LAMPIRAN A HASIL UJI MUTU FISIK GRANUL Mutu fisik yang diuji

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LAMPIRAN A

HASIL UJI MUTU FISIK GRANUL

Mutu fisik

yang diuji Batch Di Uji

Formula Tablet Parasetamol

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72

Indeks I

1 13,00 13,50 12,50 12,50

2 12,50 13,00 13,00 13,00

3 13,00 12,50 13,00 13,00

II

1 13,50 12,50 12,50 13,00

kompresi 2 13,00 12,50 12,50 12,50 5-15 = baik bilitas 3 12,50 13,50 13,00 12,50

(persen)

III

1 12,50 13,00 13,00 13,00 2 13,00 13,00 13,00 13,00 (Siregar,

1992) 3 13,50 13,50 12,50 13,00

x

12,94 13,00 12,78 12,83

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LAMPIRAN B

HASIL UJI KEKERASAN TABLET PARASETAMOL

Batch I

No Kekerasan Tablet Parasetamol (kp)

Formula A Formula B Formula C Formula D

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74

Batch III

Formula A Formula B Formula C Formula D

1 6,54 4,58 21,54 10,65

2 6,74 4,56 21,78 10,84

3 6,55 4,67 21,75 10,98

4 6,49 4,49 21,61 10,56

5 6,58 4,68 21,56 10,58

6 6,56 4,55 21,58 10,57

7 6,54 4,59 21,62 10,56

8 6,53 4,48 21,48 10,87

9 6,55 4,68 21,56 10,99

10 6,38 4,67 21,55 10,33

X

± SD 6,546 ± _0,0882 4,595 ± _0,0771 21,603 ± _0,0939 10,693 ± _0,2161 SD rel

(%) 1,3474 1,6779 0,4347 2,0209

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LAMPIRAN C

HASIL UJI KERAPUHAN TABLET PARASETAMOL

Batch I

Formula Replikasi

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76

Batch II Formula Replikasi

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77

Batch III Formula Replikasi

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LAMPIRAN D

HASIL UJI WAKTU HANCUR TABLET PARASETAMOL

Batch I

Replikasi Waktu Hancur (menit)

Formula I Formula II Formula III Formula IV

1 _3,75 _1,67 _15,67 _7,88

2 _3,87 _1,69 _16,28 _7,86

3 _3,76 _1,61 _15,59 _7,89

X

±SD 3,79 ± 0,0666 1,66 ± 0,0416 15,85 ± 0,3774 7,88 ± 0,0153

Batch II

Replikasi Waktu Hancur (menit)

Formula I Formula II Formula III Formula IV

1 _3,98 _1,64 _15,78 _7,78

Waktu Hancur (menit) Formula I Formula II Formula

III

Formula IV

1 _3,85 _1,69 _15,67 _7,84

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LAMPIRAN E

HASIL PENETAPAN KADAR TABLET PARASETAMOL

Batch I Formula Replikasi Absorbansi Csampel ( g/ml) Formula Replikasi Absorbansi Csampel

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80

Batch III Formula Replikasi Absorbansi Csampel

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LAMPIRAN F

HASIL UJI DISOLUSI TABLET PARASETAMOL PADA

T = 30 MENIT

Batch I Formula Replikasi Absorbansi Csampel

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82

Batch II Formula Replikasi Absorbansi Csampel

(13)

83

Batch III Formula Replikasi Absorbansi Csampel

(14)

LAMPIRAN G

CONTOH PERHITUNGAN SUDUT DIAM

Formula (-1):

CONTOH PERHITUNGAN INDEKS KOMPRESIBILITAS:

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85

CONTOH PERHITUNGAN AKURASI DAN PRESISI:

Replikasi Konsentrasi Absorbansi Konsentrasi ( g/ml)

Konsentrasi sebenarnya = 3,982 ppm Konsentrasi teoritis = 4,002 ppm

% perolehan kembali = (konsentrasi sebenarnya / konsentrasi teoritis) x 100%

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86

CONTOH PERHITUNGAN PERSEN OBAT TERLEPAS:

% obat terlepas = 100%

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LAMPIRAN H

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LAMPIRAN I

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94

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LAMPIRAN J

TABEL Uji R

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LAMPIRAN K

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LAMPIRAN T

HASIL UJI STATISTIK HASIL PERCOBAAN DAN HASIL TEORITIS PADA UJI KEKERASAN

Anova: Single Factor

SUMMARY

Groups Count Sum Average Variance

Column 1 4 43.405 10.85125 57.21603 Column 2 4 43.4 10.85 57.23747

ANOVA

Source of

Variation SS df MS F P-value F crit

Between

Groups 3.13E-06 1 3.13E-06 5.46E-08 0.999821 5.987378 Within Groups 343.3605 6 57.22675

Total 343.3605 7

Hipotesa Pengujian :

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LAMPIRAN U

HASIL UJI STATISTIK HASIL PERCOBAAN DAN HASIL TEORITIS PADA UJI KERAPUHAN

SUMMARY

Column 1 4 3.077 0.76925 0.329688 Column 2 4 3.08 0.77 0.257067

ANOVA

Source of

Between

Groups 1.12E-06 1 1.12E-06 3.83E-06 0.998501 5.987378 Within

Groups 1.760263 6 0.293377

Total 1.760264 7

(65)

LAMPIRAN V

HASIL UJI STATISTIK HASIL PERCOBAAN DAN HASIL TEORITIS PADA UJI WAKTU HANCUR

SUMMARY

Column 1 4 29.118 7.2795 38.59821 Column 2 4 29.12 7.28 38.53987

ANOVA

Source of

Between

Groups 5E-07 1 5E-07 1.3E-08 0.999913 5.987378 Within

Groups 231.4142 6 38.56904

Total 231.4142 7

(66)

LAMPIRAN W

HASIL UJI STATISTIK HASIL PERCOBAAN DAN HASIL TEORITIS PADA UJI PERSEN DISOLUSI

SUMMARY

Column 1 4 377.2 94.3 4.324333

Column 2 4 377.2 94.3 4.2988

ANOVA

Source of

Variation SS df MS F

P-value F crit

Between

Groups 0 1 0 0 1 5.987378

Within

Groups 25.8694 6 4.311567

Total 25.8694 7

(67)

LAMPIRAN X

HASIL UJI STATISTIK PENETAPAN KADAR ANTAR FORMULA BATCH 1

SUMMARY

Column 1 3 300.7 100.2333 0.123333 Column 2 3 300.2 100.0667 0.063333 Column 3 3 299.8 99.93333 0.173333

Column 4 3 300.6 100.2 0.16

ANOVA

Source of

Between

Groups 0.169167 3 0.056389 0.433761 0.734742 4.066181 Within

Groups 1.04 8 0.13

Total 1.209167 11

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138

BATCH 2

SUMMARY

Column 1 3 300 100 0.19

Column 2 3 299.2 99.73333 0.323333

Column 3 3 301.5 100.5 0.04

Column 4 3 299.8 99.93333 0.123333

ANOVA

Source of

Between

Groups 0.955833 3 0.318611 1.883415 0.210792 4.066181 Within

Groups 1.353333 8 0.169167

Total 2.309167 11

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139

BATCH 3

SUMMARY

Column 1 3 299.3 99.76667 0.023333

Column 2 3 301.2 100.4 0.13

Column 3 3 299.5 99.83333 0.343333 Column 4 3 301.1 100.3667 0.303333

ANOVA

Source of

Between

Groups 1.029167 3 0.343056 1.715278 0.24073 4.066181 Within

Groups 1.6 8 0.2

Total 2.629167 11

(70)

LAMPIRAN Y

UJI F KURVA BAKU

Uji Kesamaan Regresi (NaOH 0,1 N)

(71)

141

Σ X2 ΣXY Σ Y2 N SSi RDF

Regresi I 219,1209 20,2973 1,9247 5 1,8321 4 Regresi II 238,8681 22,0112 2,0304 5 1,9382 4 Regresi III 229,7865 20,1518 1,7914 5 1,7037 4

687,7754 62,4603 5,7464 5,4740

Ssc = 5,7464- (62,4603 : 687,7754) = 5,6556

(72)

LAMPIRAN Z

UJI F KURVA BAKU

(73)

143

Σ X2 ΣXY Σ Y2 N SSi RDF

Regresi I 224,4220 16,1014 1,1571 5 1,0853 4 Regresi II 231,5887 18,4721 1,4786 5 1,3989 4 Regresi III 231,3426 18,7310 1,5210 5 1,4401 4

687,3533 53,3045 4,1568 3,9243

Ssc = 4,1568- (53,3045 : 687,3533) = 4,0792