DAFTAR ISI

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FOSFOLIPIDA: BIOSURFAKTAN Dwi Hudiyanti

Desain Cover : Dwi Novidiantoko Tata Letak Isi : Nurul Fatma Subekti Sumber Gambar : https://www.wikiskripta.eu

memperbanyak sebagian atau seluruh isi buku ini tanpa izin tertulis dari Penerbit.

PENERBIT DEEPUBLISH (Grup Penerbitan CV BUDI UTAMA)

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Telp/Faks: (0274) 4533427 Website: www.deepublish.co.id

www.penerbitdeepublish.com E-mail: [email protected]

Katalog Dalam Terbitan (KDT) HUDIYANTI, Dwi

Fosfolipida: Biosurfaktan/oleh Dwi Hudiyanti.--Ed.1, Cet. 1—

Yogyakarta: Deepublish, April-2018.

xii, 79 hlm.; Uk:15.5x23 cm ISBN 978-602-475-041-1

1. Kimia I. Judul

540

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vii

DAFTAR ISI

KATA PENGANTAR ... v

KATA PENGANTAR PENERBIT ... vi

DAFTAR ISI ... vii

DAFTAR TABEL ... ix

DAFTAR GAMBAR ... xi

BAB 1 KIMIA FOSFOLIPIDA ... 1

1.1. Struktur dan Klasifikasi Fosfolipida ... 1

1.2. Fosfolipida dari Alam ... 3

1.3. Isolasi dan Analisis Fosfolipida ... 6

BAB 2 SWARAKIT (SELF-ASSEMBLY) FOSFOLIPIDA ...10

2.1. Konsep Parameter Packing ...10

2.2. Analisis Geometri Molekul Fosfolipida ...13

BAB 3 MEMBRAN FOSFOLIPIDA...14

3.1. Molekul Penyusun Dinding Membran ...14

3.2. Muatan Permukaan ...15

3.3. Hidrasi Permukaan atau Modifikasi Sterik ...16

3.4. Fluiditas Bilayer dan Mobilitas Fosfolipida ...16

3.5. Temperatur Transisi ...17

3.6. Spesies Molekul Penyusun Dinding Membran ...18

3.7. Komposisi Gugus Fungsi dalam Fosfolipida ...19

3.8. Konformasi Fosfolipida dalam Membran...19

BAB 4 LIPOSOM ...24

4.1. Pembentukan Liposom ...28

4.2. Morfologi Liposom ...30

4.2.1. Multilamelar Liposom ...30

4.2.2. Unilamelar Liposom/Vesikel ...31

4.3. Pembuatan Liposom ...32

4.3.1. Metode Hidrasi Fosfolipida ...32

4.3.2. Metode Freeze-Thaw ...32

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viii

4.3.3. Metode Sonikasi ... 33

4.3.4. Metode Ekstrusi... 33

4.3.5. Metode Solubilisasi dan Pengambilan Detergen ... 33

4.3.6. Metode Reverse Phase Evaporation (Solven Injeksi) ... 34

4.4. Pelepasan Bahan Aktif dari Liposom ... 34

4.4.1. Difusi Pasif... 34

4.4.2. Erosi Vesikel ... 34

4.5. Permeabilitas dan Kebocoran Liposom ... 35

4.6. Peranan Kolesterol pada Permeabilitas Membran ... 36

4.7. Analisis Liposom ... 38

4.8. Aplikasi Liposom ... 40

4.9. Keuntungan dan Kendala Penggunaan Liposom Sebagai Penghantar Bahan Aktif ... 43

BAB 5 FOSFOLIPIDA ALAM ... 44

5.1. Hasil Isolasi Fosfolipida Alam (81) ... 44

5.2. Identifikasi Jenis Fosfolipida dengan TLC ... 46

5.3. Identifikasi Gugus-gugus Fungsi dalam Fosfolipida dengan FTIR ... 48

5.4. Identifikasi Asam Lemak Penyusun Fosfolipida dengan GC-MS ... 52

5.4.1. Identifikasi Asam Lemak Penyusun Fosfolipida Kelapa ... 53

5.4.2. Identifikasi Asam Lemak Penyusun Fosfolipida Kemiri ... 57

5.4.3. Identifikasi Asam Lemak Penyusun Fosfolipida Wijen ... 60

5.4.4. Identifikasi Asam Lemak Penyusun Fosfolipida Kedelai ... 62

DAFTAR PUSTAKA ... 67

INDEKS ... 77

SEKILAS TENTANG PENULIS ... 79

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ix

DAFTAR TABEL

Tabel 1. Daerah Serapan Inframerah Spesifik Fosfolipida ... 9 Tabel 2. Hubungan Parameter Packing dengan Bentuk Agregat ...11 Tabel 3. Pengaruh Jumlah Atom C dan Jumlah Ikatan Rangkap

pada Temperatur Transisi Fosfolipida ...18 Tabel 4. Sudut Dihedral pada Fosfolipida ...22 Tabel 5. Analisis TLC pada Ekstrak Fosfolipida dari Kelapa,

Kemiri, dan Wijen, Sebagai Pembanding Adalah Fosfatidilkolin dari Kedelai serta Menggunakan

Senyawa Standar PC, PS, dan PE ...47 Tabel 6. Daerah Serapan Fosfolipida Alam ...51 Tabel 7. Data Massa/Muatan (m/z) dari Spektra Massa Ester

Asam Lemak dari Ekstrak Fosfolipida Kelapa ...54 Tabel 8. Data Massa/Muatan (m/z) dari Spektra Massa Ester

Asam Lemak dari Fosfolipida Kemiri ...58 Tabel 9. Data Massa/Muatan (m/z) dari Spektra Massa Ester

Asam Lemak dari Fosfolipida Wijen ...61 Tabel 10. Data Massa/Muatan (m/z) dari Spektra Massa Ester

Asam Lemak dari Fosfolipida Kedelai ...64 Tabel 11. Daftar Fosfolipida dan Asam Lemak dalam Ekstrak

Fosfolipida Kelapa ...65 Tabel 12. Daftar Fosfolipida dan Asam Lemak dalam Ekstrak

Fosfolipida Kemiri ...65 Tabel 13. Daftar Fosfolipida dan Asam Lemak dalam Ekstrak

Fosfolipida Wijen...66 Tabel 14. Daftar Fosfolipida dan Asam Lemak dalam Reagen

Fosfatidilkolin Kedelai ...66

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Fosfolipida: Biosurfaktan

by Dwi Hudiyanti

Submission date: 03-Dec-2019 10:58AM (UTC+0700) Submission ID: 1225702528

File name: C1_fosfolipida_buku_ISBN.pdf (3.75M) Word count: 17088

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Mahdi Jufri. "ARAH DAN PERKEMBANGAN LIPOSOME DRUGS DELIVERY SYSTEMS", Majalah Ilmu Kefarmasian, 2004

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Monica Kristiani, Septiana Laksmi Ramayani, Klara Yunita, Meilina Saputri. "Nanoemulsion Formulation And Activity Test Of Essential Oil Basil Leaves (Ocimum basilicum L.) Against Salmonella typhi", Jurnal Farmasi Indonesia, 2019

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DAFTAR ISI

DAFTAR TABEL

Fosfolipida: Biosurfaktan

by Dwi Hudiyanti

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Submitted to Universitas Brawijaya

id.scribd.com

Submitted to University of Auckland

repub.eur.nl

Mahdi Jufri. "ARAH DAN PERKEMBANGAN LIPOSOME DRUGS DELIVERY SYSTEMS", Majalah Ilmu Kefarmasian, 2004

Submitted to Sultan Agung Islamic University

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"Panduan cara pemberian skor dan analisis untuk menilai kesejahteraan manusia", Center for International Forestry Research (CIFOR), 2000

www.karger.com

thirdyear.mc.duke.edu

darchive.mblwhoilibrary.org

Monica Kristiani, Septiana Laksmi Ramayani, Klara Yunita, Meilina Saputri. "Nanoemulsion Formulation And Activity Test Of Essential Oil Basil Leaves (Ocimum basilicum L.) Against Salmonella typhi", Jurnal Farmasi Indonesia, 2019

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