Pembagian antibiotic berdasarkan daya kerja Bakteristatik mencegah dan
menghambat pertembuhan kuman, tidak membunuhnya sehingga pembasmiasn kuman
tergantung pada imunitas
Bakterisid à membasmi kuman
1. Tetrasiklin 1. Penisilin 2. Spectinomicin 2. cephalosporin
3. Sulphonamides 3. fluorokuinolon(ciprofloxacin) 4. Macrolides 4. Monobactam
5. chlorampenicol 5. Carbapenem
Beta-lactamase
inhibit sulbactam Clavulanic acid tazobactam Avibactam Penicinillase- sensible
Penicillins Animopenicil lin
(broad spectrum)
Amphicilin amoxicilin
Natural penicillin (narrow spectrum)
Penicillin G: Na, K, procainic, benzathine(IV/IM) Penicillin VK : VO
Penicinillase- resistance(very narrow spectrum)
Nafcilin oxacillin dicloxacillin
Antipseudomonal(extended spectrum) carboxipenici
llin ticarcillin Carbenicillin Piperacillin ureidopenicil
lin azlocillin mezlocillin
Cephalosporin First gene cephalexine cefazolin cefadroxil Cephradrine cephapirin
Second gene cefuroxime cefprozil cefaclor cefoxitin cefotetan loracarbef Third gene cefoperazone cefprozil cefaclor
cefpodoxime ceftrizoxime cefotaxime cefditoren
Fourth gene cefepime cefpirome Fifth gene ceftaroline ceftolozane
Carbapenems Meropenem Ertapenem Doripenem Imipenem+ cylastatine Panipenem
monobactams Aztreonam Tigemonam Carumonam Nocardinin A No
lactam glycopeptide vancomycin Telavancin Dalbavancin Oritavancin Other Colistin Polymycin B Daptomycin isoniazid Protein
synthesis
30S Amino-glycosides
Amikacin Gentamicin Tobramycin Streptomycin Neomycin
tetracyclins Doxycycline Minocycline Tigecyclin tetracyclin demeclocyli
50S Oxazolidon
ones Linezolid Streptogra
minis
quinupristin Chloramphenicol
Macrolides erythromycin azithromycin Clarithromycin Lincosamid
es Clindamycin lincomycin
topoisom
erase quinolon Norfloxacin Nalidixic acid Ofloxacin Enofloxacin Sparfloxacin Folic acid
synthesis
Sulfonamides Sulfamethoxa zole(SMX)
Ag
sulfadiazine
sulfasalazine sulfisoxazole DHFR inhibitor Trimethropine(TMP) Pyrimethamine
DNA (Damage )
Nitroimidazoles Metronidazoles Tinidazole
mRNA
synth. rifampim
AB Cara
pemberian Dosis dewasa Dosis anak Dosis neonates
Penisilin G IV 1-4 mU/4-6j
25.000-400.000 unit/kg/h/4-6 dosis
75.000-150.000 unit/kg/h/2-3 dosis Penisilin VK PO 0,25-0,5 g qid 25-50
mg/kg/h/4 dosis Penisilin antistafilokokus
Kloksasilin dikloksasilin
PO 0,25-0,5 g qid 25-50 mg/kg/h/4 dosis
Oksasilin IV 1-2g/4-6 j 50-100
mg/kg/h/4-6 dosis
50-75
mg/kg/h/2-3 dosis
Penisilin yang diperluas
Amoksisilin PO 0,25-0,5 g qid 20-40 mg/kg/h/3 dosis
Amoksisilin/as
. klavulanat PO 500/125-875/125 mg bid-tid
20-40 mg/kg/h/3 dosis
Piperasilin IV 3-4g/4-6 j 300
mg/kg/h/4-6 dosis
150
mg/kg/h/2 dosis
Tikarsilin IV 3g/4-6 j 300
mg/kg/h/4-6 dosis
150-200 mg/kg/h/2-3 dosis
Panduan dosis sefalosforin
AB Cara
pemberian Dosis dewasa Dosis anak Dosis neonatus First gene
Cefadroxil PO 0,5-1 g/h-2x 30
mg/kg/h/2 dosis
