: 300 mg

1. Ya

2. Tidak

1. 

2. 

Semarang, ………

Petugas pencatat

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FORM FOOD FREQUENCY SEMI-QUANTITATIVE

Nama Subjek:

No. Registrasi Penelitian:

Alamat :

Tanggal Pengambilan Data:

Petugas:

No

Makanan

Estimasi

Waktu Konsumsi

URT/

makan

… x hari

… x minggu … x bulan

1 Makanan Pokok

Nasi

Ubi

Sagu

Kentang

Ubi Garut

Ubi Jalar

Singkong

Mie kuning

Mie bihun

…….

2 Lauk Nabati

Tahu

Tempe

3 Lauk Hewani

Telur Ayam

Telur Bebek

Telur Asin

Telur Puyuh

Daging ayam

Ayam kulit

Daging sapi

Daging kambing

Ikan bandeng

Ikan mujaher

Ikan bawal

Ikan teri

Ikan kakap

Ikan gurame

Udang

Kepiting

Kerang

Srimping

Cumi-cumi

……

(10)

No

Makanan

Estimasi

Waktu Konsumsi

URT/

makan

… x hari

… x minggu … x bulan

4 Sayuran

5 Buah

6 Susu dan olahan

7 Makanan jajan

(11)

HASIL PENGHITUNGAN ASUPAN MAKANAN DENGAN PROGRAM NUTRISOFT:

Ny. STYM, SUBJEK NO.62

(12)

HASIL PENGHITUNGAN ASUPAN MAKANAN DENGAN PROGRAM NUTRISOFT:

Ny. STYM, SUBJEK NO.62 (Lanjutan 1)

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HASIL PENGHITUNGAN ASUPAN MAKANAN DENGAN PROGRAM NUTRISOFT:

Ny. STYM, SUBJEK NO.62 (Lanjutan 2)

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LAMPIRAN CONTOH HASIL USG DUPLEK

1. Subyek no. 32 (Tn Suh)

a. Ketebalan Tunika intima-media arteri karotis interna kanan : 0,5 mm

b. Ketebalan Tunika intima-media arteri karotis interna kiri : 0,6 mm

2. Subyek No 23 (Ny. Sul)

a. Ketebalan Tunika intima media arteri karotis interna kanan : 0,8 mm

b. Ketebalan Tunika intima media arteri karotis interna kiri : 0,9 mm

(15)

Analisis Deskriptif data numerik

Statistics Usia Subjek Jarak Waktu dari onset Indeks Massa Tubuh Tunika Intima

Media Asupan Serat

Asupan energi N Valid 62 62 62 62 62 62 Missing 0 0 0 0 0 0 Mean 58.71 22.68 24.046 .856 8.73 1529.85 Median 57.50 18.00 23.520 .800 8.00 1542.65 Mode 54 18 20.8a 1.0 8 1454a Std. Deviation 7.706 12.937 3.1378 .2708 3.781 210.415 Skewness .294 1.299 .762 .337 3.876 -.083 Std. Error of Skewness .304 .304 .304 .304 .304 .304 Kurtosis .681 1.264 1.024 -.251 17.110 .410 Std. Error of Kurtosis .599 .599 .599 .599 .599 .599 Minimum 36 7 17.6 .3 6 1029 Maximum 77 60 33.2 1.5 28 2011 Asupan

Cholesterol percent_fat percent_SAF

percent_ MUFA percent_ PUFA N Valid 62 62 62 62 62 Missing 0 0 0 0 0 Mean 171.92 29.8203 14.6248 5.0210 4,6919 Median 143.60 29.8716 14.1144 4.5144 4,0419 Std. Deviation 91.309 8.83361 6.84669 2.03780 2,53139 Skewness .929 .212 .561 .855 1,268 Std. Error of Skewness .304 .304 .304 .304 ,304 Kurtosis .372 -.338 -.431 1.205 1,917 Std. Error of Kurtosis .599 .599 .599 .599 ,599 Minimum 36 11.98 5.07 .23 1,69 Maximum 439 48.54 33.73 11.07 13,61

(16)

Explore

Case Processing Summary

Cases

Valid Missing Total

N Percent N Percent N Percent Tunika Intima Media 62 100.0% 0 .0% 62 100.0%

Descriptives

Statistic Std. Error

Tunika Intima Media Mean .856 .0344

95% Confidence Interval for Mean Lower Bound .788 Upper Bound .925 5% Trimmed Mean .851 Median .800 Variance .073 Std. Deviation .2708 Minimum .3 Maximum 1.5 Range 1.2 Interquartile Range .3 Skewness .337 .304 Kurtosis -.251 .599 Tests of Normality Kolmogorov-Smirnova Shapiro-Wilk

Statistic df Sig. Statistic df Sig. Tunika Intima Media .122 62 .024 .966 62 .086 a. Lilliefors Significance Correction

(17)

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Data Kategori :

Jenis Kelamin

Frequency

Percent

Valid Percent

Cumulative

Percent

Valid

L

39

62.9

62.9 P

23

37.1

100.0 Total

₆₂

_100.0

Status usia

Frequency

Percent

Valid Percent

Cumulative

Percent

Valid

> = 55

42

67.7

67.7 <55

20

32.3

100.0 Total

₆₂

_100.0

Status Jarak dari Onset

Frequency

Percent

Valid Percent

Cumulative

Percent

Valid

>24

33

53.3

53.3 < = 24

29

46.7 46,7

100.0 Total

₆₂

_100.0

Skor Mod Ran Scale

Frequency

Percent

Valid Percent

Cumulative

Percent

Valid

0

9

14.5

1

49

79.0

93.5

2

4

6.5

100.0 Total

62

100.0

100.0 Riwayat Merokok

Frequency

Percent

Valid Percent

Cumulative

Percent

Valid

Ya

24

38.7

38.7 Tidak

38

61.3

100.0 Total

₆₂

_100.0

(19)

Status Obesitas

Frequency

Percent

Valid Percent

Cumulative

Percent

Valid

Obes

23

37.1

37.1 Tidak

39

62.9

100.0 Total

₆₂

_100.0

Status Hipertensi

Frequency Percent Valid Percent

Cumulative Percent Valid Hipertensi 54 87.1 87.1 87.1

Tidak 8 12.9 12.9 100.0

Total 62 100.0 100.0

Status Diabetes Mellitus

Cumulative Percent Valid DM 19 30.6 30.6 30.6 Tidak 43 69.4 69.4 100.0 Total 62 100.0 100.0 Status Dislipidemia

Cumulative Percent Valid Dislipid 46 74.2 74.2 74.2

Tidak 16 25.8 25.8 100.0

Total 62 100.0 100.0

Penebalan Tunika Intima-Media

Cumulative Percent Valid Abnormal 25 40.3 40.3 40.3

Normal 37 59.7 59.7 100.0 Total 62 100.0 100.0

(20)

Frequency Percent Valid Percent Cumulative Percent Valid >30 % 30 48.4 48.4 48.4 <=30 % 32 51.6 51.6 100.0 Total 62 100.0 100.0 Kategori SFA

Cumulative Percent Valid >10 % 40 64.5 64.5 64.5 < = 10 % 22 35.5 35.5 100.0 Total 62 100.0 100.0 kategori PUFA

Cumulative Percent Valid < 6% 43 69.4 69.4 69.4 > = 6% 19 30.6 30.6 100.0 Total 62 100.0 100.0 Kategori MUFA

Cumulative Percent Valid < 2% 2 3.2 3.2 3.2

> = 2% 60 96.8 96.8 100.0 Total 62 100.0 100.0

Kategori Cholesterol Asupan

Cumulative Percent Valid >= 300 mg 7 11.3 11.3 11.3 < 300 mg 55 88.7 88.7 100.0 Total 62 100.0 100.0

Analisis crosstab

(21)

Chi-Square Tests Value df Asymp. Sig. (2-sided) Exact Sig. (2-sided) Exact Sig. (1-sided) Pearson Chi-Square _6.452a 1 .011 Continuity Correctionb _5.204 ₁ _.023 Likelihood Ratio _6.570 ₁ _.010

Fisher's Exact Test _.019 _.011

Linear-by-Linear Association _6.348 ₁ _.012 N of Valid Casesb ₆₂

a. 0 cells (,0%) have expected count less than 5. The minimum expected count is 12,10. b. Computed only for a 2x2 table

Risk Estimate

Value

95% Confidence Interval Lower Upper Odds Ratio for kategori lemak total

(>30 % / <=30 %) 3.923 1.335 11.527 For cohort Penebalan Tunika Intima =

Abnormal 2.267 1.152 4.460

For cohort Penebalan Tunika Intima =

Normal .578 .366 .911

N of Valid Cases ₆₂

Crosstab

Count

Penebalan Tunika Intima

Total Abnormal Normal

kategori lemak >30 % 17 13 30 <=30 % 8 24 32

(22)

**Kategori SFA * Penebalan Tunika Intima**

Crosstab

Count

Total Abnormal Normal Kategori SFA >10 % 14 26 40 < = 10 % 11 11 22 Total 25 37 62 Chi-Square Tests Value df Asymp. Sig. (2-sided) Exact Sig. (2-sided) Exact Sig. (1-sided) Pearson Chi-Square _1.327a 1 .249 Continuity Correctionb _.777 ₁ _.378 Likelihood Ratio _1.319 ₁ _.251

Risk Estimate

Value

95% Confidence Interval Lower Upper Odds Ratio for Kategori SFA (>10 %

/ < = 10 %)

.538 .187 1.552

For cohort Penebalan Tunika Intima = Abnormal

.700 .386 1.268

For cohort Penebalan Tunika Intima = Normal

1.300 .808 2.092

(23)

**kategori PUFA * Penebalan Tunika Intima**

Crosstab

Count

Total Abnormal Normal kategori PUFA < 6% 15 28 43 > = 6% 10 9 19 Total 25 37 62 Chi-Square Tests Value df Asymp. Sig. (2-sided) Exact Sig. (2-sided) Exact Sig. (1-sided) Pearson Chi-Square _1.725a 1 .189 Continuity Correctionb _1.066 ₁ _.302 Likelihood Ratio _1.708 ₁ _.191

Risk Estimate

Value

95% Confidence Interval Lower Upper Odds Ratio for kategori PUFA (< 6% / > =

6%)

.482 .161 1.445

.663 .367 1.196

1.375 .816 2.317

(24)

**Kategori MUFA * Penebalan Tunika Intima**

Crosstab

Count

Total Abnormal Normal Kategori MUFA < 2% 0 2 2 > = 2% 25 35 60 Total 25 37 62 Chi-Square Tests Value df Asymp. Sig. (2-sided) Exact Sig. (2-sided) Exact Sig. (1-sided) Pearson Chi-Square _1.396a 1 .237 Continuity Correctionb _.202 ₁ _.653 Likelihood Ratio _2.110 ₁ _.146

a. 2 cells (50,0%) have expected count less than 5. The minimum expected count is ,81. b. Computed only for a 2x2 table

Risk Estimate

Value

95% Confidence Interval Lower Upper For cohort Penebalan Tunika Intima =

Normal

1.714 1.384 2.123

(25)

**Kategori Cholesterol * Penebalan Tunika Intima**

Crosstab

Count

Total Abnormal Normal Kategori Chol >= 300 mg 4 3 7 < 300 mg 21 34 55 Total 25 37 62 Chi-Square Tests Value df Asymp. Sig. (2-sided) Exact Sig. (2-sided) Exact Sig. (1-sided) Pearson Chi-Square _.928a 1 .335 Continuity Correctionb _.307 ₁ _.579 Likelihood Ratio _.908 ₁ _.341

Linear-by-Linear Association _.913 ₁ _.339 N of Valid Casesb ₆₂

a. 2 cells (50,0%) have expected count less than 5. The minimum expected count is 2,82. b. Computed only for a 2x2 table

Risk Estimate

Value

95% Confidence Interval Lower Upper Odds Ratio for Kategori Chol (>=

300 mg / < 300 mg)

2.159 .439 10.615

1.497 .725 3.088

.693 .287 1.672

(26)

**Jenis Kelamin * Penebalan Tunika Intima**

Crosstab

Count

Total Abnormal Normal Jenis Kelamin L 17 22 39 P 8 15 23 Total 25 37 62 Chi-Square Tests Value df Asymp. Sig. (2-sided) Exact Sig. (2-sided) Exact Sig. (1-sided) Pearson Chi-Square _.466a 1 .495 Continuity Correctionb _.172 ₁ _.678 Likelihood Ratio _.470 ₁ _.493

Risk Estimate

Value

95% Confidence Interval Lower Upper Odds Ratio for Jenis Kelamin (L / P) 1.449 .499 4.208 For cohort Penebalan Tunika Intima =

Abnormal 1.253 .645 2.434

Normal .865 .576 1.299

(27)

**Status usia * Penebalan Tunika Intima**

Crosstab

Count

Total Abnormal Normal Status usia > = 55 22 20 42 <55 3 17 20 Total 25 37 62 Chi-Square Tests Value df Asymp. Sig. (2-sided) Exact Sig. (2-sided) Exact Sig. (1-sided) Pearson Chi-Square 7.867a 1 .005 Continuity Correctionb _6.391 ₁ _.011 Likelihood Ratio _8.575 ₁ _.003

Risk Estimate

Value

95% Confidence Interval Lower Upper Odds Ratio for Status usia (> = 55 /

<55) 6.233 1.586 24.497

Abnormal 3.492 1.183 10.308

Normal .560 .388 .808

(28)

**Status Jarak waktu dari Onset stroke * Penebalan Tunika Intima**

Status Onset >24 Count 19 14 33

% within Status Onset 57.6% 42.4% 100.0%

<=24 Count 6 23 29

Total Count 25 37 62

Chi-Square Tests

Value df Asymp. Sig. (2-sided) Exact Sig. (2-sided) Exact Sig. (1-sided) Pearson Chi-Square 8.727a 1 .003

Continuity Correctionb 7.262 1 .007

Likelihood Ratio 9.056 1 .003

Fisher's Exact Test .004 .003

Linear-by-Linear Association 8.587 1 .003 N of Valid Cases 62

Risk Estimate

Value

95% Confidence Interval Lower Upper Odds Ratio for Status Onset (>24 /

<=24)

5.202 1.675 16.154

2.783 1.288 6.013

.535 .345 .830

(29)

**Riwayat Merokok * Penebalan Tunika Intima**

Crosstab

Count

Total Abnormal Normal Riwayat Merokok Ya 12 12 24 Tidak 13 25 38 Total 25 37 62 Chi-Square Tests Value df Asymp. Sig. (2-sided) Exact Sig. (2-sided) Exact Sig. (1-sided) Pearson Chi-Square _1.524a 1 .217 Continuity Correctionb _.938 ₁ _.333 Likelihood Ratio _1.518 ₁ _.218

Risk Estimate

Value

95% Confidence Interval Lower Upper Odds Ratio for Riwayat Merokok (Ya

/ Tidak)

1.923 .677 5.461

1.462 .806 2.651

.760 .479 1.205

(30)

**Status Obesitas * Penebalan Tunika Intima**

Crosstab

Count

Status Obesitas Obes 10 13 23

Tidak 15 24 39 Total 25 37 62 Chi-Square Tests Value df Asymp. Sig. (2-sided) Exact Sig. (2-sided) Exact Sig. (1-sided) Pearson Chi-Square _.151a 1 .697 Continuity Correctionb _.015 ₁ _.904 Likelihood Ratio _.151 ₁ _.698

Risk Estimate

Value

95% Confidence Interval Lower Upper Odds Ratio for Status Obesitas (Obes

/ Tidak)

1.231 .432 3.506

1.130 .613 2.085

.918 .594 1.420

(31)

**Status Hipertensi * Penebalan Tunika Intima**

Crosstab

Count

Status Hipertensi Hipertensi 22 32 54

Tidak 3 5 8 Total 25 37 62 Chi-Square Tests Value df Asymp. Sig. (2-sided) Exact Sig. (2-sided) Exact Sig. (1-sided) Pearson Chi-Square _.030a 1 .862 Continuity Correctionb _.000 ₁ _1.000 Likelihood Ratio _.031 ₁ _.861

Fisher's Exact Test _1.000 _.590

a. 2 cells (50,0%) have expected count less than 5. The minimum expected count is 3,23. b. Computed only for a 2x2 table

Risk Estimate

Value

95% Confidence Interval Lower Upper Odds Ratio for Status Hipertensi

(Hipertensi / Tidak)

1.146 .248 5.296

1.086 .420 2.811

.948 .531 1.694

(32)

**Status Diabetes Mellitus * Penebalan Tunika Intima**

Crosstab

Count

Total Abnormal Normal Diabetes Mellitus DM 6 13 19 Tidak 19 24 43 Total 25 37 62 Chi-Square Tests Value Df Asymp. Sig. (2-sided) Exact Sig. (2-sided) Exact Sig. (1-sided) Pearson Chi-Square _.870a 1 .351 Continuity Correctionb _.425 ₁ _.514 Likelihood Ratio _.886 ₁ _.347

Risk Estimate

Value

95% Confidence Interval Lower Upper Odds Ratio for Diabetes Mellitus (DM / Tidak) .583 .187 1.822 For cohort Penebalan Tunika Intima = Abnormal .715 .340 1.501 For cohort Penebalan Tunika Intima = Normal 1.226 .818 1.838

(33)

Analisis HbA1C & IMT

Status HbA1c

Frequency

Percent

Valid Percent

Cumulative

Percent

Valid

Tinggi

11

17.7

17.7 Normal

51

82.3

100.0 Total

62

100.0

100.0 **Penebalan Tunika Intima * Status HbA1c Crosstabulation**

Status HbA1c

Total

Tinggi

Normal

Penebalan Tunika Intima

Abnormal

Count

5

20

25 % within Penebalan Tunika

Intima

20.0%

80.0% 100.0%

Normal

Count

6

31

37 % within Penebalan Tunika

Intima

16.2%

83.8% 100.0%

Total

Count

11

51

62 % within Penebalan Tunika

Intima

17.7%

82.3% 100.0%

Chi-Square Tests

Value

df

Asymp. Sig.

(2-sided)

Exact Sig.

(2-sided)

Exact Sig.

(1-sided)

Pearson Chi-Square

.146

a

1 .702

Continuity Correction

b

.002

1 .965

Likelihood Ratio

.145

1 .703

Fisher's Exact Test

.744

.477

Linear-by-Linear Association

.144

1 .704

N of Valid Cases

62 a. 1 cells (25,0%) have expected count less than 5. The minimum expected count is 4,44.

b. Computed only for a 2x2 table

Risk Estimate

Value

95% Confidence Interval

Lower

Upper

Odds Ratio for Penebalan

Tunika Intima (Abnormal /

Normal)

1.292 .347

4.803 For cohort Status HbA1c =

Tinggi

1.233 .422

3.606 For cohort Status HbA1c =

Normal

.955

.750

1.216

(34)

Analisis GD 1, GD 2, HbA1C & IMT

Correlations

Tunika Intima

Media

HbA1C

Gula Darah

Puasa

Gula Darah

2 jm Post

Prandial

Tunika Intima Media

Pearson Correlation

1 .048

-.044

-.032

Sig. (2-tailed)

.712

.736

.805

N

62

62 HbA1C

Pearson Correlation

.048

1 .514

**

.512

**

Sig. (2-tailed)

.712

.000

N

62

62 Gula Darah Puasa

Pearson Correlation

-.044

.514

**

1 .683

**

Sig. (2-tailed)

.736

.000

N

62

62 Gula Darah 2 jm Post

Prandial

Pearson Correlation

-.032

.512

**

.683

**

1 Sig. (2-tailed)

.805

.000

N

62

62 **. Correlation is significant at the 0.01 level (2-tailed).

Nonparametric Correlations

Correlations

Tunika Intima

Media

HbA1C

Gula Darah

Puasa

Gula Darah

2 jm Post

Prandial

Spearman's

rho

Tunika Intima

Media

Correlation Coefficient

1.000 .064

.029

-.006

Sig. (2-tailed)

.

.622

.822

.965

N

62

62 HbA1C

Correlation Coefficient

.064

1.000 .442

**

.389

**

Sig. (2-tailed)

.622

.

.000

.002

N

62

62 Gula Darah

Puasa

Correlation Coefficient

.029

.442

**

1.000 .446

**

Sig. (2-tailed)

.822

.000

.

.000

N

62

62 Gula Darah 2

jm Post

Prandial

Correlation Coefficient

.006

.389

**

.446

**

1.000 Sig. (2-tailed)

.965

.002

.000

.

N

62

(35)

**Status Dislipidemia * Penebalan Tunika Intima**

Crosstab

Count

Total Abnormal Normal Dislipidemia Dislipid 18 28 46 Tidak 7 9 16 Total 25 37 62 Chi-Square Tests Value Df Asymp. Sig. (2-sided) Exact Sig. (2-sided) Exact Sig. (1-sided) Pearson Chi-Square _.105a 1 .746 Continuity Correctionb _.001 ₁ _.977 Likelihood Ratio _.105 ₁ _.746

Risk Estimate

Value

95% Confidence Interval Lower Upper Odds Ratio for Dislipidemia (Dislipid

/ Tidak)

.827 .261 2.615

.894 .461 1.734

1.082 .663 1.767

(36)

Logistic Regression

Usia, Jarak Waktu dari Onset Stroke, Riw. Merokok, Lemak Total, SFA, MUFA

Dependent Variable Encoding

Original Value Internal Value

Normal 0

Abnormal 1

Categorical Variables Codings

Frequency Parameter coding (1) kategori PUFA < 6% 43 1.000 > = 6% 19 .000 Status Onset >24 33 1.000 <=24 29 .000 Riwayat Merokok Ya 24 1.000 Tidak 38 .000 kategori lemak >30 % 30 1.000 <=30 % 32 .000 Kategori SFA >10 % 40 1.000 < = 10 % 22 .000 Status usia > = 55 42 1.000 <55 20 .000

Block 1: Method = Backward Stepwise (Likelihood Ratio)

Model Summary

Step -2 Log likelihood

Cox & Snell R

Square Nagelkerke R Square

1 54.647a .373 .504

2 54.674a .373 .504

3 55.376a .366 .494

a. Estimation terminated at iteration number 5 because parameter estimates changed by less than ,001.

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Hosmer and Lemeshow Test

Step Chi-square df Sig.

1 13.807 8 .087

2 12.373 8 .135

3 5.556 8 .697

Contingency Table for Hosmer and Lemeshow Test

IMTproregresi = Normal IMTproregresi = Abnormal

Total Observed Expected Observed Expected

Step 1 1 7 6.819 0 .181 7 2 6 5.645 0 .355 6 3 6 5.376 0 .624 6 4 1 3.141 3 .859 4 5 4 4.242 2 1.758 6 6 4 3.352 1 1.648 5 7 3 3.577 3 2.423 6 8 3 2.747 4 4.253 7 9 3 1.132 2 3.868 5 10 0 .968 10 9.032 10 Step 2 1 7 6.820 0 .180 7 2 6 5.653 0 .347 6 3 6 5.366 0 .634 6 4 1 3.130 3 .870 4 5 4 4.213 2 1.787 6 6 6 5.288 2 2.712 8 7 2 2.714 3 2.286 5 8 3 2.016 3 3.984 6 9 2 .854 2 3.146 4 10 0 .946 10 9.054 10 Step 3 1 5 4.903 0 .097 5 2 7 6.564 0 .436 7 3 6 5.557 0 .443 6 4 3 4.565 3 1.435 6 5 3 2.898 1 1.102 4 6 4 5.199 4 2.801 8 7 4 3.502 2 2.498 6 8 3 1.831 3 4.169 6 9 2 1.795 8 8.205 10 10 0 .186 4 3.814 4

(38)

Variables in the Equation

B S.E. Wald df Sig. Exp(B)

95% C.I.for EXP(B) Lower Upper Step 1a Status_Usia(1) 2.139 .902 5.626 1 .018 8.491 1.450 49.726 Status_Onset(1) 1.936 .741 6.834 1 .009 6.930 1.623 29.589 Riw.Rokok(1) .582 .698 .695 1 .404 1.789 .456 7.026 kat_lemak(1) 2.133 .836 6.503 1 .011 8.438 1.638 43.468 kat_SFA(1) -1.553 .840 3.415 1 .065 .212 .041 1.099 kat_PUFA(1) -.151 .924 .027 1 .870 .859 .140 5.258 Constant -3.278 1.556 4.440 1 .035 .038 Step 2a Status_Usia(1) 2.159 .895 5.821 1 .016 8.661 1.499 50.026 Status_Onset(1) 1.948 .739 6.956 1 .008 7.014 1.649 29.827 Riw.Rokok(1) .583 .698 .698 1 .404 1.791 .456 7.034 kat_lemak(1) 2.190 .764 8.215 1 .004 8.935 1.999 39.947 kat_SFA(1) -1.495 .760 3.872 1 .049 .224 .051 .994 Constant -3.470 1.041 11.113 1 .001 .031 Step 3a Status_Usia(1) 2.222 .898 6.119 1 .013 9.225 1.586 53.651 Status_Onset(1) 1.910 .734 6.770 1 .009 6.756 1.602 28.488 kat_lemak(1) 2.191 .758 8.348 1 .004 8.941 2.023 39.514 kat_SFA(1) -1.447 .762 3.602 1 .058 .235 .053 1.048 Constant -3.304 .999 10.940 1 .001 .037

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